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ADAP1 (ArfGAP with dual PH domains 1)

Identity

Alias_namesCENTA1
centaurin
Alias_symbol (synonym)GCS1L
Other aliasp42IP4
HGNC (Hugo) ADAP1
LocusID (NCBI) 11033
Atlas_Id 50453
Location 7p22.3  [Link to chromosome band 7p22]
Location_base_pair Starts at 897900 and ends at 955407 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ADAP1 (7p22.3) / ATN1 (12p13.31)ADAP1 (7p22.3) / NDUFAF6 (8q22.1)ADAP1 (7p22.3) / NOLC1 (10q24.32)
ADAP1 (7p22.3) / PRKAR1B (7p22.3)ADAP1 (7p22.3) / SUN1 (7p22.3)C7orf50 (7p22.3) / ADAP1 (7p22.3)
MIOS (7p21.3) / ADAP1 (7p22.3)TNRC18 (7p22.1) / ADAP1 (7p22.3)ADAP1 7p22.3 C8orf38
MIOS 7p21.3 / ADAP1 7p22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ADAP1   16486
Cards
Entrez_Gene (NCBI)ADAP1  11033  ArfGAP with dual PH domains 1
AliasesCENTA1; GCS1L; p42IP4
GeneCards (Weizmann)ADAP1
Ensembl hg19 (Hinxton)ENSG00000105963 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105963 [Gene_View]  chr7:897900-955407 [Contig_View]  ADAP1 [Vega]
ICGC DataPortalENSG00000105963
TCGA cBioPortalADAP1
AceView (NCBI)ADAP1
Genatlas (Paris)ADAP1
WikiGenes11033
SOURCE (Princeton)ADAP1
Genetics Home Reference (NIH)ADAP1
Genomic and cartography
GoldenPath hg38 (UCSC)ADAP1  -     chr7:897900-955407 -  7p22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADAP1  -     7p22.3   [Description]    (hg19-Feb_2009)
EnsemblADAP1 - 7p22.3 [CytoView hg19]  ADAP1 - 7p22.3 [CytoView hg38]
Mapping of homologs : NCBIADAP1 [Mapview hg19]  ADAP1 [Mapview hg38]
OMIM608114   
Gene and transcription
Genbank (Entrez)AB097049 AF082324 AI910700 AJ006422 AK092471
RefSeq transcript (Entrez)NM_001284308 NM_001284309 NM_001284310 NM_001284311 NM_006869
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ADAP1
Cluster EST : UnigeneHs.602573 [ NCBI ]
CGAP (NCI)Hs.602573
Alternative Splicing GalleryENSG00000105963
Gene ExpressionADAP1 [ NCBI-GEO ]   ADAP1 [ EBI - ARRAY_EXPRESS ]   ADAP1 [ SEEK ]   ADAP1 [ MEM ]
Gene Expression Viewer (FireBrowse)ADAP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11033
GTEX Portal (Tissue expression)ADAP1
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75689   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75689  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75689
Splice isoforms : SwissVarO75689
PhosPhoSitePlusO75689
Domaine pattern : Prosite (Expaxy)ARFGAP (PS50115)    PH_DOMAIN (PS50003)   
Domains : Interpro (EBI)ArfGAP    PH_dom-like    PH_domain   
Domain families : Pfam (Sanger)ArfGap (PF01412)    PH (PF00169)   
Domain families : Pfam (NCBI)pfam01412    pfam00169   
Domain families : Smart (EMBL)ArfGap (SM00105)  PH (SM00233)  
Conserved Domain (NCBI)ADAP1
DMDM Disease mutations11033
Blocks (Seattle)ADAP1
PDB (SRS)3FEH    3FM8    3LJU    3MDB   
PDB (PDBSum)3FEH    3FM8    3LJU    3MDB   
PDB (IMB)3FEH    3FM8    3LJU    3MDB   
PDB (RSDB)3FEH    3FM8    3LJU    3MDB   
Structural Biology KnowledgeBase3FEH    3FM8    3LJU    3MDB   
SCOP (Structural Classification of Proteins)3FEH    3FM8    3LJU    3MDB   
CATH (Classification of proteins structures)3FEH    3FM8    3LJU    3MDB   
