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ADAR (adenosine deaminase, RNA-specific)

Identity

Other namesADAR1
AGS6
DRADA
DSH
DSRAD
G1P1
IFI-4
IFI4
K88DSRBP
P136
HGNC (Hugo) ADAR
LocusID (NCBI) 103
Location 1q21.3
Location_base_pair Starts at 154554534 and ends at 154600456 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

External links

Nomenclature
HGNC (Hugo)ADAR   225
Cards
Entrez_Gene (NCBI)ADAR  103  adenosine deaminase, RNA-specific
GeneCards (Weizmann)ADAR
Ensembl (Hinxton)ENSG00000160710 [Gene_View]  chr1:154554534-154600456 [Contig_View]  ADAR [Vega]
AceView (NCBI)ADAR
Genatlas (Paris)ADAR
WikiGenes103
SOURCE (Princeton)NM_001025107 NM_001111 NM_001193495 NM_015840 NM_015841
Genomic and cartography
GoldenPath (UCSC)ADAR  -  1q21.3   chr1:154554534-154600456 -  1q21.3   [Description]    (hg19-Feb_2009)
EnsemblADAR - 1q21.3 [CytoView]
Mapping of homologs : NCBIADAR [Mapview]
OMIM127400   146920   615010   
Gene and transcription
Genbank (Entrez)AA449679 AB209891 AF084516 AK097241 AK304153
RefSeq transcript (Entrez)NM_001025107 NM_001111 NM_001193495 NM_015840 NM_015841
RefSeq genomic (Entrez)AC_000133 NC_000001 NC_018912 NG_011844 NT_004487 NW_001838529 NW_004929293
Consensus coding sequences : CCDS (NCBI)ADAR
Cluster EST : UnigeneHs.12341 [ NCBI ]
CGAP (NCI)Hs.12341
Alternative Splicing : Fast-db (Paris)GSHG0002567
Alternative Splicing GalleryENSG00000160710
Gene ExpressionADAR [ NCBI-GEO ]     ADAR [ SEEK ]   ADAR [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP55265 (Uniprot)
NextProtP55265  [Medical]
With graphics : InterProP55265
Splice isoforms : SwissVarP55265 (Swissvar)
Catalytic activity : Enzyme3.5.4.37 [ Enzyme-Expasy ]   3.5.4.373.5.4.37 [ IntEnz-EBI ]   3.5.4.37 [ BRENDA ]   3.5.4.37 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)A_DEAMIN_EDITASE (PS50141)    DRADA_REPEAT (PS50139)    DS_RBD (PS50137)   
Domains : Interpro (EBI)A_deamin    dsRNA-bd_dom    dsRNA_A_deaminase    WHTH_DNA-bd_dom   
Related proteins : CluSTrP55265
Domain families : Pfam (Sanger)A_deamin (PF02137)    dsrm (PF00035)    z-alpha (PF02295)   
Domain families : Pfam (NCBI)pfam02137    pfam00035    pfam02295   
Domain families : Smart (EMBL)ADEAMc (SM00552)  DSRM (SM00358)  Zalpha (SM00550)  
DMDM Disease mutations103
Blocks (Seattle)P55265
PDB (SRS)1QBJ    1QGP    1XMK    2ACJ    2GXB    2L54    3F21    3F22    3F23    3IRQ    3IRR   
PDB (PDBSum)1QBJ    1QGP    1XMK    2ACJ    2GXB    2L54    3F21    3F22    3F23    3IRQ    3IRR   
PDB (IMB)1QBJ    1QGP    1XMK    2ACJ    2GXB    2L54    3F21    3F22    3F23    3IRQ    3IRR   
PDB (RSDB)1QBJ    1QGP    1XMK    2ACJ    2GXB    2L54    3F21    3F22    3F23    3IRQ    3IRR   
Human Protein AtlasENSG00000160710
Peptide AtlasP55265
HPRD07528
IPIIPI00394665   IPI00025057   IPI00025058   IPI00394668   IPI00760588   IPI00978400   
Protein Interaction databases
DIP (DOE-UCLA)P55265
IntAct (EBI)P55265
FunCoupENSG00000160710
BioGRIDADAR
InParanoidP55265
Interologous Interaction database P55265
IntegromeDBADAR
STRING (EMBL)ADAR
Ontologies - Pathways
Ontology : AmiGODNA binding  RNA binding  double-stranded RNA adenosine deaminase activity  double-stranded RNA adenosine deaminase activity  protein binding  nucleus  nucleus  nucleoplasm  nucleolus  cytoplasm  cytoplasm  adenosine to inosine editing  adenosine to inosine editing  adenosine to inosine editing  mRNA processing  protein import into nucleus  protein export from nucleus  response to virus  gene expression  base conversion or substitution editing  mRNA modification  cytokine-mediated signaling pathway  gene silencing by RNA  response to interferon-alpha  negative regulation of apoptotic process  negative regulation of protein kinase activity by regulation of protein phosphorylation  negative regulation of protein kinase activity by regulation of protein phosphorylation  supraspliceosomal complex  positive regulation of viral genome replication  positive regulation of viral genome replication  innate immune response  metal ion binding  defense response to virus  type I interferon signaling pathway  
Ontology : EGO-EBIDNA binding  RNA binding  double-stranded RNA adenosine deaminase activity  double-stranded RNA adenosine deaminase activity  protein binding  nucleus  nucleus  nucleoplasm  nucleolus  cytoplasm  cytoplasm  adenosine to inosine editing  adenosine to inosine editing  adenosine to inosine editing  mRNA processing  protein import into nucleus  protein export from nucleus  response to virus  gene expression  base conversion or substitution editing  mRNA modification  cytokine-mediated signaling pathway  gene silencing by RNA  response to interferon-alpha  negative regulation of apoptotic process  negative regulation of protein kinase activity by regulation of protein phosphorylation  negative regulation of protein kinase activity by regulation of protein phosphorylation  supraspliceosomal complex  positive regulation of viral genome replication  positive regulation of viral genome replication  innate immune response  metal ion binding  defense response to virus  type I interferon signaling pathway  
Pathways : BIOCARTARNA polymerase III transcription [Genes]   
Pathways : KEGGCytosolic DNA-sensing pathway    Measles    Influenza A   
REACTOMEADAR
Protein Interaction DatabaseADAR
Wikipedia pathwaysADAR
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)ADAR
SNP (GeneSNP Utah)ADAR
SNP : HGBaseADAR
Genetic variants : HAPMAPADAR
1000_GenomesADAR 
ICGC programENSG00000160710 
Somatic Mutations in Cancer : COSMICADAR 
CONAN: Copy Number AnalysisADAR 
Mutations and Diseases : HGMDADAR
OMIM127400    146920    615010   
GENETestsADAR
Disease Genetic AssociationADAR
Huge Navigator ADAR [HugePedia]  ADAR [HugeCancerGEM]
Genomic VariantsADAR  ADAR [DGVbeta]
Exome VariantADAR
dbVarADAR
ClinVarADAR
snp3D : Map Gene to Disease103
General knowledge
Homologs : HomoloGeneADAR
Homology/Alignments : Family Browser (UCSC)ADAR
Phylogenetic Trees/Animal Genes : TreeFamADAR
Chemical/Protein Interactions : CTD103
Chemical/Pharm GKB GenePA24555
Clinical trialADAR
Cancer Resource (Charite)ENSG00000160710
Other databases
Probes
Litterature
PubMed152 Pubmed reference(s) in Entrez
CoreMineADAR
iHOPADAR
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Mar 31 09:18:05 CEST 2014

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