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ADNP (activity dependent neuroprotector homeobox)

Identity

Alias (NCBI)ADNP1
HVDAS
MRD28
HGNC (Hugo) ADNP
HGNC Alias symbKIAA0784
ADNP1
HGNC Alias nameADNP homeobox 1
 activity-dependent neuroprotective protein
HGNC Previous nameactivity-dependent neuroprotector
LocusID (NCBI) 23394
Atlas_Id 585
Location 20q13.13  [Link to chromosome band 20q13]
Location_base_pair Starts at 50888918 and ends at 50931437 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADNP (20q13.13) / BMP7 (20q13.31)ADNP (20q13.13) / DDX27 (20q13.13)ADNP (20q13.13) / DLGAP4 (20q11.23)
ADNP (20q13.13) / DPM1 (20q13.13)ADNP (20q13.13) / GHRH (20q11.23)ADNP (20q13.13) / KCNG1 (20q13.13)
ADNP (20q13.13) / MMP24 (20q11.22)ADNP (20q13.13) / MROH8 (20q11.23)ADNP (20q13.13) / SCCPDH (1q44)
ADNP (20q13.13) / SYCP2 (20q13.33)ADNP (20q13.13) / TPRG1L (1p36.32)ADNP (20q13.13) / ZNF841 (19q13.41)
BCAS4 (20q13.13) / ADNP (20q13.13)DLGAP4 (20q11.23) / ADNP (20q13.13)PAFAH1B1 (17p13.3) / ADNP (20q13.13)
PHF20 (20q11.22) / ADNP (20q13.13)SHROOM2 (Xp22.2) / ADNP (20q13.13)ADNP 20q13.13 / BMP7 20q13.31
ADNP 20q13.13 / DDX27 20q13.13ADNP 20q13.13 / DPM1 20q13.13ADNP 20q13.13 / GHRH 20q11.23
ADNP 20q13.13 / KCNG1 20q13.13ADNP 20q13.13 / MMP24 20q11.22ADNP 20q13.13 / SCCPDH 1q44
ADNP 20q13.13 / SYCP2 20q13.33ADNP 20q13.13 / ZNF841 19q13.41PHF20 20q11.22 / ADNP 20q13.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)ADNP   15766
Cards
Entrez_Gene (NCBI)ADNP    activity dependent neuroprotector homeobox
AliasesADNP1; HVDAS; MRD28
GeneCards (Weizmann)ADNP
Ensembl hg19 (Hinxton)ENSG00000101126 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000101126 [Gene_View]  ENSG00000101126 [Sequence]  chr20:50888918-50931437 [Contig_View]  ADNP [Vega]
ICGC DataPortalENSG00000101126
TCGA cBioPortalADNP
AceView (NCBI)ADNP
Genatlas (Paris)ADNP
SOURCE (Princeton)ADNP
Genetics Home Reference (NIH)ADNP
Genomic and cartography
GoldenPath hg38 (UCSC)ADNP  -     chr20:50888918-50931437 -  20q13.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADNP  -     20q13.13   [Description]    (hg19-Feb_2009)
GoldenPathADNP - 20q13.13 [CytoView hg19]  ADNP - 20q13.13 [CytoView hg38]
ImmunoBaseENSG00000101126
Genome Data Viewer NCBIADNP [Mapview hg19]  
OMIM611386   615873   
Gene and transcription
Genbank (Entrez)AB018327 AF250860 AK074926 AK314734 AL080163
RefSeq transcript (Entrez)NM_001282531 NM_001282532 NM_001347511 NM_015339 NM_181442
Consensus coding sequences : CCDS (NCBI)ADNP
Gene ExpressionADNP [ NCBI-GEO ]   ADNP [ EBI - ARRAY_EXPRESS ]   ADNP [ SEEK ]   ADNP [ MEM ]
Gene Expression Viewer (FireBrowse)ADNP [ Firebrowse - Broad ]
GenevisibleExpression of ADNP in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23394
GTEX Portal (Tissue expression)ADNP
Human Protein AtlasENSG00000101126-ADNP [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H2P0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H2P0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H2P0
PhosPhoSitePlusQ9H2P0
Domaine pattern : Prosite (Expaxy)HOMEOBOX_2 (PS50071)    ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)ADNP/ADNP2    Homeobox-like_sf    Homeobox_dom    Znf_C2H2_type   
Domain families : Pfam (Sanger)Homeodomain (PF00046)   
Domain families : Pfam (NCBI)pfam00046   
Domain families : Smart (EMBL)HOX (SM00389)  ZnF_C2H2 (SM00355)  
Conserved Domain (NCBI)ADNP
SuperfamilyQ9H2P0
AlphaFold pdb e-kbQ9H2P0   
Human Protein Atlas [tissue]ENSG00000101126-ADNP [tissue]
HPRD09793
Protein Interaction databases
DIP (DOE-UCLA)Q9H2P0
IntAct (EBI)Q9H2P0
BioGRIDADNP
STRING (EMBL)ADNP
ZODIACADNP
Ontologies - Pathways
QuickGOQ9H2P0
