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ADM (adrenomedullin)

Identity

Alias_symbol (synonym)AM
Other aliasPAMP
HGNC (Hugo) ADM
LocusID (NCBI) 133
Atlas_Id 584
Location 11p15.4  [Link to chromosome band 11p15]
Location_base_pair Starts at 10304980 and ends at 10307402 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
BSCL2 (11q12.3) / ADM (11p15.4)POLE (12q24.33) / ADM (11p15.4)SLTM (15q22.1) / ADM (11p15.4)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ADM   259
Cards
Entrez_Gene (NCBI)ADM  133  adrenomedullin
AliasesAM; PAMP
GeneCards (Weizmann)ADM
Ensembl hg19 (Hinxton)ENSG00000148926 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000148926 [Gene_View]  chr11:10304980-10307402 [Contig_View]  ADM [Vega]
ICGC DataPortalENSG00000148926
TCGA cBioPortalADM
AceView (NCBI)ADM
Genatlas (Paris)ADM
WikiGenes133
SOURCE (Princeton)ADM
Genetics Home Reference (NIH)ADM
Genomic and cartography
GoldenPath hg38 (UCSC)ADM  -     chr11:10304980-10307402 +  11p15.4   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADM  -     11p15.4   [Description]    (hg19-Feb_2009)
EnsemblADM - 11p15.4 [CytoView hg19]  ADM - 11p15.4 [CytoView hg38]
Mapping of homologs : NCBIADM [Mapview hg19]  ADM [Mapview hg38]
OMIM103275   
Gene and transcription
Genbank (Entrez)AK312893 BC015961 BQ021632 BT006902 CR541995
RefSeq transcript (Entrez)NM_001124
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ADM
Cluster EST : UnigeneHs.441047 [ NCBI ]
CGAP (NCI)Hs.441047
Alternative Splicing GalleryENSG00000148926
Gene ExpressionADM [ NCBI-GEO ]   ADM [ EBI - ARRAY_EXPRESS ]   ADM [ SEEK ]   ADM [ MEM ]
Gene Expression Viewer (FireBrowse)ADM [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)133
GTEX Portal (Tissue expression)ADM
Protein : pattern, domain, 3D structure
UniProt/SwissProtP35318   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP35318  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP35318
Splice isoforms : SwissVarP35318
PhosPhoSitePlusP35318
Domains : Interpro (EBI)Adrenomedullin    Calcitonin/adrenomedullin   
Domain families : Pfam (Sanger)Calc_CGRP_IAPP (PF00214)   
Domain families : Pfam (NCBI)pfam00214   
Conserved Domain (NCBI)ADM
DMDM Disease mutations133
Blocks (Seattle)ADM
PDB (SRS)2FLY    2L7S    4RWF   
PDB (PDBSum)2FLY    2L7S    4RWF   
PDB (IMB)2FLY    2L7S    4RWF   
PDB (RSDB)2FLY    2L7S    4RWF   
Structural Biology KnowledgeBase2FLY    2L7S    4RWF   
SCOP (Structural Classification of Proteins)2FLY    2L7S    4RWF   
CATH (Classification of proteins structures)2FLY    2L7S    4RWF   
SuperfamilyP35318
Human Protein AtlasENSG00000148926
Peptide AtlasP35318
HPRD00061
IPIIPI00017968   IPI00979956   IPI00977835   IPI00980931   IPI00985487   
Protein Interaction databases
DIP (DOE-UCLA)P35318
IntAct (EBI)P35318
FunCoupENSG00000148926
BioGRIDADM
STRING (EMBL)ADM
ZODIACADM
Ontologies - Pathways
QuickGOP35318
Ontology : AmiGOvasculogenesis  response to hypoxia  neural tube closure  regulation of the force of heart contraction  G-protein coupled receptor internalization  receptor binding  hormone activity  protein binding  extracellular region  extracellular space  cytoplasm  cAMP biosynthetic process  progesterone biosynthetic process  signal transduction  positive regulation of cytosolic calcium ion concentration  cell-cell signaling  heart development  female pregnancy  aging  blood circulation  androgen metabolic process  positive regulation of cell proliferation  negative regulation of cell proliferation  response to cold  response to wounding  positive regulation of heart rate  cAMP-mediated signaling  positive regulation of cAMP biosynthetic process  animal organ regeneration  neuron projection regeneration  receptor internalization  