Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ADCY3 (adenylate cyclase 3)

Identity

Alias_symbol (synonym)AC3
Other aliasAC-III
BMIQ19
HGNC (Hugo) ADCY3
LocusID (NCBI) 109
Atlas_Id 60155
Location 2p23.3  [Link to chromosome band 2p23]
Location_base_pair Starts at 24819170 and ends at 24920017 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DNMT3A (2p23.3) / ADCY3 (2p23.3)SOS1 (2p22.1) / ADCY3 (2p23.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ADCY3   234
Cards
Entrez_Gene (NCBI)ADCY3  109  adenylate cyclase 3
AliasesAC-III; AC3; BMIQ19
GeneCards (Weizmann)ADCY3
Ensembl hg19 (Hinxton)ENSG00000138031 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138031 [Gene_View]  ENSG00000138031 [Sequence]  chr2:24819170-24920017 [Contig_View]  ADCY3 [Vega]
ICGC DataPortalENSG00000138031
TCGA cBioPortalADCY3
AceView (NCBI)ADCY3
Genatlas (Paris)ADCY3
WikiGenes109
SOURCE (Princeton)ADCY3
Genetics Home Reference (NIH)ADCY3
Genomic and cartography
GoldenPath hg38 (UCSC)ADCY3  -     chr2:24819170-24920017 -  2p23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADCY3  -     2p23.3   [Description]    (hg19-Feb_2009)
GoldenPathADCY3 - 2p23.3 [CytoView hg19]  ADCY3 - 2p23.3 [CytoView hg38]
ImmunoBaseENSG00000138031
Mapping of homologs : NCBIADCY3 [Mapview hg19]  ADCY3 [Mapview hg38]
OMIM600291   617885   
Gene and transcription
Genbank (Entrez)AB011083 AF033861 AK027857 AK075424 AK095173
RefSeq transcript (Entrez)NM_001320613 NM_004036
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ADCY3
Cluster EST : UnigeneHs.611397 [ NCBI ]
CGAP (NCI)Hs.611397
Alternative Splicing GalleryENSG00000138031
Gene ExpressionADCY3 [ NCBI-GEO ]   ADCY3 [ EBI - ARRAY_EXPRESS ]   ADCY3 [ SEEK ]   ADCY3 [ MEM ]
Gene Expression Viewer (FireBrowse)ADCY3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)109
GTEX Portal (Tissue expression)ADCY3
Human Protein AtlasENSG00000138031-ADCY3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60266   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60266  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60266
Splice isoforms : SwissVarO60266
Catalytic activity : Enzyme4.6.1.1 [ Enzyme-Expasy ]   4.6.1.14.6.1.1 [ IntEnz-EBI ]   4.6.1.1 [ BRENDA ]   4.6.1.1 [ KEGG ]   
PhosPhoSitePlusO60266
Domaine pattern : Prosite (Expaxy)GUANYLATE_CYCLASE_1 (PS00452)    GUANYLATE_CYCLASE_2 (PS50125)   
Domains : Interpro (EBI)A/G_cyclase    A/G_cyclase_CS    AC_N    Adcy    Nucleotide_cyclase   
Domain families : Pfam (Sanger)AC_N (PF16214)    Guanylate_cyc (PF00211)   
Domain families : Pfam (NCBI)pfam16214    pfam00211   
Domain families : Smart (EMBL)CYCc (SM00044)  
Conserved Domain (NCBI)ADCY3
DMDM Disease mutations109
Blocks (Seattle)ADCY3
SuperfamilyO60266
Human Protein Atlas [tissue]ENSG00000138031-ADCY3 [tissue]
Peptide AtlasO60266
HPRD02620
IPIIPI00028513   IPI00894565   IPI00893095   IPI00893775   IPI00893890   IPI00942552   IPI00893646   IPI00894191   IPI00894321   
Protein Interaction databases
DIP (DOE-UCLA)O60266
IntAct (EBI)O60266
FunCoupENSG00000138031
BioGRIDADCY3
STRING (EMBL)ADCY3
ZODIACADCY3
Ontologies - Pathways
QuickGOO60266
