Atlas of Genetics and Cytogenetics in Oncology and Haematology

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ADCY9 (adenylate cyclase 9)

Identity

Alias_symbol (synonym)AC9
Other aliasACIX
HGNC (Hugo) ADCY9
LocusID (NCBI) 115
Atlas_Id 54108
Location 16p13.3  [Link to chromosome band 16p13]
Location_base_pair Starts at 3962649 and ends at 4116185 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADCY9 (16p13.3) / BGN (Xq28)ADCY9 (16p13.3) / CDIP1 (16p13.3)ADCY9 (16p13.3) / CTDSPL (3p22.2)
ADCY9 (16p13.3) / GLYR1 (16p13.3)ADCY9 (16p13.3) / PATE3 (11q24.2)ADCY9 (16p13.3) / PRKCB (16p12.2)
ADCY9 (16p13.3) / PRSS27 (16p13.3)ADCY9 (16p13.3) / SRL (16p13.3)ADCY9 (16p13.3) / TFAP4 (16p13.3)
ADCY9 16p13.3 / GLYR1 16p13.3ADCY9 16p13.3 / PRKCB 16p12.2ADCY9 16p13.3 / PRSS27 16p13.3
ADCY9 16p13.3 / SRL 16p13.3ADCY9 16p13.3 / TFAP4 16p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 6 ]
  t(16;16)(p12;p13) ADCY9/PRKCB
ADCY9/CDIP1 (16p13)
ADCY9/GLYR1 (16p13)
ADCY9/PRSS27 (16p13)
ADCY9/SRL (16p13)
ADCY9/TFAP4 (16p13)

