Atlas of Genetics and Cytogenetics in Oncology and Haematology

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ADCY8 (adenylate cyclase 8)

Identity

Alias_namesADCY3
adenylate cyclase 8 (brain)
Alias_symbol (synonym)HBAC1
AC8
Other alias
HGNC (Hugo) ADCY8
LocusID (NCBI) 114
Atlas_Id 581
Location 16q12.1  [Link to chromosome band 16q12]
Location_base_pair Starts at 130780301 and ends at 131040589 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADCY8 (8q24.22) / DNAJC14 (12q13.2)SCAF11 (12q12) / ADCY8 (8q24.22)SCAF11 12q12 / ADCY8 8q24.22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(8;12)(q24;q12) SCAF11/ADCY8

External links

Nomenclature
HGNC (Hugo)ADCY8   239
Cards
Entrez_Gene (NCBI)ADCY8  114  adenylate cyclase 8
AliasesAC8; ADCY3; HBAC1
GeneCards (Weizmann)ADCY8
Ensembl hg19 (Hinxton)ENSG00000155897 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000155897 [Gene_View]  ENSG00000155897 [Sequence]  chr8:130780301-131040589 [Contig_View]  ADCY8 [Vega]
ICGC DataPortalENSG00000155897
TCGA cBioPortalADCY8
AceView (NCBI)ADCY8
Genatlas (Paris)ADCY8
WikiGenes114
SOURCE (Princeton)ADCY8
Genetics Home Reference (NIH)ADCY8
Genomic and cartography
GoldenPath hg38 (UCSC)ADCY8  -     chr8:130780301-131040589 -  16q12.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADCY8  -     16q12.1   [Description]    (hg19-Feb_2009)
EnsemblADCY8 - 16q12.1 [CytoView hg19]  ADCY8 - 16q12.1 [CytoView hg38]
Mapping of homologs : NCBIADCY8 [Mapview hg19]  ADCY8 [Mapview hg38]
OMIM103070   
Gene and transcription
Genbank (Entrez)DQ104739 DR003657 GQ472223 M83533 Z35309
RefSeq transcript (Entrez)NM_001115
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ADCY8
Cluster EST : UnigeneHs.591859 [ NCBI ]
CGAP (NCI)Hs.591859
Alternative Splicing GalleryENSG00000155897
Gene ExpressionADCY8 [ NCBI-GEO ]   ADCY8 [ EBI - ARRAY_EXPRESS ]   ADCY8 [ SEEK ]   ADCY8 [ MEM ]
Gene Expression Viewer (FireBrowse)ADCY8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)114
GTEX Portal (Tissue expression)ADCY8
Human Protein AtlasENSG00000155897-ADCY8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP40145   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP40145  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP40145
Splice isoforms : SwissVarP40145
Catalytic activity : Enzyme4.6.1.1 [ Enzyme-Expasy ]   4.6.1.14.6.1.1 [ IntEnz-EBI ]   4.6.1.1 [ BRENDA ]   4.6.1.1 [ KEGG ]   
PhosPhoSitePlusP40145
Domaine pattern : Prosite (Expaxy)GUANYLATE_CYCLASE_1 (PS00452)    GUANYLATE_CYCLASE_2 (PS50125)   
Domains : Interpro (EBI)A/G_cyclase    A/G_cyclase_CS    AC_N    Adcy    Adcy_conserved_dom    Nucleotide_cyclase   
Domain families : Pfam (Sanger)AC_N (PF16214)    DUF1053 (PF06327)    Guanylate_cyc (PF00211)   
Domain families : Pfam (NCBI)pfam16214    pfam06327    pfam00211   
Domain families : Smart (EMBL)CYCc (SM00044)  
Conserved Domain (NCBI)ADCY8
DMDM Disease mutations114
Blocks (Seattle)ADCY8
SuperfamilyP40145
Human Protein Atlas [tissue]ENSG00000155897-ADCY8 [tissue]
Peptide AtlasP40145
HPRD00051
IPIIPI00027356   IPI00642131   IPI00975488   
Protein Interaction databases
DIP (DOE-UCLA)P40145
IntAct (EBI)P40145
FunCoupENSG00000155897
BioGRIDADCY8
STRING (EMBL)ADCY8
ZODIACADCY8
Ontologies - Pathways
QuickGOP40145
