Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ADORA2A (adenosine A2a receptor)

Identity

Alias_namesADORA2
Alias_symbol (synonym)RDC8
Other aliasA2aR
HGNC (Hugo) ADORA2A
LocusID (NCBI) 135
Atlas_Id 49956
Location 22q11.23  [Link to chromosome band 22q11]
Location_base_pair Starts at 24427562 and ends at 24442361 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ADORA2A   263
Cards
Entrez_Gene (NCBI)ADORA2A  135  adenosine A2a receptor
AliasesA2aR; ADORA2; RDC8
GeneCards (Weizmann)ADORA2A
Ensembl hg19 (Hinxton)ENSG00000128271 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000128271 [Gene_View]  chr22:24427562-24442361 [Contig_View]  ADORA2A [Vega]
ICGC DataPortalENSG00000128271
TCGA cBioPortalADORA2A
AceView (NCBI)ADORA2A
Genatlas (Paris)ADORA2A
WikiGenes135
SOURCE (Princeton)ADORA2A
Genetics Home Reference (NIH)ADORA2A
Genomic and cartography
GoldenPath hg38 (UCSC)ADORA2A  -     chr22:24427562-24442361 +  22q11.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADORA2A  -     22q11.23   [Description]    (hg19-Feb_2009)
EnsemblADORA2A - 22q11.23 [CytoView hg19]  ADORA2A - 22q11.23 [CytoView hg38]
Mapping of homologs : NCBIADORA2A [Mapview hg19]  ADORA2A [Mapview hg38]
OMIM102776   
Gene and transcription
Genbank (Entrez)###############################################################################################################################################################################################################################################################
RefSeq transcript (Entrez)NM_000675 NM_001278497 NM_001278498 NM_001278499 NM_001278500
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ADORA2A
Cluster EST : UnigeneHs.197029 [ NCBI ]
CGAP (NCI)Hs.197029
Alternative Splicing GalleryENSG00000128271
Gene ExpressionADORA2A [ NCBI-GEO ]   ADORA2A [ EBI - ARRAY_EXPRESS ]   ADORA2A [ SEEK ]   ADORA2A [ MEM ]
Gene Expression Viewer (FireBrowse)ADORA2A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)135
GTEX Portal (Tissue expression)ADORA2A
Human Protein AtlasENSG00000128271-ADORA2A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP29274   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP29274  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP29274
Splice isoforms : SwissVarP29274
PhosPhoSitePlusP29274
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)Adeno_A2A_rcpt    Adenosn_rcpt    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Domain families : Smart (EMBL)7TM_GPCR_Srsx (SM01381)  
Conserved Domain (NCBI)ADORA2A
DMDM Disease mutations135
Blocks (Seattle)ADORA2A
PDB (SRS)1MMH    1UPE    2YDO    2YDV    3EML    3PWH    3QAK    3REY    3RFM    3UZA    3UZC    3VG9    3VGA    4EIY    4UG2    4UHR    5G53    5IU4    5IU7    5IU8    5IUA    5IUB    5K2A    5K2B    5K2C    5K2D   
PDB (PDBSum)1MMH    1UPE    2YDO    2YDV    3EML    3PWH    3QAK    3REY    3RFM    3UZA    3UZC    3VG9    3VGA    4EIY    4UG2    4UHR    5G53    5IU4    5IU7    5IU8    5IUA    5IUB    5K2A    5K2B    5K2C    5K2D   
PDB (IMB)1MMH    1UPE    2YDO    2YDV    3EML    3PWH    3QAK    3REY    3RFM    3UZA    3UZC    3VG9    3VGA    4EIY    4UG2    4UHR    5G53    5IU4    5IU7    5IU8    5IUA    5IUB    5K2A    5K2B    5K2C    5K2D   
PDB (RSDB)1MMH    1UPE    2YDO    2YDV    3EML    3PWH    3QAK    3REY    3RFM    3UZA    3UZC    3VG9    3VGA    4EIY    4UG2    4UHR    5G53    5IU4    5IU7    5IU8    5IUA    5IUB    5K2A    5K2B    5K2C    5K2D   
Structural Biology KnowledgeBase1MMH    1UPE    2YDO    2YDV    3EML    3PWH    3QAK    3REY    3RFM    3UZA    3UZC    3VG9    3VGA    4EIY    4UG2    4UHR    5G53    5IU4    5IU7    5IU8    5IUA    5IUB    5K2A    5K2B    5K2C    5K2D   
SCOP (Structural Classification of Proteins)1MMH    1UPE    2YDO    2YDV    3EML    3PWH    3QAK    3REY    3RFM    3UZA    3UZC    3VG9    3VGA    4EIY    4UG2    4UHR    5G53    5IU4    5IU7    5IU8    5IUA    5IUB    5K2A    5K2B    5K2C    5K2D   
