Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ADCY2 (adenylate cyclase 2 (brain))

Identity

Alias_namesadenylate cyclase 2 (brain)
Alias_symbol (synonym)HBAC2
KIAA1060
AC2
Other alias
HGNC (Hugo) ADCY2
LocusID (NCBI) 108
Atlas_Id 578
Location 5p15.31  [Link to chromosome band 5p15]
Location_base_pair Starts at 7396343 and ends at 7830194 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ADCY2 (5p15.31) / CNP (17q21.2)ADCY2 (5p15.31) / DZIP1L (3q22.3)ADCY2 (5p15.31) / KCTD15 (19q13.11)
ADCY2 (5p15.31) / LARP1B (4q28.2)ADCY2 (5p15.31) / MYL12A (18p11.31)ADCY2 (5p15.31) / NOL6 (9p13.3)
ADCY2 (5p15.31) / RBM39 (20q11.22)ADCY2 (5p15.31) / RNF19B (1p35.1)ADCY2 (5p15.31) / RPAP2 (1p22.1)
ADCY2 (5p15.31) / SH3BGRL3 (1p36.11)ADCY2 (5p15.31) / SPACA3 (17q11.2)ADCY2 (5p15.31) / TNKS2 (10q23.32)
ADCY2 (5p15.31) / TPRG1 (3q28)ADCY2 (5p15.31) / WBSCR16 (7q11.23)ADCY2 (5p15.31) / ZFP36L2 (2p21)
COX6C (8q22.2) / ADCY2 (5p15.31)DDB1 (11q12.2) / ADCY2 (5p15.31)FAM65A (16q22.1) / ADCY2 (5p15.31)
H1F0 (22q13.1) / ADCY2 (5p15.31)JUP (17q21.2) / ADCY2 (5p15.31)LTA4H (12q23.1) / ADCY2 (5p15.31)
MRPS16 (10q22.2) / ADCY2 (5p15.31)PLPP1 (5q11.2) / ADCY2 (5p15.31)SPOCK3 (4q32.3) / ADCY2 (5p15.31)
ADCY2 5p15.31 / RPAP2 1p22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ADCY2   233
Cards
Entrez_Gene (NCBI)ADCY2  108  adenylate cyclase 2 (brain)
AliasesAC2; HBAC2
GeneCards (Weizmann)ADCY2
Ensembl hg19 (Hinxton)ENSG00000078295 [Gene_View]  chr5:7396343-7830194 [Contig_View]  ADCY2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000078295 [Gene_View]  chr5:7396343-7830194 [Contig_View]  ADCY2 [Vega]
ICGC DataPortalENSG00000078295
TCGA cBioPortalADCY2
AceView (NCBI)ADCY2
Genatlas (Paris)ADCY2
WikiGenes108
SOURCE (Princeton)ADCY2
Genetics Home Reference (NIH)ADCY2
Genomic and cartography
GoldenPath hg19 (UCSC)ADCY2  -     chr5:7396343-7830194 +  5p15.31   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ADCY2  -     5p15.31   [Description]    (hg38-Dec_2013)
EnsemblADCY2 - 5p15.31 [CytoView hg19]  ADCY2 - 5p15.31 [CytoView hg38]
Mapping of homologs : NCBIADCY2 [Mapview hg19]  ADCY2 [Mapview hg38]
OMIM103071   
Gene and transcription
Genbank (Entrez)AB028983 AF070583 AF410885 AK123013 AK127036
RefSeq transcript (Entrez)NM_020546
RefSeq genomic (Entrez)NC_000005 NC_018916 NT_006576 NW_004929321
Consensus coding sequences : CCDS (NCBI)ADCY2
Cluster EST : UnigeneHs.481545 [ NCBI ]
CGAP (NCI)Hs.481545
Alternative Splicing GalleryENSG00000078295
Gene ExpressionADCY2 [ NCBI-GEO ]   ADCY2 [ EBI - ARRAY_EXPRESS ]   ADCY2 [ SEEK ]   ADCY2 [ MEM ]
Gene Expression Viewer (FireBrowse)ADCY2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)108
GTEX Portal (Tissue expression)ADCY2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ08462   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ08462  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ08462
Splice isoforms : SwissVarQ08462
PhosPhoSitePlusQ08462
Domaine pattern : Prosite (Expaxy)GUANYLATE_CYCLASE_1 (PS00452)    GUANYLATE_CYCLASE_2 (PS50125)   
Domains : Interpro (EBI)A/G_cyclase    A/G_cyclase_CS    AC_N    Adcy    Adcy_conserved_dom    Nucleotide_cyclase   
Domain families : Pfam (Sanger)AC_N (PF16214)    DUF1053 (PF06327)    Guanylate_cyc (PF00211)   
Domain families : Pfam (NCBI)pfam16214    pfam06327    pfam00211   
Domain families : Smart (EMBL)CYCc (SM00044)  
Conserved Domain (NCBI)ADCY2
DMDM Disease mutations108
Blocks (Seattle)ADCY2
SuperfamilyQ08462
Human Protein AtlasENSG00000078295
Peptide AtlasQ08462
HPRD00052
IPIIPI00328273   IPI00963888   IPI01013101   IPI00470803   IPI00964717   
Protein Interaction databases
DIP (DOE-UCLA)Q08462
IntAct (EBI)Q08462
FunCoupENSG00000078295
BioGRIDADCY2
STRING (EMBL)ADCY2
ZODIACADCY2
Ontologies - Pathways
QuickGOQ08462
