Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ADRA1A (adrenoceptor alpha 1A)

Identity

Alias_namesADRA1C
adrenergic
Alias_symbol (synonym)ADRA1L1
Other aliasALPHA1AAR
HGNC (Hugo) ADRA1A
LocusID (NCBI) 148
Atlas_Id 45787
Location 8p21.2  [Link to chromosome band 8p21]
Location_base_pair Starts at 26627222 and ends at 26722922 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ADRA1A   277
Cards
Entrez_Gene (NCBI)ADRA1A  148  adrenoceptor alpha 1A
AliasesADRA1C; ADRA1L1; ALPHA1AAR
GeneCards (Weizmann)ADRA1A
Ensembl hg19 (Hinxton)ENSG00000120907 [Gene_View]  chr8:26627222-26722922 [Contig_View]  ADRA1A [Vega]
Ensembl hg38 (Hinxton)ENSG00000120907 [Gene_View]  chr8:26627222-26722922 [Contig_View]  ADRA1A [Vega]
ICGC DataPortalENSG00000120907
TCGA cBioPortalADRA1A
AceView (NCBI)ADRA1A
Genatlas (Paris)ADRA1A
WikiGenes148
SOURCE (Princeton)ADRA1A
Genetics Home Reference (NIH)ADRA1A
Genomic and cartography
GoldenPath hg19 (UCSC)ADRA1A  -     chr8:26627222-26722922 -  8p21.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ADRA1A  -     8p21.2   [Description]    (hg38-Dec_2013)
EnsemblADRA1A - 8p21.2 [CytoView hg19]  ADRA1A - 8p21.2 [CytoView hg38]
Mapping of homologs : NCBIADRA1A [Mapview hg19]  ADRA1A [Mapview hg38]
OMIM104221   
Gene and transcription
Genbank (Entrez)AA383170 AA568306 AF013261 AF395806 AK289548
RefSeq transcript (Entrez)NM_000680 NM_001322502 NM_001322503 NM_001322504 NM_033302 NM_033303 NM_033304
RefSeq genomic (Entrez)NC_000008 NC_018919 NG_029395 NT_167187 NW_004929337
Consensus coding sequences : CCDS (NCBI)ADRA1A
Cluster EST : UnigeneHs.709175 [ NCBI ]
CGAP (NCI)Hs.709175
Alternative Splicing GalleryENSG00000120907
Gene ExpressionADRA1A [ NCBI-GEO ]   ADRA1A [ EBI - ARRAY_EXPRESS ]   ADRA1A [ SEEK ]   ADRA1A [ MEM ]
Gene Expression Viewer (FireBrowse)ADRA1A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)148
GTEX Portal (Tissue expression)ADRA1A
Protein : pattern, domain, 3D structure
UniProt/SwissProtP35348   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP35348  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP35348
Splice isoforms : SwissVarP35348
PhosPhoSitePlusP35348
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)ADR_fam    ADRA1A_rcpt    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)ADRA1A
DMDM Disease mutations148
Blocks (Seattle)ADRA1A
SuperfamilyP35348
Human Protein AtlasENSG00000120907
Peptide AtlasP35348
HPRD00081
IPIIPI00430195   IPI00954300   IPI00430197   IPI00430199   IPI00430201   IPI00430202   IPI00430203   IPI00430204   IPI00430205   IPI00983651   
Protein Interaction databases
DIP (DOE-UCLA)P35348
IntAct (EBI)P35348
FunCoupENSG00000120907
BioGRIDADRA1A
STRING (EMBL)ADRA1A
ZODIACADRA1A
Ontologies - Pathways
QuickGOP35348
Ontology : AmiGOnegative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure  norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure  positive regulation of heart rate by epinephrine-norepinephrine  positive regulation of the force of heart contraction by epinephrine-norepinephrine  positive regulation of systemic arterial blood pressure  alpha1-adrenergic receptor activity  alpha1-adrenergic receptor activity  alpha1-adrenergic receptor activity  nucleus  cytosol  plasma membrane  integral component of plasma membrane  apoptotic process  smooth muscle contraction  signal transduction  G-protein coupled receptor signaling pathway  phospholipase C-activating G-protein coupled receptor signaling pathway  activation of phospholipase C activity  positive regulation of cytosolic calcium ion concentration  positive regulation of cytosolic calcium ion concentration  cell-cell signaling  adult heart development  aging  negative regulation of cell proliferation  response to hormone  cell growth  Z disc  T-tubule  nuclear membrane  positive regulation of synaptic transmission, GABAergic  negative regulation of Rho protein signal transduction  organ growth  intracellular signal transduction  response to drug  positive regulation of MAPK cascade  positive regulation of action potential  positive regulation of vasoconstriction  positive regulation of vasoconstriction  positive regulation of smooth muscle contraction  protein heterodimerization activity  micturition  calcium ion transport into cytosol  positive regulation of cardiac muscle contraction  positive regulation of ERK1 and ERK2 cascade  adenylate cyclase-activating adrenergic receptor signaling pathway  positive regulation of protein kinase C signaling  pilomotor reflex  
