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ADGRB2 (adhesion G protein-coupled receptor B2)

Identity

Alias_namesBAI2
brain-specific angiogenesis inhibitor 2
Other alias
HGNC (Hugo) ADGRB2
LocusID (NCBI) 576
Atlas_Id 750
Location 1p35.2  [Link to chromosome band 1p35]
Location_base_pair Starts at 31727105 and ends at 31764063 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ADGRB2 (1p35.2) / HS3ST4 (16p12.1)ADGRB2 (1p35.2) / SLC3A2 (11q12.3)ADGRB2 (1p35.2) / SPOCD1 (1p35.2)
ADGRB2 (1p35.2) / WWOX (16q23.1)SNRNP40 (1p35.2) / ADGRB2 (1p35.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ADGRB2   944
Cards
Entrez_Gene (NCBI)ADGRB2  576  adhesion G protein-coupled receptor B2
AliasesBAI2
GeneCards (Weizmann)ADGRB2
Ensembl hg19 (Hinxton)ENSG00000121753 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000121753 [Gene_View]  chr1:31727105-31764063 [Contig_View]  ADGRB2 [Vega]
ICGC DataPortalENSG00000121753
TCGA cBioPortalADGRB2
AceView (NCBI)ADGRB2
Genatlas (Paris)ADGRB2
WikiGenes576
SOURCE (Princeton)ADGRB2
Genetics Home Reference (NIH)ADGRB2
Genomic and cartography
GoldenPath hg38 (UCSC)ADGRB2  -     chr1:31727105-31764063 -  1p35.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADGRB2  -     1p35.2   [Description]    (hg19-Feb_2009)
EnsemblADGRB2 - 1p35.2 [CytoView hg19]  ADGRB2 - 1p35.2 [CytoView hg38]
Mapping of homologs : NCBIADGRB2 [Mapview hg19]  ADGRB2 [Mapview hg38]
OMIM602683   
Gene and transcription
Genbank (Entrez)AB005298 AI291691 AK123392 AK294361 AK294999
RefSeq transcript (Entrez)NM_001294335 NM_001294336 NM_001703
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ADGRB2
Cluster EST : UnigeneHs.524138 [ NCBI ]
CGAP (NCI)Hs.524138
Alternative Splicing GalleryENSG00000121753
Gene ExpressionADGRB2 [ NCBI-GEO ]   ADGRB2 [ EBI - ARRAY_EXPRESS ]   ADGRB2 [ SEEK ]   ADGRB2 [ MEM ]
Gene Expression Viewer (FireBrowse)ADGRB2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)576
GTEX Portal (Tissue expression)ADGRB2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60241   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60241  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60241
Splice isoforms : SwissVarO60241
PhosPhoSitePlusO60241
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F2_3 (PS50227)    G_PROTEIN_RECEP_F2_4 (PS50261)    GPS (PS50221)    TSP1 (PS50092)   
Domains : Interpro (EBI)GAIN_dom_N    GPCR_2-like    GPCR_2_brain_angio_inhib    GPCR_2_extracellular_dom    GPCR_2_secretin-like    GPS    TSP1_rpt   
Domain families : Pfam (Sanger)7tm_2 (PF00002)    GAIN (PF16489)    GPS (PF01825)    TSP_1 (PF00090)   
Domain families : Pfam (NCBI)pfam00002    pfam16489    pfam01825    pfam00090   
Domain families : Smart (EMBL)GPS (SM00303)  HormR (SM00008)  TSP1 (SM00209)  
Conserved Domain (NCBI)ADGRB2
DMDM Disease mutations576
Blocks (Seattle)ADGRB2
SuperfamilyO60241
Human Protein AtlasENSG00000121753
Peptide AtlasO60241
HPRD04063
IPIIPI00746807   IPI00929479   IPI00297188   IPI00929545   IPI00910074   IPI00853397   IPI00853453   IPI00853506   IPI00853588   IPI00940590   IPI00981683   
Protein Interaction databases
DIP (DOE-UCLA)O60241
IntAct (EBI)O60241
FunCoupENSG00000121753
BioGRIDADGRB2
STRING (EMBL)ADGRB2
ZODIACADGRB2
Ontologies - Pathways
QuickGOO60241
Ontology : AmiGOG-protein coupled receptor activity  plasma membrane  cell surface receptor signaling pathway  G-protein coupled receptor signaling pathway  peripheral nervous system development  integral component of membrane  negative regulation of angiogenesis  positive regulation of synapse assembly  
Ontology : EGO-EBIG-protein coupled receptor activity  plasma membrane  cell surface receptor signaling pathway  G-protein coupled receptor signaling pathway  peripheral nervous system development  integral component of membrane  negative regulation of angiogenesis  positive regulation of synapse assembly  
NDEx NetworkADGRB2
Atlas of Cancer Signalling NetworkADGRB2
Wikipedia pathwaysADGRB2
Orthology - Evolution
OrthoDB576
GeneTree (enSembl)ENSG00000121753
Phylogenetic Trees/Animal Genes : TreeFamADGRB2
HOVERGENO60241
HOGENOMO60241
Homologs : HomoloGeneADGRB2
Homology/Alignments : Family Browser (UCSC)ADGRB2
Gene fusions - Rearrangements
Fusion : MitelmanADGRB2/HS3ST4 [1p35.2/16p12.1]  
Fusion : MitelmanADGRB2/SPOCD1 [1p35.2/1p35.2]  [t(1;1)(p35;p35)]  
Fusion : MitelmanSNRNP40/ADGRB2 [1p35.2/1p35.2]  [t(1;1)(p35;p35)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADGRB2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADGRB2
dbVarADGRB2
ClinVarADGRB2
1000_GenomesADGRB2 
Exome Variant ServerADGRB2
ExAC (Exome Aggregation Consortium)ADGRB2 (select the gene name)
Genetic variants : HAPMAP576
Genomic Variants (DGV)ADGRB2 [DGVbeta]
DECIPHERADGRB2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADGRB2 
Mutations
ICGC Data PortalADGRB2 
TCGA Data PortalADGRB2 
Broad Tumor PortalADGRB2
OASIS PortalADGRB2 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDADGRB2
BioMutasearch ADGRB2
DgiDB (Drug Gene Interaction Database)ADGRB2
DoCM (Curated mutations)ADGRB2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADGRB2 (select a term)
intoGenADGRB2
Cancer3DADGRB2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602683   
Orphanet
MedgenADGRB2
Genetic Testing Registry ADGRB2
NextProtO60241 [Medical]
TSGene576
GENETestsADGRB2
Target ValidationADGRB2
Huge Navigator ADGRB2 [HugePedia]
snp3D : Map Gene to Disease576
BioCentury BCIQADGRB2
ClinGenADGRB2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD576
Chemical/Pharm GKB GenePA25248
Clinical trialADGRB2
Miscellaneous
canSAR (ICR)ADGRB2 (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADGRB2
EVEXADGRB2
GoPubMedADGRB2
iHOPADGRB2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:46:14 CEST 2017

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