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ADGRA3 (adhesion G protein-coupled receptor A3)

Identity

Alias_namesGPR125
G protein-coupled receptor 125
Alias_symbol (synonym)FLJ38547
PGR21
Other aliasTEM5L
HGNC (Hugo) ADGRA3
LocusID (NCBI) 166647
Atlas_Id 77422
Location 4p15.2  [Link to chromosome band 4p15]
Location_base_pair Starts at 22388997 and ends at 22517677 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
KIAA1109 (4q27) / ADGRA3 (4p15.2)TSPAN7 (Xp11.4) / ADGRA3 (4p15.2)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute


External links

Nomenclature
HGNC (Hugo)ADGRA3   13839
Cards
Entrez_Gene (NCBI)ADGRA3  166647  adhesion G protein-coupled receptor A3
AliasesGPR125; PGR21; TEM5L
GeneCards (Weizmann)ADGRA3
Ensembl hg19 (Hinxton)ENSG00000152990 [Gene_View]  chr4:22388997-22517677 [Contig_View]  ADGRA3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000152990 [Gene_View]  chr4:22388997-22517677 [Contig_View]  ADGRA3 [Vega]
ICGC DataPortalENSG00000152990
TCGA cBioPortalADGRA3
AceView (NCBI)ADGRA3
Genatlas (Paris)ADGRA3
WikiGenes166647
SOURCE (Princeton)ADGRA3
Genetics Home Reference (NIH)ADGRA3
Genomic and cartography
GoldenPath hg19 (UCSC)ADGRA3  -     chr4:22388997-22517677 -  4p15.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ADGRA3  -     4p15.2   [Description]    (hg38-Dec_2013)
EnsemblADGRA3 - 4p15.2 [CytoView hg19]  ADGRA3 - 4p15.2 [CytoView hg38]
Mapping of homologs : NCBIADGRA3 [Mapview hg19]  ADGRA3 [Mapview hg38]
OMIM612303   
Gene and transcription
Genbank (Entrez)AI198439 AK027494 AK095866 AK299168 AL832257
RefSeq transcript (Entrez)NM_145290
RefSeq genomic (Entrez)NC_000004 NC_018915 NG_032963 NT_006316 NW_004929315
Consensus coding sequences : CCDS (NCBI)ADGRA3
Cluster EST : UnigeneHs.684429 [ NCBI ]
CGAP (NCI)Hs.684429
Alternative Splicing GalleryENSG00000152990
Gene ExpressionADGRA3 [ NCBI-GEO ]   ADGRA3 [ EBI - ARRAY_EXPRESS ]   ADGRA3 [ SEEK ]   ADGRA3 [ MEM ]
Gene Expression Viewer (FireBrowse)ADGRA3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)166647
GTEX Portal (Tissue expression)ADGRA3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IWK6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IWK6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IWK6
Splice isoforms : SwissVarQ8IWK6
PhosPhoSitePlusQ8IWK6
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F2_3 (PS50227)    G_PROTEIN_RECEP_F2_4 (PS50261)    GPS (PS50221)    IG_LIKE (PS50835)    LRR (PS51450)   
Domains : Interpro (EBI)Cys-rich_flank_reg_C    GPCR_2-like    GPCR_2_extracellular_dom    GPCR_2_secretin-like    GPS    Ig-like_dom    Ig-like_fold    Ig_I-set    Ig_sub    Leu-rich_rpt    Leu-rich_rpt_typical-subtyp   
Domain families : Pfam (Sanger)7tm_2 (PF00002)    GPS (PF01825)    HRM (PF02793)    I-set (PF07679)    LRR_8 (PF13855)   
Domain families : Pfam (NCBI)pfam00002    pfam01825    pfam02793    pfam07679    pfam13855   
Domain families : Smart (EMBL)GPS (SM00303)  IG (SM00409)  LRR_TYP (SM00369)  LRRCT (SM00082)  
Conserved Domain (NCBI)ADGRA3
DMDM Disease mutations166647
Blocks (Seattle)ADGRA3
SuperfamilyQ8IWK6
Human Protein AtlasENSG00000152990
Peptide AtlasQ8IWK6
HPRD11011
IPIIPI00452590   IPI00452591   IPI00452592   IPI00452593   IPI00967038   IPI00966781   
Protein Interaction databases
DIP (DOE-UCLA)Q8IWK6
IntAct (EBI)Q8IWK6
FunCoupENSG00000152990
BioGRIDADGRA3
STRING (EMBL)ADGRA3
ZODIACADGRA3
Ontologies - Pathways
QuickGOQ8IWK6
Ontology : AmiGOG-protein coupled receptor activity  G-protein coupled receptor signaling pathway  external side of plasma membrane  integral component of membrane  
Ontology : EGO-EBIG-protein coupled receptor activity  G-protein coupled receptor signaling pathway  external side of plasma membrane  integral component of membrane  
NDEx NetworkADGRA3
Atlas of Cancer Signalling NetworkADGRA3
Wikipedia pathwaysADGRA3
Orthology - Evolution
OrthoDB166647
GeneTree (enSembl)ENSG00000152990
Phylogenetic Trees/Animal Genes : TreeFamADGRA3
HOVERGENQ8IWK6
HOGENOMQ8IWK6
Homologs : HomoloGeneADGRA3
Homology/Alignments : Family Browser (UCSC)ADGRA3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADGRA3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADGRA3
dbVarADGRA3
ClinVarADGRA3
1000_GenomesADGRA3 
Exome Variant ServerADGRA3
ExAC (Exome Aggregation Consortium)ADGRA3 (select the gene name)
Genetic variants : HAPMAP166647
Genomic Variants (DGV)ADGRA3 [DGVbeta]
DECIPHER (Syndromes)4:22388997-22517677  ENSG00000152990
CONAN: Copy Number AnalysisADGRA3 
Mutations
ICGC Data PortalADGRA3 
TCGA Data PortalADGRA3 
Broad Tumor PortalADGRA3
OASIS PortalADGRA3 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDADGRA3
BioMutasearch ADGRA3
DgiDB (Drug Gene Interaction Database)ADGRA3
DoCM (Curated mutations)ADGRA3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADGRA3 (select a term)
intoGenADGRA3
Cancer3DADGRA3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612303   
Orphanet
MedgenADGRA3
Genetic Testing Registry ADGRA3
NextProtQ8IWK6 [Medical]
TSGene166647
GENETestsADGRA3
Huge Navigator ADGRA3 [HugePedia]
snp3D : Map Gene to Disease166647
BioCentury BCIQADGRA3
ClinGenADGRA3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD166647
Chemical/Pharm GKB GenePA134919579
Clinical trialADGRA3
Miscellaneous
canSAR (ICR)ADGRA3 (select the gene name)
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADGRA3
EVEXADGRA3
GoPubMedADGRA3
iHOPADGRA3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 11:53:45 CET 2017

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