Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ADCY6 (adenylate cyclase 6)

Identity

Alias_symbol (synonym)AC6
Other aliasLCCS8
HGNC (Hugo) ADCY6
LocusID (NCBI) 112
Atlas_Id 579
Location 12q13.12  [Link to chromosome band 12q13]
Location_base_pair Starts at 48766191 and ends at 48789096 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ADCY6   237
Cards
Entrez_Gene (NCBI)ADCY6  112  adenylate cyclase 6
AliasesAC6; LCCS8
GeneCards (Weizmann)ADCY6
Ensembl hg19 (Hinxton)ENSG00000174233 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000174233 [Gene_View]  chr12:48766191-48789096 [Contig_View]  ADCY6 [Vega]
ICGC DataPortalENSG00000174233
TCGA cBioPortalADCY6
AceView (NCBI)ADCY6
Genatlas (Paris)ADCY6
WikiGenes112
SOURCE (Princeton)ADCY6
Genetics Home Reference (NIH)ADCY6
Genomic and cartography
GoldenPath hg38 (UCSC)ADCY6  -     chr12:48766191-48789096 -  12q13.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADCY6  -     12q13.12   [Description]    (hg19-Feb_2009)
EnsemblADCY6 - 12q13.12 [CytoView hg19]  ADCY6 - 12q13.12 [CytoView hg38]
Mapping of homologs : NCBIADCY6 [Mapview hg19]  ADCY6 [Mapview hg38]
OMIM600294   616287   
Gene and transcription
Genbank (Entrez)AA628691 AB007882 AF250226 AK225224 AK294446
RefSeq transcript (Entrez)NM_015270 NM_020983
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ADCY6
Cluster EST : UnigeneHs.694408 [ NCBI ]
CGAP (NCI)Hs.694408
Alternative Splicing GalleryENSG00000174233
Gene ExpressionADCY6 [ NCBI-GEO ]   ADCY6 [ EBI - ARRAY_EXPRESS ]   ADCY6 [ SEEK ]   ADCY6 [ MEM ]
Gene Expression Viewer (FireBrowse)ADCY6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)112
GTEX Portal (Tissue expression)ADCY6
Human Protein AtlasENSG00000174233-ADCY6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43306   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43306  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43306
Splice isoforms : SwissVarO43306
PhosPhoSitePlusO43306
Domaine pattern : Prosite (Expaxy)GUANYLATE_CYCLASE_1 (PS00452)    GUANYLATE_CYCLASE_2 (PS50125)   
Domains : Interpro (EBI)A/G_cyclase    A/G_cyclase_CS    AC_N    Adcy    Adcy_conserved_dom    Nucleotide_cyclase   
Domain families : Pfam (Sanger)AC_N (PF16214)    DUF1053 (PF06327)    Guanylate_cyc (PF00211)   
Domain families : Pfam (NCBI)pfam16214    pfam06327    pfam00211   
Domain families : Smart (EMBL)CYCc (SM00044)  
Conserved Domain (NCBI)ADCY6
DMDM Disease mutations112
Blocks (Seattle)ADCY6
SuperfamilyO43306
Human Protein Atlas [tissue]ENSG00000174233-ADCY6 [tissue]
Peptide AtlasO43306
HPRD02621
IPIIPI00011938   IPI00220444   IPI00910029   IPI01022435   
Protein Interaction databases
DIP (DOE-UCLA)O43306
IntAct (EBI)O43306
FunCoupENSG00000174233
BioGRIDADCY6
STRING (EMBL)ADCY6
ZODIACADCY6
Ontologies - Pathways
QuickGOO43306
Ontology : AmiGOrenal water homeostasis  renal water homeostasis  adenylate cyclase activity  guanylate cyclase activity  protein binding  ATP binding  plasma membrane  plasma membrane  cilium  cAMP biosynthetic process  cGMP biosynthetic process  adenylate cyclase-activating G-protein coupled receptor signaling pathway  adenylate cyclase-activating G-protein coupled receptor signaling pathway  activation of adenylate cyclase activity  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  dopamine receptor signaling pathway  guanylate cyclase complex, soluble  negative regulation of neuron projection development  membrane  integral component of membrane  protein kinase binding  intrinsic component of plasma membrane  activation of protein kinase A activity  intracellular signal transduction  negative regulation of urine volume  metal ion binding  cellular response to glucagon stimulus  cellular response to prostaglandin E stimulus  cellular response to catecholamine stimulus  regulation of blood vessel diameter  cellular response to vasopressin  cellular response to forskolin  
Ontology : EGO-EBIrenal water homeostasis  renal water homeostasis  adenylate cyclase activity  guanylate cyclase activity  protein binding  ATP binding  plasma membrane  plasma membrane  cilium  cAMP biosynthetic process  cGMP biosynthetic process  adenylate cyclase-activating G-protein coupled receptor signaling pathway  adenylate cyclase-activating G-protein coupled receptor signaling pathway  activation of adenylate cyclase activity  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  dopamine receptor signaling pathway  guanylate cyclase complex, soluble  negative regulation of neuron projection development  membrane  integral component of membrane  protein kinase binding  intrinsic component of plasma membrane  activation of protein kinase A activity  intracellular signal transduction  negative regulation of urine volume  metal ion binding  cellular response to glucagon stimulus  cellular response to prostaglandin E stimulus  cellular response to catecholamine stimulus  regulation of blood vessel diameter  cellular response to vasopressin  cellular response to forskolin  
Pathways : KEGG   
NDEx NetworkADCY6
Atlas of Cancer Signalling NetworkADCY6
Wikipedia pathwaysADCY6
Orthology - Evolution
OrthoDB112
GeneTree (enSembl)ENSG00000174233
Phylogenetic Trees/Animal Genes : TreeFamADCY6
HOVERGENO43306
HOGENOMO43306
Homologs : HomoloGeneADCY6
Homology/Alignments : Family Browser (UCSC)ADCY6
Gene fusions - Rearrangements
Fusion: Tumor Portal ADCY6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADCY6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADCY6
dbVarADCY6
ClinVarADCY6
1000_GenomesADCY6 
Exome Variant ServerADCY6
ExAC (Exome Aggregation Consortium)ENSG00000174233
GNOMAD BrowserENSG00000174233
Genetic variants : HAPMAP112
Genomic Variants (DGV)ADCY6 [DGVbeta]
DECIPHERADCY6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADCY6 
Mutations
ICGC Data PortalADCY6 
TCGA Data PortalADCY6 
Broad Tumor PortalADCY6
OASIS PortalADCY6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADCY6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADCY6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ADCY6
DgiDB (Drug Gene Interaction Database)ADCY6
DoCM (Curated mutations)ADCY6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADCY6 (select a term)
intoGenADCY6
Cancer3DADCY6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600294    616287   
Orphanet3207   
MedgenADCY6
Genetic Testing Registry ADCY6
NextProtO43306 [Medical]
TSGene112
GENETestsADCY6
Target ValidationADCY6
Huge Navigator ADCY6 [HugePedia]
snp3D : Map Gene to Disease112
BioCentury BCIQADCY6
ClinGenADCY6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD112
Chemical/Pharm GKB GenePA27
Clinical trialADCY6
Miscellaneous
canSAR (ICR)ADCY6 (select the gene name)
Probes
Litterature
PubMed51 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADCY6
EVEXADCY6
GoPubMedADCY6
iHOPADCY6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 9 12:39:21 CET 2017

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