Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ADCY5 (adenylate cyclase 5)

Identity

Other aliasAC5
FDFM
HGNC (Hugo) ADCY5
LocusID (NCBI) 111
Atlas_Id 57259
Location 3q21.1  [Link to chromosome band 3q21]
Location_base_pair Starts at 123284552 and ends at 123447446 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADCY5 (3q21.1) / ADCY5 (3q21.1)ADCY5 (3q21.1) / GLIS1 (1p32.3)ADCY5 (3q21.1) / HACD2 (3q21.1)
TSC22D2 (3q25.1) / ADCY5 (3q21.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ADCY5   236
Cards
Entrez_Gene (NCBI)ADCY5  111  adenylate cyclase 5
AliasesAC5; FDFM
GeneCards (Weizmann)ADCY5
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]  chr3:123284552-123447446 [Contig_View]  ADCY5 [Vega]
TCGA cBioPortalADCY5
AceView (NCBI)ADCY5
Genatlas (Paris)ADCY5
WikiGenes111
SOURCE (Princeton)ADCY5
Genetics Home Reference (NIH)ADCY5
Genomic and cartography
GoldenPath hg38 (UCSC)ADCY5  -     chr3:123284552-123447446 -  3q21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADCY5  -     3q21.1   [Description]    (hg19-Feb_2009)
EnsemblADCY5 - 3q21.1 [CytoView hg19]  ADCY5 - 3q21.1 [CytoView hg38]
Mapping of homologs : NCBIADCY5 [Mapview hg19]  ADCY5 [Mapview hg38]
OMIM600293   606703   
Gene and transcription
Genbank (Entrez)AF497517 AK093840 AK098381 AK124691 AK294565
RefSeq transcript (Entrez)NM_001199642 NM_183357
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ADCY5
Cluster EST : UnigeneHs.593292 [ NCBI ]
CGAP (NCI)Hs.593292
Gene ExpressionADCY5 [ NCBI-GEO ]   ADCY5 [ EBI - ARRAY_EXPRESS ]   ADCY5 [ SEEK ]   ADCY5 [ MEM ]
Gene Expression Viewer (FireBrowse)ADCY5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)111
GTEX Portal (Tissue expression)ADCY5
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95622   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95622  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95622
Splice isoforms : SwissVarO95622
PhosPhoSitePlusO95622
Domaine pattern : Prosite (Expaxy)GUANYLATE_CYCLASE_1 (PS00452)    GUANYLATE_CYCLASE_2 (PS50125)   
Domains : Interpro (EBI)A/G_cyclase    A/G_cyclase_CS    AC_N    Adcy    Adcy_conserved_dom    Nucleotide_cyclase   
Domain families : Pfam (Sanger)AC_N (PF16214)    DUF1053 (PF06327)    Guanylate_cyc (PF00211)   
Domain families : Pfam (NCBI)pfam16214    pfam06327    pfam00211   
Domain families : Smart (EMBL)CYCc (SM00044)  
Conserved Domain (NCBI)ADCY5
DMDM Disease mutations111
Blocks (Seattle)ADCY5
SuperfamilyO95622
Peptide AtlasO95622
IPIIPI00339214   IPI00943063   IPI00946756   IPI00945594   IPI01021032   IPI00947390   
Protein Interaction databases
DIP (DOE-UCLA)O95622
IntAct (EBI)O95622
BioGRIDADCY5
STRING (EMBL)ADCY5
ZODIACADCY5
Ontologies - Pathways
QuickGOO95622
Ontology : AmiGOadenosine receptor signaling pathway  renal water homeostasis  adenylate cyclase activity  adenylate cyclase activity  guanylate cyclase activity  ATP binding  plasma membrane  plasma membrane  plasma membrane  cilium  cAMP biosynthetic process  cAMP biosynthetic process  cGMP biosynthetic process  G-protein coupled receptor signaling pathway  adenylate cyclase-activating G-protein coupled receptor signaling pathway  adenylate cyclase-activating G-protein coupled receptor signaling pathway  activation of adenylate cyclase activity  adenylate cyclase-activating dopamine receptor signaling pathway  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  adenylate cyclase-inhibiting dopamine receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  locomotory behavior  guanylate cyclase complex, soluble  adenylate cyclase binding  integral component of membrane  activation of protein kinase A activity  intermediate filament cytoskeleton  metal ion binding  protein heterodimerization activity  neuromuscular process controlling balance  regulation of insulin secretion involved in cellular response to glucose stimulus  cellular response to glucagon stimulus  scaffold protein binding  cellular response to forskolin  
