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ADARB1 (adenosine deaminase, RNA specific B1)

Identity

Alias_namesadenosine deaminase
Alias_symbol (synonym)ADAR2
DRADA2
ADAR2g
DRABA2
RED1
hRED1
ADAR2a-L1
ADAR2a-L2
ADAR2a-L3
ADAR2a
ADAR2b
ADAR2c
ADAR2d
Other alias
HGNC (Hugo) ADARB1
LocusID (NCBI) 104
Atlas_Id 53086
Location 21q22.3  [Link to chromosome band 21q22]
Location_base_pair Starts at 45074578 and ends at 45226563 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ADARB1 (21q22.3) / ADARB1 (21q22.3)ADARB1 (21q22.3) / NFKBIZ (3q12.3)CLEC2B (12p13.31) / ADARB1 (21q22.3)
COL18A1 (21q22.3) / ADARB1 (21q22.3)SBNO2 (19p13.3) / ADARB1 (21q22.3)COL18A1 21q22.3 / ADARB1 21q22.3
SBNO2 19p13.3 / ADARB1 21q22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ADARB1   226
Cards
Entrez_Gene (NCBI)ADARB1  104  adenosine deaminase, RNA specific B1
AliasesADAR2; DRABA2; DRADA2; RED1
GeneCards (Weizmann)ADARB1
Ensembl hg19 (Hinxton)ENSG00000197381 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000197381 [Gene_View]  chr21:45074578-45226563 [Contig_View]  ADARB1 [Vega]
ICGC DataPortalENSG00000197381
TCGA cBioPortalADARB1
AceView (NCBI)ADARB1
Genatlas (Paris)ADARB1
WikiGenes104
SOURCE (Princeton)ADARB1
Genetics Home Reference (NIH)ADARB1
Genomic and cartography
GoldenPath hg38 (UCSC)ADARB1  -     chr21:45074578-45226563 +  21q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADARB1  -     21q22.3   [Description]    (hg19-Feb_2009)
EnsemblADARB1 - 21q22.3 [CytoView hg19]  ADARB1 - 21q22.3 [CytoView hg38]
Mapping of homologs : NCBIADARB1 [Mapview hg19]  ADARB1 [Mapview hg38]
OMIM601218   
Gene and transcription
Genbank (Entrez)AB194369 AB194370 AB194371 AB194372 AB194373
RefSeq transcript (Entrez)NM_001033049 NM_001112 NM_001160230 NM_001346687 NM_001346688 NM_015833 NM_015834
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ADARB1
Cluster EST : UnigeneHs.474018 [ NCBI ]
CGAP (NCI)Hs.474018
Alternative Splicing GalleryENSG00000197381
Gene ExpressionADARB1 [ NCBI-GEO ]   ADARB1 [ EBI - ARRAY_EXPRESS ]   ADARB1 [ SEEK ]   ADARB1 [ MEM ]
Gene Expression Viewer (FireBrowse)ADARB1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)104
GTEX Portal (Tissue expression)ADARB1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP78563   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP78563  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP78563
Splice isoforms : SwissVarP78563
Catalytic activity : Enzyme3.5.4.37 [ Enzyme-Expasy ]   3.5.4.373.5.4.37 [ IntEnz-EBI ]   3.5.4.37 [ BRENDA ]   3.5.4.37 [ KEGG ]   
PhosPhoSitePlusP78563
Domaine pattern : Prosite (Expaxy)A_DEAMIN_EDITASE (PS50141)    DS_RBD (PS50137)   
Domains : Interpro (EBI)A_deamin    dsRBD_dom    IL1/FGF   
Domain families : Pfam (Sanger)A_deamin (PF02137)    dsrm (PF00035)   
Domain families : Pfam (NCBI)pfam02137    pfam00035   
Domain families : Smart (EMBL)ADEAMc (SM00552)  DSRM (SM00358)  
Conserved Domain (NCBI)ADARB1
DMDM Disease mutations104
Blocks (Seattle)ADARB1
PDB (SRS)1ZY7    5ED1    5ED2    5HP2    5HP3   
PDB (PDBSum)1ZY7    5ED1    5ED2    5HP2    5HP3   
PDB (IMB)1ZY7    5ED1    5ED2    5HP2    5HP3   
PDB (RSDB)1ZY7    5ED1    5ED2    5HP2    5HP3   
Structural Biology KnowledgeBase1ZY7    5ED1    5ED2    5HP2    5HP3   
SCOP (Structural Classification of Proteins)1ZY7    5ED1    5ED2    5HP2    5HP3   
CATH (Classification of proteins structures)1ZY7    5ED1    5ED2    5HP2    5HP3   
SuperfamilyP78563
Human Protein AtlasENSG00000197381
Peptide AtlasP78563
HPRD06777
IPIIPI00020368   IPI00477012   IPI00334613   IPI01019091   IPI00642385   IPI00384573   IPI00152475   IPI00783018   IPI00184874   
Protein Interaction databases
DIP (DOE-UCLA)P78563
IntAct (EBI)P78563
FunCoupENSG00000197381
BioGRIDADARB1
STRING (EMBL)ADARB1
ZODIACADARB1
Ontologies - Pathways
QuickGOP78563
