ADH4 (alcohol dehydrogenase 4 (class II), pi polypeptide)

2012-12-01  

Identity

HGNC
LOCATION
4q23
LOCUSID
ALIAS
ADH-2,HEL-S-4
FUSION GENES

Other Information

Locus ID:

NCBI: 127
MIM: 103740
HGNC: 252
Ensembl: ENSG00000198099

Variants:

dbSNP: 127
ClinVar: 127
TCGA: ENSG00000198099
COSMIC: ADH4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198099ENST00000265512P08319
ENSG00000198099ENST00000504125D6RIB1
ENSG00000198099ENST00000504894D6RF43
ENSG00000198099ENST00000505590P08319
ENSG00000198099ENST00000506705D6RF43
ENSG00000198099ENST00000508393P08319
ENSG00000198099ENST00000509471H0Y9N0
ENSG00000198099ENST00000512499D6R9K8
ENSG00000198099ENST00000629236A0A0D9SFB5

Expression (GTEx)

0
100
200
300
400
500
600

Pathways

PathwaySourceExternal ID
Glycolysis / GluconeogenesisKEGGko00010
Fatty acid degradationKEGGko00071
Tyrosine metabolismKEGGko00350
Retinol metabolismKEGGko00830
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Drug metabolism - cytochrome P450KEGGko00982
Glycolysis / GluconeogenesisKEGGhsa00010
Fatty acid degradationKEGGhsa00071
Tyrosine metabolismKEGGhsa00350
Retinol metabolismKEGGhsa00830
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
Drug metabolism - cytochrome P450KEGGhsa00982
Metabolic pathwaysKEGGhsa01100
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
Signal TransductionREACTOMER-HSA-162582
Signaling by Retinoic AcidREACTOMER-HSA-5362517
RA biosynthesis pathwayREACTOMER-HSA-5365859
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
Ethanol oxidationREACTOMER-HSA-71384

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
198745742009Genetical genomic determinants of alcohol consumption in rats and humans.93
189969232009Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis.89
198984822009Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.84
162201082005ADH4 gene variation is associated with alcohol and drug dependence: results from family controlled and population-structured association studies.48
162201082005ADH4 gene variation is associated with alcohol and drug dependence: results from family controlled and population-structured association studies.48
183313772008Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample.43
162373922006ADH4 gene variation is associated with alcohol dependence and drug dependence in European Americans: results from HWD tests and case-control association studies.40
162373922006ADH4 gene variation is associated with alcohol dependence and drug dependence in European Americans: results from HWD tests and case-control association studies.40
147452972004Alcohol dehydrogenase polymorphisms influence alcohol-elimination rates in a male Jewish population.33
191936282009ADH single nucleotide polymorphism associations with alcohol metabolism in vivo.33

Citation

Dessen P

ADH4 (alcohol dehydrogenase 4 (class II), pi polypeptide)

Atlas Genet Cytogenet Oncol Haematol. 2012-12-01

Online version: http://atlasgeneticsoncology.org/gene/53070/adh4