Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ADCY4 (adenylate cyclase 4)

Identity

Alias_symbol (synonym)AC4
Other alias
HGNC (Hugo) ADCY4
LocusID (NCBI) 196883
Atlas_Id 60156
Location 14q12  [Link to chromosome band 14q12]
Location_base_pair Starts at 24787555 and ends at 24804277 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CIDEB (14q12) / ADCY4 (14q12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ADCY4   235
Cards
Entrez_Gene (NCBI)ADCY4  196883  adenylate cyclase 4
AliasesAC4
GeneCards (Weizmann)ADCY4
Ensembl hg19 (Hinxton)ENSG00000129467 [Gene_View]  chr14:24787555-24804277 [Contig_View]  ADCY4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000129467 [Gene_View]  chr14:24787555-24804277 [Contig_View]  ADCY4 [Vega]
ICGC DataPortalENSG00000129467
TCGA cBioPortalADCY4
AceView (NCBI)ADCY4
Genatlas (Paris)ADCY4
WikiGenes196883
SOURCE (Princeton)ADCY4
Genetics Home Reference (NIH)ADCY4
Genomic and cartography
GoldenPath hg19 (UCSC)ADCY4  -     chr14:24787555-24804277 -  14q12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ADCY4  -     14q12   [Description]    (hg38-Dec_2013)
EnsemblADCY4 - 14q12 [CytoView hg19]  ADCY4 - 14q12 [CytoView hg38]
Mapping of homologs : NCBIADCY4 [Mapview hg19]  ADCY4 [Mapview hg38]
OMIM600292   
Gene and transcription
Genbank (Entrez)AF086230 AF088070 AF497516 AK056745 AK122714
RefSeq transcript (Entrez)NM_001198568 NM_001198592 NM_139247
RefSeq genomic (Entrez)NC_000014 NC_018925 NT_026437 NW_004929393
Consensus coding sequences : CCDS (NCBI)ADCY4
Cluster EST : UnigeneHs.443428 [ NCBI ]
CGAP (NCI)Hs.443428
Alternative Splicing GalleryENSG00000129467
Gene ExpressionADCY4 [ NCBI-GEO ]   ADCY4 [ EBI - ARRAY_EXPRESS ]   ADCY4 [ SEEK ]   ADCY4 [ MEM ]
Gene Expression Viewer (FireBrowse)ADCY4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)196883
GTEX Portal (Tissue expression)ADCY4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NFM4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NFM4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NFM4
Splice isoforms : SwissVarQ8NFM4
Catalytic activity : Enzyme4.6.1.1 [ Enzyme-Expasy ]   4.6.1.14.6.1.1 [ IntEnz-EBI ]   4.6.1.1 [ BRENDA ]   4.6.1.1 [ KEGG ]   
PhosPhoSitePlusQ8NFM4
Domaine pattern : Prosite (Expaxy)GUANYLATE_CYCLASE_1 (PS00452)    GUANYLATE_CYCLASE_2 (PS50125)   
Domains : Interpro (EBI)A/G_cyclase    A/G_cyclase_CS    Adcy    Adcy_conserved_dom    Nucleotide_cyclase   
Domain families : Pfam (Sanger)DUF1053 (PF06327)    Guanylate_cyc (PF00211)   
Domain families : Pfam (NCBI)pfam06327    pfam00211   
Domain families : Smart (EMBL)CYCc (SM00044)  
Conserved Domain (NCBI)ADCY4
DMDM Disease mutations196883
Blocks (Seattle)ADCY4
SuperfamilyQ8NFM4
Human Protein AtlasENSG00000129467
Peptide AtlasQ8NFM4
HPRD11614
IPIIPI00465156   IPI00442208   IPI00939850   IPI01024760   IPI01024879   IPI01024976   
Protein Interaction databases
DIP (DOE-UCLA)Q8NFM4
IntAct (EBI)Q8NFM4
FunCoupENSG00000129467
BioGRIDADCY4
STRING (EMBL)ADCY4
ZODIACADCY4
Ontologies - Pathways
QuickGOQ8NFM4
Ontology : AmiGOrenal water homeostasis  adenylate cyclase activity  protein binding  ATP binding  cytoplasm  plasma membrane  energy reserve metabolic process  cAMP biosynthetic process  water transport  signal transduction  epidermal growth factor receptor signaling pathway  adenylate cyclase-modulating G-protein coupled receptor signaling pathway  adenylate cyclase-activating G-protein coupled receptor signaling pathway  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  activation of phospholipase C activity  synaptic transmission  fibroblast growth factor receptor signaling pathway  membrane  integral component of membrane  dendrite  activation of protein kinase A activity  intracellular signal transduction  small molecule metabolic process  innate immune response  metal ion binding  neurotrophin TRK receptor signaling pathway  transmembrane transport  cellular response to glucagon stimulus  
