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ADAP2 (ArfGAP with dual PH domains 2)

Identity

Alias_namesCENTA2
centaurin, alpha 2
Other aliasHSA272195
cent-b
HGNC (Hugo) ADAP2
LocusID (NCBI) 55803
Atlas_Id 60148
Location 17q11.2  [Link to chromosome band 17q11]
Location_base_pair Starts at 30921736 and ends at 30959193 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADAP2 (17q11.2) / ADAP2 (17q11.2)ADAP2 (17q11.2) / GSTZ1 (14q24.3)ADAP2 (17q11.2) / RNF135 (17q11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ADAP2   16487
Cards
Entrez_Gene (NCBI)ADAP2  55803  ArfGAP with dual PH domains 2
AliasesCENTA2; HSA272195; cent-b
GeneCards (Weizmann)ADAP2
Ensembl hg19 (Hinxton)ENSG00000184060 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000184060 [Gene_View]  chr17:30921736-30959193 [Contig_View]  ADAP2 [Vega]
ICGC DataPortalENSG00000184060
TCGA cBioPortalADAP2
AceView (NCBI)ADAP2
Genatlas (Paris)ADAP2
WikiGenes55803
SOURCE (Princeton)ADAP2
Genetics Home Reference (NIH)ADAP2
Genomic and cartography
GoldenPath hg38 (UCSC)ADAP2  -     chr17:30921736-30959193 +  17q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADAP2  -     17q11.2   [Description]    (hg19-Feb_2009)
EnsemblADAP2 - 17q11.2 [CytoView hg19]  ADAP2 - 17q11.2 [CytoView hg38]
Mapping of homologs : NCBIADAP2 [Mapview hg19]  ADAP2 [Mapview hg38]
OMIM608635   
Gene and transcription
Genbank (Entrez)AJ238994 AJ242782 AJ272195 AK074196 AK074204
RefSeq transcript (Entrez)NM_001346712 NM_001346714 NM_001346716 NM_018404
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ADAP2
Cluster EST : UnigeneHs.514063 [ NCBI ]
CGAP (NCI)Hs.514063
Alternative Splicing GalleryENSG00000184060
Gene ExpressionADAP2 [ NCBI-GEO ]   ADAP2 [ EBI - ARRAY_EXPRESS ]   ADAP2 [ SEEK ]   ADAP2 [ MEM ]
Gene Expression Viewer (FireBrowse)ADAP2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55803
GTEX Portal (Tissue expression)ADAP2
Human Protein AtlasENSG00000184060-ADAP2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NPF8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NPF8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NPF8
Splice isoforms : SwissVarQ9NPF8
PhosPhoSitePlusQ9NPF8
Domaine pattern : Prosite (Expaxy)ARFGAP (PS50115)    PH_DOMAIN (PS50003)   
Domains : Interpro (EBI)ArfGAP    PH_dom-like    PH_domain   
Domain families : Pfam (Sanger)ArfGap (PF01412)    PH (PF00169)   
Domain families : Pfam (NCBI)pfam01412    pfam00169   
Domain families : Smart (EMBL)ArfGap (SM00105)  PH (SM00233)  
Conserved Domain (NCBI)ADAP2
DMDM Disease mutations55803
Blocks (Seattle)ADAP2
SuperfamilyQ9NPF8
Human Protein Atlas [tissue]ENSG00000184060-ADAP2 [tissue]
Peptide AtlasQ9NPF8
HPRD16357
IPIIPI00456640   IPI00020090   
Protein Interaction databases
DIP (DOE-UCLA)Q9NPF8
IntAct (EBI)Q9NPF8
FunCoupENSG00000184060
BioGRIDADAP2
STRING (EMBL)ADAP2
ZODIACADAP2
Ontologies - Pathways
QuickGOQ9NPF8
Ontology : AmiGOGTPase activator activity  protein binding  phosphatidylinositol-4,5-bisphosphate binding  phosphatidylinositol-3,4,5-trisphosphate binding  cytoplasm  mitochondrial envelope  plasma membrane  heart development  protein binding, bridging  phosphatidylinositol-3,4-bisphosphate binding  inositol 1,3,4,5 tetrakisphosphate binding  positive regulation of GTPase activity  metal ion binding  
Ontology : EGO-EBIGTPase activator activity  protein binding  phosphatidylinositol-4,5-bisphosphate binding  phosphatidylinositol-3,4,5-trisphosphate binding  cytoplasm  mitochondrial envelope  plasma membrane  heart development  protein binding, bridging  phosphatidylinositol-3,4-bisphosphate binding  inositol 1,3,4,5 tetrakisphosphate binding  positive regulation of GTPase activity  metal ion binding  
NDEx NetworkADAP2
Atlas of Cancer Signalling NetworkADAP2
Wikipedia pathwaysADAP2
Orthology - Evolution
OrthoDB55803
GeneTree (enSembl)ENSG00000184060
Phylogenetic Trees/Animal Genes : TreeFamADAP2
HOVERGENQ9NPF8
HOGENOMQ9NPF8
Homologs : HomoloGeneADAP2
Homology/Alignments : Family Browser (UCSC)ADAP2
Gene fusions - Rearrangements
Fusion: Tumor Portal ADAP2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADAP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADAP2
dbVarADAP2
ClinVarADAP2
1000_GenomesADAP2 
Exome Variant ServerADAP2
ExAC (Exome Aggregation Consortium)ENSG00000184060
GNOMAD BrowserENSG00000184060
Genetic variants : HAPMAP55803
Genomic Variants (DGV)ADAP2 [DGVbeta]
DECIPHERADAP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADAP2 
Mutations
ICGC Data PortalADAP2 
TCGA Data PortalADAP2 
Broad Tumor PortalADAP2
OASIS PortalADAP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADAP2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADAP2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ADAP2
DgiDB (Drug Gene Interaction Database)ADAP2
DoCM (Curated mutations)ADAP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADAP2 (select a term)
intoGenADAP2
Cancer3DADAP2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608635   
Orphanet
MedgenADAP2
Genetic Testing Registry ADAP2
NextProtQ9NPF8 [Medical]
TSGene55803
GENETestsADAP2
Target ValidationADAP2
Huge Navigator ADAP2 [HugePedia]
snp3D : Map Gene to Disease55803
BioCentury BCIQADAP2
ClinGenADAP2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55803
Chemical/Pharm GKB GenePA26405
Clinical trialADAP2
Miscellaneous
canSAR (ICR)ADAP2 (select the gene name)
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADAP2
EVEXADAP2
GoPubMedADAP2
iHOPADAP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Nov 9 11:37:06 CET 2017

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