Ontology : AmiGOchromatin  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA binding  chromatin binding  copper ion binding  protein binding  extracellular space  nucleus  cytoplasm  regulation of transcription by RNA polymerase II  short-term memory  response to carbohydrate  response to inorganic substance  regulation of gene expression  negative regulation of gene expression  regulation of protein ADP-ribosylation  positive regulation of neuron projection development  cGMP-mediated signaling  axon  dendrite  cellular response to extracellular stimulus  negative regulation of protein binding  activation of protein kinase activity  nitric oxide homeostasis  peptide binding  neuronal cell body  negative regulation of neuron apoptotic process  estrous cycle  positive regulation of axon extension  beta-tubulin binding  positive regulation of peptidyl-tyrosine phosphorylation  negative regulation of synaptic transmission  positive regulation of synapse assembly  RNA polymerase II transcription regulator complex  
Ontology : EGO-EBIchromatin  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA binding  chromatin binding  copper ion binding  protein binding  extracellular space  nucleus  cytoplasm  regulation of transcription by RNA polymerase II  short-term memory  response to carbohydrate  response to inorganic substance  regulation of gene expression  negative regulation of gene expression  regulation of protein ADP-ribosylation  positive regulation of neuron projection development  cGMP-mediated signaling  axon  dendrite  cellular response to extracellular stimulus  negative regulation of protein binding  activation of protein kinase activity  nitric oxide homeostasis  peptide binding  neuronal cell body  negative regulation of neuron apoptotic process  estrous cycle  positive regulation of axon extension  beta-tubulin binding  positive regulation of peptidyl-tyrosine phosphorylation  negative regulation of synaptic transmission  positive regulation of synapse assembly  RNA polymerase II transcription regulator complex  
NDEx NetworkADNP
Atlas of Cancer Signalling NetworkADNP
Wikipedia pathwaysADNP
Orthology - Evolution
OrthoDB23394
GeneTree (enSembl)ENSG00000101126
Phylogenetic Trees/Animal Genes : TreeFamADNP
Homologs : HomoloGeneADNP
Homology/Alignments : Family Browser (UCSC)ADNP
Gene fusions - Rearrangements
Fusion : MitelmanADNP/BMP7 [20q13.13/20q13.31]  
Fusion : MitelmanADNP/DDX27 [20q13.13/20q13.13]  
Fusion : MitelmanADNP/DLGAP4 [20q13.13/20q11.23]  
Fusion : MitelmanADNP/DPM1 [20q13.13/20q13.13]  
Fusion : MitelmanADNP/GHRH [20q13.13/20q11.23]  
Fusion : MitelmanADNP/KCNG1 [20q13.13/20q13.13]  
Fusion : MitelmanADNP/MMP24 [20q13.13/20q11.22]  
Fusion : MitelmanADNP/MROH8 [20q13.13/20q11.23]  
Fusion : MitelmanADNP/SCCPDH [20q13.13/1q44]  
Fusion : MitelmanADNP/SYCP2 [20q13.13/20q13.33]  
Fusion : MitelmanADNP/ZNF841 [20q13.13/19q13.41]  
Fusion : MitelmanDLGAP4/ADNP [20q11.23/20q13.13]  
Fusion : MitelmanPHF20/ADNP [20q11.22/20q13.13]  
Fusion : QuiverADNP
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADNP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADNP
dbVarADNP
ClinVarADNP
MonarchADNP
1000_GenomesADNP 
Exome Variant ServerADNP
GNOMAD BrowserENSG00000101126
Varsome BrowserADNP
ACMGADNP variants
VarityQ9H2P0
Genomic Variants (DGV)ADNP [DGVbeta]
DECIPHERADNP [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADNP 
Mutations
ICGC Data PortalADNP 
TCGA Data PortalADNP 
Broad Tumor PortalADNP
OASIS PortalADNP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADNP  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DADNP
Mutations and Diseases : HGMDADNP
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaADNP
DgiDB (Drug Gene Interaction Database)ADNP
DoCM (Curated mutations)ADNP
CIViC (Clinical Interpretations of Variants in Cancer)ADNP
Cancer3DADNP
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611386    615873   
Orphanet22921   
DisGeNETADNP
MedgenADNP
Genetic Testing Registry ADNP
NextProtQ9H2P0 [Medical]
GENETestsADNP
Target ValidationADNP
Huge Navigator ADNP [HugePedia]
ClinGenADNP
Clinical trials, drugs, therapy
MyCancerGenomeADNP
Protein Interactions : CTDADNP
Pharm GKB GenePA24582
PharosQ9H2P0
Clinical trialADNP
Miscellaneous
canSAR (ICR)ADNP
HarmonizomeADNP
DataMed IndexADNP
Probes
Litterature
PubMed91 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXADNP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 14:58:41 CEST 2021

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