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ADNP (activity-dependent neuroprotector homeobox)

Identity

Alias_namesactivity-dependent neuroprotector
Alias_symbol (synonym)KIAA0784
ADNP1
Other aliasHVDAS
MRD28
HGNC (Hugo) ADNP
LocusID (NCBI) 23394
Atlas_Id 585
Location 20q13.13  [Link to chromosome band 20q13]
Location_base_pair Starts at 49505455 and ends at 49547527 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ADNP (20q13.13) / BMP7 (20q13.31)ADNP (20q13.13) / DDX27 (20q13.13)ADNP (20q13.13) / DLGAP4 (20q11.23)
ADNP (20q13.13) / DPM1 (20q13.13)ADNP (20q13.13) / GHRH (20q11.23)ADNP (20q13.13) / KCNG1 (20q13.13)
ADNP (20q13.13) / MMP24 (20q11.22)ADNP (20q13.13) / MROH8 (20q11.23)ADNP (20q13.13) / SCCPDH (1q44)
ADNP (20q13.13) / SYCP2 (20q13.33)ADNP (20q13.13) / TPRG1L (1p36.32)ADNP (20q13.13) / ZNF841 (19q13.41)
BCAS4 (20q13.13) / ADNP (20q13.13)DLGAP4 (20q11.23) / ADNP (20q13.13)PAFAH1B1 (17p13.3) / ADNP (20q13.13)
PHF20 (20q11.22) / ADNP (20q13.13)SHROOM2 (Xp22.2) / ADNP (20q13.13)ADNP 20q13.13 / BMP7 20q13.31
ADNP 20q13.13 / DDX27 20q13.13ADNP 20q13.13 / DPM1 20q13.13ADNP 20q13.13 / GHRH 20q11.23
ADNP 20q13.13 / KCNG1 20q13.13ADNP 20q13.13 / MMP24 20q11.22ADNP 20q13.13 / SCCPDH 1q44
ADNP 20q13.13 / SYCP2 20q13.33ADNP 20q13.13 / ZNF841 19q13.41PHF20 20q11.22 / ADNP 20q13.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)ADNP   15766
Cards
Entrez_Gene (NCBI)ADNP  23394  activity-dependent neuroprotector homeobox
AliasesADNP1; HVDAS; MRD28
GeneCards (Weizmann)ADNP
Ensembl hg19 (Hinxton)ENSG00000101126 [Gene_View]  chr20:49505455-49547527 [Contig_View]  ADNP [Vega]
Ensembl hg38 (Hinxton)ENSG00000101126 [Gene_View]  chr20:49505455-49547527 [Contig_View]  ADNP [Vega]
ICGC DataPortalENSG00000101126
TCGA cBioPortalADNP
AceView (NCBI)ADNP
Genatlas (Paris)ADNP
WikiGenes23394
SOURCE (Princeton)ADNP
Genetics Home Reference (NIH)ADNP
Genomic and cartography
GoldenPath hg19 (UCSC)ADNP  -     chr20:49505455-49547527 -  20q13.13   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ADNP  -     20q13.13   [Description]    (hg38-Dec_2013)
EnsemblADNP - 20q13.13 [CytoView hg19]  ADNP - 20q13.13 [CytoView hg38]
Mapping of homologs : NCBIADNP [Mapview hg19]  ADNP [Mapview hg38]
OMIM611386   615873   
Gene and transcription
Genbank (Entrez)AB018327 AF250860 AK074926 AK314734 AL080163
RefSeq transcript (Entrez)NM_001282531 NM_001282532 NM_015339 NM_181442
RefSeq genomic (Entrez)NC_000020 NC_018931 NG_034200 NT_011362 NW_004929418
Consensus coding sequences : CCDS (NCBI)ADNP
Cluster EST : UnigeneHs.570355 [ NCBI ]
CGAP (NCI)Hs.570355
Alternative Splicing GalleryENSG00000101126
Gene ExpressionADNP [ NCBI-GEO ]   ADNP [ EBI - ARRAY_EXPRESS ]   ADNP [ SEEK ]   ADNP [ MEM ]
Gene Expression Viewer (FireBrowse)ADNP [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23394
GTEX Portal (Tissue expression)ADNP
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H2P0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H2P0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H2P0
Splice isoforms : SwissVarQ9H2P0
PhosPhoSitePlusQ9H2P0
Domaine pattern : Prosite (Expaxy)HOMEOBOX_2 (PS50071)    ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)Homeobox_dom    Homeodomain-like    Znf_C2H2    Znf_C2H2-like   
Domain families : Pfam (Sanger)Homeobox (PF00046)   
Domain families : Pfam (NCBI)pfam00046   
Domain families : Smart (EMBL)HOX (SM00389)  ZnF_C2H2 (SM00355)  
Conserved Domain (NCBI)ADNP
DMDM Disease mutations23394
Blocks (Seattle)ADNP
SuperfamilyQ9H2P0
Human Protein AtlasENSG00000101126
Peptide AtlasQ9H2P0
HPRD09793
IPIIPI00022215   IPI00983130   
Protein Interaction databases
DIP (DOE-UCLA)Q9H2P0
IntAct (EBI)Q9H2P0
FunCoupENSG00000101126
BioGRIDADNP
STRING (EMBL)ADNP
ZODIACADNP
Ontologies - Pathways
QuickGOQ9H2P0
Ontology : AmiGODNA binding  chromatin binding  copper ion binding  protein binding  extracellular space  nucleus  cytoplasm  transcription, DNA-templated  regulation of transcription, DNA-templated  short-term memory  response to carbohydrate  response to inorganic substance  negative regulation of gene expression  regulation of protein ADP-ribosylation  axon  dendrite  positive regulation of cGMP biosynthetic process  cellular response to extracellular stimulus  negative regulation of protein binding  activation of protein kinase activity  nitric oxide homeostasis  peptide binding  neuronal cell body  negative regulation of neuron apoptotic process  estrous cycle  positive regulation of axon extension  beta-tubulin binding  positive regulation of peptidyl-tyrosine phosphorylation  negative regulation of synaptic transmission  positive regulation of synapse assembly  
