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ADRA2A (adrenoceptor alpha 2A)

Identity

Alias_namesADRA2
ADRA2R
adrenergic
Alias_symbol (synonym)ADRAR
Other aliasALPHA2AAR
ZNF32
HGNC (Hugo) ADRA2A
LocusID (NCBI) 150
Atlas_Id 55181
Location 10q25.2  [Link to chromosome band 10q25]
Location_base_pair Starts at 111077032 and ends at 111080904 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ADRA2A   281
Cards
Entrez_Gene (NCBI)ADRA2A  150  adrenoceptor alpha 2A
AliasesADRA2; ADRA2R; ADRAR; ALPHA2AAR; 
ZNF32
GeneCards (Weizmann)ADRA2A
Ensembl hg19 (Hinxton)ENSG00000150594 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000150594 [Gene_View]  chr10:111077032-111080904 [Contig_View]  ADRA2A [Vega]
ICGC DataPortalENSG00000150594
TCGA cBioPortalADRA2A
AceView (NCBI)ADRA2A
Genatlas (Paris)ADRA2A
WikiGenes150
SOURCE (Princeton)ADRA2A
Genetics Home Reference (NIH)ADRA2A
Genomic and cartography
GoldenPath hg38 (UCSC)ADRA2A  -     chr10:111077032-111080904 +  10q25.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADRA2A  -     10q25.2   [Description]    (hg19-Feb_2009)
EnsemblADRA2A - 10q25.2 [CytoView hg19]  ADRA2A - 10q25.2 [CytoView hg38]
Mapping of homologs : NCBIADRA2A [Mapview hg19]  ADRA2A [Mapview hg38]
OMIM104210   
Gene and transcription
Genbank (Entrez)AF284095 BC035047 BC050414 BM682651
RefSeq transcript (Entrez)NM_000681
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ADRA2A
Cluster EST : UnigeneHs.249159 [ NCBI ]
CGAP (NCI)Hs.249159
Alternative Splicing GalleryENSG00000150594
Gene ExpressionADRA2A [ NCBI-GEO ]   ADRA2A [ EBI - ARRAY_EXPRESS ]   ADRA2A [ SEEK ]   ADRA2A [ MEM ]
Gene Expression Viewer (FireBrowse)ADRA2A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)150
GTEX Portal (Tissue expression)ADRA2A
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08913   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP08913  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP08913
Splice isoforms : SwissVarP08913
PhosPhoSitePlusP08913
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)ADR_fam    ADRA2A_rcpt    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Domain families : Smart (EMBL)7TM_GPCR_Srsx (SM01381)  
Conserved Domain (NCBI)ADRA2A
DMDM Disease mutations150
Blocks (Seattle)ADRA2A
PDB (SRS)1HLL    1HO9    1HOD    1HOF   
PDB (PDBSum)1HLL    1HO9    1HOD    1HOF   
PDB (IMB)1HLL    1HO9    1HOD    1HOF   
PDB (RSDB)1HLL    1HO9    1HOD    1HOF   
Structural Biology KnowledgeBase1HLL    1HO9    1HOD    1HOF   
SCOP (Structural Classification of Proteins)1HLL    1HO9    1HOD    1HOF   
CATH (Classification of proteins structures)1HLL    1HO9    1HOD    1HOF   
SuperfamilyP08913
Human Protein AtlasENSG00000150594
Peptide AtlasP08913
HPRD00078
IPIIPI00797870   
Protein Interaction databases
DIP (DOE-UCLA)P08913
IntAct (EBI)P08913
FunCoupENSG00000150594
BioGRIDADRA2A
STRING (EMBL)ADRA2A
ZODIACADRA2A
Ontologies - Pathways
QuickGOP08913
Ontology : AmiGOpositive regulation of cytokine production  alpha2-adrenergic receptor activity  alpha2-adrenergic receptor activity  protein binding  cytoplasm  plasma membrane  integral component of plasma membrane  movement of cell or subcellular component  regulation of smooth muscle contraction  signal transduction  G-protein coupled receptor signaling pathway  negative regulation of adenylate cyclase activity  Ras protein signal transduction  Rho protein signal transduction  positive regulation of cell proliferation  negative regulation of norepinephrine secretion  negative regulation of norepinephrine secretion  basolateral plasma membrane  regulation of vasoconstriction  protein kinase binding  actin cytoskeleton organization  platelet activation  positive regulation of cell migration  negative regulation of cAMP biosynthetic process  negative regulation of cAMP biosynthetic process  alpha-1B adrenergic receptor binding  alpha-2C adrenergic receptor binding  thioesterase binding  activation of protein kinase activity  activation of protein kinase B activity  heterotrimeric G-protein binding  negative regulation of epinephrine secretion  cellular response to hormone stimulus  epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway  glucose homeostasis  protein homodimerization activity  receptor complex  positive regulation of potassium ion transport  positive regulation of MAP kinase activity  positive regulation of epidermal growth factor-activated receptor activity  negative regulation of calcium ion-dependent exocytosis  negative regulation of insulin secretion  protein heterodimerization activity  protein heterodimerization activity  regulation of insulin secretion  intestinal absorption  negative regulation of lipid catabolic process  positive regulation of membrane protein ectodomain proteolysis  epinephrine binding  norepinephrine binding  negative regulation of calcium ion transport  negative regulation of insulin secretion involved in cellular response to glucose stimulus  negative regulation of adrenergic receptor signaling pathway  adenylate cyclase-activating adrenergic receptor signaling pathway  adenylate cyclase-inhibiting adrenergic receptor signaling pathway  phospholipase C-activating adrenergic receptor signaling pathway  activation of MAPK activity by adrenergic receptor signaling pathway  positive regulation of wound healing  negative regulation of calcium ion transmembrane transporter activity  
