Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ADGRL1 (adhesion G protein-coupled receptor L1)

Identity

Alias_namesLPHN1
latrophilin 1
Alias_symbol (synonym)KIAA0821
CIRL1
LEC2
Other aliasCL1
HGNC (Hugo) ADGRL1
LocusID (NCBI) 22859
Atlas_Id 77209
Location 19p13.12  [Link to chromosome band 19p13]
Location_base_pair Starts at 14147737 and ends at 14206185 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
POLR2M (15q21.3) / ADGRL1 (19p13.12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ADGRL1   20973
Cards
Entrez_Gene (NCBI)ADGRL1  22859  adhesion G protein-coupled receptor L1
AliasesCIRL1; CL1; LEC2; LPHN1
GeneCards (Weizmann)ADGRL1
Ensembl hg19 (Hinxton)ENSG00000072071 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000072071 [Gene_View]  chr19:14147737-14206185 [Contig_View]  ADGRL1 [Vega]
ICGC DataPortalENSG00000072071
TCGA cBioPortalADGRL1
AceView (NCBI)ADGRL1
Genatlas (Paris)ADGRL1
WikiGenes22859
SOURCE (Princeton)ADGRL1
Genetics Home Reference (NIH)ADGRL1
Genomic and cartography
GoldenPath hg38 (UCSC)ADGRL1  -     chr19:14147737-14206185 -  19p13.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADGRL1  -     19p13.12   [Description]    (hg19-Feb_2009)
EnsemblADGRL1 - 19p13.12 [CytoView hg19]  ADGRL1 - 19p13.12 [CytoView hg38]
Mapping of homologs : NCBIADGRL1 [Mapview hg19]  ADGRL1 [Mapview hg38]
OMIM616416   
Gene and transcription
Genbank (Entrez)AB020628 AF307079 AK022001 BC002974 BC007587
RefSeq transcript (Entrez)NM_001008701 NM_014921
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ADGRL1
Cluster EST : UnigeneHs.94229 [ NCBI ]
CGAP (NCI)Hs.94229
Alternative Splicing GalleryENSG00000072071
Gene ExpressionADGRL1 [ NCBI-GEO ]   ADGRL1 [ EBI - ARRAY_EXPRESS ]   ADGRL1 [ SEEK ]   ADGRL1 [ MEM ]
Gene Expression Viewer (FireBrowse)ADGRL1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)22859
GTEX Portal (Tissue expression)ADGRL1
Human Protein AtlasENSG00000072071-ADGRL1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO94910   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO94910  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO94910
Splice isoforms : SwissVarO94910
PhosPhoSitePlusO94910
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F2_2 (PS00650)    G_PROTEIN_RECEP_F2_3 (PS50227)    G_PROTEIN_RECEP_F2_4 (PS50261)    GPS (PS50221)    OLF (PS51132)    SUEL_LECTIN (PS50228)   
Domains : Interpro (EBI)GAIN_dom_N    GPCR_2-like    GPCR_2_extracellular_dom    GPCR_2_latrophilin    GPCR_2_latrophilin_rcpt_C    GPCR_2_secretin-like    GPCR_2_secretin-like_CS    GPS    Lectin_gal-bd_dom    Olfac-like_dom   
Domain families : Pfam (Sanger)7tm_2 (PF00002)    GAIN (PF16489)    Gal_Lectin (PF02140)    GPS (PF01825)    HRM (PF02793)    Latrophilin (PF02354)    OLF (PF02191)   
Domain families : Pfam (NCBI)pfam00002    pfam16489    pfam02140    pfam01825    pfam02793    pfam02354    pfam02191   
Domain families : Smart (EMBL)GPS (SM00303)  HormR (SM00008)  OLF (SM00284)  
Conserved Domain (NCBI)ADGRL1
DMDM Disease mutations22859
Blocks (Seattle)ADGRL1
SuperfamilyO94910
Human Protein Atlas [tissue]ENSG00000072071-ADGRL1 [tissue]
Peptide AtlasO94910
HPRD14305
IPIIPI00183445   IPI00410210   IPI00815674   IPI00002954   
Protein Interaction databases
DIP (DOE-UCLA)O94910
IntAct (EBI)O94910
FunCoupENSG00000072071
BioGRIDADGRL1
STRING (EMBL)ADGRL1
ZODIACADGRL1
Ontologies - Pathways
QuickGOO94910
Ontology : AmiGOG-protein coupled receptor activity  protein binding  intracellular  plasma membrane  heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  cell surface receptor signaling pathway  G-protein coupled receptor signaling pathway  integral component of membrane  latrotoxin receptor activity  cell junction  carbohydrate binding  axon  growth cone  calcium-mediated signaling using intracellular calcium source  presynaptic membrane  neuron projection  synapse  cell adhesion molecule binding  positive regulation of synapse assembly  positive regulation of synapse maturation  
Ontology : EGO-EBIG-protein coupled receptor activity  protein binding  intracellular  plasma membrane  heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  cell surface receptor signaling pathway  G-protein coupled receptor signaling pathway  integral component of membrane  latrotoxin receptor activity  cell junction  carbohydrate binding  axon  growth cone  calcium-mediated signaling using intracellular calcium source  presynaptic membrane  neuron projection  synapse  cell adhesion molecule binding  positive regulation of synapse assembly  positive regulation of synapse maturation  
NDEx NetworkADGRL1
Atlas of Cancer Signalling NetworkADGRL1
Wikipedia pathwaysADGRL1
Orthology - Evolution
OrthoDB22859
GeneTree (enSembl)ENSG00000072071
Phylogenetic Trees/Animal Genes : TreeFamADGRL1
HOVERGENO94910
HOGENOMO94910
Homologs : HomoloGeneADGRL1
Homology/Alignments : Family Browser (UCSC)ADGRL1
Gene fusions - Rearrangements
Fusion: Tumor Portal ADGRL1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADGRL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADGRL1
dbVarADGRL1
ClinVarADGRL1
1000_GenomesADGRL1 
Exome Variant ServerADGRL1
ExAC (Exome Aggregation Consortium)ENSG00000072071
GNOMAD BrowserENSG00000072071
Genetic variants : HAPMAP22859
Genomic Variants (DGV)ADGRL1 [DGVbeta]
DECIPHERADGRL1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADGRL1 
Mutations
ICGC Data PortalADGRL1 
TCGA Data PortalADGRL1 
Broad Tumor PortalADGRL1
OASIS PortalADGRL1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDADGRL1
BioMutasearch ADGRL1
DgiDB (Drug Gene Interaction Database)ADGRL1
DoCM (Curated mutations)ADGRL1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADGRL1 (select a term)
intoGenADGRL1
Cancer3DADGRL1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616416   
Orphanet
ADGRL1
Genetic Testing Registry ADGRL1
NextProtO94910 [Medical]
TSGene22859
GENETestsADGRL1
Target ValidationADGRL1
Huge Navigator ADGRL1 [HugePedia]
snp3D : Map Gene to Disease22859
BioCentury BCIQADGRL1
ClinGenADGRL1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD22859
Chemical/Pharm GKB GenePA134868822
Clinical trialADGRL1
Miscellaneous
canSAR (ICR)ADGRL1 (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADGRL1
EVEXADGRL1
GoPubMedADGRL1
iHOPADGRL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 9 11:37:10 CET 2017

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