CATH (Classification of proteins structures)1MMH    1UPE    2YDO    2YDV    3EML    3PWH    3QAK    3REY    3RFM    3UZA    3UZC    3VG9    3VGA    4EIY    4UG2    4UHR    5G53    5IU4    5IU7    5IU8    5IUA    5IUB    5K2A    5K2B    5K2C    5K2D   
SuperfamilyP29274
Human Protein Atlas [tissue]ENSG00000128271-ADORA2A [tissue]
Peptide AtlasP29274
HPRD00043
IPIIPI00020974   IPI00878972   IPI00878800   IPI00878320   IPI00969437   
Protein Interaction databases
DIP (DOE-UCLA)P29274
IntAct (EBI)P29274
FunCoupENSG00000128271
BioGRIDADORA2A
STRING (EMBL)ADORA2A
ZODIACADORA2A
Ontologies - Pathways
QuickGOP29274
Ontology : AmiGOG-protein coupled adenosine receptor activity  synaptic transmission, dopaminergic  adenosine receptor signaling pathway  response to amphetamine  protein binding  intermediate filament  plasma membrane  plasma membrane  integral component of plasma membrane  cAMP biosynthetic process  regulation of transcription, DNA-templated  negative regulation of protein kinase activity  phagocytosis  apoptotic process  inflammatory response  cellular defense response  adenylate cyclase-modulating G-protein coupled receptor signaling pathway  protein kinase C-activating G-protein coupled receptor signaling pathway  cell-cell signaling  synaptic transmission, cholinergic  central nervous system development  blood coagulation  sensory perception  locomotory behavior  blood circulation  negative regulation of cell proliferation  positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway  endomembrane system  positive regulation of glutamate secretion  positive regulation of acetylcholine secretion, neurotransmission  regulation of norepinephrine secretion  postsynaptic density  membrane  enzyme binding  dendrite  axolemma  response to caffeine  type 5 metabotropic glutamate receptor binding  positive regulation of synaptic transmission, GABAergic  synaptic transmission, glutamatergic  positive regulation of urine volume  positive regulation of renal sodium excretion  negative regulation of locomotion  vasodilation  response to drug  presynaptic membrane  eating behavior  identical protein binding  neuronal cell body  negative regulation of vascular permeability  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  negative regulation of neuron apoptotic process  cellular protein metabolic process  postsynaptic membrane  positive regulation of circadian sleep/wake cycle, sleep  negative regulation of alpha-beta T cell activation  protein heterodimerization activity  astrocyte activation  regulation of synaptic plasticity  presynaptic active zone  neuron projection morphogenesis  positive regulation of protein secretion  negative regulation of inflammatory response  alpha-actinin binding  regulation of mitochondrial membrane potential  membrane depolarization  regulation of calcium ion transport  positive regulation of synaptic transmission, glutamatergic  excitatory postsynaptic potential  inhibitory postsynaptic potential  prepulse inhibition  positive regulation of apoptotic signaling pathway  
Ontology : EGO-EBIG-protein coupled adenosine receptor activity  synaptic transmission, dopaminergic  adenosine receptor signaling pathway  response to amphetamine  protein binding  intermediate filament  plasma membrane  plasma membrane  integral component of plasma membrane  cAMP biosynthetic process  regulation of transcription, DNA-templated  negative regulation of protein kinase activity  phagocytosis  apoptotic process  inflammatory response  cellular defense response  adenylate cyclase-modulating G-protein coupled receptor signaling pathway  protein kinase C-activating G-protein coupled receptor signaling pathway  cell-cell signaling  synaptic transmission, cholinergic  central nervous system development  blood coagulation  sensory perception  