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ADAR (adenosine deaminase, RNA-specific)

Identity

Other namesADAR1
AGS6
DRADA
DSH
DSRAD
G1P1
IFI-4
IFI4
K88DSRBP
P136
HGNC (Hugo) ADAR
LocusID (NCBI) 103
Atlas_Id 52214
Location 1q21.3
Location_base_pair Starts at 154554534 and ends at 154600456 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ADAR (1q21.3) / ADAR (1q21.3)ADAR (1q21.3) / GPATCH4 (1q23.1)ADAR (1q21.3) / PLS3 (Xq23)
CASP2 (7q34) / ADAR (1q21.3)EIF5A (17p13.1) / ADAR (1q21.3)FTL (19q13.33) / ADAR (1q21.3)
PSG6 (19q13.31) / ADAR (1q21.3)SDCBP2 (20p13) / ADAR (1q21.3)SNX27 (1q21.3) / ADAR (1q21.3)
SYNRG (17q12) / ADAR (1q21.3)ADAR 1q21.3 / GPATCH4 1q23.1SNX27 1q21.3 / ADAR 1q21.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ADAR   225
Cards
Entrez_Gene (NCBI)ADAR  103  adenosine deaminase, RNA-specific
GeneCards (Weizmann)ADAR
Ensembl hg19 (Hinxton)ENSG00000160710 [Gene_View]  chr1:154554534-154600456 [Contig_View]  ADAR [Vega]
Ensembl hg38 (Hinxton)ENSG00000160710 [Gene_View]  chr1:154554534-154600456 [Contig_View]  ADAR [Vega]
ICGC DataPortalENSG00000160710
TCGA cBioPortalADAR
AceView (NCBI)ADAR
Genatlas (Paris)ADAR
WikiGenes103
SOURCE (Princeton)ADAR
Genomic and cartography
GoldenPath hg19 (UCSC)ADAR  -     chr1:154554534-154600456 -  1q21.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ADAR  -     1q21.3   [Description]    (hg38-Dec_2013)
EnsemblADAR - 1q21.3 [CytoView hg19]  ADAR - 1q21.3 [CytoView hg38]
Mapping of homologs : NCBIADAR [Mapview hg19]  ADAR [Mapview hg38]
OMIM127400   146920   615010   
Gene and transcription
Genbank (Entrez)AA449679 AB209891 AF084516 AK097241 AK304153
RefSeq transcript (Entrez)NM_001025107 NM_001111 NM_001193495 NM_015840 NM_015841
RefSeq genomic (Entrez)NC_000001 NC_018912 NG_011844 NT_004487 NW_004929293
Consensus coding sequences : CCDS (NCBI)ADAR
Cluster EST : UnigeneHs.12341 [ NCBI ]
CGAP (NCI)Hs.12341
Alternative Splicing GalleryENSG00000160710
Gene ExpressionADAR [ NCBI-GEO ]   ADAR [ EBI - ARRAY_EXPRESS ]   ADAR [ SEEK ]   ADAR [ MEM ]
Gene Expression Viewer (FireBrowse)ADAR [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)103
GTEX Portal (Tissue expression)ADAR
Protein : pattern, domain, 3D structure
UniProt/SwissProtP55265 (Uniprot)
NextProtP55265  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP55265
Splice isoforms : SwissVarP55265 (Swissvar)
Catalytic activity : Enzyme3.5.4.37 [ Enzyme-Expasy ]   3.5.4.373.5.4.37 [ IntEnz-EBI ]   3.5.4.37 [ BRENDA ]   3.5.4.37 [ KEGG ]   
PhosPhoSitePlusP55265
Domaine pattern : Prosite (Expaxy)A_DEAMIN_EDITASE (PS50141)    DRADA_REPEAT (PS50139)    DS_RBD (PS50137)   
Domains : Interpro (EBI)A_deamin    dsRBD_dom    dsRNA_A_deaminase    WHTH_DNA-bd_dom   
Domain families : Pfam (Sanger)A_deamin (PF02137)    dsrm (PF00035)    z-alpha (PF02295)   
Domain families : Pfam (NCBI)pfam02137    pfam00035    pfam02295   
Domain families : Smart (EMBL)ADEAMc (SM00552)  DSRM (SM00358)  Zalpha (SM00550)  
DMDM Disease mutations103
Blocks (Seattle)ADAR
PDB (SRS)1QBJ    1QGP    1XMK    2ACJ    2GXB    2L54    2MDR    3F21    3F22    3F23    3IRQ    3IRR   
PDB (PDBSum)1QBJ    1QGP    1XMK    2ACJ    2GXB    2L54    2MDR    3F21    3F22    3F23    3IRQ    3IRR   
PDB (IMB)1QBJ    1QGP    1XMK    2ACJ    2GXB    2L54    2MDR    3F21    3F22    3F23    3IRQ    3IRR   
PDB (RSDB)1QBJ    1QGP    1XMK    2ACJ    2GXB    2L54    2MDR    3F21    3F22    3F23    3IRQ    3IRR   
Structural Biology KnowledgeBase1QBJ    1QGP    1XMK    2ACJ    2GXB    2L54    2MDR    3F21    3F22    3F23    3IRQ    3IRR   
SCOP (Structural Classification of Proteins)1QBJ    1QGP    1XMK    2ACJ    2GXB    2L54    2MDR    3F21    3F22    3F23    3IRQ    3IRR   
CATH (Classification of proteins structures)1QBJ    1QGP    1XMK    2ACJ    2GXB    2L54    2MDR    3F21    3F22    3F23    3IRQ    3IRR   
SuperfamilyP55265
Human Protein AtlasENSG00000160710
Peptide AtlasP55265
HPRD07528
IPIIPI00394665   IPI00025057   IPI00025058   IPI00394668   IPI00760588   IPI00978400   
Protein Interaction databases
DIP (DOE-UCLA)P55265
IntAct (EBI)P55265
FunCoupENSG00000160710
BioGRIDADAR
STRING (EMBL)ADAR
ZODIACADAR
Ontologies - Pathways
QuickGOP55265