Ontology : AmiGOrenal water homeostasis  adenylate cyclase activity  ATP binding  plasma membrane  cAMP biosynthetic process  cAMP biosynthetic process  signal transduction  G-protein coupled receptor signaling pathway  adenylate cyclase-activating G-protein coupled receptor signaling pathway  adenylate cyclase-activating G-protein coupled receptor signaling pathway  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  learning or memory  long-term memory  calcium- and calmodulin-responsive adenylate cyclase activity  membrane  integral component of membrane  cAMP-mediated signaling  metal ion binding  cellular response to glucagon stimulus  
Ontology : EGO-EBIrenal water homeostasis  adenylate cyclase activity  ATP binding  plasma membrane  cAMP biosynthetic process  cAMP biosynthetic process  signal transduction  G-protein coupled receptor signaling pathway  adenylate cyclase-activating G-protein coupled receptor signaling pathway  adenylate cyclase-activating G-protein coupled receptor signaling pathway  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  learning or memory  long-term memory  calcium- and calmodulin-responsive adenylate cyclase activity  membrane  integral component of membrane  cAMP-mediated signaling  metal ion binding  cellular response to glucagon stimulus  
Pathways : KEGG   
NDEx NetworkADCY8
Atlas of Cancer Signalling NetworkADCY8
Wikipedia pathwaysADCY8
Orthology - Evolution
OrthoDB114
GeneTree (enSembl)ENSG00000155897
Phylogenetic Trees/Animal Genes : TreeFamADCY8
HOVERGENP40145
HOGENOMP40145
Homologs : HomoloGeneADCY8
Homology/Alignments : Family Browser (UCSC)ADCY8
Gene fusions - Rearrangements
Fusion : MitelmanSCAF11/ADCY8 [12q12/8q24.22]  [t(8;12)(q24;q12)]  
Fusion PortalSCAF11 12q12 ADCY8 8q24.22 LUSC
Fusion : QuiverADCY8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADCY8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADCY8
dbVarADCY8
ClinVarADCY8
1000_GenomesADCY8 
Exome Variant ServerADCY8
ExAC (Exome Aggregation Consortium)ENSG00000155897
GNOMAD BrowserENSG00000155897
Varsome BrowserADCY8
Genetic variants : HAPMAP114
Genomic Variants (DGV)ADCY8 [DGVbeta]
DECIPHERADCY8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADCY8 
Mutations
ICGC Data PortalADCY8 
TCGA Data PortalADCY8 
Broad Tumor PortalADCY8
OASIS PortalADCY8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADCY8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADCY8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ADCY8
DgiDB (Drug Gene Interaction Database)ADCY8
DoCM (Curated mutations)ADCY8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADCY8 (select a term)
intoGenADCY8
Cancer3DADCY8(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM103070   
Orphanet
DisGeNETADCY8
MedgenADCY8
Genetic Testing Registry ADCY8
NextProtP40145 [Medical]
TSGene114
GENETestsADCY8
Target ValidationADCY8
Huge Navigator ADCY8 [HugePedia]
snp3D : Map Gene to Disease114
BioCentury BCIQADCY8
ClinGenADCY8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD114
Chemical/Pharm GKB GenePA29
Clinical trialADCY8
Miscellaneous
canSAR (ICR)ADCY8 (select the gene name)
Probes
Litterature
PubMed48 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADCY8
EVEXADCY8
GoPubMedADCY8
iHOPADCY8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Aug 16 10:45:29 CEST 2018
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