locomotory behavior  blood circulation  negative regulation of cell proliferation  positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway  endomembrane system  positive regulation of glutamate secretion  positive regulation of acetylcholine secretion, neurotransmission  regulation of norepinephrine secretion  postsynaptic density  membrane  enzyme binding  dendrite  axolemma  response to caffeine  type 5 metabotropic glutamate receptor binding  positive regulation of synaptic transmission, GABAergic  synaptic transmission, glutamatergic  positive regulation of urine volume  positive regulation of renal sodium excretion  negative regulation of locomotion  vasodilation  response to drug  presynaptic membrane  eating behavior  identical protein binding  neuronal cell body  negative regulation of vascular permeability  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  negative regulation of neuron apoptotic process  cellular protein metabolic process  postsynaptic membrane  positive regulation of circadian sleep/wake cycle, sleep  negative regulation of alpha-beta T cell activation  protein heterodimerization activity  astrocyte activation  regulation of synaptic plasticity  presynaptic active zone  neuron projection morphogenesis  positive regulation of protein secretion  negative regulation of inflammatory response  alpha-actinin binding  regulation of mitochondrial membrane potential  membrane depolarization  regulation of calcium ion transport  positive regulation of synaptic transmission, glutamatergic  excitatory postsynaptic potential  inhibitory postsynaptic potential  prepulse inhibition  positive regulation of apoptotic signaling pathway  
Pathways : KEGGRap1 signaling pathway    Calcium signaling pathway    Neuroactive ligand-receptor interaction    Vascular smooth muscle contraction    Parkinson's disease    Alcoholism   
NDEx NetworkADORA2A
Atlas of Cancer Signalling NetworkADORA2A
Wikipedia pathwaysADORA2A
Orthology - Evolution
OrthoDB135
GeneTree (enSembl)ENSG00000128271
Phylogenetic Trees/Animal Genes : TreeFamADORA2A
HOVERGENP29274
HOGENOMP29274
Homologs : HomoloGeneADORA2A
Homology/Alignments : Family Browser (UCSC)ADORA2A
Gene fusions - Rearrangements
Tumor Fusion PortalADORA2A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADORA2A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADORA2A
dbVarADORA2A
ClinVarADORA2A
1000_GenomesADORA2A 
Exome Variant ServerADORA2A
ExAC (Exome Aggregation Consortium)ENSG00000128271
GNOMAD BrowserENSG00000128271
Genetic variants : HAPMAP135
Genomic Variants (DGV)ADORA2A [DGVbeta]
DECIPHERADORA2A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADORA2A 
Mutations
ICGC Data PortalADORA2A 
TCGA Data PortalADORA2A 
Broad Tumor PortalADORA2A
OASIS PortalADORA2A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADORA2A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADORA2A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ADORA2A
DgiDB (Drug Gene Interaction Database)ADORA2A
DoCM (Curated mutations)ADORA2A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADORA2A (select a term)
intoGenADORA2A
Cancer3DADORA2A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM102776   
Orphanet22322   
DisGeNETADORA2A
MedgenADORA2A
Genetic Testing Registry ADORA2A
NextProtP29274 [Medical]
TSGene135
GENETestsADORA2A
Target ValidationADORA2A
Huge Navigator ADORA2A [HugePedia]
snp3D : Map Gene to Disease135
BioCentury BCIQADORA2A
ClinGenADORA2A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD135
Chemical/Pharm GKB GenePA24584
Clinical trialADORA2A
Miscellaneous
canSAR (ICR)ADORA2A (select the gene name)
Probes
Litterature
PubMed291 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADORA2A
EVEXADORA2A
GoPubMedADORA2A
iHOPADORA2A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:02:19 CET 2017

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