Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ADGRB3 (adhesion G protein-coupled receptor B3)

Identity

Alias_namesBAI3
brain-specific angiogenesis inhibitor 3
Alias_symbol (synonym)KIAA0550
Other alias
HGNC (Hugo) ADGRB3
LocusID (NCBI) 577
Atlas_Id 751
Location 6q12  [Link to chromosome band 6q12]
Location_base_pair Starts at 68635740 and ends at 69389511 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADGRB3 (6q12) / ALOXE3 (17p13.1)ADGRB3 (6q12) / C1orf56 (1q21.3)ADGRB3 (6q12) / MTURN (7p14.3)
ADGRB3 (6q12) / TNIK (3q26.2)ADGRB3 (6q12) / TUBGCP5 (15q11.2)RORA (15q22.2) / ADGRB3 (6q12)
TM4SF1 (3q25.1) / ADGRB3 (6q12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ADGRB3   945
Cards
Entrez_Gene (NCBI)ADGRB3  577  adhesion G protein-coupled receptor B3
AliasesBAI3
GeneCards (Weizmann)ADGRB3
Ensembl hg19 (Hinxton)ENSG00000135298 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000135298 [Gene_View]  ENSG00000135298 [Sequence]  chr6:68635740-69389511 [Contig_View]  ADGRB3 [Vega]
ICGC DataPortalENSG00000135298
TCGA cBioPortalADGRB3
AceView (NCBI)ADGRB3
Genatlas (Paris)ADGRB3
WikiGenes577
SOURCE (Princeton)ADGRB3
Genetics Home Reference (NIH)ADGRB3
Genomic and cartography
GoldenPath hg38 (UCSC)ADGRB3  -     chr6:68635740-69389511 +  6q12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADGRB3  -     6q12   [Description]    (hg19-Feb_2009)
EnsemblADGRB3 - 6q12 [CytoView hg19]  ADGRB3 - 6q12 [CytoView hg38]
Mapping of homologs : NCBIADGRB3 [Mapview hg19]  ADGRB3 [Mapview hg38]
OMIM602684   
Gene and transcription
Genbank (Entrez)AB005299 AB011122 AK289696 AK293560 AK295516
RefSeq transcript (Entrez)NM_001704
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ADGRB3
Cluster EST : UnigeneHs.13261 [ NCBI ]
CGAP (NCI)Hs.13261
Alternative Splicing GalleryENSG00000135298
Gene ExpressionADGRB3 [ NCBI-GEO ]   ADGRB3 [ EBI - ARRAY_EXPRESS ]   ADGRB3 [ SEEK ]   ADGRB3 [ MEM ]
Gene Expression Viewer (FireBrowse)ADGRB3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)577
GTEX Portal (Tissue expression)ADGRB3
Human Protein AtlasENSG00000135298-ADGRB3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60242   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60242  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60242
Splice isoforms : SwissVarO60242
PhosPhoSitePlusO60242
Domaine pattern : Prosite (Expaxy)CUB (PS01180)    G_PROTEIN_RECEP_F2_2 (PS00650)    G_PROTEIN_RECEP_F2_3 (PS50227)    G_PROTEIN_RECEP_F2_4 (PS50261)    GPS (PS50221)    TSP1 (PS50092)   
Domains : Interpro (EBI)CUB_dom    GAIN_dom_N    GPCR_2-like    GPCR_2_brain_angio_inhib    GPCR_2_extracellular_dom    GPCR_2_secretin-like    GPCR_2_secretin-like_CS    GPS    TSP1_rpt   
Domain families : Pfam (Sanger)7tm_2 (PF00002)    GAIN (PF16489)    GPS (PF01825)    HRM (PF02793)    TSP_1 (PF00090)   
Domain families : Pfam (NCBI)pfam00002    pfam16489    pfam01825    pfam02793    pfam00090   
Domain families : Smart (EMBL)GPS (SM00303)  HormR (SM00008)  TSP1 (SM00209)  
Conserved Domain (NCBI)ADGRB3
DMDM Disease mutations577
Blocks (Seattle)ADGRB3
PDB (SRS)4DLO   
PDB (PDBSum)4DLO   
PDB (IMB)4DLO   
PDB (RSDB)4DLO   
Structural Biology KnowledgeBase4DLO   
SCOP (Structural Classification of Proteins)4DLO   
