Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ADCY3 (adenylate cyclase 3)

Identity

Alias (NCBI)AC-III
AC3
BMIQ19
HGNC (Hugo) ADCY3
HGNC Alias symbAC3
LocusID (NCBI) 109
Atlas_Id 60155
Location 2p23.3  [Link to chromosome band 2p23]
Location_base_pair Starts at 24819170 and ends at 24920237 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DNMT3A (2p23.3) / ADCY3 (2p23.3)SOS1 (2p22.1) / ADCY3 (2p23.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)ADCY3   234
Cards
Entrez_Gene (NCBI)ADCY3    adenylate cyclase 3
AliasesAC-III; AC3; BMIQ19
GeneCards (Weizmann)ADCY3
Ensembl hg19 (Hinxton)ENSG00000138031 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138031 [Gene_View]  ENSG00000138031 [Sequence]  chr2:24819170-24920237 [Contig_View]  ADCY3 [Vega]
ICGC DataPortalENSG00000138031
TCGA cBioPortalADCY3
AceView (NCBI)ADCY3
Genatlas (Paris)ADCY3
SOURCE (Princeton)ADCY3
Genetics Home Reference (NIH)ADCY3
Genomic and cartography
GoldenPath hg38 (UCSC)ADCY3  -     chr2:24819170-24920237 -  2p23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADCY3  -     2p23.3   [Description]    (hg19-Feb_2009)
GoldenPathADCY3 - 2p23.3 [CytoView hg19]  ADCY3 - 2p23.3 [CytoView hg38]
ImmunoBaseENSG00000138031
Genome Data Viewer NCBIADCY3 [Mapview hg19]  
OMIM600291   617885   
Gene and transcription
Genbank (Entrez)AB011083 AF033861 AK027857 AK075424 AK095173
RefSeq transcript (Entrez)NM_001320613 NM_001377128 NM_001377129 NM_001377130 NM_001377131 NM_001377132 NM_004036
Consensus coding sequences : CCDS (NCBI)ADCY3
Gene ExpressionADCY3 [ NCBI-GEO ]   ADCY3 [ EBI - ARRAY_EXPRESS ]   ADCY3 [ SEEK ]   ADCY3 [ MEM ]
Gene Expression Viewer (FireBrowse)ADCY3 [ Firebrowse - Broad ]
GenevisibleExpression of ADCY3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)109
GTEX Portal (Tissue expression)ADCY3
Human Protein AtlasENSG00000138031-ADCY3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60266   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60266  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60266
Catalytic activity : Enzyme4.6.1.1 [ Enzyme-Expasy ]   4.6.1.14.6.1.1 [ IntEnz-EBI ]   4.6.1.1 [ BRENDA ]   4.6.1.1 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusO60266
Domaine pattern : Prosite (Expaxy)GUANYLATE_CYCLASE_1 (PS00452)    GUANYLATE_CYCLASE_2 (PS50125)   
Domains : Interpro (EBI)A/G_cyclase    A/G_cyclase_CS    AC_N    Adcy    Nucleotide_cyclase   
Domain families : Pfam (Sanger)AC_N (PF16214)    Guanylate_cyc (PF00211)   
Domain families : Pfam (NCBI)pfam16214    pfam00211   
Domain families : Smart (EMBL)CYCc (SM00044)  
Conserved Domain (NCBI)ADCY3
SuperfamilyO60266
AlphaFold pdb e-kbO60266   
Human Protein Atlas [tissue]ENSG00000138031-ADCY3 [tissue]
HPRD02620
Protein Interaction databases
DIP (DOE-UCLA)O60266
IntAct (EBI)O60266
BioGRIDADCY3
STRING (EMBL)ADCY3
ZODIACADCY3
Ontologies - Pathways
QuickGOO60266
Ontology : AmiGOnegative regulation of inflammatory response to antigenic stimulus  renal water homeostasis  adenylate cyclase activity  adenylate cyclase activity  calmodulin binding  ATP binding  cytoplasm  Golgi apparatus  plasma membrane  plasma membrane  integral component of plasma membrane  cilium  cAMP biosynthetic process  cAMP biosynthetic process  signal transduction  G protein-coupled receptor signaling pathway  adenylate cyclase-activating G protein-coupled receptor signaling pathway  adenylate cyclase-activating G protein-coupled receptor signaling pathway  adenylate cyclase-activating G protein-coupled receptor signaling pathway  activation of adenylate cyclase activity  adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  single fertilization  acrosome reaction  sensory perception of smell  olfactory learning  membrane  integral component of membrane  flagellated sperm motility  activation of protein kinase A activity  intracellular signal transduction  metal ion binding  cellular response to glucagon stimulus  cellular response to forskolin  
