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ADH1B (alcohol dehydrogenase 1B (class I), beta polypeptide)

Identity

Alias_namesADH2
Other aliasHEL-S-117
HGNC (Hugo) ADH1B
LocusID (NCBI) 125
Atlas_Id 582
Location 4q23  [Link to chromosome band 4q23]
Location_base_pair Starts at 99306387 and ends at 99321442 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ADH1B   250
Cards
Entrez_Gene (NCBI)ADH1B  125  alcohol dehydrogenase 1B (class I), beta polypeptide
AliasesADH2; HEL-S-117
GeneCards (Weizmann)ADH1B
Ensembl hg19 (Hinxton)ENSG00000196616 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000196616 [Gene_View]  ENSG00000196616 [Sequence]  chr4:99306387-99321442 [Contig_View]  ADH1B [Vega]
ICGC DataPortalENSG00000196616
TCGA cBioPortalADH1B
AceView (NCBI)ADH1B
Genatlas (Paris)ADH1B
WikiGenes125
SOURCE (Princeton)ADH1B
Genetics Home Reference (NIH)ADH1B
Genomic and cartography
GoldenPath hg38 (UCSC)ADH1B  -     chr4:99306387-99321442 -  4q23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADH1B  -     4q23   [Description]    (hg19-Feb_2009)
EnsemblADH1B - 4q23 [CytoView hg19]  ADH1B - 4q23 [CytoView hg38]
Mapping of homologs : NCBIADH1B [Mapview hg19]  ADH1B [Mapview hg38]
OMIM103720   103780   
Gene and transcription
Genbank (Entrez)AF153821 AI702614 AK299409 AK301018 AK303945
RefSeq transcript (Entrez)NM_000668 NM_001286650
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ADH1B
Cluster EST : UnigeneHs.4 [ NCBI ]
CGAP (NCI)Hs.4
Alternative Splicing GalleryENSG00000196616
Gene ExpressionADH1B [ NCBI-GEO ]   ADH1B [ EBI - ARRAY_EXPRESS ]   ADH1B [ SEEK ]   ADH1B [ MEM ]
Gene Expression Viewer (FireBrowse)ADH1B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)125
GTEX Portal (Tissue expression)ADH1B
Human Protein AtlasENSG00000196616-ADH1B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP00325   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP00325  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP00325
Splice isoforms : SwissVarP00325
Catalytic activity : Enzyme1.1.1.1 [ Enzyme-Expasy ]   1.1.1.11.1.1.1 [ IntEnz-EBI ]   1.1.1.1 [ BRENDA ]   1.1.1.1 [ KEGG ]   
PhosPhoSitePlusP00325
Domaine pattern : Prosite (Expaxy)ADH_ZINC (PS00059)   
Domains : Interpro (EBI)ADH_C    ADH_N    ADH_Zn_CS    GroES-like    NAD(P)-bd_dom    PKS_ER   
Domain families : Pfam (Sanger)ADH_N (PF08240)    ADH_zinc_N (PF00107)   
Domain families : Pfam (NCBI)pfam08240    pfam00107   
Domain families : Smart (EMBL)PKS_ER (SM00829)  
Conserved Domain (NCBI)ADH1B
DMDM Disease mutations125
Blocks (Seattle)ADH1B
PDB (SRS)1DEH    1HDX    1HDY    1HDZ    1HSZ    1HTB    1U3U    1U3V    3HUD   
PDB (PDBSum)1DEH    1HDX    1HDY    1HDZ    1HSZ    1HTB    1U3U    1U3V    3HUD   
PDB (IMB)1DEH    1HDX    1HDY    1HDZ    1HSZ    1HTB    1U3U    1U3V    3HUD   
PDB (RSDB)1DEH    1HDX    1HDY    1HDZ    1HSZ    1HTB    1U3U    1U3V    3HUD   
Structural Biology KnowledgeBase1DEH    1HDX    1HDY    1HDZ    1HSZ    1HTB    1U3U    1U3V    3HUD   
SCOP (Structural Classification of Proteins)1DEH    1HDX    1HDY    1HDZ    1HSZ    1HTB    1U3U    1U3V    3HUD   
CATH (Classification of proteins structures)1DEH    1HDX    1HDY    1HDZ    1HSZ    1HTB    1U3U    1U3V    3HUD   
SuperfamilyP00325
Human Protein Atlas [tissue]ENSG00000196616-ADH1B [tissue]
Peptide AtlasP00325
HPRD00065
IPIIPI00473031   IPI00872991   IPI01018979   IPI00965164   
Protein Interaction databases
DIP (DOE-UCLA)P00325
IntAct (EBI)P00325
FunCoupENSG00000196616
BioGRIDADH1B
STRING (EMBL)ADH1B
ZODIACADH1B
Ontologies - Pathways
QuickGOP00325
Ontology : AmiGOalcohol dehydrogenase activity, zinc-dependent  alcohol dehydrogenase activity, zinc-dependent  nucleoplasm  cytosol  cytosol  plasma membrane  ethanol oxidation  ethanol oxidation  zinc ion binding  
Ontology : EGO-EBIalcohol dehydrogenase activity, zinc-dependent  alcohol dehydrogenase activity, zinc-dependent  nucleoplasm  cytosol  cytosol  plasma membrane  ethanol oxidation  ethanol oxidation  zinc ion binding  
Pathways : KEGGFatty acid metabolism    Tyrosine metabolism    Bile acid biosynthesis    Glycerolipid metabolism    Glycolysis / Gluconeogenesis    Metabolism of xenobiotics by cytochrome P450    1- and 2-Methylnaphthalene degradation   
NDEx NetworkADH1B
Atlas of Cancer Signalling NetworkADH1B
Wikipedia pathwaysADH1B
Orthology - Evolution
OrthoDB125
GeneTree (enSembl)ENSG00000196616
Phylogenetic Trees/Animal Genes : TreeFamADH1B
HOVERGENP00325
HOGENOMP00325
Homologs : HomoloGeneADH1B
Homology/Alignments : Family Browser (UCSC)ADH1B
Gene fusions - Rearrangements
Fusion : QuiverADH1B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADH1B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADH1B
dbVarADH1B
ClinVarADH1B
1000_GenomesADH1B 
Exome Variant ServerADH1B
ExAC (Exome Aggregation Consortium)ENSG00000196616
GNOMAD BrowserENSG00000196616
Genetic variants : HAPMAP125
Genomic Variants (DGV)ADH1B [DGVbeta]
DECIPHERADH1B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADH1B 
Mutations
ICGC Data PortalADH1B 
TCGA Data PortalADH1B 
Broad Tumor PortalADH1B
OASIS PortalADH1B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADH1B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADH1B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ADH1B
DgiDB (Drug Gene Interaction Database)ADH1B
DoCM (Curated mutations)ADH1B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADH1B (select a term)
intoGenADH1B
Cancer3DADH1B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM103720    103780   
Orphanet
DisGeNETADH1B
MedgenADH1B
Genetic Testing Registry ADH1B
NextProtP00325 [Medical]
TSGene125
GENETestsADH1B
Target ValidationADH1B
Huge Navigator ADH1B [HugePedia]
snp3D : Map Gene to Disease125
BioCentury BCIQADH1B
ClinGenADH1B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD125
Chemical/Pharm GKB GenePA24571
Clinical trialADH1B
Miscellaneous
canSAR (ICR)ADH1B (select the gene name)
Probes
Litterature
PubMed357 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADH1B
EVEXADH1B
GoPubMedADH1B
iHOPADH1B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jun 22 16:13:14 CEST 2018
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