Ontology : EGO-EBIadenosine receptor signaling pathway  renal water homeostasis  adenylate cyclase activity  adenylate cyclase activity  guanylate cyclase activity  ATP binding  plasma membrane  plasma membrane  plasma membrane  cilium  cAMP biosynthetic process  cAMP biosynthetic process  cGMP biosynthetic process  G-protein coupled receptor signaling pathway  adenylate cyclase-activating G-protein coupled receptor signaling pathway  adenylate cyclase-activating G-protein coupled receptor signaling pathway  activation of adenylate cyclase activity  adenylate cyclase-activating dopamine receptor signaling pathway  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  adenylate cyclase-inhibiting dopamine receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  locomotory behavior  guanylate cyclase complex, soluble  adenylate cyclase binding  integral component of membrane  activation of protein kinase A activity  intermediate filament cytoskeleton  metal ion binding  protein heterodimerization activity  neuromuscular process controlling balance  regulation of insulin secretion involved in cellular response to glucose stimulus  cellular response to glucagon stimulus  scaffold protein binding  cellular response to forskolin  
Pathways : KEGGPurine metabolism    Rap1 signaling pathway    Chemokine signaling pathway    Oocyte meiosis    Adrenergic signaling in cardiomyocytes    Vascular smooth muscle contraction    Gap junction    Circadian entrainment    Retrograde endocannabinoid signaling    Glutamatergic synapse    Cholinergic synapse    Serotonergic synapse    GABAergic synapse    Dopaminergic synapse    Insulin secretion    GnRH signaling pathway    Ovarian steroidogenesis    Progesterone-mediated oocyte maturation    Estrogen signaling pathway    Melanogenesis    Thyroid hormone synthesis    Salivary secretion    Gastric acid secretion    Pancreatic secretion    Bile secretion    Parkinson's disease    Cocaine addiction    Amphetamine addiction    Morphine addiction    Alcoholism    HTLV-I infection    Dilated cardiomyopathy   
NDEx NetworkADCY5
Atlas of Cancer Signalling NetworkADCY5
Wikipedia pathwaysADCY5
Orthology - Evolution
OrthoDB111
Phylogenetic Trees/Animal Genes : TreeFamADCY5
HOVERGENO95622
HOGENOMO95622
Homologs : HomoloGeneADCY5
Homology/Alignments : Family Browser (UCSC)ADCY5
Gene fusions - Rearrangements
Tumor Fusion PortalADCY5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADCY5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADCY5
dbVarADCY5
ClinVarADCY5
1000_GenomesADCY5 
Exome Variant ServerADCY5
ExAC (Exome Aggregation Consortium)
Genetic variants : HAPMAP111
Genomic Variants (DGV)ADCY5 [DGVbeta]
DECIPHERADCY5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADCY5 
Mutations
ICGC Data PortalADCY5 
TCGA Data PortalADCY5 
Broad Tumor PortalADCY5
OASIS PortalADCY5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADCY5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADCY5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ADCY5
DgiDB (Drug Gene Interaction Database)ADCY5
DoCM (Curated mutations)ADCY5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADCY5 (select a term)
intoGenADCY5
Cancer3DADCY5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600293    606703   
Orphanet
DisGeNETADCY5
MedgenADCY5
Genetic Testing Registry ADCY5
NextProtO95622 [Medical]
TSGene111
GENETestsADCY5
Target ValidationADCY5
Huge Navigator ADCY5 [HugePedia]
snp3D : Map Gene to Disease111
BioCentury BCIQADCY5
ClinGenADCY5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD111
Chemical/Pharm GKB GenePA24563
Clinical trialADCY5
Miscellaneous
canSAR (ICR)ADCY5 (select the gene name)
Probes
Litterature
PubMed63 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADCY5
EVEXADCY5
GoPubMedADCY5
iHOPADCY5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:02:10 CET 2017

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