Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ADCY1 (adenylate cyclase 1)

Identity

Other aliasAC1
DFNB44
HGNC (Hugo) ADCY1
LocusID (NCBI) 107
Atlas_Id 57160
Location 7p12.3  [Link to chromosome band 7p12]
Location_base_pair Starts at 45574581 and ends at 45714490 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADCY1 (7p12.3) / ADCY1 (7p12.3)ADCY1 (7p12.3) / EYA4 (6q23.2)ADCY1 (7p12.3) / JUN (1p32.1)
ADCY1 (7p12.3) / KDM3A (2p11.2)KDM3A (2p11.2) / ADCY1 (7p12.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ADCY1   232
Cards
Entrez_Gene (NCBI)ADCY1  107  adenylate cyclase 1
AliasesAC1; DFNB44
GeneCards (Weizmann)ADCY1
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]  chr7:45574581-45714490 [Contig_View]  ADCY1 [Vega]
TCGA cBioPortalADCY1
AceView (NCBI)ADCY1
Genatlas (Paris)ADCY1
WikiGenes107
SOURCE (Princeton)ADCY1
Genetics Home Reference (NIH)ADCY1
Genomic and cartography
GoldenPath hg38 (UCSC)ADCY1  -     chr7:45574581-45714490 +  7p12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADCY1  -     7p12.3   [Description]    (hg19-Feb_2009)
EnsemblADCY1 - 7p12.3 [CytoView hg19]  ADCY1 - 7p12.3 [CytoView hg38]
Mapping of homologs : NCBIADCY1 [Mapview hg19]  ADCY1 [Mapview hg38]
OMIM103072   610154   
Gene and transcription
Genbank (Entrez)AB209496 AF086306 AF497515 AK024415 AK055343
RefSeq transcript (Entrez)NM_001281768 NM_021116
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ADCY1
Cluster EST : UnigeneHs.192215 [ NCBI ]
CGAP (NCI)Hs.192215
Gene ExpressionADCY1 [ NCBI-GEO ]   ADCY1 [ EBI - ARRAY_EXPRESS ]   ADCY1 [ SEEK ]   ADCY1 [ MEM ]
Gene Expression Viewer (FireBrowse)ADCY1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)107
GTEX Portal (Tissue expression)ADCY1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ08828   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ08828  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ08828
Splice isoforms : SwissVarQ08828
PhosPhoSitePlusQ08828
Domaine pattern : Prosite (Expaxy)GUANYLATE_CYCLASE_1 (PS00452)    GUANYLATE_CYCLASE_2 (PS50125)   
Domains : Interpro (EBI)A/G_cyclase    A/G_cyclase_CS    AC_N    Adcy    Nucleotide_cyclase   
Domain families : Pfam (Sanger)AC_N (PF16214)    Guanylate_cyc (PF00211)   
Domain families : Pfam (NCBI)pfam16214    pfam00211   
Domain families : Smart (EMBL)CYCc (SM00044)  
Conserved Domain (NCBI)ADCY1
DMDM Disease mutations107
Blocks (Seattle)ADCY1
SuperfamilyQ08828
Peptide AtlasQ08828
IPIIPI00784385   IPI01014407   IPI00925610   
Protein Interaction databases
DIP (DOE-UCLA)Q08828
IntAct (EBI)Q08828
BioGRIDADCY1
STRING (EMBL)ADCY1
ZODIACADCY1
Ontologies - Pathways
QuickGOQ08828
Ontology : AmiGOrenal water homeostasis  adenylate cyclase activity  adenylate cyclase activity  guanylate cyclase activity  calmodulin binding  ATP binding  nucleus  cytoplasm  plasma membrane  plasma membrane  integral component of plasma membrane  cAMP biosynthetic process  cGMP biosynthetic process  signal transduction  adenylate cyclase-activating G-protein coupled receptor signaling pathway  adenylate cyclase-activating G-protein coupled receptor signaling pathway  activation of adenylate cyclase activity  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  axonogenesis  long-term memory  circadian rhythm  guanylate cyclase complex, soluble  calcium- and calmodulin-responsive adenylate cyclase activity  calcium- and calmodulin-responsive adenylate cyclase activity  response to lithium ion  cAMP-mediated signaling  activation of protein kinase A activity  response to drug  regulation of circadian rhythm  membrane raft  metal ion binding  extracellular exosome  cellular response to calcium ion  cellular response to glucagon stimulus  cellular response to forskolin  
