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ADAR (adenosine deaminase RNA specific)

Identity

Alias (NCBI)ADAR1
AGS6
DRADA
DSH
DSRAD
G1P1
IFI-4
IFI4
K88DSRBP
P136
HGNC (Hugo) ADAR
HGNC Alias symbADAR1
HGNC Previous nameIFI4
 G1P1
HGNC Previous nameinterferon-induced protein 4
LocusID (NCBI) 103
Atlas_Id 52214
Location 1q21.3  [Link to chromosome band 1q21]
Location_base_pair Starts at 154582058 and ends at 154608186 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADAR (1q21.3) / ADAR (1q21.3)ADAR (1q21.3) / GPATCH4 (1q23.1)ADAR (1q21.3) / PLS3 (Xq23)
CASP2 (7q34) / ADAR (1q21.3)EIF5A (17p13.1) / ADAR (1q21.3)FTL (19q13.33) / ADAR (1q21.3)
PSG6 (19q13.31) / ADAR (1q21.3)SDCBP2 (20p13) / ADAR (1q21.3)SNX27 (1q21.3) / ADAR (1q21.3)
SYNRG (17q12) / ADAR (1q21.3)ADAR 1q21.3 / GPATCH4 1q23.1SNX27 1q21.3 / ADAR 1q21.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)ADAR   225
Cards
Entrez_Gene (NCBI)ADAR    adenosine deaminase RNA specific
AliasesADAR1; AGS6; DRADA; DSH; 
DSRAD; G1P1; IFI-4; IFI4; K88DSRBP; P136
GeneCards (Weizmann)ADAR
Ensembl hg19 (Hinxton)ENSG00000160710 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000160710 [Gene_View]  ENSG00000160710 [Sequence]  chr1:154582058-154608186 [Contig_View]  ADAR [Vega]
ICGC DataPortalENSG00000160710
TCGA cBioPortalADAR
AceView (NCBI)ADAR
Genatlas (Paris)ADAR
SOURCE (Princeton)ADAR
Genetics Home Reference (NIH)ADAR
Genomic and cartography
GoldenPath hg38 (UCSC)ADAR  -     chr1:154582058-154608186 -  1q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADAR  -     1q21.3   [Description]    (hg19-Feb_2009)
GoldenPathADAR - 1q21.3 [CytoView hg19]  ADAR - 1q21.3 [CytoView hg38]
ImmunoBaseENSG00000160710
Genome Data Viewer NCBIADAR [Mapview hg19]  
OMIM127400   146920   615010   
Gene and transcription
Genbank (Entrez)AA449679 AB209891 AF084516 AI309328 AK097241
RefSeq transcript (Entrez)NM_001025107 NM_001111 NM_001193495 NM_001365045 NM_001365046 NM_001365047 NM_001365048 NM_001365049 NM_015840 NM_015841
Consensus coding sequences : CCDS (NCBI)ADAR
Gene ExpressionADAR [ NCBI-GEO ]   ADAR [ EBI - ARRAY_EXPRESS ]   ADAR [ SEEK ]   ADAR [ MEM ]
Gene Expression Viewer (FireBrowse)ADAR [ Firebrowse - Broad ]
GenevisibleExpression of ADAR in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)103
GTEX Portal (Tissue expression)ADAR
Human Protein AtlasENSG00000160710-ADAR [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP55265   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP55265  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP55265
PhosPhoSitePlusP55265
Domaine pattern : Prosite (Expaxy)A_DEAMIN_EDITASE (PS50141)    DS_RBD (PS50137)    Z_BINDING (PS50139)   
Domains : Interpro (EBI)A_deamin    dsRBD_dom    dsRNA_A_deaminase_rpt    WH-like_DNA-bd_sf    WH_DNA-bd_sf    Zalpha_dom   
Domain families : Pfam (Sanger)A_deamin (PF02137)    dsrm (PF00035)    z-alpha (PF02295)   
Domain families : Pfam (NCBI)pfam02137    pfam00035    pfam02295   
Domain families : Smart (EMBL)ADEAMc (SM00552)  DSRM (SM00358)  Zalpha (SM00550)  
Conserved Domain (NCBI)ADAR
PDB (RSDB)1QBJ    1QGP    1XMK    2ACJ    2GXB    2L54    2MDR    3F21    3F22    3F23    3IRQ    3IRR    5ZU1    5ZUO    5ZUP   
PDB Europe1QBJ    1QGP    1XMK    2ACJ    2GXB    2L54    2MDR    3F21    3F22    3F23    3IRQ    3IRR    5ZU1    5ZUO    5ZUP   
PDB (PDBSum)1QBJ    1QGP    1XMK    2ACJ    2GXB    2L54    2MDR    3F21    3F22    3F23    3IRQ    3IRR    5ZU1    5ZUO    5ZUP   
PDB (IMB)1QBJ    1QGP    1XMK    2ACJ    2GXB    2L54    2MDR    3F21    3F22    3F23    3IRQ    3IRR    5ZU1    5ZUO    5ZUP   
Structural Biology KnowledgeBase1QBJ    1QGP    1XMK    2ACJ    2GXB    2L54    2MDR    3F21    3F22    3F23    3IRQ    3IRR    5ZU1    5ZUO    5ZUP   
SCOP (Structural Classification of Proteins)1QBJ    1QGP    1XMK    2ACJ    2GXB    2L54    2MDR    3F21    3F22    3F23    3IRQ    3IRR    5ZU1    5ZUO    5ZUP   
CATH (Classification of proteins structures)1QBJ    1QGP    1XMK    2ACJ    2GXB    2L54    2MDR    3F21    3F22    3F23    3IRQ    3IRR    5ZU1    5ZUO    5ZUP   
SuperfamilyP55265
AlphaFold pdb e-kbP55265   
Human Protein Atlas [tissue]ENSG00000160710-ADAR [tissue]
HPRD07528
Protein Interaction databases
DIP (DOE-UCLA)P55265
IntAct (EBI)P55265
BioGRIDADAR
STRING (EMBL)ADAR
ZODIACADAR
Ontologies - Pathways
QuickGOP55265