Ontology : EGO-EBIDNA binding  chromatin binding  copper ion binding  protein binding  extracellular space  nucleus  cytoplasm  transcription, DNA-templated  regulation of transcription, DNA-templated  short-term memory  response to carbohydrate  response to inorganic substance  negative regulation of gene expression  regulation of protein ADP-ribosylation  axon  dendrite  positive regulation of cGMP biosynthetic process  cellular response to extracellular stimulus  negative regulation of protein binding  activation of protein kinase activity  nitric oxide homeostasis  peptide binding  neuronal cell body  negative regulation of neuron apoptotic process  estrous cycle  positive regulation of axon extension  beta-tubulin binding  positive regulation of peptidyl-tyrosine phosphorylation  negative regulation of synaptic transmission  positive regulation of synapse assembly  
NDEx NetworkADNP
Atlas of Cancer Signalling NetworkADNP
Wikipedia pathwaysADNP
Orthology - Evolution
OrthoDB23394
GeneTree (enSembl)ENSG00000101126
Phylogenetic Trees/Animal Genes : TreeFamADNP
HOVERGENQ9H2P0
HOGENOMQ9H2P0
Homologs : HomoloGeneADNP
Homology/Alignments : Family Browser (UCSC)ADNP
Gene fusions - Rearrangements
Fusion : MitelmanADNP/BMP7 [20q13.13/20q13.31]  
Fusion : MitelmanADNP/DDX27 [20q13.13/20q13.13]  [t(20;20)(q13;q13)]  
Fusion : MitelmanADNP/DLGAP4 [20q13.13/20q11.23]  [t(20;20)(q11;q13)]  
Fusion : MitelmanADNP/DPM1 [20q13.13/20q13.13]  [t(20;20)(q13;q13)]  
Fusion : MitelmanADNP/GHRH [20q13.13/20q11.23]  [t(20;20)(q11;q13)]  
Fusion : MitelmanADNP/KCNG1 [20q13.13/20q13.13]  [t(20;20)(q13;q13)]  
Fusion : MitelmanADNP/MMP24 [20q13.13/20q11.22]  [t(20;20)(q11;q13)]  
Fusion : MitelmanADNP/MROH8 [20q13.13/20q11.23]  [t(20;20)(q11;q13)]  
Fusion : MitelmanADNP/SCCPDH [20q13.13/1q44]  [t(1;20)(q44;q13)]  
Fusion : MitelmanADNP/SYCP2 [20q13.13/20q13.33]  [t(20;20)(q13;q13)]  
Fusion : MitelmanADNP/ZNF841 [20q13.13/19q13.41]  [t(19;20)(q13;q13)]  
Fusion : MitelmanDLGAP4/ADNP [20q11.23/20q13.13]  [t(20;20)(q11;q13)]  
Fusion : MitelmanPHF20/ADNP [20q11.22/20q13.13]  [t(20;20)(q11;q13)]  
Fusion: TCGAADNP 20q13.13 BMP7 20q13.31 SKCM
Fusion: TCGAADNP 20q13.13 DDX27 20q13.13 LUAD
Fusion: TCGAADNP 20q13.13 DPM1 20q13.13 BRCA
Fusion: TCGAADNP 20q13.13 GHRH 20q11.23 BRCA
Fusion: TCGAADNP 20q13.13 KCNG1 20q13.13 OV
Fusion: TCGAADNP 20q13.13 MMP24 20q11.22 BRCA
Fusion: TCGAADNP 20q13.13 SCCPDH 1q44 PRAD
Fusion: TCGAADNP 20q13.13 SYCP2 20q13.33 BRCA
Fusion: TCGAADNP 20q13.13 ZNF841 19q13.41 BRCA
Fusion: TCGAPHF20 20q11.22 ADNP 20q13.13 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADNP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADNP
dbVarADNP
ClinVarADNP
1000_GenomesADNP 
Exome Variant ServerADNP
ExAC (Exome Aggregation Consortium)ADNP (select the gene name)
Genetic variants : HAPMAP23394
Genomic Variants (DGV)ADNP [DGVbeta]
DECIPHER (Syndromes)20:49505455-49547527  ENSG00000101126
CONAN: Copy Number AnalysisADNP 
Mutations
ICGC Data PortalADNP 
TCGA Data PortalADNP 
Broad Tumor PortalADNP
OASIS PortalADNP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADNP  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADNP
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ADNP
DgiDB (Drug Gene Interaction Database)ADNP
DoCM (Curated mutations)ADNP (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADNP (select a term)
intoGenADNP
Cancer3DADNP(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611386    615873   
Orphanet22921   
MedgenADNP
Genetic Testing Registry ADNP
NextProtQ9H2P0 [Medical]
TSGene23394
GENETestsADNP
Huge Navigator ADNP [HugePedia]
snp3D : Map Gene to Disease23394
BioCentury BCIQADNP
ClinGenADNP
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23394
Chemical/Pharm GKB GenePA24582
Clinical trialADNP
Miscellaneous
canSAR (ICR)ADNP (select the gene name)
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADNP
EVEXADNP
GoPubMedADNP
iHOPADNP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 14:51:46 CEST 2017

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