Atlas of Genetics and Cytogenetics in Oncology and Haematology

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ADK (adenosine kinase)

Identity

Alias_symbol (synonym)AK
Other alias
HGNC (Hugo) ADK
LocusID (NCBI) 132
Atlas_Id 583
Location 10q22.2  [Link to chromosome band 10q22]
Location_base_pair Starts at 74151185 and ends at 74709303 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADD1 (4p16.3) / ADK (10q22.2)ADK (10q22.2) / FAM149B1 (10q22.2)ADK (10q22.2) / KCNMA1 (10q22.3)
ADK (10q22.2) / LRRTM3 (10q21.3)ADK (10q22.2) / LSAMP (3q13.31)ADK (10q22.2) / RP11-548K23.11 ()
ADK (10q22.2) / SPTAN1 (9q34.11)ADK (10q22.2) / TTC23 (15q26.3)ADK (10q22.2) / ZNF644 (1p22.2)
C10orf11 (10q22.2) / ADK (10q22.2)DNAJC19 (3q26.33) / ADK (10q22.2)FAM149B1 (10q22.2) / ADK (10q22.2)
KAT6B (10q22.2) / ADK (10q22.2)RWDD1 (6q22.1) / ADK (10q22.2)SLC16A9 (10q21.2) / ADK (10q22.2)
TRIP12 (2q36.3) / ADK (10q22.2)VCL (10q22.2) / ADK (10q22.2)ADD1 4p16.3 / ADK 10q22.2
ADK 10q22.2 / FAM149B1 10q22.2ADK 10q22.2 / KCNMA1 10q22.3ADK 10q22.2 / LRRTM3 10q21.3
ADK 10q22.2 RP11-548K23.11ADK 10q22.2 / SPTAN1 9q34.11ADK 10q22.2 / TTC23 15q26.3
C10orf11 10q22.2 / ADK 10q22.2DNAJC19 3q26.33 / ADK 10q22.2FAM149B1 10q22.2 / ADK 10q22.2
KAT6B 10q22.2 / ADK 10q22.2SLC16A9 10q21.2 / ADK 10q22.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 10 ]
  t(3;10)(q26;q22) DNAJC19/ADK
t(4;10)(p16;q22) ADD1/ADK
t(9;10)(q34;q22) ADK/SPTAN1
t(10;10)(q21;q22) ADK/LRRTM3
t(10;10)(q21;q22) SLC16A9/ADK
ADK/FAM149B1 (10q22)
ADK/KCNMA1 (10q22)
FAM149B1/ADK (10q22)
KAT6B/ADK (10q22)
t(10;15)(q22;q26) ADK/TTC23