Ontology : EGO-EBInegative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure  norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure  positive regulation of heart rate by epinephrine-norepinephrine  positive regulation of the force of heart contraction by epinephrine-norepinephrine  positive regulation of systemic arterial blood pressure  alpha1-adrenergic receptor activity  alpha1-adrenergic receptor activity  alpha1-adrenergic receptor activity  nucleus  cytosol  plasma membrane  integral component of plasma membrane  apoptotic process  smooth muscle contraction  signal transduction  G-protein coupled receptor signaling pathway  phospholipase C-activating G-protein coupled receptor signaling pathway  activation of phospholipase C activity  positive regulation of cytosolic calcium ion concentration  positive regulation of cytosolic calcium ion concentration  cell-cell signaling  adult heart development  aging  negative regulation of cell proliferation  response to hormone  cell growth  Z disc  T-tubule  nuclear membrane  positive regulation of synaptic transmission, GABAergic  negative regulation of Rho protein signal transduction  organ growth  intracellular signal transduction  response to drug  positive regulation of MAPK cascade  positive regulation of action potential  positive regulation of vasoconstriction  positive regulation of vasoconstriction  positive regulation of smooth muscle contraction  protein heterodimerization activity  micturition  calcium ion transport into cytosol  positive regulation of cardiac muscle contraction  positive regulation of ERK1 and ERK2 cascade  adenylate cyclase-activating adrenergic receptor signaling pathway  positive regulation of protein kinase C signaling  pilomotor reflex  
Pathways : KEGGCalcium signaling pathway    Neuroactive ligand-receptor interaction    Adrenergic signaling in cardiomyocytes    Vascular smooth muscle contraction    Salivary secretion   
NDEx NetworkADRA1A
Atlas of Cancer Signalling NetworkADRA1A
Wikipedia pathwaysADRA1A
Orthology - Evolution
OrthoDB148
GeneTree (enSembl)ENSG00000120907
Phylogenetic Trees/Animal Genes : TreeFamADRA1A
HOVERGENP35348
HOGENOMP35348
Homologs : HomoloGeneADRA1A
Homology/Alignments : Family Browser (UCSC)ADRA1A
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADRA1A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADRA1A
dbVarADRA1A
ClinVarADRA1A
1000_GenomesADRA1A 
Exome Variant ServerADRA1A
ExAC (Exome Aggregation Consortium)ADRA1A (select the gene name)
Genetic variants : HAPMAP148
Genomic Variants (DGV)ADRA1A [DGVbeta]
DECIPHER (Syndromes)8:26627222-26722922  ENSG00000120907
CONAN: Copy Number AnalysisADRA1A 
Mutations
ICGC Data PortalADRA1A 
TCGA Data PortalADRA1A 
Broad Tumor PortalADRA1A
OASIS PortalADRA1A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADRA1A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADRA1A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ADRA1A
DgiDB (Drug Gene Interaction Database)ADRA1A
DoCM (Curated mutations)ADRA1A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADRA1A (select a term)
intoGenADRA1A
Cancer3DADRA1A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM104221   
Orphanet
MedgenADRA1A
Genetic Testing Registry ADRA1A
NextProtP35348 [Medical]
TSGene148
GENETestsADRA1A
Huge Navigator ADRA1A [HugePedia]
snp3D : Map Gene to Disease148
BioCentury BCIQADRA1A
ClinGenADRA1A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD148
Chemical/Pharm GKB GenePA34
Clinical trialADRA1A
Miscellaneous
canSAR (ICR)ADRA1A (select the gene name)
Probes
Litterature
PubMed112 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADRA1A
EVEXADRA1A
GoPubMedADRA1A
iHOPADRA1A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 14:51:48 CEST 2017

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