Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ADGRA2 (adhesion G protein-coupled receptor A2)

Identity

Alias_namesGPR124
G protein-coupled receptor 124
Alias_symbol (synonym)TEM5
DKFZp434C211
DKFZp434J0911
KIAA1531
FLJ14390
Other alias
HGNC (Hugo) ADGRA2
LocusID (NCBI) 25960
Atlas_Id 45576
Location 8p11.23  [Link to chromosome band 8p11]
Location_base_pair Starts at 37654401 and ends at 37701504 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ADGRA2 (8p11.23) / PRAMEF17 (1p36.21)ADGRA2 (8p11.23) / ZNF593 (1p36.11)PACS2 (14q32.33) / ADGRA2 (8p11.23)
SENP6 (6q14.1) / ADGRA2 (8p11.23)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ADGRA2   17849
Cards
Entrez_Gene (NCBI)ADGRA2  25960  adhesion G protein-coupled receptor A2
AliasesGPR124; TEM5
GeneCards (Weizmann)ADGRA2
Ensembl hg19 (Hinxton)ENSG00000020181 [Gene_View]  chr8:37654401-37701504 [Contig_View]  ADGRA2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000020181 [Gene_View]  chr8:37654401-37701504 [Contig_View]  ADGRA2 [Vega]
ICGC DataPortalENSG00000020181
TCGA cBioPortalADGRA2
AceView (NCBI)ADGRA2
Genatlas (Paris)ADGRA2
WikiGenes25960
SOURCE (Princeton)ADGRA2
Genetics Home Reference (NIH)ADGRA2
Genomic and cartography
GoldenPath hg19 (UCSC)ADGRA2  -     chr8:37654401-37701504 +  8p11.23   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ADGRA2  -     8p11.23   [Description]    (hg38-Dec_2013)
EnsemblADGRA2 - 8p11.23 [CytoView hg19]  ADGRA2 - 8p11.23 [CytoView hg38]
Mapping of homologs : NCBIADGRA2 [Mapview hg19]  ADGRA2 [Mapview hg38]
OMIM606823   
Gene and transcription
Genbank (Entrez)AB040964 AF378755 AI346793 AK027296 AK074099
RefSeq transcript (Entrez)NM_032777
RefSeq genomic (Entrez)NC_000008 NC_018919 NT_167187 NW_004929337
Consensus coding sequences : CCDS (NCBI)ADGRA2
Cluster EST : UnigeneHs.274136 [ NCBI ]
CGAP (NCI)Hs.274136
Alternative Splicing GalleryENSG00000020181
Gene ExpressionADGRA2 [ NCBI-GEO ]   ADGRA2 [ EBI - ARRAY_EXPRESS ]   ADGRA2 [ SEEK ]   ADGRA2 [ MEM ]
Gene Expression Viewer (FireBrowse)ADGRA2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)25960
GTEX Portal (Tissue expression)ADGRA2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96PE1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96PE1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96PE1
Splice isoforms : SwissVarQ96PE1
PhosPhoSitePlusQ96PE1
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F2_2 (PS00650)    G_PROTEIN_RECEP_F2_3 (PS50227)    G_PROTEIN_RECEP_F2_4 (PS50261)    GPS (PS50221)    IG_LIKE (PS50835)    LRR (PS51450)   
Domains : Interpro (EBI)Cys-rich_flank_reg_C    GPCR_2-like    GPCR_2_extracellular_dom    GPCR_2_secretin-like    GPCR_2_secretin-like_CS    GPS    Ig-like_dom    Ig-like_fold    Ig_sub    L_dom-like    Leu-rich_rpt    Leu-rich_rpt_typical-subtyp   
Domain families : Pfam (Sanger)7tm_2 (PF00002)    GPS (PF01825)    LRR_8 (PF13855)   
Domain families : Pfam (NCBI)pfam00002    pfam01825    pfam13855   
Domain families : Smart (EMBL)GPS (SM00303)  IG (SM00409)  LRR_TYP (SM00369)  LRRCT (SM00082)  
Conserved Domain (NCBI)ADGRA2
DMDM Disease mutations25960
Blocks (Seattle)ADGRA2
SuperfamilyQ96PE1
Human Protein AtlasENSG00000020181
Peptide AtlasQ96PE1