SuperfamilyO75689
Human Protein AtlasENSG00000105963
Peptide AtlasO75689
HPRD09733
IPIIPI00009992   IPI00892713   IPI01011441   IPI00893823   IPI00941118   IPI00893970   IPI00893486   IPI00893187   IPI00894327   
Protein Interaction databases
DIP (DOE-UCLA)O75689
IntAct (EBI)O75689
FunCoupENSG00000105963
BioGRIDADAP1
STRING (EMBL)ADAP1
ZODIACADAP1
Ontologies - Pathways
QuickGOO75689
Ontology : AmiGOGTPase activator activity  protein binding  phosphatidylinositol-3,4,5-trisphosphate binding  nucleus  cytoplasm  cytosol  plasma membrane  cell surface receptor signaling pathway  regulation of GTPase activity  inositol 1,3,4,5 tetrakisphosphate binding  positive regulation of GTPase activity  metal ion binding  
Ontology : EGO-EBIGTPase activator activity  protein binding  phosphatidylinositol-3,4,5-trisphosphate binding  nucleus  cytoplasm  cytosol  plasma membrane  cell surface receptor signaling pathway  regulation of GTPase activity  inositol 1,3,4,5 tetrakisphosphate binding  positive regulation of GTPase activity  metal ion binding  
NDEx NetworkADAP1
Atlas of Cancer Signalling NetworkADAP1
Wikipedia pathwaysADAP1
Orthology - Evolution
OrthoDB11033
GeneTree (enSembl)ENSG00000105963
Phylogenetic Trees/Animal Genes : TreeFamADAP1
HOVERGENO75689
HOGENOMO75689
Homologs : HomoloGeneADAP1
Homology/Alignments : Family Browser (UCSC)ADAP1
Gene fusions - Rearrangements
Fusion : MitelmanADAP1/NDUFAF6 [7p22.3/8q22.1]  
Fusion : MitelmanMIOS/ADAP1 [7p21.3/7p22.3]  [t(7;7)(p21;p22)]  
Fusion: TCGAADAP1 7p22.3 C8orf38 BRCA
Fusion: TCGAMIOS 7p21.3 ADAP1 7p22.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADAP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADAP1
dbVarADAP1
ClinVarADAP1
1000_GenomesADAP1 
Exome Variant ServerADAP1
ExAC (Exome Aggregation Consortium)ADAP1 (select the gene name)
Genetic variants : HAPMAP11033
Genomic Variants (DGV)ADAP1 [DGVbeta]
DECIPHERADAP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADAP1 
Mutations
ICGC Data PortalADAP1 
TCGA Data PortalADAP1 
Broad Tumor PortalADAP1
OASIS PortalADAP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADAP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADAP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ADAP1
DgiDB (Drug Gene Interaction Database)ADAP1
DoCM (Curated mutations)ADAP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADAP1 (select a term)
intoGenADAP1
Cancer3DADAP1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608114   
Orphanet
MedgenADAP1
Genetic Testing Registry ADAP1
NextProtO75689 [Medical]
TSGene11033
GENETestsADAP1
Target ValidationADAP1
Huge Navigator ADAP1 [HugePedia]
snp3D : Map Gene to Disease11033
BioCentury BCIQADAP1
ClinGenADAP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11033
Chemical/Pharm GKB GenePA26404
Clinical trialADAP1
Miscellaneous
canSAR (ICR)ADAP1 (select the gene name)
Probes
Litterature
PubMed37 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADAP1
EVEXADAP1
GoPubMedADAP1
iHOPADAP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:22:49 CEST 2017

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