Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

ADORA2B (adenosine A2b receptor)

Identity

Other aliasADORA2
HGNC (Hugo) ADORA2B
LocusID (NCBI) 136
Atlas_Id 53079
Location 17p12  [Link to chromosome band 17p12]
Location_base_pair Starts at 15944917 and ends at 15975896 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ADORA2B (17p12) / SYN3 (22q12.3)SPINT2 (19q13.2) / ADORA2B (17p12)ADORA2B 17p12 / SYN3 22q12.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ADORA2B   264
Cards
Entrez_Gene (NCBI)ADORA2B  136  adenosine A2b receptor
AliasesADORA2
GeneCards (Weizmann)ADORA2B
Ensembl hg19 (Hinxton)ENSG00000170425 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000170425 [Gene_View]  chr17:15944917-15975896 [Contig_View]  ADORA2B [Vega]
ICGC DataPortalENSG00000170425
TCGA cBioPortalADORA2B
AceView (NCBI)ADORA2B
Genatlas (Paris)ADORA2B
WikiGenes136
SOURCE (Princeton)ADORA2B
Genetics Home Reference (NIH)ADORA2B
Genomic and cartography
GoldenPath hg38 (UCSC)ADORA2B  -     chr17:15944917-15975896 +  17p12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADORA2B  -     17p12   [Description]    (hg19-Feb_2009)
EnsemblADORA2B - 17p12 [CytoView hg19]  ADORA2B - 17p12 [CytoView hg38]
Mapping of homologs : NCBIADORA2B [Mapview hg19]  ADORA2B [Mapview hg38]
OMIM600446   
Gene and transcription
Genbank (Entrez)AK172851 AY136748 BC025722 DQ891714 DQ894891
RefSeq transcript (Entrez)NM_000676
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ADORA2B
Cluster EST : UnigeneHs.167046 [ NCBI ]
CGAP (NCI)Hs.167046
Alternative Splicing GalleryENSG00000170425
Gene ExpressionADORA2B [ NCBI-GEO ]   ADORA2B [ EBI - ARRAY_EXPRESS ]   ADORA2B [ SEEK ]   ADORA2B [ MEM ]
Gene Expression Viewer (FireBrowse)ADORA2B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)136
GTEX Portal (Tissue expression)ADORA2B
Protein : pattern, domain, 3D structure
UniProt/SwissProtP29275   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP29275  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP29275
Splice isoforms : SwissVarP29275
PhosPhoSitePlusP29275
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)Adeno_A2B_rcpt    Adenosn_rcpt    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Domain families : Smart (EMBL)7TM_GPCR_Srsx (SM01381)  
Conserved Domain (NCBI)ADORA2B
DMDM Disease mutations136
Blocks (Seattle)ADORA2B
SuperfamilyP29275
Human Protein AtlasENSG00000170425
Peptide AtlasP29275
HPRD15971
IPIIPI00020976   
Protein Interaction databases
DIP (DOE-UCLA)P29275
IntAct (EBI)P29275
FunCoupENSG00000170425
BioGRIDADORA2B
STRING (EMBL)ADORA2B
ZODIACADORA2B
Ontologies - Pathways
QuickGOP29275
Ontology : AmiGOactivation of MAPK activity  G-protein coupled adenosine receptor activity  adenosine receptor signaling pathway  positive regulation of chronic inflammatory response to non-antigenic stimulus  intracellular  plasma membrane  integral component of plasma membrane  cellular defense response  G-protein coupled receptor signaling pathway  adenylate cyclase-activating G-protein coupled receptor signaling pathway  activation of adenylate cyclase activity  JNK cascade  excretion  positive regulation of vascular endothelial growth factor production  positive regulation of guanylate cyclase activity  cellular response to extracellular stimulus  positive regulation of chemokine production  positive regulation of interleukin-6 production  positive regulation of mast cell degranulation  cellular protein metabolic process  relaxation of vascular smooth muscle  
Ontology : EGO-EBIactivation of MAPK activity  G-protein coupled adenosine receptor activity  adenosine receptor signaling pathway  positive regulation of chronic inflammatory response to non-antigenic stimulus  intracellular  plasma membrane  integral component of plasma membrane  cellular defense response  G-protein coupled receptor signaling pathway  adenylate cyclase-activating G-protein coupled receptor signaling pathway  activation of adenylate cyclase activity  JNK cascade  excretion  positive regulation of vascular endothelial growth factor production  positive regulation of guanylate cyclase activity  cellular response to extracellular stimulus  positive regulation of chemokine production  positive regulation of interleukin-6 production  positive regulation of mast cell degranulation  cellular protein metabolic process  relaxation of vascular smooth muscle  
Pathways : KEGGRap1 signaling pathway    Calcium signaling pathway    Neuroactive ligand-receptor interaction    Vascular smooth muscle contraction    Alcoholism   
NDEx NetworkADORA2B
Atlas of Cancer Signalling NetworkADORA2B
Wikipedia pathwaysADORA2B
Orthology - Evolution
OrthoDB136
GeneTree (enSembl)ENSG00000170425
Phylogenetic Trees/Animal Genes : TreeFamADORA2B
HOVERGENP29275
HOGENOMP29275
Homologs : HomoloGeneADORA2B
Homology/Alignments : Family Browser (UCSC)ADORA2B
Gene fusions - Rearrangements
Fusion : MitelmanADORA2B/SYN3 [17p12/22q12.3]  
Fusion: TCGAADORA2B 17p12 SYN3 22q12.3 BLCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADORA2B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADORA2B
dbVarADORA2B
ClinVarADORA2B
1000_GenomesADORA2B 
Exome Variant ServerADORA2B
ExAC (Exome Aggregation Consortium)ADORA2B (select the gene name)
Genetic variants : HAPMAP136
Genomic Variants (DGV)ADORA2B [DGVbeta]
DECIPHERADORA2B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADORA2B 
Mutations
ICGC Data PortalADORA2B 
TCGA Data PortalADORA2B 
Broad Tumor PortalADORA2B
OASIS PortalADORA2B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADORA2B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADORA2B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ADORA2B
DgiDB (Drug Gene Interaction Database)ADORA2B
DoCM (Curated mutations)ADORA2B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADORA2B (select a term)
intoGenADORA2B
Cancer3DADORA2B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600446   
Orphanet
MedgenADORA2B
Genetic Testing Registry ADORA2B
NextProtP29275 [Medical]
TSGene136
GENETestsADORA2B
Huge Navigator ADORA2B [HugePedia]
snp3D : Map Gene to Disease136
BioCentury BCIQADORA2B
ClinGenADORA2B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD136
Chemical/Pharm GKB GenePA24585
Clinical trialADORA2B
Miscellaneous
canSAR (ICR)ADORA2B (select the gene name)
Probes
Litterature
PubMed106 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADORA2B
EVEXADORA2B
GoPubMedADORA2B
iHOPADORA2B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:05:15 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.