Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ADCY5 (adenylate cyclase 5)

Identity

Alias_symbol (synonym)AC5
Other aliasFDFM
HGNC (Hugo) ADCY5
LocusID (NCBI) 111
Atlas_Id 60157
Location 3q21.1  [Link to chromosome band 3q21]
Location_base_pair Starts at 123001143 and ends at 123135189 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ADCY5 (3q21.1) / ADCY5 (3q21.1)ADCY5 (3q21.1) / GLIS1 (1p32.3)ADCY5 (3q21.1) / HACD2 (3q21.1)
TSC22D2 (3q25.1) / ADCY5 (3q21.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ADCY5   236
Cards
Entrez_Gene (NCBI)ADCY5  111  adenylate cyclase 5
AliasesAC5; FDFM
GeneCards (Weizmann)ADCY5
Ensembl hg19 (Hinxton)ENSG00000173175 [Gene_View]  chr3:123001143-123135189 [Contig_View]  ADCY5 [Vega]
Ensembl hg38 (Hinxton)ENSG00000173175 [Gene_View]  chr3:123001143-123135189 [Contig_View]  ADCY5 [Vega]
ICGC DataPortalENSG00000173175
TCGA cBioPortalADCY5
AceView (NCBI)ADCY5
Genatlas (Paris)ADCY5
WikiGenes111
SOURCE (Princeton)ADCY5
Genetics Home Reference (NIH)ADCY5
Genomic and cartography
GoldenPath hg19 (UCSC)ADCY5  -     chr3:123001143-123135189 -  3q21.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ADCY5  -     3q21.1   [Description]    (hg38-Dec_2013)
EnsemblADCY5 - 3q21.1 [CytoView hg19]  ADCY5 - 3q21.1 [CytoView hg38]
Mapping of homologs : NCBIADCY5 [Mapview hg19]  ADCY5 [Mapview hg38]
OMIM600293   606703   
Gene and transcription
Genbank (Entrez)AF497517 AK093840 AK098381 AK124691 AK294565
RefSeq transcript (Entrez)NM_001199642 NM_183357
RefSeq genomic (Entrez)NC_000003 NC_018914 NG_033882 NT_005612 NW_004929311
Consensus coding sequences : CCDS (NCBI)ADCY5
Cluster EST : UnigeneHs.593292 [ NCBI ]
CGAP (NCI)Hs.593292
Alternative Splicing GalleryENSG00000173175
Gene ExpressionADCY5 [ NCBI-GEO ]   ADCY5 [ EBI - ARRAY_EXPRESS ]   ADCY5 [ SEEK ]   ADCY5 [ MEM ]
Gene Expression Viewer (FireBrowse)ADCY5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)111
GTEX Portal (Tissue expression)ADCY5
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95622   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95622  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95622
Splice isoforms : SwissVarO95622
Catalytic activity : Enzyme4.6.1.1 [ Enzyme-Expasy ]   4.6.1.14.6.1.1 [ IntEnz-EBI ]   4.6.1.1 [ BRENDA ]   4.6.1.1 [ KEGG ]   
PhosPhoSitePlusO95622
Domaine pattern : Prosite (Expaxy)GUANYLATE_CYCLASE_1 (PS00452)    GUANYLATE_CYCLASE_2 (PS50125)   
Domains : Interpro (EBI)A/G_cyclase    A/G_cyclase_CS    Adcy    Adcy_conserved_dom    Nucleotide_cyclase   
Domain families : Pfam (Sanger)DUF1053 (PF06327)    Guanylate_cyc (PF00211)   
Domain families : Pfam (NCBI)pfam06327    pfam00211   
Domain families : Smart (EMBL)CYCc (SM00044)  
Conserved Domain (NCBI)ADCY5
DMDM Disease mutations111
Blocks (Seattle)ADCY5
SuperfamilyO95622
Human Protein AtlasENSG00000173175
Peptide AtlasO95622
HPRD08973
IPIIPI00339214   IPI00943063   IPI00946756   IPI00945594   IPI01021032   IPI00947390   
Protein Interaction databases
DIP (DOE-UCLA)O95622
IntAct (EBI)O95622
FunCoupENSG00000173175
BioGRIDADCY5
STRING (EMBL)ADCY5
ZODIACADCY5
Ontologies - Pathways
QuickGOO95622
Ontology : AmiGOadenosine receptor signaling pathway  renal water homeostasis  adenylate cyclase activity  ATP binding  intracellular  plasma membrane  plasma membrane  energy reserve metabolic process  cAMP biosynthetic process  water transport  signal transduction  epidermal growth factor receptor signaling pathway  adenylate cyclase-activating G-protein coupled receptor signaling pathway  adenylate cyclase-activating dopamine receptor signaling pathway  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  adenylate cyclase-inhibiting dopamine receptor signaling pathway  activation of phospholipase C activity  synaptic transmission  locomotory behavior  adenylate cyclase binding  fibroblast growth factor receptor signaling pathway  integral component of membrane  activation of protein kinase A activity  intracellular signal transduction  small molecule metabolic process  innate immune response  metal ion binding  protein heterodimerization activity  neurotrophin TRK receptor signaling pathway  neuromuscular process controlling balance  transmembrane transport  cellular response to glucagon stimulus  primary cilium  