Ontology : AmiGOosteoblast differentiation  hematopoietic progenitor cell differentiation  somatic diversification of immune receptors via somatic mutation  DNA binding  RNA binding  double-stranded RNA binding  double-stranded RNA adenosine deaminase activity  double-stranded RNA adenosine deaminase activity  double-stranded RNA adenosine deaminase activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  nucleolus  nucleolus  cytoplasm  cytoplasm  cytoplasm  adenosine to inosine editing  adenosine to inosine editing  adenosine to inosine editing  adenosine to inosine editing  RNA processing  mRNA processing  tRNA-specific adenosine deaminase activity  response to virus  membrane  base conversion or substitution editing  erythrocyte differentiation  pre-miRNA processing  miRNA loading onto RISC involved in gene silencing by miRNA  response to interferon-alpha  negative regulation of apoptotic process  negative regulation of protein kinase activity by regulation of protein phosphorylation  negative regulation of protein kinase activity by regulation of protein phosphorylation  supraspliceosomal complex  positive regulation of viral genome replication  positive regulation of viral genome replication  innate immune response  metal ion binding  defense response to virus  definitive hemopoiesis  type I interferon signaling pathway  negative regulation of type I interferon-mediated signaling pathway  hematopoietic stem cell homeostasis  cellular response to virus  negative regulation of RNA interference  
Ontology : EGO-EBIosteoblast differentiation  hematopoietic progenitor cell differentiation  somatic diversification of immune receptors via somatic mutation  DNA binding  RNA binding  double-stranded RNA binding  double-stranded RNA adenosine deaminase activity  double-stranded RNA adenosine deaminase activity  double-stranded RNA adenosine deaminase activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  nucleolus  nucleolus  cytoplasm  cytoplasm  cytoplasm  adenosine to inosine editing  adenosine to inosine editing  adenosine to inosine editing  adenosine to inosine editing  RNA processing  mRNA processing  tRNA-specific adenosine deaminase activity  response to virus  membrane  base conversion or substitution editing  erythrocyte differentiation  pre-miRNA processing  miRNA loading onto RISC involved in gene silencing by miRNA  response to interferon-alpha  negative regulation of apoptotic process  negative regulation of protein kinase activity by regulation of protein phosphorylation  negative regulation of protein kinase activity by regulation of protein phosphorylation  supraspliceosomal complex  positive regulation of viral genome replication  positive regulation of viral genome replication  innate immune response  metal ion binding  defense response to virus  definitive hemopoiesis  type I interferon signaling pathway  negative regulation of type I interferon-mediated signaling pathway  hematopoietic stem cell homeostasis  cellular response to virus  negative regulation of RNA interference  
Pathways : BIOCARTARNA polymerase III transcription [Genes]   
Pathways : KEGGCytosolic DNA-sensing pathway    Measles    Influenza A   
NDEx NetworkADAR
Atlas of Cancer Signalling NetworkADAR
Wikipedia pathwaysADAR
Orthology - Evolution
OrthoDB103
GeneTree (enSembl)ENSG00000160710
Phylogenetic Trees/Animal Genes : TreeFamADAR
Homologs : HomoloGeneADAR
Homology/Alignments : Family Browser (UCSC)ADAR
Gene fusions - Rearrangements
Fusion : MitelmanADAR/GPATCH4 [1q21.3/1q23.1]  
Fusion : MitelmanSNX27/ADAR [1q21.3/1q21.3]  
Fusion : QuiverADAR
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADAR [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADAR
dbVarADAR
ClinVarADAR
MonarchADAR
1000_GenomesADAR 
Exome Variant ServerADAR
GNOMAD BrowserENSG00000160710
Varsome BrowserADAR
ACMGADAR variants
VarityP55265
Genomic Variants (DGV)ADAR [DGVbeta]
DECIPHERADAR [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADAR 
Mutations
ICGC Data PortalADAR 
TCGA Data PortalADAR 
Broad Tumor PortalADAR
OASIS PortalADAR [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADAR  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DADAR
Mutations and Diseases : HGMDADAR
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaADAR
DgiDB (Drug Gene Interaction Database)ADAR
DoCM (Curated mutations)ADAR
CIViC (Clinical Interpretations of Variants in Cancer)ADAR
Cancer3DADAR
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM127400    146920    615010   
Orphanet1309    18978    8626   
DisGeNETADAR
MedgenADAR
Genetic Testing Registry ADAR
NextProtP55265 [Medical]
GENETestsADAR
Target ValidationADAR
Huge Navigator ADAR [HugePedia]
ClinGenADAR
Clinical trials, drugs, therapy
MyCancerGenomeADAR
Protein Interactions : CTDADAR
Pharm GKB GenePA24555
Pharm GKB PathwaysPA166126086   
PharosP55265
Clinical trialADAR
Miscellaneous
canSAR (ICR)ADAR
HarmonizomeADAR
DataMed IndexADAR
Probes
Litterature
PubMed359 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXADAR
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 14:58:31 CEST 2021

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