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ADH4 (alcohol dehydrogenase 4 (class II), pi polypeptide)

Identity

Alias_symbol (synonym)ADH-2
Other aliasHEL-S-4
HGNC (Hugo) ADH4
LocusID (NCBI) 127
Atlas_Id 53070
Location 4q23  [Link to chromosome band 4q23]
Location_base_pair Starts at 100044808 and ends at 100065449 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
TSPAN5 (4q23) / ADH4 (4q23)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ADH4   252
Cards
Entrez_Gene (NCBI)ADH4  127  alcohol dehydrogenase 4 (class II), pi polypeptide
AliasesADH-2; HEL-S-4
GeneCards (Weizmann)ADH4
Ensembl hg19 (Hinxton)ENSG00000198099 [Gene_View]  chr4:100044808-100065449 [Contig_View]  ADH4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000198099 [Gene_View]  chr4:100044808-100065449 [Contig_View]  ADH4 [Vega]
ICGC DataPortalENSG00000198099
TCGA cBioPortalADH4
AceView (NCBI)ADH4
Genatlas (Paris)ADH4
WikiGenes127
SOURCE (Princeton)ADH4
Genetics Home Reference (NIH)ADH4
Genomic and cartography
GoldenPath hg19 (UCSC)ADH4  -     chr4:100044808-100065449 -  4q23   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ADH4  -     4q23   [Description]    (hg38-Dec_2013)
EnsemblADH4 - 4q23 [CytoView hg19]  ADH4 - 4q23 [CytoView hg38]
Mapping of homologs : NCBIADH4 [Mapview hg19]  ADH4 [Mapview hg38]
OMIM103740   
Gene and transcription
Genbank (Entrez)AK290835 AK295556 AK313649 AV658711 AV659353
RefSeq transcript (Entrez)NM_000670 NM_001306171 NM_001306172
RefSeq genomic (Entrez)NC_000004 NC_018915 NT_016354 NW_004929320
Consensus coding sequences : CCDS (NCBI)ADH4
Cluster EST : UnigeneHs.1219 [ NCBI ]
CGAP (NCI)Hs.1219
Alternative Splicing GalleryENSG00000198099
Gene ExpressionADH4 [ NCBI-GEO ]   ADH4 [ EBI - ARRAY_EXPRESS ]   ADH4 [ SEEK ]   ADH4 [ MEM ]
Gene Expression Viewer (FireBrowse)ADH4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)127
GTEX Portal (Tissue expression)ADH4
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08319   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP08319  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP08319
Splice isoforms : SwissVarP08319
Catalytic activity : Enzyme1.1.1.1 [ Enzyme-Expasy ]   1.1.1.11.1.1.1 [ IntEnz-EBI ]   1.1.1.1 [ BRENDA ]   1.1.1.1 [ KEGG ]   
PhosPhoSitePlusP08319
Domaine pattern : Prosite (Expaxy)ADH_ZINC (PS00059)   
Domains : Interpro (EBI)ADH_C    ADH_N    ADH_SF_Zn-type    ADH_Zn_CS    GroES-like    NAD(P)-bd_dom    Zinc_ADH_II   
Domain families : Pfam (Sanger)ADH_N (PF08240)    ADH_zinc_N (PF00107)   
Domain families : Pfam (NCBI)pfam08240    pfam00107   
Conserved Domain (NCBI)ADH4
DMDM Disease mutations127
Blocks (Seattle)ADH4
PDB (SRS)3COS   
PDB (PDBSum)3COS   
PDB (IMB)3COS   
PDB (RSDB)3COS   
Structural Biology KnowledgeBase3COS   
SCOP (Structural Classification of Proteins)3COS   
CATH (Classification of proteins structures)3COS   
SuperfamilyP08319
Human Protein AtlasENSG00000198099
Peptide AtlasP08319
HPRD00068
IPIIPI00927949   IPI00218899   IPI00964325   IPI00966461   IPI00964982   IPI00969124   
Protein Interaction databases
DIP (DOE-UCLA)P08319
IntAct (EBI)P08319
FunCoupENSG00000198099
BioGRIDADH4
STRING (EMBL)ADH4
ZODIACADH4
Ontologies - Pathways
QuickGOP08319
Ontology : AmiGOretinoid metabolic process  NADPH:quinone reductase activity  alcohol dehydrogenase (NAD) activity  alcohol dehydrogenase activity, zinc-dependent  alcohol dehydrogenase activity, zinc-dependent  alditol:NADP+ 1-oxidoreductase activity  retinol dehydrogenase activity  retinol dehydrogenase activity  all-trans retinal binding  cytosol  alcohol metabolic process  ethanol oxidation  ethanol oxidation  cellular aldehyde metabolic process  zinc ion binding  oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor  benzaldehyde dehydrogenase activity  retinol binding  ethanol binding  retinol metabolic process  alcohol catabolic process  NAD binding  quinone metabolic process  
Ontology : EGO-EBIretinoid metabolic process  NADPH:quinone reductase activity  alcohol dehydrogenase (NAD) activity  alcohol dehydrogenase activity, zinc-dependent  alcohol dehydrogenase activity, zinc-dependent  alditol:NADP+ 1-oxidoreductase activity  retinol dehydrogenase activity  retinol dehydrogenase activity  all-trans retinal binding  cytosol  alcohol metabolic process  ethanol oxidation  ethanol oxidation  cellular aldehyde metabolic process  zinc ion binding  oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor  benzaldehyde dehydrogenase activity  retinol binding  ethanol binding  retinol metabolic process  alcohol catabolic process  NAD binding  quinone metabolic process  
Pathways : KEGGGlycolysis / Gluconeogenesis    Fatty acid degradation    Tyrosine metabolism    Retinol metabolism    Metabolism of xenobiotics by cytochrome P450    Drug metabolism - cytochrome P450    Chemical carcinogenesis   
NDEx NetworkADH4
Atlas of Cancer Signalling NetworkADH4
Wikipedia pathwaysADH4
Orthology - Evolution
OrthoDB127
GeneTree (enSembl)ENSG00000198099
Phylogenetic Trees/Animal Genes : TreeFamADH4
HOVERGENP08319
HOGENOMP08319
Homologs : HomoloGeneADH4
Homology/Alignments : Family Browser (UCSC)ADH4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADH4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADH4
dbVarADH4
ClinVarADH4
1000_GenomesADH4 
Exome Variant ServerADH4
ExAC (Exome Aggregation Consortium)ADH4 (select the gene name)
Genetic variants : HAPMAP127
Genomic Variants (DGV)ADH4 [DGVbeta]
DECIPHER (Syndromes)4:100044808-100065449  ENSG00000198099
CONAN: Copy Number AnalysisADH4 
Mutations
ICGC Data PortalADH4 
TCGA Data PortalADH4 
Broad Tumor PortalADH4
OASIS PortalADH4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADH4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADH4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ADH4
DgiDB (Drug Gene Interaction Database)ADH4
DoCM (Curated mutations)ADH4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADH4 (select a term)
intoGenADH4
Cancer3DADH4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM103740   
Orphanet
MedgenADH4
Genetic Testing Registry ADH4
NextProtP08319 [Medical]
TSGene127
GENETestsADH4
Huge Navigator ADH4 [HugePedia]
snp3D : Map Gene to Disease127
BioCentury BCIQADH4
ClinGenADH4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD127
Chemical/Pharm GKB GenePA24573
Clinical trialADH4
Miscellaneous
canSAR (ICR)ADH4 (select the gene name)
Probes
Litterature
PubMed59 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADH4
EVEXADH4
GoPubMedADH4
iHOPADH4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 14:51:44 CEST 2017

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