External links

Nomenclature
HGNC (Hugo)ADCY9   240
Cards
Entrez_Gene (NCBI)ADCY9  115  adenylate cyclase 9
AliasesAC9; ACIX
GeneCards (Weizmann)ADCY9
Ensembl hg19 (Hinxton)ENSG00000162104 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000162104 [Gene_View]  ENSG00000162104 [Sequence]  chr16:3962649-4116185 [Contig_View]  ADCY9 [Vega]
ICGC DataPortalENSG00000162104
TCGA cBioPortalADCY9
AceView (NCBI)ADCY9
Genatlas (Paris)ADCY9
WikiGenes115
SOURCE (Princeton)ADCY9
Genetics Home Reference (NIH)ADCY9
Genomic and cartography
GoldenPath hg38 (UCSC)ADCY9  -     chr16:3962649-4116185 -  16p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADCY9  -     16p13.3   [Description]    (hg19-Feb_2009)
EnsemblADCY9 - 16p13.3 [CytoView hg19]  ADCY9 - 16p13.3 [CytoView hg38]
Mapping of homologs : NCBIADCY9 [Mapview hg19]  ADCY9 [Mapview hg38]
OMIM603302   
Gene and transcription
Genbank (Entrez)AB011092 AF036927 AJ133123 AK022108 AU141090
RefSeq transcript (Entrez)NM_001116
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ADCY9
Cluster EST : UnigeneHs.610484 [ NCBI ]
CGAP (NCI)Hs.610484
Alternative Splicing GalleryENSG00000162104
Gene ExpressionADCY9 [ NCBI-GEO ]   ADCY9 [ EBI - ARRAY_EXPRESS ]   ADCY9 [ SEEK ]   ADCY9 [ MEM ]
Gene Expression Viewer (FireBrowse)ADCY9 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)115
GTEX Portal (Tissue expression)ADCY9
Human Protein AtlasENSG00000162104-ADCY9 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60503   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60503  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60503
Splice isoforms : SwissVarO60503
PhosPhoSitePlusO60503
Domaine pattern : Prosite (Expaxy)GUANYLATE_CYCLASE_1 (PS00452)    GUANYLATE_CYCLASE_2 (PS50125)   
Domains : Interpro (EBI)A/G_cyclase    A/G_cyclase_CS    Nucleotide_cyclase   
Domain families : Pfam (Sanger)Guanylate_cyc (PF00211)   
Domain families : Pfam (NCBI)pfam00211   
Domain families : Smart (EMBL)CYCc (SM00044)  
Conserved Domain (NCBI)ADCY9
DMDM Disease mutations115
Blocks (Seattle)ADCY9
SuperfamilyO60503
Human Protein Atlas [tissue]ENSG00000162104-ADCY9 [tissue]
Peptide AtlasO60503
HPRD04489
IPIIPI00030099   
Protein Interaction databases
DIP (DOE-UCLA)O60503
IntAct (EBI)O60503
FunCoupENSG00000162104
BioGRIDADCY9
STRING (EMBL)ADCY9
ZODIACADCY9
Ontologies - Pathways
QuickGOO60503
Ontology : AmiGOrenal water homeostasis  adenylate cyclase activity  adenylate cyclase activity  ATP binding  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  cAMP biosynthetic process  signal transduction  G protein-coupled receptor signaling pathway  adenylate cyclase-activating G protein-coupled receptor signaling pathway  adenylate cyclase-activating G protein-coupled receptor signaling pathway  adenylate cyclase-activating G protein-coupled receptor signaling pathway  adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  integral component of membrane  axon  dendrite  metal ion binding  cellular response to glucagon stimulus  adenylate cyclase-activating adrenergic receptor signaling pathway  
Ontology : EGO-EBIrenal water homeostasis  adenylate cyclase activity  adenylate cyclase activity  ATP binding  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  cAMP biosynthetic process  signal transduction  G protein-coupled receptor signaling pathway  adenylate cyclase-activating G protein-coupled receptor signaling pathway  adenylate cyclase-activating G protein-coupled receptor signaling pathway  adenylate cyclase-activating G protein-coupled receptor signaling pathway  adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  integral component of membrane  axon  dendrite  metal ion binding  cellular response to glucagon stimulus  adenylate cyclase-activating adrenergic receptor signaling pathway  
Pathways : KEGGPurine metabolism    Rap1 signaling pathway    Calcium signaling pathway    Chemokine signaling pathway    Oocyte meiosis    Adrenergic signaling in cardiomyocytes    Vascular smooth muscle contraction    Gap junction    Circadian entrainment    Retrograde endocannabinoid signaling    Glutamatergic synapse    Cholinergic synapse    GABAergic synapse    Insulin secretion    GnRH signaling pathway    Ovarian steroidogenesis    Progesterone-mediated oocyte maturation    Estrogen signaling pathway    Melanogenesis    Thyroid hormone synthesis    Endocrine and other factor-regulated calcium reabsorption    Vasopressin-regulated water reabsorption    Salivary secretion    Gastric acid secretion    Pancreatic secretion    Bile secretion    Morphine addiction    Vibrio cholerae infection    HTLV-I infection    Dilated cardiomyopathy   
NDEx NetworkADCY9
Atlas of Cancer Signalling NetworkADCY9
Wikipedia pathwaysADCY9
Orthology - Evolution
OrthoDB115
GeneTree (enSembl)ENSG00000162104
Phylogenetic Trees/Animal Genes : TreeFamADCY9
HOGENOMO60503
Homologs : HomoloGeneADCY9
Homology/Alignments : Family Browser (UCSC)ADCY9
Gene fusions - Rearrangements
Fusion : MitelmanADCY9/GLYR1 [16p13.3/16p13.3]  
Fusion : MitelmanADCY9/PRKCB [16p13.3/16p12.2]  [t(16;16)(p12;p13)]  
Fusion : MitelmanADCY9/PRSS27 [16p13.3/16p13.3]  [t(16;16)(p13;p13)]  
Fusion : MitelmanADCY9/SRL [16p13.3/16p13.3]  [t(16;16)(p13;p13)]  
Fusion : MitelmanADCY9/TFAP4 [16p13.3/16p13.3]  [t(16;16)(p13;p13)]  
Fusion PortalADCY9 16p13.3 GLYR1 16p13.3 BRCA
Fusion PortalADCY9 16p13.3 PRKCB 16p12.2 LUSC
Fusion PortalADCY9 16p13.3 PRSS27 16p13.3 BRCA
Fusion PortalADCY9 16p13.3 SRL 16p13.3 BRCA
Fusion PortalADCY9 16p13.3 TFAP4 16p13.3 BLCA
Fusion : QuiverADCY9
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADCY9 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADCY9
dbVarADCY9
ClinVarADCY9
1000_GenomesADCY9 
Exome Variant ServerADCY9
ExAC (Exome Aggregation Consortium)ENSG00000162104
GNOMAD BrowserENSG00000162104
Varsome BrowserADCY9
Genetic variants : HAPMAP115
Genomic Variants (DGV)ADCY9 [DGVbeta]
DECIPHERADCY9 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADCY9 
Mutations
ICGC Data PortalADCY9 
TCGA Data PortalADCY9 
Broad Tumor PortalADCY9
OASIS PortalADCY9 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADCY9  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADCY9
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ADCY9
DgiDB (Drug Gene Interaction Database)ADCY9
DoCM (Curated mutations)ADCY9 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADCY9 (select a term)
intoGenADCY9
Cancer3DADCY9(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603302   
Orphanet
DisGeNETADCY9
MedgenADCY9
Genetic Testing Registry ADCY9
NextProtO60503 [Medical]
TSGene115
GENETestsADCY9
Target ValidationADCY9
Huge Navigator ADCY9 [HugePedia]
snp3D : Map Gene to Disease115
BioCentury BCIQADCY9
ClinGenADCY9
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD115
Chemical/Pharm GKB GenePA30
Clinical trialADCY9
Miscellaneous
canSAR (ICR)ADCY9 (select the gene name)
DataMed IndexADCY9
Probes
Litterature
PubMed48 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADCY9
EVEXADCY9
GoPubMedADCY9
iHOPADCY9
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Feb 14 16:16:27 CET 2019
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