Ontology : AmiGOrenal water homeostasis  adenylate cyclase activity  adenylate cyclase activity  calmodulin binding  ATP binding  cytoplasm  Golgi apparatus  plasma membrane  plasma membrane  integral component of plasma membrane  cilium  cAMP biosynthetic process  cAMP biosynthetic process  signal transduction  G protein-coupled receptor signaling pathway  adenylate cyclase-activating G protein-coupled receptor signaling pathway  adenylate cyclase-activating G protein-coupled receptor signaling pathway  adenylate cyclase-activating G protein-coupled receptor signaling pathway  activation of adenylate cyclase activity  adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  single fertilization  acrosome reaction  sensory perception of smell  olfactory learning  membrane  integral component of membrane  flagellated sperm motility  activation of protein kinase A activity  metal ion binding  cellular response to glucagon stimulus  cellular response to forskolin  
Ontology : EGO-EBIrenal water homeostasis  adenylate cyclase activity  adenylate cyclase activity  calmodulin binding  ATP binding  cytoplasm  Golgi apparatus  plasma membrane  plasma membrane  integral component of plasma membrane  cilium  cAMP biosynthetic process  cAMP biosynthetic process  signal transduction  G protein-coupled receptor signaling pathway  adenylate cyclase-activating G protein-coupled receptor signaling pathway  adenylate cyclase-activating G protein-coupled receptor signaling pathway  adenylate cyclase-activating G protein-coupled receptor signaling pathway  activation of adenylate cyclase activity  adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  single fertilization  acrosome reaction  sensory perception of smell  olfactory learning  membrane  integral component of membrane  flagellated sperm motility  activation of protein kinase A activity  metal ion binding  cellular response to glucagon stimulus  cellular response to forskolin  
Pathways : KEGGCalcium signaling pathway    Purine metabolism    GnRH signaling pathway    Gap junction    Olfactory transduction   
NDEx NetworkADCY3
Atlas of Cancer Signalling NetworkADCY3
Wikipedia pathwaysADCY3
Orthology - Evolution
OrthoDB109
GeneTree (enSembl)ENSG00000138031
Phylogenetic Trees/Animal Genes : TreeFamADCY3
HOGENOMO60266
Homologs : HomoloGeneADCY3
Homology/Alignments : Family Browser (UCSC)ADCY3
Gene fusions - Rearrangements
Fusion : QuiverADCY3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADCY3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADCY3
dbVarADCY3
ClinVarADCY3
1000_GenomesADCY3 
Exome Variant ServerADCY3
ExAC (Exome Aggregation Consortium)ENSG00000138031
GNOMAD BrowserENSG00000138031
Varsome BrowserADCY3
Genetic variants : HAPMAP109
Genomic Variants (DGV)ADCY3 [DGVbeta]
DECIPHERADCY3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADCY3 
Mutations
ICGC Data PortalADCY3 
TCGA Data PortalADCY3 
Broad Tumor PortalADCY3
OASIS PortalADCY3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADCY3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DADCY3
Mutations and Diseases : HGMDADCY3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ADCY3
DgiDB (Drug Gene Interaction Database)ADCY3
DoCM (Curated mutations)ADCY3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADCY3 (select a term)
intoGenADCY3
Cancer3DADCY3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600291    617885   
Orphanet
DisGeNETADCY3
MedgenADCY3
Genetic Testing Registry ADCY3
NextProtO60266 [Medical]
TSGene109
GENETestsADCY3
Target ValidationADCY3
Huge Navigator ADCY3 [HugePedia]
snp3D : Map Gene to Disease109
BioCentury BCIQADCY3
ClinGenADCY3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD109
Chemical/Pharm GKB GenePA164741137
Clinical trialADCY3
Miscellaneous
canSAR (ICR)ADCY3 (select the gene name)
DataMed IndexADCY3
Probes
Litterature
PubMed65 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADCY3
EVEXADCY3
GoPubMedADCY3
iHOPADCY3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Sep 3 15:18:52 CEST 2019

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