Ontology : EGO-EBIadenosine receptor signaling pathway  renal water homeostasis  adenylate cyclase activity  ATP binding  intracellular  plasma membrane  plasma membrane  energy reserve metabolic process  cAMP biosynthetic process  water transport  signal transduction  epidermal growth factor receptor signaling pathway  adenylate cyclase-activating G-protein coupled receptor signaling pathway  adenylate cyclase-activating dopamine receptor signaling pathway  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  adenylate cyclase-inhibiting dopamine receptor signaling pathway  activation of phospholipase C activity  synaptic transmission  locomotory behavior  adenylate cyclase binding  fibroblast growth factor receptor signaling pathway  integral component of membrane  activation of protein kinase A activity  intracellular signal transduction  small molecule metabolic process  innate immune response  metal ion binding  protein heterodimerization activity  neurotrophin TRK receptor signaling pathway  neuromuscular process controlling balance  transmembrane transport  cellular response to glucagon stimulus  primary cilium  
Pathways : KEGGPurine metabolism    Rap1 signaling pathway    Chemokine signaling pathway    Oocyte meiosis    Adrenergic signaling in cardiomyocytes    Vascular smooth muscle contraction    Gap junction    Circadian entrainment    Retrograde endocannabinoid signaling    Glutamatergic synapse    Cholinergic synapse    Serotonergic synapse    GABAergic synapse    Dopaminergic synapse    Insulin secretion    GnRH signaling pathway    Ovarian steroidogenesis    Progesterone-mediated oocyte maturation    Estrogen signaling pathway    Melanogenesis    Thyroid hormone synthesis    Salivary secretion    Gastric acid secretion    Pancreatic secretion    Bile secretion    Parkinson's disease    Cocaine addiction    Amphetamine addiction    Morphine addiction    Alcoholism    HTLV-I infection    Dilated cardiomyopathy   
NDEx NetworkADCY5
Atlas of Cancer Signalling NetworkADCY5
Wikipedia pathwaysADCY5
Orthology - Evolution
OrthoDB111
GeneTree (enSembl)ENSG00000173175
Phylogenetic Trees/Animal Genes : TreeFamADCY5
HOVERGENO95622
HOGENOMO95622
Homologs : HomoloGeneADCY5
Homology/Alignments : Family Browser (UCSC)ADCY5
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADCY5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADCY5
dbVarADCY5
ClinVarADCY5
1000_GenomesADCY5 
Exome Variant ServerADCY5
ExAC (Exome Aggregation Consortium)ADCY5 (select the gene name)
Genetic variants : HAPMAP111
Genomic Variants (DGV)ADCY5 [DGVbeta]
DECIPHER (Syndromes)3:123001143-123135189  ENSG00000173175
CONAN: Copy Number AnalysisADCY5 
Mutations
ICGC Data PortalADCY5 
TCGA Data PortalADCY5 
Broad Tumor PortalADCY5
OASIS PortalADCY5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADCY5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADCY5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ADCY5
DgiDB (Drug Gene Interaction Database)ADCY5
DoCM (Curated mutations)ADCY5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADCY5 (select a term)
intoGenADCY5
Cancer3DADCY5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600293    606703   
Orphanet1634    21790   
MedgenADCY5
Genetic Testing Registry ADCY5
NextProtO95622 [Medical]
TSGene111
GENETestsADCY5
Huge Navigator ADCY5 [HugePedia]
snp3D : Map Gene to Disease111
BioCentury BCIQADCY5
ClinGenADCY5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD111
Chemical/Pharm GKB GenePA24563
Clinical trialADCY5
Miscellaneous
canSAR (ICR)ADCY5 (select the gene name)
Probes
Litterature
PubMed53 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADCY5
EVEXADCY5
GoPubMedADCY5
iHOPADCY5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 11:53:44 CET 2017

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