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ADGRE2 (adhesion G protein-coupled receptor E2)

Identity

Alias_namesEMR2
egf-like module containing, mucin-like, hormone receptor-like sequence 2
egf-like module containing, mucin-like, hormone receptor-like 2
Alias_symbol (synonym)CD312
Other aliasVBU
HGNC (Hugo) ADGRE2
LocusID (NCBI) 30817
Atlas_Id 52210
Location 19p13.12  [Link to chromosome band 19p13]
Location_base_pair Starts at 14732697 and ends at 14776927 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ADGRE2   3337
Cards
Entrez_Gene (NCBI)ADGRE2  30817  adhesion G protein-coupled receptor E2
AliasesCD312; EMR2; VBU
GeneCards (Weizmann)ADGRE2
Ensembl hg19 (Hinxton)ENSG00000127507 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000127507 [Gene_View]  chr19:14732697-14776927 [Contig_View]  ADGRE2 [Vega]
ICGC DataPortalENSG00000127507
TCGA cBioPortalADGRE2
AceView (NCBI)ADGRE2
Genatlas (Paris)ADGRE2
WikiGenes30817
SOURCE (Princeton)ADGRE2
Genetics Home Reference (NIH)ADGRE2
Genomic and cartography
GoldenPath hg38 (UCSC)ADGRE2  -     chr19:14732697-14776927 -  19p13.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADGRE2  -     19p13.12   [Description]    (hg19-Feb_2009)
EnsemblADGRE2 - 19p13.12 [CytoView hg19]  ADGRE2 - 19p13.12 [CytoView hg38]
Mapping of homologs : NCBIADGRE2 [Mapview hg19]  ADGRE2 [Mapview hg38]
OMIM125630   606100   
Gene and transcription
Genbank (Entrez)AF114491 AK024426 AK024454 AK222891 AK291776
RefSeq transcript (Entrez)NM_001271052 NM_013447 NM_152916 NM_152917 NM_152918 NM_152919 NM_152920 NM_152921
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ADGRE2
Cluster EST : UnigeneHs.531619 [ NCBI ]
CGAP (NCI)Hs.531619
Alternative Splicing GalleryENSG00000127507
Gene ExpressionADGRE2 [ NCBI-GEO ]   ADGRE2 [ EBI - ARRAY_EXPRESS ]   ADGRE2 [ SEEK ]   ADGRE2 [ MEM ]
Gene Expression Viewer (FireBrowse)ADGRE2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)30817
GTEX Portal (Tissue expression)ADGRE2
Human Protein AtlasENSG00000127507-ADGRE2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UHX3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UHX3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UHX3
Splice isoforms : SwissVarQ9UHX3
PhosPhoSitePlusQ9UHX3
Domaine pattern : Prosite (Expaxy)ASX_HYDROXYL (PS00010)    EGF_3 (PS50026)    EGF_CA (PS01187)    G_PROTEIN_RECEP_F2_2 (PS00650)    G_PROTEIN_RECEP_F2_4 (PS50261)    GPS (PS50221)   
Domains : Interpro (EBI)EGF-like_Ca-bd_dom    EGF-like_dom    EGF-type_Asp/Asn_hydroxyl_site    EGF_Ca-bd_CS    GPCR_2-like    GPCR_2_CD97    GPCR_2_secretin-like    GPCR_2_secretin-like_CS    GPS    Growth_fac_rcpt_   
Domain families : Pfam (Sanger)7tm_2 (PF00002)    EGF_CA (PF07645)    GPS (PF01825)   
Domain families : Pfam (NCBI)pfam00002    pfam07645    pfam01825   
Domain families : Smart (EMBL)EGF (SM00181)  EGF_CA (SM00179)  GPS (SM00303)  
Conserved Domain (NCBI)ADGRE2
DMDM Disease mutations30817
Blocks (Seattle)ADGRE2
PDB (SRS)2BO2    2BOU    2BOX   
PDB (PDBSum)2BO2    2BOU    2BOX   
PDB (IMB)2BO2    2BOU    2BOX   
PDB (RSDB)2BO2    2BOU    2BOX   
Structural Biology KnowledgeBase2BO2    2BOU    2BOX   
