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ADORA3 (adenosine A3 receptor)

Identity

Alias_symbol (synonym)AD026
Other aliasA3AR
HGNC (Hugo) ADORA3
LocusID (NCBI) 140
Atlas_Id 53089
Location 1p13.2  [Link to chromosome band 1p13]
Location_base_pair Starts at 111499429 and ends at 111504121 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GDAP2 (1p12) / ADORA3 (1p13.2)TMED5 (1p22.1) / ADORA3 (1p13.2)TRIP4 (15q22.31) / ADORA3 (1p13.2)
GDAP2 1p12 / ADORA3 1p13.2TMED5 1p22.1 / ADORA3 1p13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(1;1)(p12;p13) GDAP2/ADORA3
t(1;1)(p13;p22) TMED5/ADORA3


External links

Nomenclature
HGNC (Hugo)ADORA3   268
LRG (Locus Reference Genomic)LRG_424
Cards
Entrez_Gene (NCBI)ADORA3  140  adenosine A3 receptor
AliasesA3AR
GeneCards (Weizmann)ADORA3
Ensembl hg19 (Hinxton)ENSG00000121933 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000121933 [Gene_View]  ENSG00000121933 [Sequence]  chr1:111499429-111504121 [Contig_View]  ADORA3 [Vega]
ICGC DataPortalENSG00000121933
TCGA cBioPortalADORA3
AceView (NCBI)ADORA3
Genatlas (Paris)ADORA3
WikiGenes140
SOURCE (Princeton)ADORA3
Genetics Home Reference (NIH)ADORA3
Genomic and cartography
GoldenPath hg38 (UCSC)ADORA3  -     chr1:111499429-111504121 -  1p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADORA3  -     1p13.2   [Description]    (hg19-Feb_2009)
EnsemblADORA3 - 1p13.2 [CytoView hg19]  ADORA3 - 1p13.2 [CytoView hg38]
Mapping of homologs : NCBIADORA3 [Mapview hg19]  ADORA3 [Mapview hg38]
OMIM600445   
Gene and transcription
Genbank (Entrez)AK313095 AY136749 BF432324 BM675096 BX283401
RefSeq transcript (Entrez)NM_000677 NM_001302678 NM_001302679
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ADORA3
Cluster EST : UnigeneHs.281342 [ NCBI ]
CGAP (NCI)Hs.281342
Alternative Splicing GalleryENSG00000121933
Gene ExpressionADORA3 [ NCBI-GEO ]   ADORA3 [ EBI - ARRAY_EXPRESS ]   ADORA3 [ SEEK ]   ADORA3 [ MEM ]
Gene Expression Viewer (FireBrowse)ADORA3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)140
GTEX Portal (Tissue expression)ADORA3
Human Protein AtlasENSG00000121933-ADORA3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP0DMS8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP0DMS8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP0DMS8
Splice isoforms : SwissVarP0DMS8
PhosPhoSitePlusP0DMS8
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)Adeno_A3_rcpt    Adenosn_rcpt    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Domain families : Smart (EMBL)7TM_GPCR_Srsx (SM01381)  
Conserved Domain (NCBI)ADORA3
DMDM Disease mutations140
Blocks (Seattle)ADORA3
PDB (SRS)1OEA    1R7N   
PDB (PDBSum)1OEA    1R7N   
PDB (IMB)1OEA    1R7N   
PDB (RSDB)1OEA    1R7N   
Structural Biology KnowledgeBase1OEA    1R7N   
SCOP (Structural Classification of Proteins)1OEA    1R7N   
CATH (Classification of proteins structures)1OEA    1R7N   
SuperfamilyP0DMS8
Human Protein Atlas [tissue]ENSG00000121933-ADORA3 [tissue]
Peptide AtlasP0DMS8
HPRD08984
IPIIPI00016753   IPI00419658   IPI00515048   IPI00816455   IPI00010253   IPI00645655   IPI00107252   IPI00746372   
Protein Interaction databases
DIP (DOE-UCLA)P0DMS8
IntAct (EBI)P0DMS8
FunCoupENSG00000121933
BioGRIDADORA3
STRING (EMBL)ADORA3
ZODIACADORA3
Ontologies - Pathways
QuickGOP0DMS8
Ontology : AmiGOG-protein coupled adenosine receptor activity  adenosine receptor signaling pathway  plasma membrane  integral component of plasma membrane  inflammatory response  signal transduction  G-protein coupled receptor signaling pathway  activation of adenylate cyclase activity  regulation of heart contraction  negative regulation of cell proliferation  response to wounding  negative regulation of cell migration  negative regulation of NF-kappaB transcription factor activity  
Ontology : EGO-EBIG-protein coupled adenosine receptor activity  adenosine receptor signaling pathway  plasma membrane  integral component of plasma membrane  inflammatory response  signal transduction  G-protein coupled receptor signaling pathway  activation of adenylate cyclase activity  regulation of heart contraction  negative regulation of cell proliferation  response to wounding  negative regulation of cell migration  negative regulation of NF-kappaB transcription factor activity  
Pathways : KEGGNeuroactive ligand-receptor interaction   
NDEx NetworkADORA3
Atlas of Cancer Signalling NetworkADORA3
Wikipedia pathwaysADORA3
Orthology - Evolution
OrthoDB140
GeneTree (enSembl)ENSG00000121933
Phylogenetic Trees/Animal Genes : TreeFamADORA3
HOVERGENP0DMS8
HOGENOMP0DMS8
Homologs : HomoloGeneADORA3
Homology/Alignments : Family Browser (UCSC)ADORA3
Gene fusions - Rearrangements
Fusion : MitelmanGDAP2/ADORA3 [1p12/1p13.2]  [t(1;1)(p12;p13)]  
Fusion : MitelmanTMED5/ADORA3 [1p22.1/1p13.2]  [t(1;1)(p13;p22)]  
Fusion PortalGDAP2 1p12 ADORA3 1p13.2 BRCA
Fusion PortalTMED5 1p22.1 ADORA3 1p13.2 LUAD
Fusion : QuiverADORA3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADORA3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADORA3
dbVarADORA3
ClinVarADORA3
1000_GenomesADORA3 
Exome Variant ServerADORA3
ExAC (Exome Aggregation Consortium)ENSG00000121933
GNOMAD BrowserENSG00000121933
Varsome BrowserADORA3
Genetic variants : HAPMAP140
Genomic Variants (DGV)ADORA3 [DGVbeta]
DECIPHERADORA3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADORA3 
Mutations
ICGC Data PortalADORA3 
TCGA Data PortalADORA3 
Broad Tumor PortalADORA3
OASIS PortalADORA3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADORA3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADORA3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ADORA3
DgiDB (Drug Gene Interaction Database)ADORA3
DoCM (Curated mutations)ADORA3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADORA3 (select a term)
intoGenADORA3
Cancer3DADORA3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600445   
Orphanet
DisGeNETADORA3
MedgenADORA3
Genetic Testing Registry ADORA3
NextProtP0DMS8 [Medical]
TSGene140
GENETestsADORA3
Target ValidationADORA3
Huge Navigator ADORA3 [HugePedia]
snp3D : Map Gene to Disease140
BioCentury BCIQADORA3
ClinGenADORA3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD140
Chemical/Pharm GKB GenePA24589
Clinical trialADORA3
Miscellaneous
canSAR (ICR)ADORA3 (select the gene name)
Probes
Litterature
PubMed96 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADORA3
EVEXADORA3
GoPubMedADORA3
iHOPADORA3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Aug 27 11:08:05 CEST 2018

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