HPRD08437
IPIIPI00743456   IPI00292834   IPI00971009   IPI00942694   IPI00927092   
Protein Interaction databases
DIP (DOE-UCLA)Q96PE1
IntAct (EBI)Q96PE1
FunCoupENSG00000020181
BioGRIDADGRA2
STRING (EMBL)ADGRA2
ZODIACADGRA2
Ontologies - Pathways
QuickGOQ96PE1
Ontology : AmiGOsprouting angiogenesis  G-protein coupled receptor activity  protein binding  plasma membrane  cell surface receptor signaling pathway  G-protein coupled receptor signaling pathway  central nervous system development  cell surface  positive regulation of endothelial cell migration  integral component of membrane  filopodium  endothelial cell migration  regulation of angiogenesis  regulation of chemotaxis  regulation of establishment of blood-brain barrier  negative regulation of vascular endothelial growth factor signaling pathway  
Ontology : EGO-EBIsprouting angiogenesis  G-protein coupled receptor activity  protein binding  plasma membrane  cell surface receptor signaling pathway  G-protein coupled receptor signaling pathway  central nervous system development  cell surface  positive regulation of endothelial cell migration  integral component of membrane  filopodium  endothelial cell migration  regulation of angiogenesis  regulation of chemotaxis  regulation of establishment of blood-brain barrier  negative regulation of vascular endothelial growth factor signaling pathway  
NDEx NetworkADGRA2
Atlas of Cancer Signalling NetworkADGRA2
Wikipedia pathwaysADGRA2
Orthology - Evolution
OrthoDB25960
GeneTree (enSembl)ENSG00000020181
Phylogenetic Trees/Animal Genes : TreeFamADGRA2
HOVERGENQ96PE1
HOGENOMQ96PE1
Homologs : HomoloGeneADGRA2
Homology/Alignments : Family Browser (UCSC)ADGRA2
Gene fusions - Rearrangements
Fusion : MitelmanSENP6/ADGRA2 [6q14.1/8p11.23]  [t(6;8)(q14;p11)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADGRA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADGRA2
dbVarADGRA2
ClinVarADGRA2
1000_GenomesADGRA2 
Exome Variant ServerADGRA2
ExAC (Exome Aggregation Consortium)ADGRA2 (select the gene name)
Genetic variants : HAPMAP25960
Genomic Variants (DGV)ADGRA2 [DGVbeta]
DECIPHER (Syndromes)8:37654401-37701504  ENSG00000020181
CONAN: Copy Number AnalysisADGRA2 
Mutations
ICGC Data PortalADGRA2 
TCGA Data PortalADGRA2 
Broad Tumor PortalADGRA2
OASIS PortalADGRA2 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDADGRA2
BioMutasearch ADGRA2
DgiDB (Drug Gene Interaction Database)ADGRA2
DoCM (Curated mutations)ADGRA2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADGRA2 (select a term)
intoGenADGRA2
Cancer3DADGRA2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606823   
Orphanet
MedgenADGRA2
Genetic Testing Registry ADGRA2
NextProtQ96PE1 [Medical]
TSGene25960
GENETestsADGRA2
Huge Navigator ADGRA2 [HugePedia]
snp3D : Map Gene to Disease25960
BioCentury BCIQADGRA2
ClinGenADGRA2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD25960
Chemical/Pharm GKB GenePA134869404
Clinical trialADGRA2
Miscellaneous
canSAR (ICR)ADGRA2 (select the gene name)
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADGRA2
EVEXADGRA2
GoPubMedADGRA2
iHOPADGRA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 14:51:41 CEST 2017

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