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ADCYAP1R1 (ADCYAP receptor type I)

Identity

Alias_namesadenylate cyclase activating polypeptide 1 (pituitary) receptor type I
Alias_symbol (synonym)PAC1
PACAPR
PAC1R
Other aliasPACAPRI
HGNC (Hugo) ADCYAP1R1
LocusID (NCBI) 117
Atlas_Id 43913
Location 7p14.3  [Link to chromosome band 7p14]
Location_base_pair Starts at 31092076 and ends at 31151093 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ADCYAP1R1 (7p14.3) / ADCYAP1R1 (7p14.3)ADCYAP1R1 (7p14.3) / DFNA5 (7p15.3)ADCYAP1R1 (7p14.3) / MACF1 (1p34.3)
ADCYAP1R1 7p14.3 / DFNA5 7p15.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ADCYAP1R1   242
Cards
Entrez_Gene (NCBI)ADCYAP1R1  117  ADCYAP receptor type I
AliasesPAC1; PAC1R; PACAPR; PACAPRI
GeneCards (Weizmann)ADCYAP1R1
Ensembl hg19 (Hinxton)ENSG00000078549 [Gene_View]  chr7:31092076-31151093 [Contig_View]  ADCYAP1R1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000078549 [Gene_View]  chr7:31092076-31151093 [Contig_View]  ADCYAP1R1 [Vega]
ICGC DataPortalENSG00000078549
TCGA cBioPortalADCYAP1R1
AceView (NCBI)ADCYAP1R1
Genatlas (Paris)ADCYAP1R1
WikiGenes117
SOURCE (Princeton)ADCYAP1R1
Genetics Home Reference (NIH)ADCYAP1R1
Genomic and cartography
GoldenPath hg19 (UCSC)ADCYAP1R1  -     chr7:31092076-31151093 +  7p14.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ADCYAP1R1  -     7p14.3   [Description]    (hg38-Dec_2013)
EnsemblADCYAP1R1 - 7p14.3 [CytoView hg19]  ADCYAP1R1 - 7p14.3 [CytoView hg38]
Mapping of homologs : NCBIADCYAP1R1 [Mapview hg19]  ADCYAP1R1 [Mapview hg38]
OMIM102981   
Gene and transcription
Genbank (Entrez)AI815550 AK096545 AK124304 AK226138 AK290046
RefSeq transcript (Entrez)NM_001118 NM_001199635 NM_001199636 NM_001199637
RefSeq genomic (Entrez)NC_000007 NC_018918 NG_029869 NT_007819 NW_004929329
Consensus coding sequences : CCDS (NCBI)ADCYAP1R1
Cluster EST : UnigeneHs.377783 [ NCBI ]
CGAP (NCI)Hs.377783
Alternative Splicing GalleryENSG00000078549
Gene ExpressionADCYAP1R1 [ NCBI-GEO ]   ADCYAP1R1 [ EBI - ARRAY_EXPRESS ]   ADCYAP1R1 [ SEEK ]   ADCYAP1R1 [ MEM ]
Gene Expression Viewer (FireBrowse)ADCYAP1R1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)117
GTEX Portal (Tissue expression)ADCYAP1R1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP41586   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP41586  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP41586
Splice isoforms : SwissVarP41586
PhosPhoSitePlusP41586
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F2_1 (PS00649)    G_PROTEIN_RECEP_F2_2 (PS00650)    G_PROTEIN_RECEP_F2_3 (PS50227)    G_PROTEIN_RECEP_F2_4 (PS50261)   
Domains : Interpro (EBI)GPCR_2-like    GPCR_2_extracellular_dom    GPCR_2_PACAP_1_rcpt    GPCR_2_secretin-like    GPCR_2_secretin-like_CS   
Domain families : Pfam (Sanger)7tm_2 (PF00002)    HRM (PF02793)   
Domain families : Pfam (NCBI)pfam00002    pfam02793   
Domain families : Smart (EMBL)HormR (SM00008)  
Conserved Domain (NCBI)ADCYAP1R1
DMDM Disease mutations117
Blocks (Seattle)ADCYAP1R1
PDB (SRS)2JOD    3N94   
PDB (PDBSum)2JOD    3N94   
PDB (IMB)2JOD    3N94   
PDB (RSDB)2JOD    3N94   
Structural Biology KnowledgeBase2JOD    3N94   
SCOP (Structural Classification of Proteins)2JOD    3N94   
CATH (Classification of proteins structures)2JOD    3N94   
SuperfamilyP41586
Human Protein AtlasENSG00000078549
Peptide AtlasP41586
HPRD00045
IPIIPI00299406   IPI00434023   IPI00983773   IPI00917967   IPI00437612   IPI00437613   IPI00915782   
Protein Interaction databases
DIP (DOE-UCLA)P41586
IntAct (EBI)P41586
FunCoupENSG00000078549
BioGRIDADCYAP1R1
STRING (EMBL)ADCYAP1R1
ZODIACADCYAP1R1
Ontologies - Pathways
QuickGOP41586