CATH (Classification of proteins structures)4DLO   
SuperfamilyO60242
Human Protein Atlas [tissue]ENSG00000135298-ADGRB3 [tissue]
Peptide AtlasO60242
HPRD04064
IPIIPI00028448   IPI01015311   IPI01014475   
Protein Interaction databases
DIP (DOE-UCLA)O60242
IntAct (EBI)O60242
FunCoupENSG00000135298
BioGRIDADGRB3
STRING (EMBL)ADGRB3
ZODIACADGRB3
Ontologies - Pathways
QuickGOO60242
Ontology : AmiGOG-protein coupled receptor activity  GTPase activator activity  protein binding  plasma membrane  cell surface receptor signaling pathway  G-protein coupled receptor signaling pathway  myoblast fusion  integral component of membrane  neuron remodeling  negative regulation of angiogenesis  synaptic cleft  positive regulation of GTPase activity  regulation of dendrite morphogenesis  positive regulation of synapse assembly  motor learning  postsynapse  maintenance of synapse structure  
Ontology : EGO-EBIG-protein coupled receptor activity  GTPase activator activity  protein binding  plasma membrane  cell surface receptor signaling pathway  G-protein coupled receptor signaling pathway  myoblast fusion  integral component of membrane  neuron remodeling  negative regulation of angiogenesis  synaptic cleft  positive regulation of GTPase activity  regulation of dendrite morphogenesis  positive regulation of synapse assembly  motor learning  postsynapse  maintenance of synapse structure  
NDEx NetworkADGRB3
Atlas of Cancer Signalling NetworkADGRB3
Wikipedia pathwaysADGRB3
Orthology - Evolution
OrthoDB577
GeneTree (enSembl)ENSG00000135298
Phylogenetic Trees/Animal Genes : TreeFamADGRB3
HOVERGENO60242
HOGENOMO60242
Homologs : HomoloGeneADGRB3
Homology/Alignments : Family Browser (UCSC)ADGRB3
Gene fusions - Rearrangements
Fusion : QuiverADGRB3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADGRB3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADGRB3
dbVarADGRB3
ClinVarADGRB3
1000_GenomesADGRB3 
Exome Variant ServerADGRB3
ExAC (Exome Aggregation Consortium)ENSG00000135298
GNOMAD BrowserENSG00000135298
Genetic variants : HAPMAP577
Genomic Variants (DGV)ADGRB3 [DGVbeta]
DECIPHERADGRB3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADGRB3 
Mutations
ICGC Data PortalADGRB3 
TCGA Data PortalADGRB3 
Broad Tumor PortalADGRB3
OASIS PortalADGRB3 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDADGRB3
BioMutasearch ADGRB3
DgiDB (Drug Gene Interaction Database)ADGRB3
DoCM (Curated mutations)ADGRB3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADGRB3 (select a term)
intoGenADGRB3
Cancer3DADGRB3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602684   
Orphanet
DisGeNETADGRB3
MedgenADGRB3
Genetic Testing Registry ADGRB3
NextProtO60242 [Medical]
TSGene577
GENETestsADGRB3
Target ValidationADGRB3
Huge Navigator ADGRB3 [HugePedia]
snp3D : Map Gene to Disease577
BioCentury BCIQADGRB3
ClinGenADGRB3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD577
Chemical/Pharm GKB GenePA25249
Clinical trialADGRB3
Miscellaneous
canSAR (ICR)ADGRB3 (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADGRB3
EVEXADGRB3
GoPubMedADGRB3
iHOPADGRB3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jun 22 16:13:10 CEST 2018

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