Ontology : AmiGORNA binding  double-stranded RNA adenosine deaminase activity  mRNA binding  protein binding  nucleoplasm  nucleoplasm  nucleolus  cytosol  adenosine to inosine editing  adenosine to inosine editing  mRNA processing  neuromuscular synaptic transmission  negative regulation of cell proliferation  facial nerve morphogenesis  hypoglossal nerve morphogenesis  spinal cord ventral commissure morphogenesis  negative regulation of cell migration  multicellular organism growth  negative regulation of protein kinase activity by regulation of protein phosphorylation  positive regulation of viral genome replication  innate immune response  metal ion binding  neuromuscular process controlling posture  defense response to virus  regulation of cell cycle  innervation  muscle tissue morphogenesis  motor behavior  motor neuron apoptotic process  
Ontology : EGO-EBIRNA binding  double-stranded RNA adenosine deaminase activity  mRNA binding  protein binding  nucleoplasm  nucleoplasm  nucleolus  cytosol  adenosine to inosine editing  adenosine to inosine editing  mRNA processing  neuromuscular synaptic transmission  negative regulation of cell proliferation  facial nerve morphogenesis  hypoglossal nerve morphogenesis  spinal cord ventral commissure morphogenesis  negative regulation of cell migration  multicellular organism growth  negative regulation of protein kinase activity by regulation of protein phosphorylation  positive regulation of viral genome replication  innate immune response  metal ion binding  neuromuscular process controlling posture  defense response to virus  regulation of cell cycle  innervation  muscle tissue morphogenesis  motor behavior  motor neuron apoptotic process  
NDEx NetworkADARB1
Atlas of Cancer Signalling NetworkADARB1
Wikipedia pathwaysADARB1
Orthology - Evolution
OrthoDB104
GeneTree (enSembl)ENSG00000197381
Phylogenetic Trees/Animal Genes : TreeFamADARB1
HOVERGENP78563
HOGENOMP78563
Homologs : HomoloGeneADARB1
Homology/Alignments : Family Browser (UCSC)ADARB1
Gene fusions - Rearrangements
Fusion : MitelmanCOL18A1/ADARB1 [21q22.3/21q22.3]  [t(21;21)(q22;q22)]  
Fusion : MitelmanSBNO2/ADARB1 [19p13.3/21q22.3]  [t(19;21)(p13;q22)]  
Fusion: TCGACOL18A1 21q22.3 ADARB1 21q22.3 KIRC
Fusion: TCGASBNO2 19p13.3 ADARB1 21q22.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADARB1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADARB1
dbVarADARB1
ClinVarADARB1
1000_GenomesADARB1 
Exome Variant ServerADARB1
ExAC (Exome Aggregation Consortium)ADARB1 (select the gene name)
Genetic variants : HAPMAP104
Genomic Variants (DGV)ADARB1 [DGVbeta]
DECIPHERADARB1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADARB1 
Mutations
ICGC Data PortalADARB1 
TCGA Data PortalADARB1 
Broad Tumor PortalADARB1
OASIS PortalADARB1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADARB1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADARB1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ADARB1
DgiDB (Drug Gene Interaction Database)ADARB1
DoCM (Curated mutations)ADARB1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADARB1 (select a term)
intoGenADARB1
Cancer3DADARB1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601218   
Orphanet
MedgenADARB1
Genetic Testing Registry ADARB1
NextProtP78563 [Medical]
TSGene104
GENETestsADARB1
Target ValidationADARB1
Huge Navigator ADARB1 [HugePedia]
snp3D : Map Gene to Disease104
BioCentury BCIQADARB1
ClinGenADARB1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD104
Chemical/Pharm GKB GenePA24556
Clinical trialADARB1
Miscellaneous
canSAR (ICR)ADARB1 (select the gene name)
Probes
Litterature
PubMed70 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADARB1
EVEXADARB1
GoPubMedADARB1
iHOPADARB1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 18:56:15 CEST 2017

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