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ADGRL3 (adhesion G protein-coupled receptor L3)

Identity

Alias_namesLPHN3
latrophilin 3
Alias_symbol (synonym)KIAA0768
LEC3
Other aliasCIRL3
CL3
HGNC (Hugo) ADGRL3
LocusID (NCBI) 23284
Atlas_Id 53471
Location 4q13.1  [Link to chromosome band 4q13]
Location_base_pair Starts at 61201256 and ends at 62078335 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADGRL3 (4q13.1) / AMTN (4q13.3)ADGRL3 (4q13.1) / PPP3CA (4q24)ADGRL3 (4q13.1) / SLC26A7 (8q21.3)
ADGRL3 (4q13.1) / ST3GAL5 (2p11.2)CALD1 (7q33) / ADGRL3 (4q13.1)CHIC2 (4q12) / ADGRL3 (4q13.1)
EFHC1 (6p12.2) / ADGRL3 (4q13.1)TMTC4 (13q32.3) / ADGRL3 (4q13.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ADGRL3   20974
Cards
Entrez_Gene (NCBI)ADGRL3  23284  adhesion G protein-coupled receptor L3
AliasesCIRL3; CL3; LEC3; LPHN3
GeneCards (Weizmann)ADGRL3
Ensembl hg19 (Hinxton)ENSG00000150471 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000150471 [Gene_View]  chr4:61201256-62078335 [Contig_View]  ADGRL3 [Vega]
ICGC DataPortalENSG00000150471
TCGA cBioPortalADGRL3
AceView (NCBI)ADGRL3
Genatlas (Paris)ADGRL3
WikiGenes23284
SOURCE (Princeton)ADGRL3
Genetics Home Reference (NIH)ADGRL3
Genomic and cartography
GoldenPath hg38 (UCSC)ADGRL3  -     chr4:61201256-62078335 +  4q13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADGRL3  -     4q13.1   [Description]    (hg19-Feb_2009)
EnsemblADGRL3 - 4q13.1 [CytoView hg19]  ADGRL3 - 4q13.1 [CytoView hg38]
Mapping of homologs : NCBIADGRL3 [Mapview hg19]  ADGRL3 [Mapview hg38]
OMIM616417   
Gene and transcription
Genbank (Entrez)AB018311 AK000781 AK094703 AK294689 AK299651
RefSeq transcript (Entrez)NM_001322246 NM_001322402 NM_015236
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ADGRL3
Cluster EST : UnigeneHs.570770 [ NCBI ]
CGAP (NCI)Hs.570770
Alternative Splicing GalleryENSG00000150471
Gene ExpressionADGRL3 [ NCBI-GEO ]   ADGRL3 [ EBI - ARRAY_EXPRESS ]   ADGRL3 [ SEEK ]   ADGRL3 [ MEM ]
Gene Expression Viewer (FireBrowse)ADGRL3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23284
GTEX Portal (Tissue expression)ADGRL3
Human Protein AtlasENSG00000150471-ADGRL3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HAR2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HAR2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HAR2
Splice isoforms : SwissVarQ9HAR2
PhosPhoSitePlusQ9HAR2
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F2_2 (PS00650)    G_PROTEIN_RECEP_F2_3 (PS50227)    G_PROTEIN_RECEP_F2_4 (PS50261)    GPS (PS50221)    OLF (PS51132)    SUEL_LECTIN (PS50228)   
Domains : Interpro (EBI)GAIN_dom_N    GPCR_2-like    GPCR_2_extracellular_dom    GPCR_2_latrophilin    GPCR_2_latrophilin_rcpt_C    GPCR_2_secretin-like    GPCR_2_secretin-like_CS    GPS    Latrophilin-3    Lectin_gal-bd_dom    Olfac-like_dom   
Domain families : Pfam (Sanger)7tm_2 (PF00002)    GAIN (PF16489)    Gal_Lectin (PF02140)    GPS (PF01825)    HRM (PF02793)    Latrophilin (PF02354)    OLF (PF02191)   
Domain families : Pfam (NCBI)pfam00002    pfam16489    pfam02140    pfam01825    pfam02793    pfam02354    pfam02191   
Domain families : Smart (EMBL)GPS (SM00303)  HormR (SM00008)  OLF (SM00284)  
Conserved Domain (NCBI)ADGRL3
DMDM Disease mutations23284
Blocks (Seattle)ADGRL3
PDB (SRS)5CMN   
PDB (PDBSum)5CMN   
PDB (IMB)5CMN   
PDB (RSDB)5CMN   
Structural Biology KnowledgeBase5CMN   
SCOP (Structural Classification of Proteins)5CMN   
