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ADCK4 (aarF domain containing kinase 4)

Identity

Other aliasNPHS9
HGNC (Hugo) ADCK4
LocusID (NCBI) 79934
Atlas_Id 43104
Location 19q13.2  [Link to chromosome band 19q13]
Location_base_pair Starts at 41197434 and ends at 41221011 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ADCK4 (19q13.2) / AKAP8 (19p13.12)ADCK4 (19q13.2) / NUMBL (19q13.2)PPM1A (14q23.1) / ADCK4 (19q13.2)
TMEM161A (19p13.11) / ADCK4 (19q13.2)ADCK4 19q13.2 / AKAP8 19p13.12PPM1A 14q23.1 / ADCK4 19q13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ADCK4   19041
Cards
Entrez_Gene (NCBI)ADCK4  79934  aarF domain containing kinase 4
AliasesNPHS9
GeneCards (Weizmann)ADCK4
Ensembl hg19 (Hinxton)ENSG00000123815 [Gene_View]  chr19:41197434-41221011 [Contig_View]  ADCK4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000123815 [Gene_View]  chr19:41197434-41221011 [Contig_View]  ADCK4 [Vega]
ICGC DataPortalENSG00000123815
TCGA cBioPortalADCK4
AceView (NCBI)ADCK4
Genatlas (Paris)ADCK4
WikiGenes79934
SOURCE (Princeton)ADCK4
Genetics Home Reference (NIH)ADCK4
Genomic and cartography
GoldenPath hg19 (UCSC)ADCK4  -     chr19:41197434-41221011 -  19q13.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ADCK4  -     19q13.2   [Description]    (hg38-Dec_2013)
EnsemblADCK4 - 19q13.2 [CytoView hg19]  ADCK4 - 19q13.2 [CytoView hg38]
Mapping of homologs : NCBIADCK4 [Mapview hg19]  ADCK4 [Mapview hg38]
OMIM615567   615573   
Gene and transcription
Genbank (Entrez)AF052122 AK022291 AK057199 AU121879 BC013114
RefSeq transcript (Entrez)NM_001142555 NM_024876
RefSeq genomic (Entrez)NC_000019 NC_018930 NG_027800 NT_011109 NW_004929415
Consensus coding sequences : CCDS (NCBI)ADCK4
Cluster EST : UnigeneHs.130712 [ NCBI ]
CGAP (NCI)Hs.130712
Alternative Splicing GalleryENSG00000123815
Gene ExpressionADCK4 [ NCBI-GEO ]   ADCK4 [ EBI - ARRAY_EXPRESS ]   ADCK4 [ SEEK ]   ADCK4 [ MEM ]
Gene Expression Viewer (FireBrowse)ADCK4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79934
GTEX Portal (Tissue expression)ADCK4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96D53   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96D53  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96D53
Splice isoforms : SwissVarQ96D53
PhosPhoSitePlusQ96D53
Domains : Interpro (EBI)Kinase-like_dom    UbiB_dom   
Domain families : Pfam (Sanger)ABC1 (PF03109)   
Domain families : Pfam (NCBI)pfam03109   
Conserved Domain (NCBI)ADCK4
DMDM Disease mutations79934
Blocks (Seattle)ADCK4
SuperfamilyQ96D53
Human Protein AtlasENSG00000123815
Peptide AtlasQ96D53
HPRD10632
IPIIPI00647707   IPI00178315   
Protein Interaction databases
DIP (DOE-UCLA)Q96D53
IntAct (EBI)Q96D53
FunCoupENSG00000123815
BioGRIDADCK4
STRING (EMBL)ADCK4
ZODIACADCK4
Ontologies - Pathways
QuickGOQ96D53
Ontology : AmiGOprotein serine/threonine kinase activity  cytosol  plasma membrane  protein phosphorylation  integral component of membrane  mitochondrial membrane  
Ontology : EGO-EBIprotein serine/threonine kinase activity  cytosol  plasma membrane  protein phosphorylation  integral component of membrane  mitochondrial membrane  
NDEx NetworkADCK4
Atlas of Cancer Signalling NetworkADCK4
Wikipedia pathwaysADCK4
Orthology - Evolution
OrthoDB79934
GeneTree (enSembl)ENSG00000123815
Phylogenetic Trees/Animal Genes : TreeFamADCK4
HOVERGENQ96D53
HOGENOMQ96D53
Homologs : HomoloGeneADCK4
Homology/Alignments : Family Browser (UCSC)ADCK4
Gene fusions - Rearrangements
Fusion : MitelmanADCK4/AKAP8 [19q13.2/19p13.12]  
Fusion : MitelmanADCK4/NUMBL [19q13.2/19q13.2]  [t(19;19)(q13;q13)]  
Fusion : MitelmanPPM1A/ADCK4 [14q23.1/19q13.2]  [t(14;19)(q23;q13)]  
Fusion: TCGAADCK4 19q13.2 AKAP8 19p13.12 LUAD
Fusion: TCGAPPM1A 14q23.1 ADCK4 19q13.2 LGG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADCK4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADCK4
dbVarADCK4
ClinVarADCK4
1000_GenomesADCK4 
Exome Variant ServerADCK4
ExAC (Exome Aggregation Consortium)ADCK4 (select the gene name)
Genetic variants : HAPMAP79934
Genomic Variants (DGV)ADCK4 [DGVbeta]
DECIPHER (Syndromes)19:41197434-41221011  ENSG00000123815
CONAN: Copy Number AnalysisADCK4 
Mutations
ICGC Data PortalADCK4 
TCGA Data PortalADCK4 
Broad Tumor PortalADCK4
OASIS PortalADCK4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADCK4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADCK4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch ADCK4
DgiDB (Drug Gene Interaction Database)ADCK4
DoCM (Curated mutations)ADCK4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADCK4 (select a term)
intoGenADCK4
Cancer3DADCK4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615567    615573   
Orphanet12191   
MedgenADCK4
Genetic Testing Registry ADCK4
NextProtQ96D53 [Medical]
TSGene79934
GENETestsADCK4
Huge Navigator ADCK4 [HugePedia]
snp3D : Map Gene to Disease79934
BioCentury BCIQADCK4
ClinGenADCK4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD79934
Chemical/Pharm GKB GenePA134988974
Clinical trialADCK4
Miscellaneous
canSAR (ICR)ADCK4 (select the gene name)
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADCK4
EVEXADCK4
GoPubMedADCK4
iHOPADCK4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 14:51:39 CEST 2017

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