Ontology : EGO-EBIrenal water homeostasis  adenylate cyclase activity  protein binding  ATP binding  cytoplasm  plasma membrane  energy reserve metabolic process  cAMP biosynthetic process  water transport  signal transduction  epidermal growth factor receptor signaling pathway  adenylate cyclase-modulating G-protein coupled receptor signaling pathway  adenylate cyclase-activating G-protein coupled receptor signaling pathway  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  activation of phospholipase C activity  synaptic transmission  fibroblast growth factor receptor signaling pathway  membrane  integral component of membrane  dendrite  activation of protein kinase A activity  intracellular signal transduction  small molecule metabolic process  innate immune response  metal ion binding  neurotrophin TRK receptor signaling pathway  transmembrane transport  cellular response to glucagon stimulus  
Pathways : KEGGPurine metabolism    Rap1 signaling pathway    Calcium signaling pathway    Chemokine signaling pathway    Oocyte meiosis    Adrenergic signaling in cardiomyocytes    Vascular smooth muscle contraction    Gap junction    Circadian entrainment    Retrograde endocannabinoid signaling    Glutamatergic synapse    Cholinergic synapse    GABAergic synapse    Taste transduction    Insulin secretion    GnRH signaling pathway    Ovarian steroidogenesis    Progesterone-mediated oocyte maturation    Estrogen signaling pathway    Melanogenesis    Thyroid hormone synthesis    Salivary secretion    Gastric acid secretion    Pancreatic secretion    Bile secretion    Morphine addiction    HTLV-I infection    Dilated cardiomyopathy   
NDEx NetworkADCY4
Atlas of Cancer Signalling NetworkADCY4
Wikipedia pathwaysADCY4
Orthology - Evolution
OrthoDB196883
GeneTree (enSembl)ENSG00000129467
Phylogenetic Trees/Animal Genes : TreeFamADCY4
HOVERGENQ8NFM4
HOGENOMQ8NFM4
Homologs : HomoloGeneADCY4
Homology/Alignments : Family Browser (UCSC)ADCY4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADCY4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADCY4
dbVarADCY4
ClinVarADCY4
1000_GenomesADCY4 
Exome Variant ServerADCY4
ExAC (Exome Aggregation Consortium)ADCY4 (select the gene name)
Genetic variants : HAPMAP196883
Genomic Variants (DGV)ADCY4 [DGVbeta]
DECIPHER (Syndromes)14:24787555-24804277  ENSG00000129467
CONAN: Copy Number AnalysisADCY4 
Mutations
ICGC Data PortalADCY4 
TCGA Data PortalADCY4 
Broad Tumor PortalADCY4
OASIS PortalADCY4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADCY4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADCY4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ADCY4
DgiDB (Drug Gene Interaction Database)ADCY4
DoCM (Curated mutations)ADCY4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADCY4 (select a term)
intoGenADCY4
Cancer3DADCY4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600292   
Orphanet
MedgenADCY4
Genetic Testing Registry ADCY4
NextProtQ8NFM4 [Medical]
TSGene196883
GENETestsADCY4
Huge Navigator ADCY4 [HugePedia]
snp3D : Map Gene to Disease196883
BioCentury BCIQADCY4
ClinGenADCY4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD196883
Chemical/Pharm GKB GenePA24562
Clinical trialADCY4
Miscellaneous
canSAR (ICR)ADCY4 (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADCY4
EVEXADCY4
GoPubMedADCY4
iHOPADCY4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 11:53:44 CET 2017

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