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ADAP1 (ArfGAP with dual PH domains 1)

Identity

Alias (NCBI)CENTA1
GCS1L
p42IP4
HGNC (Hugo) ADAP1
HGNC Alias symbGCS1L
HGNC Previous nameCENTA1
HGNC Previous namecentaurin, alpha 1
LocusID (NCBI) 11033
Atlas_Id 50453
Location 7p22.3  [Link to chromosome band 7p22]
Location_base_pair Starts at 897900 and ends at 954680 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADAP1 (7p22.3) / ATN1 (12p13.31)ADAP1 (7p22.3) / NDUFAF6 (8q22.1)ADAP1 (7p22.3) / NOLC1 (10q24.32)
ADAP1 (7p22.3) / PRKAR1B (7p22.3)ADAP1 (7p22.3) / SUN1 (7p22.3)C7orf50 (7p22.3) / ADAP1 (7p22.3)
MIOS (7p21.3) / ADAP1 (7p22.3)TNRC18 (7p22.1) / ADAP1 (7p22.3)ADAP1 7p22.3 C8orf38
MIOS 7p21.3 / ADAP1 7p22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)ADAP1   16486
Cards
Entrez_Gene (NCBI)ADAP1    ArfGAP with dual PH domains 1
AliasesCENTA1; GCS1L; p42IP4
GeneCards (Weizmann)ADAP1
Ensembl hg19 (Hinxton)ENSG00000105963 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105963 [Gene_View]  ENSG00000105963 [Sequence]  chr7:897900-954680 [Contig_View]  ADAP1 [Vega]
ICGC DataPortalENSG00000105963
TCGA cBioPortalADAP1
AceView (NCBI)ADAP1
Genatlas (Paris)ADAP1
SOURCE (Princeton)ADAP1
Genetics Home Reference (NIH)ADAP1
Genomic and cartography
GoldenPath hg38 (UCSC)ADAP1  -     chr7:897900-954680 -  7p22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADAP1  -     7p22.3   [Description]    (hg19-Feb_2009)
GoldenPathADAP1 - 7p22.3 [CytoView hg19]  ADAP1 - 7p22.3 [CytoView hg38]
ImmunoBaseENSG00000105963
Genome Data Viewer NCBIADAP1 [Mapview hg19]  
OMIM608114   
Gene and transcription
Genbank (Entrez)AB097049 AF082324 AI910700 AJ006422 AK092471
RefSeq transcript (Entrez)NM_001284308 NM_001284309 NM_001284310 NM_001284311 NM_006869
Consensus coding sequences : CCDS (NCBI)ADAP1
Gene ExpressionADAP1 [ NCBI-GEO ]   ADAP1 [ EBI - ARRAY_EXPRESS ]   ADAP1 [ SEEK ]   ADAP1 [ MEM ]
Gene Expression Viewer (FireBrowse)ADAP1 [ Firebrowse - Broad ]
GenevisibleExpression of ADAP1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11033
GTEX Portal (Tissue expression)ADAP1
Human Protein AtlasENSG00000105963-ADAP1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75689   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75689  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75689
PhosPhoSitePlusO75689
Domaine pattern : Prosite (Expaxy)ARFGAP (PS50115)    PH_DOMAIN (PS50003)   
Domains : Interpro (EBI)ARFGAP/RecO    ArfGAP_dom    ArfGAP_dom_sf    PH-like_dom_sf    PH1_ADAP    PH2_ADAP    PH_domain   
Domain families : Pfam (Sanger)ArfGap (PF01412)    PH (PF00169)   
Domain families : Pfam (NCBI)pfam01412    pfam00169   
Domain families : Smart (EMBL)ArfGap (SM00105)  PH (SM00233)  
Conserved Domain (NCBI)ADAP1
PDB (RSDB)3FEH    3FM8    3LJU    3MDB   
PDB Europe3FEH    3FM8    3LJU    3MDB   
PDB (PDBSum)3FEH    3FM8    3LJU    3MDB   
PDB (IMB)3FEH    3FM8    3LJU    3MDB   
Structural Biology KnowledgeBase3FEH    3FM8    3LJU    3MDB   
SCOP (Structural Classification of Proteins)3FEH    3FM8    3LJU    3MDB   
