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ADK (adenosine kinase)

Identity

Alias (NCBI)AK
HGNC (Hugo) ADK
HGNC Alias symbAK
HGNC Alias nameadenosine 5'-phosphotransferase
LocusID (NCBI) 132
Atlas_Id 583
Location 10q22.2  [Link to chromosome band 10q22]
Location_base_pair Starts at 74151221 and ends at 74709290 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADD1 (4p16.3) / ADK (10q22.2)ADK (10q22.2) / FAM149B1 (10q22.2)ADK (10q22.2) / KCNMA1 (10q22.3)
ADK (10q22.2) / LRRTM3 (10q21.3)ADK (10q22.2) / LSAMP (3q13.31)ADK (10q22.2) / RP11-548K23.11 ()
ADK (10q22.2) / SPTAN1 (9q34.11)ADK (10q22.2) / TTC23 (15q26.3)ADK (10q22.2) / ZNF644 (1p22.2)
C10orf11 (10q22.2) / ADK (10q22.2)DNAJC19 (3q26.33) / ADK (10q22.2)FAM149B1 (10q22.2) / ADK (10q22.2)
KAT6B (10q22.2) / ADK (10q22.2)RWDD1 (6q22.1) / ADK (10q22.2)SLC16A9 (10q21.2) / ADK (10q22.2)
TRIP12 (2q36.3) / ADK (10q22.2)VCL (10q22.2) / ADK (10q22.2)ADD1 4p16.3 / ADK 10q22.2
ADK 10q22.2 / FAM149B1 10q22.2ADK 10q22.2 / KCNMA1 10q22.3ADK 10q22.2 / LRRTM3 10q21.3
ADK 10q22.2 RP11-548K23.11ADK 10q22.2 / SPTAN1 9q34.11ADK 10q22.2 / TTC23 15q26.3
C10orf11 10q22.2 / ADK 10q22.2DNAJC19 3q26.33 / ADK 10q22.2FAM149B1 10q22.2 / ADK 10q22.2
KAT6B 10q22.2 / ADK 10q22.2SLC16A9 10q21.2 / ADK 10q22.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)ADK   257
Cards
Entrez_Gene (NCBI)ADK    adenosine kinase
AliasesAK
GeneCards (Weizmann)ADK
Ensembl hg19 (Hinxton)ENSG00000156110 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000156110 [Gene_View]  ENSG00000156110 [Sequence]  chr10:74151221-74709290 [Contig_View]  ADK [Vega]
ICGC DataPortalENSG00000156110
TCGA cBioPortalADK
AceView (NCBI)ADK
Genatlas (Paris)ADK
SOURCE (Princeton)ADK
Genetics Home Reference (NIH)ADK
Genomic and cartography
GoldenPath hg38 (UCSC)ADK  -     chr10:74151221-74709290 +  10q22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADK  -     10q22.2   [Description]    (hg19-Feb_2009)
GoldenPathADK - 10q22.2 [CytoView hg19]  ADK - 10q22.2 [CytoView hg38]
ImmunoBaseENSG00000156110
Genome Data Viewer NCBIADK [Mapview hg19]  
OMIM102750   614300   
Gene and transcription
Genbank (Entrez)AI188809 AI608983 AK290633 AK301590 AK302706
RefSeq transcript (Entrez)NM_001123 NM_001202449 NM_001202450 NM_001369123 NM_001369124 NM_006721
Consensus coding sequences : CCDS (NCBI)ADK
Gene ExpressionADK [ NCBI-GEO ]   ADK [ EBI - ARRAY_EXPRESS ]   ADK [ SEEK ]   ADK [ MEM ]
Gene Expression Viewer (FireBrowse)ADK [ Firebrowse - Broad ]
GenevisibleExpression of ADK in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)132
GTEX Portal (Tissue expression)ADK
Human Protein AtlasENSG00000156110-ADK [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP55263   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP55263  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP55263
Catalytic activity : Enzyme2.7.1.20 [ Enzyme-Expasy ]   2.7.1.202.7.1.20 [ IntEnz-EBI ]   2.7.1.20 [ BRENDA ]   2.7.1.20 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP55263
Domaine pattern : Prosite (Expaxy)PFKB_KINASES_2 (PS00584)   
Domains : Interpro (EBI)Adenokinase    Carboh/pur_kinase_PfkB_CS    PfkB_dom    Ribokinase-like   
Domain families : Pfam (Sanger)PfkB (PF00294)   
Domain families : Pfam (NCBI)pfam00294   
Conserved Domain (NCBI)ADK
PDB (RSDB)1BX4    2I6A    2I6B    4O1L   
PDB Europe1BX4    2I6A    2I6B    4O1L   
PDB (PDBSum)1BX4    2I6A    2I6B    4O1L   
PDB (IMB)1BX4    2I6A    2I6B    4O1L   