External links

Nomenclature
HGNC (Hugo)ADK   257
Cards
Entrez_Gene (NCBI)ADK  132  adenosine kinase
AliasesAK
GeneCards (Weizmann)ADK
Ensembl hg19 (Hinxton)ENSG00000156110 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000156110 [Gene_View]  ENSG00000156110 [Sequence]  chr10:74151185-74709303 [Contig_View]  ADK [Vega]
ICGC DataPortalENSG00000156110
TCGA cBioPortalADK
AceView (NCBI)ADK
Genatlas (Paris)ADK
WikiGenes132
SOURCE (Princeton)ADK
Genetics Home Reference (NIH)ADK
Genomic and cartography
GoldenPath hg38 (UCSC)ADK  -     chr10:74151185-74709303 +  10q22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADK  -     10q22.2   [Description]    (hg19-Feb_2009)
GoldenPathADK - 10q22.2 [CytoView hg19]  ADK - 10q22.2 [CytoView hg38]
ImmunoBaseENSG00000156110
Mapping of homologs : NCBIADK [Mapview hg19]  ADK [Mapview hg38]
OMIM102750   614300   
Gene and transcription
Genbank (Entrez)AI188809 AI608983 AK290633 AK301590 AK302706
RefSeq transcript (Entrez)NM_001123 NM_001202449 NM_001202450 NM_001369123 NM_001369124 NM_006721
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ADK
Cluster EST : UnigeneHs.656586 [ NCBI ]
CGAP (NCI)Hs.656586
Alternative Splicing GalleryENSG00000156110
Gene ExpressionADK [ NCBI-GEO ]   ADK [ EBI - ARRAY_EXPRESS ]   ADK [ SEEK ]   ADK [ MEM ]
Gene Expression Viewer (FireBrowse)ADK [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)132
GTEX Portal (Tissue expression)ADK
Human Protein AtlasENSG00000156110-ADK [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP55263   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP55263  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP55263
Splice isoforms : SwissVarP55263
Catalytic activity : Enzyme2.7.1.20 [ Enzyme-Expasy ]   2.7.1.202.7.1.20 [ IntEnz-EBI ]   2.7.1.20 [ BRENDA ]   2.7.1.20 [ KEGG ]   
PhosPhoSitePlusP55263
Domaine pattern : Prosite (Expaxy)PFKB_KINASES_2 (PS00584)   
Domains : Interpro (EBI)Adenokinase    Carboh/pur_kinase_PfkB_CS    PfkB_dom    Ribokinase-like   
Domain families : Pfam (Sanger)PfkB (PF00294)   
Domain families : Pfam (NCBI)pfam00294   
Conserved Domain (NCBI)ADK
DMDM Disease mutations132
Blocks (Seattle)ADK
PDB (RSDB)1BX4    2I6A    2I6B    4O1L   
PDB Europe1BX4    2I6A    2I6B    4O1L   
PDB (PDBSum)1BX4    2I6A    2I6B    4O1L   
PDB (IMB)1BX4    2I6A    2I6B    4O1L   
Structural Biology KnowledgeBase1BX4    2I6A    2I6B    4O1L   
SCOP (Structural Classification of Proteins)1BX4    2I6A    2I6B    4O1L   
CATH (Classification of proteins structures)1BX4    2I6A    2I6B    4O1L   
SuperfamilyP55263
Human Protein Atlas [tissue]ENSG00000156110-ADK [tissue]
Peptide AtlasP55263
HPRD00039
IPIIPI00290279   IPI00234368   IPI00976200   IPI00983658   
Protein Interaction databases
DIP (DOE-UCLA)P55263
IntAct (EBI)P55263
FunCoupENSG00000156110
BioGRIDADK
STRING (EMBL)ADK
ZODIACADK
Ontologies - Pathways
QuickGOP55263
Ontology : AmiGORNA binding  adenosine kinase activity  ATP binding  nucleus  nucleoplasm  cytosol  cytosol  cytosol  purine ribonucleoside salvage  dATP biosynthetic process  ribonucleoside monophosphate biosynthetic process  phosphorylation  purine-containing compound salvage  AMP salvage  metal ion binding  
Ontology : EGO-EBIRNA binding  adenosine kinase activity  ATP binding  nucleus  nucleoplasm  cytosol  cytosol  cytosol  purine ribonucleoside salvage  dATP biosynthetic process  ribonucleoside monophosphate biosynthetic process  phosphorylation  purine-containing compound salvage  AMP salvage  metal ion binding  
Pathways : KEGGPurine metabolism   
NDEx NetworkADK
Atlas of Cancer Signalling NetworkADK
Wikipedia pathwaysADK
Orthology - Evolution
OrthoDB132
GeneTree (enSembl)ENSG00000156110
Phylogenetic Trees/Animal Genes : TreeFamADK
HOGENOMP55263
Homologs : HomoloGeneADK
Homology/Alignments : Family Browser (UCSC)ADK
Gene fusions - Rearrangements
Fusion : MitelmanADD1/ADK [4p16.3/10q22.2]  [t(4;10)(p16;q22)]  
Fusion : MitelmanADK/FAM149B1 [10q22.2/10q22.2]  [t(10;10)(q22;q22)]  
Fusion : MitelmanADK/KCNMA1 [10q22.2/10q22.3]  [t(10;10)(q22;q22)]  
Fusion : MitelmanADK/LRRTM3 [10q22.2/10q21.3]  [t(10;10)(q21;q22)]  
Fusion : MitelmanADK/SPTAN1 [10q22.2/9q34.11]  [t(9;10)(q34;q22)]  
Fusion : MitelmanADK/TTC23 [10q22.2/15q26.3]  [t(10;15)(q22;q26)]  
Fusion : MitelmanC10orf11/ADK [10q22.2/10q22.2]  [t(10;10)(q22;q22)]  
Fusion : MitelmanDNAJC19/ADK [3q26.33/10q22.2]  [t(3;10)(q26;q22)]  
Fusion : MitelmanFAM149B1/ADK [10q22.2/10q22.2]  [t(10;10)(q22;q22)]  
Fusion : MitelmanKAT6B/ADK [10q22.2/10q22.2]  [t(10;10)(q22;q22)]  
Fusion : MitelmanSLC16A9/ADK [10q21.2/10q22.2]  [t(10;10)(q21;q22)]  
Fusion PortalADD1 4p16.3 ADK 10q22.2 HNSC
Fusion PortalADK 10q22.2 FAM149B1 10q22.2 OV
Fusion PortalADK 10q22.2 KCNMA1 10q22.3 BRCA PRAD
Fusion PortalADK 10q22.2 LRRTM3 10q21.3 BRCA
Fusion PortalADK 10q22.2 RP11-548K23.11 BRCA
Fusion PortalADK 10q22.2 SPTAN1 9q34.11 BRCA
Fusion PortalADK 10q22.2 TTC23 15q26.3 BRCA
Fusion PortalC10orf11 10q22.2 ADK 10q22.2 BRCA LUSC
Fusion PortalDNAJC19 3q26.33 ADK 10q22.2 HNSC
Fusion PortalFAM149B1 10q22.2 ADK 10q22.2 GBM
Fusion PortalKAT6B 10q22.2 ADK 10q22.2 BRCA LUAD OV
Fusion PortalSLC16A9 10q21.2 ADK 10q22.2 BRCA
Fusion : QuiverADK
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADK
dbVarADK
ClinVarADK
1000_GenomesADK 
Exome Variant ServerADK
ExAC (Exome Aggregation Consortium)ENSG00000156110
GNOMAD BrowserENSG00000156110
Varsome BrowserADK
Genetic variants : HAPMAP132
Genomic Variants (DGV)ADK [DGVbeta]
DECIPHERADK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADK 
Mutations
ICGC Data PortalADK 
TCGA Data PortalADK 
Broad Tumor PortalADK
OASIS PortalADK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADK  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DADK
Mutations and Diseases : HGMDADK
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ADK
DgiDB (Drug Gene Interaction Database)ADK
DoCM (Curated mutations)ADK (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADK (select a term)
intoGenADK
Cancer3DADK(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM102750    614300   
Orphanet20707   
DisGeNETADK
MedgenADK
Genetic Testing Registry ADK
NextProtP55263 [Medical]
TSGene132
GENETestsADK
Target ValidationADK
Huge Navigator ADK [HugePedia]
snp3D : Map Gene to Disease132
BioCentury BCIQADK
ClinGenADK
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD132
Chemical/Pharm GKB GenePA24579
Clinical trialADK
Miscellaneous
canSAR (ICR)ADK (select the gene name)
DataMed IndexADK
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADK
EVEXADK
GoPubMedADK
iHOPADK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:31:24 CET 2019
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