CATH (Classification of proteins structures)5CMN   
SuperfamilyQ9HAR2
Human Protein Atlas [tissue]ENSG00000150471-ADGRL3 [tissue]
Peptide AtlasQ9HAR2
HPRD10055
IPIIPI00965650   IPI00162547   IPI00410312   IPI00410310   IPI00964226   IPI00966292   IPI00966947   IPI00964853   IPI00968003   IPI00966716   IPI00964987   IPI00967357   IPI00965366   IPI00966314   IPI01019069   IPI00966608   
Protein Interaction databases
DIP (DOE-UCLA)Q9HAR2
IntAct (EBI)Q9HAR2
FunCoupENSG00000150471
BioGRIDADGRL3
STRING (EMBL)ADGRL3
ZODIACADGRL3
Ontologies - Pathways
QuickGOQ9HAR2
Ontology : AmiGOneuron migration  G-protein coupled receptor activity  calcium ion binding  protein binding &nbs;integral component of plasma membrane  cell-cell junction  cell surface receptor signaling pathway  G-protein coupled receptor signaling pathway  synapse assembly  integral component of membrane  carbohydrate binding  axon  locomotion involved in locomotory behavior  response to cocaine  positive regulation of synapse assembly  cell-cell adhesion via plasma-membrane adhesion molecules  
Ontology : EGO-EBIneuron migration  G-protein coupled receptor activity  calcium ion binding  protein binding  integral component of plasma membrane  cell-cell junction  cell surface receptor signaling pathway  G-protein coupled receptor signaling pathway  synapse assembly  integral component of membrane  carbohydrate binding  axon  locomotion involved in locomotory behavior  response to cocaine  positive regulation of synapse assembly  cell-cell adhesion via plasma-membrane adhesion molecules  
NDEx NetworkADGRL3
Atlas of Cancer Signalling NetworkADGRL3
Wikipedia pathwaysADGRL3
Orthology - Evolution
OrthoDB23284
GeneTree (enSembl)ENSG00000150471
Phylogenetic Trees/Animal Genes : TreeFamADGRL3
HOVERGENQ9HAR2
HOGENOMQ9HAR2
Homologs : HomoloGeneADGRL3
Homology/Alignments : Family Browser (UCSC)ADGRL3
Gene fusions - Rearrangements
Tumor Fusion PortalADGRL3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADGRL3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADGRL3
dbVarADGRL3
ClinVarADGRL3
1000_GenomesADGRL3 
Exome Variant ServerADGRL3
ExAC (Exome Aggregation Consortium)ENSG00000150471
GNOMAD BrowserENSG00000150471
Genetic variants : HAPMAP23284
Genomic Variants (DGV)ADGRL3 [DGVbeta]
DECIPHERADGRL3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADGRL3 
Mutations
ICGC Data PortalADGRL3 
TCGA Data PortalADGRL3 
Broad Tumor PortalADGRL3
OASIS PortalADGRL3 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDADGRL3
BioMutasearch ADGRL3
DgiDB (Drug Gene Interaction Database)ADGRL3
DoCM (Curated mutations)ADGRL3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADGRL3 (select a term)
intoGenADGRL3
Cancer3DADGRL3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616417   
Orphanet
DisGeNETADGRL3
MedgenADGRL3
Genetic Testing Registry ADGRL3
NextProtQ9HAR2 [Medical]
TSGene23284
GENETestsADGRL3
Target ValidationADGRL3
Huge Navigator ADGRL3 [HugePedia]
snp3D : Map Gene to Disease23284
BioCentury BCIQADGRL3
ClinGenADGRL3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23284
Chemical/Pharm GKB GenePA134968284
Clinical trialADGRL3
Miscellaneous
canSAR (ICR)ADGRL3 (select the gene name)
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADGRL3
EVEXADGRL3
GoPubMedADGRL3
iHOPADGRL3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:02:15 CET 2017

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