adrenomedullin receptor binding  response to lipopolysaccharide  response to insulin  odontogenesis of dentin-containing tooth  response to starvation  positive regulation of apoptotic process  negative regulation of vascular permeability  positive regulation of angiogenesis  negative regulation of vasoconstriction  hormone secretion  developmental growth  response to glucocorticoid  branching involved in labyrinthine layer morphogenesis  spongiotrophoblast layer development  vascular smooth muscle cell development  positive regulation of vasculogenesis  
Ontology : EGO-EBIvasculogenesis  response to hypoxia  neural tube closure  regulation of the force of heart contraction  G-protein coupled receptor internalization  receptor binding  hormone activity  protein binding  extracellular region  extracellular space  cytoplasm  cAMP biosynthetic process  progesterone biosynthetic process  signal transduction  positive regulation of cytosolic calcium ion concentration  cell-cell signaling  heart development  female pregnancy  aging  blood circulation  androgen metabolic process  positive regulation of cell proliferation  negative regulation of cell proliferation  response to cold  response to wounding  positive regulation of heart rate  cAMP-mediated signaling  positive regulation of cAMP biosynthetic process  animal organ regeneration  neuron projection regeneration  receptor internalization  adrenomedullin receptor binding  response to lipopolysaccharide  response to insulin  odontogenesis of dentin-containing tooth  response to starvation  positive regulation of apoptotic process  negative regulation of vascular permeability  positive regulation of angiogenesis  negative regulation of vasoconstriction  hormone secretion  developmental growth  response to glucocorticoid  branching involved in labyrinthine layer morphogenesis  spongiotrophoblast layer development  vascular smooth muscle cell development  positive regulation of vasculogenesis  
NDEx NetworkADM
Atlas of Cancer Signalling NetworkADM
Wikipedia pathwaysADM
Orthology - Evolution
OrthoDB133
GeneTree (enSembl)ENSG00000148926
Phylogenetic Trees/Animal Genes : TreeFamADM
HOVERGENP35318
HOGENOMP35318
Homologs : HomoloGeneADM
Homology/Alignments : Family Browser (UCSC)ADM
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADM [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADM
dbVarADM
ClinVarADM
1000_GenomesADM 
Exome Variant ServerADM
ExAC (Exome Aggregation Consortium)ADM (select the gene name)
Genetic variants : HAPMAP133
Genomic Variants (DGV)ADM [DGVbeta]
DECIPHERADM [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADM 
Mutations
ICGC Data PortalADM 
TCGA Data PortalADM 
Broad Tumor PortalADM
OASIS PortalADM [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADM  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADM
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ADM
DgiDB (Drug Gene Interaction Database)ADM
DoCM (Curated mutations)ADM (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADM (select a term)
intoGenADM
Cancer3DADM(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM103275   
Orphanet
MedgenADM
Genetic Testing Registry ADM
NextProtP35318 [Medical]
TSGene133
GENETestsADM
Target ValidationADM
Huge Navigator ADM [HugePedia]
snp3D : Map Gene to Disease133
BioCentury BCIQADM
ClinGenADM
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD133
Chemical/Pharm GKB GenePA24580
Clinical trialADM
Miscellaneous
canSAR (ICR)ADM (select the gene name)
Probes
Litterature
PubMed317 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADM
EVEXADM
GoPubMedADM
iHOPADM
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 18:56:26 CEST 2017

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