Ontology : EGO-EBIpositive regulation of cytokine production  alpha2-adrenergic receptor activity  alpha2-adrenergic receptor activity  protein binding  cytoplasm  plasma membrane  integral component of plasma membrane  movement of cell or subcellular component  regulation of smooth muscle contraction  signal transduction  G-protein coupled receptor signaling pathway  negative regulation of adenylate cyclase activity  Ras protein signal transduction  Rho protein signal transduction  positive regulation of cell proliferation  negative regulation of norepinephrine secretion  negative regulation of norepinephrine secretion  basolateral plasma membrane  regulation of vasoconstriction  protein kinase binding  actin cytoskeleton organization  platelet activation  positive regulation of cell migration  negative regulation of cAMP biosynthetic process  negative regulation of cAMP biosynthetic process  alpha-1B adrenergic receptor binding  alpha-2C adrenergic receptor binding  thioesterase binding  activation of protein kinase activity  activation of protein kinase B activity  heterotrimeric G-protein binding  negative regulation of epinephrine secretion  cellular response to hormone stimulus  epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway  glucose homeostasis  protein homodimerization activity  receptor complex  positive regulation of potassium ion transport  positive regulation of MAP kinase activity  positive regulation of epidermal growth factor-activated receptor activity  negative regulation of calcium ion-dependent exocytosis  negative regulation of insulin secretion  protein heterodimerization activity  protein heterodimerization activity  regulation of insulin secretion  intestinal absorption  negative regulation of lipid catabolic process  positive regulation of membrane protein ectodomain proteolysis  epinephrine binding  norepinephrine binding  negative regulation of calcium ion transport  negative regulation of insulin secretion involved in cellular response to glucose stimulus  negative regulation of adrenergic receptor signaling pathway  adenylate cyclase-activating adrenergic receptor signaling pathway  adenylate cyclase-inhibiting adrenergic receptor signaling pathway  phospholipase C-activating adrenergic receptor signaling pathway  activation of MAPK activity by adrenergic receptor signaling pathway  positive regulation of wound healing  negative regulation of calcium ion transmembrane transporter activity  
Pathways : KEGGNeuroactive ligand-receptor interaction   
NDEx NetworkADRA2A
Atlas of Cancer Signalling NetworkADRA2A
Wikipedia pathwaysADRA2A
Orthology - Evolution
OrthoDB150
GeneTree (enSembl)ENSG00000150594
Phylogenetic Trees/Animal Genes : TreeFamADRA2A
HOVERGENP08913
HOGENOMP08913
Homologs : HomoloGeneADRA2A
Homology/Alignments : Family Browser (UCSC)ADRA2A
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADRA2A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADRA2A
dbVarADRA2A
ClinVarADRA2A
1000_GenomesADRA2A 
Exome Variant ServerADRA2A
ExAC (Exome Aggregation Consortium)ADRA2A (select the gene name)
Genetic variants : HAPMAP150
Genomic Variants (DGV)ADRA2A [DGVbeta]
DECIPHERADRA2A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADRA2A 
Mutations
ICGC Data PortalADRA2A 
TCGA Data PortalADRA2A 
Broad Tumor PortalADRA2A
OASIS PortalADRA2A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADRA2A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADRA2A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ADRA2A
DgiDB (Drug Gene Interaction Database)ADRA2A
DoCM (Curated mutations)ADRA2A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADRA2A (select a term)
intoGenADRA2A
Cancer3DADRA2A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM104210   
Orphanet
MedgenADRA2A
Genetic Testing Registry ADRA2A
NextProtP08913 [Medical]
TSGene150
GENETestsADRA2A
Huge Navigator ADRA2A [HugePedia]
snp3D : Map Gene to Disease150
BioCentury BCIQADRA2A
ClinGenADRA2A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD150
Chemical/Pharm GKB GenePA35
Clinical trialADRA2A
Miscellaneous
canSAR (ICR)ADRA2A (select the gene name)
Probes
Litterature
PubMed207 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADRA2A
EVEXADRA2A
GoPubMedADRA2A
iHOPADRA2A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:05:17 CEST 2017

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