Ontology : AmiGOmagnesium ion binding  renal water homeostasis  adenylate cyclase activity  adenylate cyclase activity  adenylate cyclase activity  ATP binding  intracellular  cytoplasm  plasma membrane  plasma membrane  integral component of plasma membrane  cAMP biosynthetic process  cAMP biosynthetic process  adenylate cyclase-modulating G-protein coupled receptor signaling pathway  adenylate cyclase-activating G-protein coupled receptor signaling pathway  adenylate cyclase-activating G-protein coupled receptor signaling pathway  adenylate cyclase-activating G-protein coupled receptor signaling pathway  activation of adenylate cyclase activity  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  adenylate cyclase binding  membrane  cAMP-mediated signaling  cAMP-mediated signaling  manganese ion binding  dendrite  activation of protein kinase A activity  membrane raft  protein heterodimerization activity  cellular response to glucagon stimulus  cellular response to forskolin  
Ontology : EGO-EBImagnesium ion binding  renal water homeostasis  adenylate cyclase activity  adenylate cyclase activity  adenylate cyclase activity  ATP binding  intracellular  cytoplasm  plasma membrane  plasma membrane  integral component of plasma membrane  cAMP biosynthetic process  cAMP biosynthetic process  adenylate cyclase-modulating G-protein coupled receptor signaling pathway  adenylate cyclase-activating G-protein coupled receptor signaling pathway  adenylate cyclase-activating G-protein coupled receptor signaling pathway  adenylate cyclase-activating G-protein coupled receptor signaling pathway  activation of adenylate cyclase activity  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  adenylate cyclase binding  membrane  cAMP-mediated signaling  cAMP-mediated signaling  manganese ion binding  dendrite  activation of protein kinase A activity  membrane raft  protein heterodimerization activity  cellular response to glucagon stimulus  cellular response to forskolin  
Pathways : KEGGPurine metabolism    Rap1 signaling pathway    Calcium signaling pathway    Chemokine signaling pathway    Oocyte meiosis    Adrenergic signaling in cardiomyocytes    Vascular smooth muscle contraction    Gap junction    Circadian entrainment    Retrograde endocannabinoid signaling    Glutamatergic synapse    Cholinergic synapse    GABAergic synapse    Insulin secretion    GnRH signaling pathway    Ovarian steroidogenesis    Progesterone-mediated oocyte maturation    Estrogen signaling pathway    Melanogenesis    Thyroid hormone synthesis    Salivary secretion    Gastric acid secretion    Pancreatic secretion    Bile secretion    Morphine addiction    HTLV-I infection    Dilated cardiomyopathy   
NDEx NetworkADCY2
Atlas of Cancer Signalling NetworkADCY2
Wikipedia pathwaysADCY2
Orthology - Evolution
OrthoDB108
GeneTree (enSembl)ENSG00000078295
Phylogenetic Trees/Animal Genes : TreeFamADCY2
HOVERGENQ08462
HOGENOMQ08462
Homologs : HomoloGeneADCY2
Homology/Alignments : Family Browser (UCSC)ADCY2
Gene fusions - Rearrangements
Fusion : MitelmanADCY2/RPAP2 [5p15.31/1p22.1]  
Fusion: TCGAADCY2 5p15.31 RPAP2 1p22.1 BLCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADCY2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADCY2
dbVarADCY2
ClinVarADCY2
1000_GenomesADCY2 
Exome Variant ServerADCY2
ExAC (Exome Aggregation Consortium)ADCY2 (select the gene name)
Genetic variants : HAPMAP108
Genomic Variants (DGV)ADCY2 [DGVbeta]
DECIPHER (Syndromes)5:7396343-7830194  ENSG00000078295
CONAN: Copy Number AnalysisADCY2 
Mutations
ICGC Data PortalADCY2 
TCGA Data PortalADCY2 
Broad Tumor PortalADCY2
OASIS PortalADCY2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADCY2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADCY2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ADCY2
DgiDB (Drug Gene Interaction Database)ADCY2
DoCM (Curated mutations)ADCY2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADCY2 (select a term)
intoGenADCY2
Cancer3DADCY2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM103071   
Orphanet
MedgenADCY2
Genetic Testing Registry ADCY2
NextProtQ08462 [Medical]
TSGene108
GENETestsADCY2
Huge Navigator ADCY2 [HugePedia]
snp3D : Map Gene to Disease108
BioCentury BCIQADCY2
ClinGenADCY2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD108
Chemical/Pharm GKB GenePA24561
Clinical trialADCY2
Miscellaneous
canSAR (ICR)ADCY2 (select the gene name)
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADCY2
EVEXADCY2
GoPubMedADCY2
iHOPADCY2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 14:51:39 CEST 2017

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