CATH (Classification of proteins structures)3FEH    3FM8    3LJU    3MDB   
SuperfamilyO75689
AlphaFold pdb e-kbO75689   
Human Protein Atlas [tissue]ENSG00000105963-ADAP1 [tissue]
HPRD09733
Protein Interaction databases
DIP (DOE-UCLA)O75689
IntAct (EBI)O75689
BioGRIDADAP1
STRING (EMBL)ADAP1
ZODIACADAP1
Ontologies - Pathways
QuickGOO75689
Ontology : AmiGOGTPase activator activity  protein binding  phosphatidylinositol-3,4,5-trisphosphate binding  nucleus  cytoplasm  cytosol  cytosol  plasma membrane  plasma membrane  cell surface receptor signaling pathway  regulation of GTPase activity  intracellular membrane-bounded organelle  inositol 1,3,4,5 tetrakisphosphate binding  positive regulation of GTPase activity  metal ion binding  phosphatidylinositol bisphosphate binding  
Ontology : EGO-EBIGTPase activator activity  protein binding  phosphatidylinositol-3,4,5-trisphosphate binding  nucleus  cytoplasm  cytosol  cytosol  plasma membrane  plasma membrane  cell surface receptor signaling pathway  regulation of GTPase activity  intracellular membrane-bounded organelle  inositol 1,3,4,5 tetrakisphosphate binding  positive regulation of GTPase activity  metal ion binding  phosphatidylinositol bisphosphate binding  
NDEx NetworkADAP1
Atlas of Cancer Signalling NetworkADAP1
Wikipedia pathwaysADAP1
Orthology - Evolution
OrthoDB11033
GeneTree (enSembl)ENSG00000105963
Phylogenetic Trees/Animal Genes : TreeFamADAP1
Homologs : HomoloGeneADAP1
Homology/Alignments : Family Browser (UCSC)ADAP1
Gene fusions - Rearrangements
Fusion : MitelmanADAP1/NDUFAF6 [7p22.3/8q22.1]  
Fusion : MitelmanMIOS/ADAP1 [7p21.3/7p22.3]  
Fusion : QuiverADAP1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADAP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADAP1
dbVarADAP1
ClinVarADAP1
MonarchADAP1
1000_GenomesADAP1 
Exome Variant ServerADAP1
GNOMAD BrowserENSG00000105963
Varsome BrowserADAP1
ACMGADAP1 variants
VarityO75689
Genomic Variants (DGV)ADAP1 [DGVbeta]
DECIPHERADAP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADAP1 
Mutations
ICGC Data PortalADAP1 
TCGA Data PortalADAP1 
Broad Tumor PortalADAP1
OASIS PortalADAP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADAP1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DADAP1
Mutations and Diseases : HGMDADAP1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaADAP1
DgiDB (Drug Gene Interaction Database)ADAP1
DoCM (Curated mutations)ADAP1
CIViC (Clinical Interpretations of Variants in Cancer)ADAP1
Cancer3DADAP1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608114   
Orphanet
DisGeNETADAP1
MedgenADAP1
Genetic Testing Registry ADAP1
NextProtO75689 [Medical]
GENETestsADAP1
Target ValidationADAP1
Huge Navigator ADAP1 [HugePedia]
ClinGenADAP1
Clinical trials, drugs, therapy
MyCancerGenomeADAP1
Protein Interactions : CTDADAP1
Pharm GKB GenePA26404
PharosO75689
Clinical trialADAP1
Miscellaneous
canSAR (ICR)ADAP1
HarmonizomeADAP1
DataMed IndexADAP1
Probes
Litterature
PubMed43 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXADAP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 14:58:30 CEST 2021

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