ADRA1D (adrenoceptor alpha 1D)

2015-08-01  

Identity

HGNC
LOCATION
20p13
LOCUSID
ALIAS
ADRA1,ADRA1A,ADRA1R,ALPHA1,DAR,dJ779E11.2
FUSION GENES

Other Information

Locus ID:

NCBI: 146
MIM: 104219
HGNC: 280
Ensembl: ENSG00000171873

Variants:

dbSNP: 146
ClinVar: 146
TCGA: ENSG00000171873
COSMIC: ADRA1D

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171873ENST00000379453P25100
ENSG00000171873ENST00000379453B0ZBE0

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Neuroactive ligand-receptor interactionKEGGko04080
Calcium signaling pathwayKEGGhsa04020
Neuroactive ligand-receptor interactionKEGGhsa04080
Vascular smooth muscle contractionKEGGhsa04270
Vascular smooth muscle contractionKEGGko04270
Salivary secretionKEGGko04970
Salivary secretionKEGGhsa04970
Adrenergic signaling in cardiomyocytesKEGGhsa04261
Adrenergic signaling in cardiomyocytesKEGGko04261
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Amine ligand-binding receptorsREACTOMER-HSA-375280
AdrenoceptorsREACTOMER-HSA-390696
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
G alpha (12/13) signalling eventsREACTOMER-HSA-416482
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164712344Alpha-adrenoreceptor antagonistsChemicalPathwayassociated
PA449396dopamineChemicalPathwayassociated
PA449470epinephrineChemicalPathwayassociated
PA450121isoproterenolChemicalPathwayassociated
PA450431methoxamineChemicalPathwayassociated
PA450649norepinephrineChemicalPathwayassociated
PA450935phenylephrineChemicalPathwayassociated

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
147368742004Cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors.55
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.34
156903612005Evidence for the presence of alpha1 adrenoceptor subtypes in the human ureter.32
165338132006Syntrophins regulate alpha1D-adrenergic receptors through a PDZ domain-mediated interaction.27
211158372010Alpha-dystrobrevin-1 recruits alpha-catulin to the alpha1D-adrenergic receptor/dystrophin-associated protein complex signalosome.18
176810682007Examination of alpha 1 adrenoceptor subtypes in the human ureter.17
173841462007Epigenetic regulation of human alpha1d-adrenergic receptor gene expression: a role for DNA methylation in Sp1-dependent regulation.16
152974462004Differential regulation of the cell cycle by alpha1-adrenergic receptor subtypes.13
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11

Citation

Dessen P

ADRA1D (adrenoceptor alpha 1D)

Atlas Genet Cytogenet Oncol Haematol. 2015-08-01

Online version: http://atlasgeneticsoncology.org/gene/55369/adra1d