ADAR (adenosine deaminase RNA specific)

2011-05-01  

Identity

HGNC
LOCATION
1q21.3
LOCUSID
ALIAS
ADAR1,AGS6,DRADA,DSH,DSRAD,G1P1,IFI-4,IFI4,K88DSRBP,P136
FUSION GENES

Other Information

Locus ID:

NCBI: 103
MIM: 146920
HGNC: 225
Ensembl: ENSG00000160710

Variants:

dbSNP: 103
ClinVar: 103
TCGA: ENSG00000160710
COSMIC: ADAR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160710ENST00000368471P55265
ENSG00000160710ENST00000368474P55265
ENSG00000160710ENST00000529168P55265
ENSG00000160710ENST00000648231P55265
ENSG00000160710ENST00000648311P55265
ENSG00000160710ENST00000648714A0A3B3ISX1
ENSG00000160710ENST00000648871A0A3B3ITG9
ENSG00000160710ENST00000649022A0A3B3IRQ9
ENSG00000160710ENST00000649042P55265
ENSG00000160710ENST00000649408A0A3B3ISU1
ENSG00000160710ENST00000649724P55265
ENSG00000160710ENST00000649749P55265

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Cytosolic DNA-sensing pathwayKEGGko04623
Cytosolic DNA-sensing pathwayKEGGhsa04623
MeaslesKEGGko05162
MeaslesKEGGhsa05162
Influenza AKEGGko05164
Influenza AKEGGhsa05164
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon alpha/beta signalingREACTOMER-HSA-909733
Gene ExpressionREACTOMER-HSA-74160
mRNA EditingREACTOMER-HSA-75072
mRNA Editing: A to I ConversionREACTOMER-HSA-75064
Formation of editosomes by ADAR proteinsREACTOMER-HSA-77042
C6 deamination of adenosineREACTOMER-HSA-75102

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
230011232012Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature.224
254561372014The RNA-editing enzyme ADAR1 controls innate immune responses to RNA.145
215872362011Predicting sites of ADAR editing in double-stranded RNA.115
197139322009Editing independent effects of ADARs on the miRNA/siRNA pathways.81
181785532008Down-regulation of RNA editing in pediatric astrocytomas: ADAR2 editing activity inhibits cell migration and proliferation.75
241836642013ADAR regulates RNA editing, transcript stability, and gene expression.68
237664402014A disrupted RNA editing balance mediated by ADARs (Adenosine DeAminases that act on RNA) in human hepatocellular carcinoma.64
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
197100212009RNA-specific adenosine deaminase ADAR1 suppresses measles virus-induced apoptosis and activation of protein kinase PKR.61
237281762013MicroRNA-mediated loss of ADAR1 in metastatic melanoma promotes tumor growth.59

Citation

Dessen P

ADAR (adenosine deaminase RNA specific)

Atlas Genet Cytogenet Oncol Haematol. 2011-05-01

Online version: http://atlasgeneticsoncology.org/gene/52214/adar