Ontology : AmiGOreceptor activity  vasoactive intestinal polypeptide receptor activity  protein binding  endosome  rough endoplasmic reticulum  plasma membrane  integral component of plasma membrane  caveola  bicellular tight junction  cell surface receptor signaling pathway  G-protein coupled receptor signaling pathway  activation of phospholipase C activity  spermatogenesis  adenylate cyclase binding  cell surface  positive regulation of calcium ion transport into cytosol  cAMP-mediated signaling  cell differentiation  ADP-ribosylation factor binding  positive regulation of cAMP biosynthetic process  response to estradiol  multicellular organismal response to stress  response to drug  neuropeptide binding  neuron projection  receptor complex  response to ethanol  development of primary female sexual characteristics  negative regulation of cell death  positive regulation of inositol phosphate biosynthetic process  
Ontology : EGO-EBIreceptor activity  vasoactive intestinal polypeptide receptor activity  protein binding  endosome  rough endoplasmic reticulum  plasma membrane  integral component of plasma membrane  caveola  bicellular tight junction  cell surface receptor signaling pathway  G-protein coupled receptor signaling pathway  activation of phospholipase C activity  spermatogenesis  adenylate cyclase binding  cell surface  positive regulation of calcium ion transport into cytosol  cAMP-mediated signaling  cell differentiation  ADP-ribosylation factor binding  positive regulation of cAMP biosynthetic process  response to estradiol  multicellular organismal response to stress  response to drug  neuropeptide binding  neuron projection  receptor complex  response to ethanol  development of primary female sexual characteristics  negative regulation of cell death  positive regulation of inositol phosphate biosynthetic process  
Pathways : KEGGNeuroactive ligand-receptor interaction    Circadian entrainment    Insulin secretion   
NDEx NetworkADCYAP1R1
Atlas of Cancer Signalling NetworkADCYAP1R1
Wikipedia pathwaysADCYAP1R1
Orthology - Evolution
OrthoDB117
GeneTree (enSembl)ENSG00000078549
Phylogenetic Trees/Animal Genes : TreeFamADCYAP1R1
HOVERGENP41586
HOGENOMP41586
Homologs : HomoloGeneADCYAP1R1
Homology/Alignments : Family Browser (UCSC)ADCYAP1R1
Gene fusions - Rearrangements
Fusion : MitelmanADCYAP1R1/DFNA5 [7p14.3/7p15.3]  
Fusion: TCGAADCYAP1R1 7p14.3 DFNA5 7p15.3 LGG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADCYAP1R1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADCYAP1R1
dbVarADCYAP1R1
ClinVarADCYAP1R1
1000_GenomesADCYAP1R1 
Exome Variant ServerADCYAP1R1
ExAC (Exome Aggregation Consortium)ADCYAP1R1 (select the gene name)
Genetic variants : HAPMAP117
Genomic Variants (DGV)ADCYAP1R1 [DGVbeta]
DECIPHER (Syndromes)7:31092076-31151093  ENSG00000078549
CONAN: Copy Number AnalysisADCYAP1R1 
Mutations
ICGC Data PortalADCYAP1R1 
TCGA Data PortalADCYAP1R1 
Broad Tumor PortalADCYAP1R1
OASIS PortalADCYAP1R1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADCYAP1R1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADCYAP1R1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ADCYAP1R1
DgiDB (Drug Gene Interaction Database)ADCYAP1R1
DoCM (Curated mutations)ADCYAP1R1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADCYAP1R1 (select a term)
intoGenADCYAP1R1
Cancer3DADCYAP1R1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM102981   
Orphanet
MedgenADCYAP1R1
Genetic Testing Registry ADCYAP1R1
NextProtP41586 [Medical]
TSGene117
GENETestsADCYAP1R1
Huge Navigator ADCYAP1R1 [HugePedia]
snp3D : Map Gene to Disease117
BioCentury BCIQADCYAP1R1
ClinGenADCYAP1R1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD117
Chemical/Pharm GKB GenePA24565
Clinical trialADCYAP1R1
Miscellaneous
canSAR (ICR)ADCYAP1R1 (select the gene name)
Probes
Litterature
PubMed70 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADCYAP1R1
EVEXADCYAP1R1
GoPubMedADCYAP1R1
iHOPADCYAP1R1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:54:58 CET 2017

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