Structural Biology KnowledgeBase1BX4    2I6A    2I6B    4O1L   
SCOP (Structural Classification of Proteins)1BX4    2I6A    2I6B    4O1L   
CATH (Classification of proteins structures)1BX4    2I6A    2I6B    4O1L   
SuperfamilyP55263
AlphaFold pdb e-kbP55263   
Human Protein Atlas [tissue]ENSG00000156110-ADK [tissue]
HPRD00039
Protein Interaction databases
DIP (DOE-UCLA)P55263
IntAct (EBI)P55263
BioGRIDADK
STRING (EMBL)ADK
ZODIACADK
Ontologies - Pathways
QuickGOP55263
Ontology : AmiGORNA binding  adenosine kinase activity  ATP binding  nucleus  nucleoplasm  cytosol  cytosol  cytosol  plasma membrane  purine ribonucleoside salvage  dATP biosynthetic process  ribonucleoside monophosphate biosynthetic process  phosphorylation  purine-containing compound salvage  AMP salvage  metal ion binding  
Ontology : EGO-EBIRNA binding  adenosine kinase activity  ATP binding  nucleus  nucleoplasm  cytosol  cytosol  cytosol  plasma membrane  purine ribonucleoside salvage  dATP biosynthetic process  ribonucleoside monophosphate biosynthetic process  phosphorylation  purine-containing compound salvage  AMP salvage  metal ion binding  
Pathways : KEGGPurine metabolism   
NDEx NetworkADK
Atlas of Cancer Signalling NetworkADK
Wikipedia pathwaysADK
Orthology - Evolution
OrthoDB132
GeneTree (enSembl)ENSG00000156110
Phylogenetic Trees/Animal Genes : TreeFamADK
Homologs : HomoloGeneADK
Homology/Alignments : Family Browser (UCSC)ADK
Gene fusions - Rearrangements
Fusion : MitelmanADD1/ADK [4p16.3/10q22.2]  
Fusion : MitelmanADK/FAM149B1 [10q22.2/10q22.2]  
Fusion : MitelmanADK/KCNMA1 [10q22.2/10q22.3]  
Fusion : MitelmanADK/LRRTM3 [10q22.2/10q21.3]  
Fusion : MitelmanADK/SPTAN1 [10q22.2/9q34.11]  
Fusion : MitelmanADK/TTC23 [10q22.2/15q26.3]  
Fusion : MitelmanC10orf11/ADK [10q22.2/10q22.2]  
Fusion : MitelmanDNAJC19/ADK [3q26.33/10q22.2]  
Fusion : MitelmanFAM149B1/ADK [10q22.2/10q22.2]  
Fusion : MitelmanKAT6B/ADK [10q22.2/10q22.2]  
Fusion : MitelmanSLC16A9/ADK [10q21.2/10q22.2]  
Fusion : QuiverADK
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADK
dbVarADK
ClinVarADK
MonarchADK
1000_GenomesADK 
Exome Variant ServerADK
GNOMAD BrowserENSG00000156110
Varsome BrowserADK
ACMGADK variants
VarityP55263
Genomic Variants (DGV)ADK [DGVbeta]
DECIPHERADK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADK 
Mutations
ICGC Data PortalADK 
TCGA Data PortalADK 
Broad Tumor PortalADK
OASIS PortalADK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADK  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DADK
Mutations and Diseases : HGMDADK
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaADK
DgiDB (Drug Gene Interaction Database)ADK
DoCM (Curated mutations)ADK
CIViC (Clinical Interpretations of Variants in Cancer)ADK
Cancer3DADK
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM102750    614300   
Orphanet20707   
DisGeNETADK
MedgenADK
Genetic Testing Registry ADK
NextProtP55263 [Medical]
GENETestsADK
Target ValidationADK
Huge Navigator ADK [HugePedia]
ClinGenADK
Clinical trials, drugs, therapy
MyCancerGenomeADK
Protein Interactions : CTDADK
Pharm GKB GenePA24579
Pharm GKB PathwaysPA166104634   
PharosP55263
Clinical trialADK
Miscellaneous
canSAR (ICR)ADK
HarmonizomeADK
DataMed IndexADK
Probes
Litterature
PubMed45 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXADK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 14:58:40 CEST 2021

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