Ontology : EGO-EBIrenal water homeostasis  adenylate cyclase activity  adenylate cyclase activity  guanylate cyclase activity  calmodulin binding  ATP binding  nucleus  cytoplasm  plasma membrane  plasma membrane  integral component of plasma membrane  cAMP biosynthetic process  cGMP biosynthetic process  signal transduction  adenylate cyclase-activating G-protein coupled receptor signaling pathway  adenylate cyclase-activating G-protein coupled receptor signaling pathway  activation of adenylate cyclase activity  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  axonogenesis  long-term memory  circadian rhythm  guanylate cyclase complex, soluble  calcium- and calmodulin-responsive adenylate cyclase activity  calcium- and calmodulin-responsive adenylate cyclase activity  response to lithium ion  cAMP-mediated signaling  activation of protein kinase A activity  response to drug  regulation of circadian rhythm  membrane raft  metal ion binding  extracellular exosome  cellular response to calcium ion  cellular response to glucagon stimulus  cellular response to forskolin  
Pathways : BIOCARTAActivation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor [Genes]    Cystic fibrosis transmembrane conductance regulator (CFTR) and beta 2 adrenergic receptor (b2AR) pathway [Genes]    Phospholipase C-epsilon pathway [Genes]    Transcription factor CREB and its extracellular signals [Genes]    Ion Channels and Their Functional Role in Vascular Endothelium [Genes]    Thrombin signaling and protease-activated receptors [Genes]    Roles of -arrestin-dependent Recruitment of Src Kinases in GPCR Signaling [Genes]    Regulation of Spermatogenesis by CREM [Genes]    Regulation of BAD phosphorylation [Genes]    ChREBP regulation by carbohydrates and cAMP [Genes]    Phospholipids as signalling intermediaries [Genes]    Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation [Genes]    Role of -arrestins in the activation and targeting of MAP kinases [Genes]    Signaling Pathway from G-Protein Families [Genes]    Activation of cAMP-dependent protein kinase, PKA [Genes]    How Progesterone Initiates the Oocyte Maturation [Genes]    -arrestins in GPCR Desensitization [Genes]   
Pathways : KEGGPurine metabolism    Rap1 signaling pathway    Calcium signaling pathway    Chemokine signaling pathway    Oocyte meiosis    Adrenergic signaling in cardiomyocytes    Vascular smooth muscle contraction    Gap junction    Circadian entrainment    Long-term potentiation    Retrograde endocannabinoid signaling    Glutamatergic synapse    Cholinergic synapse    GABAergic synapse    Insulin secretion    GnRH signaling pathway    Ovarian steroidogenesis    Progesterone-mediated oocyte maturation    Estrogen signaling pathway    Melanogenesis    Thyroid hormone synthesis    Salivary secretion    Gastric acid secretion    Pancreatic secretion    Bile secretion    Morphine addiction    Chagas disease (American trypanosomiasis)    Amoebiasis    HTLV-I infection    Dilated cardiomyopathy   
NDEx NetworkADCY1
Atlas of Cancer Signalling NetworkADCY1
Wikipedia pathwaysADCY1
Orthology - Evolution
OrthoDB107
Phylogenetic Trees/Animal Genes : TreeFamADCY1
HOVERGENQ08828
HOGENOMQ08828
Homologs : HomoloGeneADCY1
Homology/Alignments : Family Browser (UCSC)ADCY1
Gene fusions - Rearrangements
Tumor Fusion PortalADCY1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADCY1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADCY1
dbVarADCY1
ClinVarADCY1
1000_GenomesADCY1 
Exome Variant ServerADCY1
ExAC (Exome Aggregation Consortium)
Genetic variants : HAPMAP107
Genomic Variants (DGV)ADCY1 [DGVbeta]
DECIPHERADCY1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADCY1 
Mutations
ICGC Data PortalADCY1 
TCGA Data PortalADCY1 
Broad Tumor PortalADCY1
OASIS PortalADCY1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADCY1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADCY1
BioMutasearch ADCY1
DgiDB (Drug Gene Interaction Database)ADCY1
DoCM (Curated mutations)ADCY1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADCY1 (select a term)
intoGenADCY1
Cancer3DADCY1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM103072    610154   
Orphanet
DisGeNETADCY1
MedgenADCY1
Genetic Testing Registry ADCY1
NextProtQ08828 [Medical]
TSGene107
GENETestsADCY1
Target ValidationADCY1
Huge Navigator ADCY1 [HugePedia]
snp3D : Map Gene to Disease107
BioCentury BCIQADCY1
ClinGenADCY1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD107
Chemical/Pharm GKB GenePA24560
Clinical trialADCY1
Miscellaneous
canSAR (ICR)ADCY1 (select the gene name)
Probes
Litterature
PubMed43 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADCY1
EVEXADCY1
GoPubMedADCY1
iHOPADCY1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:02:10 CET 2017

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