Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

ADRA1B (adrenoceptor alpha 1B)

Identity

Alias_namesadrenergic
Other aliasADRA1
ALPHA1BAR
HGNC (Hugo) ADRA1B
LocusID (NCBI) 147
Atlas_Id 589
Location 5q33.3  [Link to chromosome band 5q33]
Location_base_pair Starts at 159916733 and ends at 159973010 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ADRA1B   278
Cards
Entrez_Gene (NCBI)ADRA1B  147  adrenoceptor alpha 1B
AliasesADRA1; ALPHA1BAR
GeneCards (Weizmann)ADRA1B
Ensembl hg19 (Hinxton)ENSG00000170214 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000170214 [Gene_View]  ENSG00000170214 [Sequence]  chr5:159916733-159973010 [Contig_View]  ADRA1B [Vega]
ICGC DataPortalENSG00000170214
TCGA cBioPortalADRA1B
AceView (NCBI)ADRA1B
Genatlas (Paris)ADRA1B
WikiGenes147
SOURCE (Princeton)ADRA1B
Genetics Home Reference (NIH)ADRA1B
Genomic and cartography
GoldenPath hg38 (UCSC)ADRA1B  -     chr5:159916733-159973010 +  5q33.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADRA1B  -     5q33.3   [Description]    (hg19-Feb_2009)
EnsemblADRA1B - 5q33.3 [CytoView hg19]  ADRA1B - 5q33.3 [CytoView hg38]
Mapping of homologs : NCBIADRA1B [Mapview hg19]  ADRA1B [Mapview hg38]
OMIM104220   
Gene and transcription
Genbank (Entrez)AK309989 BC136568 BC136569 BQ576306 BX648936
RefSeq transcript (Entrez)NM_000679
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ADRA1B
Cluster EST : UnigeneHs.670012 [ NCBI ]
CGAP (NCI)Hs.670012
Alternative Splicing GalleryENSG00000170214
Gene ExpressionADRA1B [ NCBI-GEO ]   ADRA1B [ EBI - ARRAY_EXPRESS ]   ADRA1B [ SEEK ]   ADRA1B [ MEM ]
Gene Expression Viewer (FireBrowse)ADRA1B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)147
GTEX Portal (Tissue expression)ADRA1B
Human Protein AtlasENSG00000170214-ADRA1B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP35368   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP35368  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP35368
Splice isoforms : SwissVarP35368
PhosPhoSitePlusP35368
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)ADR_fam    ADRA1B_rcpt    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Domain families : Smart (EMBL)7TM_GPCR_Srsx (SM01381)  
Conserved Domain (NCBI)ADRA1B
DMDM Disease mutations147
Blocks (Seattle)ADRA1B
SuperfamilyP35368
Human Protein Atlas [tissue]ENSG00000170214-ADRA1B [tissue]
Peptide AtlasP35368
HPRD00080
IPIIPI00218912   
Protein Interaction databases
DIP (DOE-UCLA)P35368
IntAct (EBI)P35368
FunCoupENSG00000170214
BioGRIDADRA1B
STRING (EMBL)ADRA1B
ZODIACADRA1B
Ontologies - Pathways
QuickGOP35368
Ontology : AmiGOnorepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure  adrenergic receptor activity  alpha1-adrenergic receptor activity  protein binding  nucleus  cytoplasm  plasma membrane  plasma membrane  integral component of plasma membrane  caveola  G protein-coupled receptor signaling pathway  adenylate cyclase-modulating G protein-coupled receptor signaling pathway  phospholipase C-activating G protein-coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  cell-cell signaling  multicellular organism development  cell proliferation  nuclear membrane  intracellular signal transduction  glucose homeostasis  positive regulation of MAPK cascade  positive regulation of vasoconstriction  positive regulation of smooth muscle contraction  protein heterodimerization activity  regulation of cardiac muscle contraction  adenylate cyclase-activating adrenergic receptor signaling pathway  
Ontology : EGO-EBInorepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure  adrenergic receptor activity  alpha1-adrenergic receptor activity  protein binding  nucleus  cytoplasm  plasma membrane  plasma membrane  integral component of plasma membrane  caveola  G protein-coupled receptor signaling pathway  adenylate cyclase-modulating G protein-coupled receptor signaling pathway  phospholipase C-activating G protein-coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  cell-cell signaling  multicellular organism development  cell proliferation  nuclear membrane  intracellular signal transduction  glucose homeostasis  positive regulation of MAPK cascade  positive regulation of vasoconstriction  positive regulation of smooth muscle contraction  protein heterodimerization activity  regulation of cardiac muscle contraction  adenylate cyclase-activating adrenergic receptor signaling pathway  
Pathways : KEGGCalcium signaling pathway    Neuroactive ligand-receptor interaction    Adrenergic signaling in cardiomyocytes    Vascular smooth muscle contraction    Salivary secretion   
NDEx NetworkADRA1B
Atlas of Cancer Signalling NetworkADRA1B
Wikipedia pathwaysADRA1B
Orthology - Evolution
OrthoDB147
GeneTree (enSembl)ENSG00000170214
Phylogenetic Trees/Animal Genes : TreeFamADRA1B
HOVERGENP35368
HOGENOMP35368
Homologs : HomoloGeneADRA1B
Homology/Alignments : Family Browser (UCSC)ADRA1B
Gene fusions - Rearrangements
Fusion : QuiverADRA1B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADRA1B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADRA1B
dbVarADRA1B
ClinVarADRA1B
1000_GenomesADRA1B 
Exome Variant ServerADRA1B
ExAC (Exome Aggregation Consortium)ENSG00000170214
GNOMAD BrowserENSG00000170214
Varsome BrowserADRA1B
Genetic variants : HAPMAP147
Genomic Variants (DGV)ADRA1B [DGVbeta]
DECIPHERADRA1B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADRA1B 
Mutations
ICGC Data PortalADRA1B 
TCGA Data PortalADRA1B 
Broad Tumor PortalADRA1B
OASIS PortalADRA1B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADRA1B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADRA1B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ADRA1B
DgiDB (Drug Gene Interaction Database)ADRA1B
DoCM (Curated mutations)ADRA1B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADRA1B (select a term)
intoGenADRA1B
Cancer3DADRA1B(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM104220   
Orphanet
DisGeNETADRA1B
MedgenADRA1B
Genetic Testing Registry ADRA1B
NextProtP35368 [Medical]
TSGene147
GENETestsADRA1B
Target ValidationADRA1B
Huge Navigator ADRA1B [HugePedia]
snp3D : Map Gene to Disease147
BioCentury BCIQADRA1B
ClinGenADRA1B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD147
Chemical/Pharm GKB GenePA33
Clinical trialADRA1B
Miscellaneous
canSAR (ICR)ADRA1B (select the gene name)
Probes
Litterature
PubMed73 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADRA1B
EVEXADRA1B
GoPubMedADRA1B
iHOPADRA1B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 10:50:08 CET 2018

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.