Ontology : EGO-EBInegative regulation of inflammatory response to antigenic stimulus  renal water homeostasis  adenylate cyclase activity  adenylate cyclase activity  calmodulin binding  ATP binding  cytoplasm  Golgi apparatus  plasma membrane  plasma membrane  integral component of plasma membrane  cilium  cAMP biosynthetic process  cAMP biosynthetic process  signal transduction  G protein-coupled receptor signaling pathway  adenylate cyclase-activating G protein-coupled receptor signaling pathway  adenylate cyclase-activating G protein-coupled receptor signaling pathway  adenylate cyclase-activating G protein-coupled receptor signaling pathway  activation of adenylate cyclase activity  adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  single fertilization  acrosome reaction  sensory perception of smell  olfactory learning  membrane  integral component of membrane  flagellated sperm motility  activation of protein kinase A activity  intracellular signal transduction  metal ion binding  cellular response to glucagon stimulus  cellular response to forskolin  
Pathways : KEGGCalcium signaling pathway    Purine metabolism    GnRH signaling pathway    Gap junction    Olfactory transduction   
NDEx NetworkADCY3
Atlas of Cancer Signalling NetworkADCY3
Wikipedia pathwaysADCY3
Orthology - Evolution
OrthoDB109
GeneTree (enSembl)ENSG00000138031
Phylogenetic Trees/Animal Genes : TreeFamADCY3
Homologs : HomoloGeneADCY3
Homology/Alignments : Family Browser (UCSC)ADCY3
Gene fusions - Rearrangements
Fusion : QuiverADCY3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADCY3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADCY3
dbVarADCY3
ClinVarADCY3
MonarchADCY3
1000_GenomesADCY3 
Exome Variant ServerADCY3
GNOMAD BrowserENSG00000138031
Varsome BrowserADCY3
ACMGADCY3 variants
VarityO60266
Genomic Variants (DGV)ADCY3 [DGVbeta]
DECIPHERADCY3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADCY3 
Mutations
ICGC Data PortalADCY3 
TCGA Data PortalADCY3 
Broad Tumor PortalADCY3
OASIS PortalADCY3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADCY3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DADCY3
Mutations and Diseases : HGMDADCY3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaADCY3
DgiDB (Drug Gene Interaction Database)ADCY3
DoCM (Curated mutations)ADCY3
CIViC (Clinical Interpretations of Variants in Cancer)ADCY3
Cancer3DADCY3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600291    617885   
Orphanet
DisGeNETADCY3
MedgenADCY3
Genetic Testing Registry ADCY3
NextProtO60266 [Medical]
GENETestsADCY3
Target ValidationADCY3
Huge Navigator ADCY3 [HugePedia]
ClinGenADCY3
Clinical trials, drugs, therapy
MyCancerGenomeADCY3
Protein Interactions : CTDADCY3
Pharm GKB GenePA164741137
PharosO60266
Clinical trialADCY3
Miscellaneous
canSAR (ICR)ADCY3
HarmonizomeADCY3
DataMed IndexADCY3
Probes
Litterature
PubMed66 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXADCY3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:41:34 CEST 2021

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