ADH1C (alcohol dehydrogenase 1C (class I), gamma polypeptide)

2012-12-01  

Identity

HGNC
LOCATION
4q23
LOCUSID
ALIAS
ADH3

Other Information

Locus ID:

NCBI: 126
MIM: 103730
HGNC: 251
Ensembl: ENSG00000248144

Variants:

dbSNP: 126
ClinVar: 126
TCGA: ENSG00000248144
COSMIC: ADH1C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000248144ENST00000510055A0A087WU81
ENSG00000248144ENST00000511397A0A087WUC4
ENSG00000248144ENST00000515683P00326

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Glycolysis / GluconeogenesisKEGGko00010
Fatty acid degradationKEGGko00071
Tyrosine metabolismKEGGko00350
Retinol metabolismKEGGko00830
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Drug metabolism - cytochrome P450KEGGko00982
Glycolysis / GluconeogenesisKEGGhsa00010
Fatty acid degradationKEGGhsa00071
Tyrosine metabolismKEGGhsa00350
Retinol metabolismKEGGhsa00830
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
Drug metabolism - cytochrome P450KEGGhsa00982
Metabolic pathwaysKEGGhsa01100
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
Signal TransductionREACTOMER-HSA-162582
Signaling by Retinoic AcidREACTOMER-HSA-5362517
RA biosynthesis pathwayREACTOMER-HSA-5365859
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
Ethanol oxidationREACTOMER-HSA-71384

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA166156476rs698VariantVipGeneassociated16792560, 14693654
PA443309AlcoholismDiseaseClinicalAnnotation, VipGeneassociatedPD17285601, 17134660, 32451486
PA445204Ovarian NeoplasmsDiseaseClinicalAnnotationassociatedPD24533712
PA448004abacavirChemicalPathwayassociated24625462
PA448073ethanolChemicalClinicalAnnotation, VipGeneassociatedPD14693654, 32451486
PA449014cisplatinChemicalClinicalAnnotationassociatedPD24533712
PA449165cyclophosphamideChemicalClinicalAnnotationassociatedPD24533712

References

Pubmed IDYearTitleCitations
195815692009Genome-wide association study of alcohol dependence.165
198745742009Genetical genomic determinants of alcohol consumption in rats and humans.93
189969232009Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis.89
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
198984822009Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.84
170187852006Commonly studied single-nucleotide polymorphisms and breast cancer: results from the Breast Cancer Association Consortium.83
220044712012Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster.70
166856482006Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence.63
164403622006Do alcohol-metabolizing enzyme gene polymorphisms increase the risk of alcoholism and alcoholic liver disease?52
146936542004Pooled analysis of alcohol dehydrogenase genotypes and head and neck cancer: a HuGE review.47

Citation

Dessen P

ADH1C (alcohol dehydrogenase 1C (class I), gamma polypeptide)

Atlas Genet Cytogenet Oncol Haematol. 2012-12-01

Online version: http://atlasgeneticsoncology.org/gene/53084/adh1c