SCOP (Structural Classification of Proteins)2BO2    2BOU    2BOX   
CATH (Classification of proteins structures)2BO2    2BOU    2BOX   
SuperfamilyQ9UHX3
Human Protein Atlas [tissue]ENSG00000127507-ADGRE2 [tissue]
Peptide AtlasQ9UHX3
HPRD07308
IPIIPI00296277   IPI00375382   IPI00183280   IPI00183838   IPI00549702   IPI00744940   IPI00909910   IPI00910804   IPI00644566   IPI00375383   IPI00375384   
Protein Interaction databases
DIP (DOE-UCLA)Q9UHX3
IntAct (EBI)Q9UHX3
FunCoupENSG00000127507
BioGRIDADGRE2
STRING (EMBL)ADGRE2
ZODIACADGRE2
Ontologies - Pathways
QuickGOQ9UHX3
Ontology : AmiGOG-protein coupled receptor activity  calcium ion binding  plasma membrane  inflammatory response  cell adhesion  cell surface receptor signaling pathway  G-protein coupled receptor signaling pathway  integral component of membrane  cell migration  leading edge membrane  ruffle membrane  chondroitin sulfate binding  granulocyte chemotaxis  
Ontology : EGO-EBIG-protein coupled receptor activity  calcium ion binding  plasma membrane  inflammatory response  cell adhesion  cell surface receptor signaling pathway  G-protein coupled receptor signaling pathway  integral component of membrane  cell migration  leading edge membrane  ruffle membrane  chondroitin sulfate binding  granulocyte chemotaxis  
NDEx NetworkADGRE2
Atlas of Cancer Signalling NetworkADGRE2
Wikipedia pathwaysADGRE2
Orthology - Evolution
OrthoDB30817
GeneTree (enSembl)ENSG00000127507
Phylogenetic Trees/Animal Genes : TreeFamADGRE2
HOVERGENQ9UHX3
HOGENOMQ9UHX3
Homologs : HomoloGeneADGRE2
Homology/Alignments : Family Browser (UCSC)ADGRE2
Gene fusions - Rearrangements
Fusion: Tumor Portal ADGRE2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADGRE2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADGRE2
dbVarADGRE2
ClinVarADGRE2
1000_GenomesADGRE2 
Exome Variant ServerADGRE2
ExAC (Exome Aggregation Consortium)ENSG00000127507
GNOMAD BrowserENSG00000127507
Genetic variants : HAPMAP30817
Genomic Variants (DGV)ADGRE2 [DGVbeta]
DECIPHERADGRE2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADGRE2 
Mutations
ICGC Data PortalADGRE2 
TCGA Data PortalADGRE2 
Broad Tumor PortalADGRE2
OASIS PortalADGRE2 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDADGRE2
BioMutasearch ADGRE2
DgiDB (Drug Gene Interaction Database)ADGRE2
DoCM (Curated mutations)ADGRE2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADGRE2 (select a term)
intoGenADGRE2
Cancer3DADGRE2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM125630    606100   
Orphanet
MedgenADGRE2
Genetic Testing Registry ADGRE2
NextProtQ9UHX3 [Medical]
TSGene30817
GENETestsADGRE2
Target ValidationADGRE2Huge Navigator ADGRE2 [HugePedia]
snp3D : Map Gene to Disease30817
BioCentury BCIQADGRE2
ClinGenADGRE2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD30817
Chemical/Pharm GKB GenePA27774
Clinical trialADGRE2
Miscellaneous
canSAR (ICR)ADGRE2 (select the gene name)
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADGRE2
EVEXADGRE2
GoPubMedADGRE2
iHOPADGRE2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Nov 9 12:39:25 CET 2017

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