Ontology : AmiGOosteoblast differentiation  in utero embryonic development  hematopoietic progenitor cell differentiation  somatic diversification of immune receptors via somatic mutation  DNA binding  double-stranded RNA adenosine deaminase activity  double-stranded RNA adenosine deaminase activity  double-stranded RNA adenosine deaminase activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  nucleolus  cytoplasm  cytoplasm  adenosine to inosine editing  adenosine to inosine editing  adenosine to inosine editing  mRNA processing  protein import into nucleus  protein export from nucleus  response to virus  membrane  base conversion or substitution editing  erythrocyte differentiation  pre-miRNA processing  miRNA loading onto RISC involved in gene silencing by miRNA  response to interferon-alpha  negative regulation of apoptotic process  negative regulation of protein kinase activity by regulation of protein phosphorylation  negative regulation of protein kinase activity by regulation of protein phosphorylation  supraspliceosomal complex  poly(A) RNA binding  positive regulation of viral genome replication  positive regulation of viral genome replication  negative regulation of viral genome replication  innate immune response  metal ion binding  defense response to virus  definitive hemopoiesis  type I interferon signaling pathway  negative regulation of type I interferon-mediated signaling pathway  hematopoietic stem cell homeostasis  cellular response to virus  negative regulation of RNA interference  
Ontology : EGO-EBIosteoblast differentiation  in utero embryonic development  hematopoietic progenitor cell differentiation  somatic diversification of immune receptors via somatic mutation  DNA binding  double-stranded RNA adenosine deaminase activity  double-stranded RNA adenosine deaminase activity  double-stranded RNA adenosine deaminase activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  nucleolus  cytoplasm  cytoplasm  adenosine to inosine editing  adenosine to inosine editing  adenosine to inosine editing  mRNA processing  protein import into nucleus  protein export from nucleus  response to virus  membrane  base conversion or substitution editing  erythrocyte differentiation  pre-miRNA processing  miRNA loading onto RISC involved in gene silencing by miRNA  response to interferon-alpha  negative regulation of apoptotic process  negative regulation of protein kinase activity by regulation of protein phosphorylation  negative regulation of protein kinase activity by regulation of protein phosphorylation  supraspliceosomal complex  poly(A) RNA binding  positive regulation of viral genome replication  positive regulation of viral genome replication  negative regulation of viral genome replication  innate immune response  metal ion binding  defense response to virus  definitive hemopoiesis  type I interferon signaling pathway  negative regulation of type I interferon-mediated signaling pathway  hematopoietic stem cell homeostasis  cellular response to virus  negative regulation of RNA interference  
Pathways : BIOCARTARNA polymerase III transcription [Genes]   
Pathways : KEGGCytosolic DNA-sensing pathway    Measles    Influenza A   
NDEx Network
Atlas of Cancer Signalling NetworkADAR
Wikipedia pathwaysADAR
Orthology - Evolution
OrthoDB103
GeneTree (enSembl)ENSG00000160710
Phylogenetic Trees/Animal Genes : TreeFamADAR
Homologs : HomoloGeneADAR
Homology/Alignments : Family Browser (UCSC)ADAR
Gene fusions - Rearrangements
Fusion: TCGAADAR 1q21.3 GPATCH4 1q23.1 LUAD
Fusion: TCGASNX27 1q21.3 ADAR 1q21.3 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerADAR [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADAR
dbVarADAR
ClinVarADAR
1000_GenomesADAR 
Exome Variant ServerADAR
ExAC (Exome Aggregation Consortium)ADAR (select the gene name)
Genetic variants : HAPMAP103
Genomic Variants (DGV)ADAR [DGVbeta]
Mutations
ICGC Data PortalADAR 
TCGA Data PortalADAR 
Broad Tumor PortalADAR
OASIS PortalADAR [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADAR 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)Pharmacogenomics of Infectious Diseases (PGx_IfD )
BioMutasearch ADAR
DgiDB (Drug Gene Interaction Database)ADAR
DoCM (Curated mutations)ADAR (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADAR (select a term)
intoGenADAR
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)1:154554534-154600456  ENSG00000160710
CONAN: Copy Number AnalysisADAR 
Mutations and Diseases : HGMDADAR
OMIM127400    146920    615010   
MedgenADAR
Genetic Testing Registry ADAR
NextProtP55265 [Medical]
TSGene103
GENETestsADAR
Huge Navigator ADAR [HugePedia]
snp3D : Map Gene to Disease103
BioCentury BCIQADAR
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD103
Chemical/Pharm GKB GenePA24555
Clinical trialADAR
Miscellaneous
canSAR (ICR)ADAR (select the gene name)
Probes
Litterature
PubMed207 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADAR
EVEXADAR
GoPubMedADAR
iHOPADAR
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sun May 8 18:36:03 CEST 2016

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