Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ADRA2B (adrenoceptor alpha 2B)

Identity

Alias_namesADRA2L1
ADRA2RL1
adrenergic
Alias_symbol (synonym)ADRARL1
Other aliasALPHA2BAR
FAME2
alpha-2BAR
HGNC (Hugo) ADRA2B
LocusID (NCBI) 151
Atlas_Id 43106
Location 2q11.2  [Link to chromosome band 2q11]
Location_base_pair Starts at 96112875 and ends at 96116245 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ADRA2B   282
Cards
Entrez_Gene (NCBI)ADRA2B  151  adrenoceptor alpha 2B
AliasesADRA2L1; ADRA2RL1; ADRARL1; ALPHA2BAR; 
FAME2; alpha-2BAR
GeneCards (Weizmann)ADRA2B
Ensembl hg19 (Hinxton)ENSG00000274286 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000274286 [Gene_View]  chr2:96112875-96116245 [Contig_View]  ADRA2B [Vega]
ICGC DataPortalENSG00000274286
TCGA cBioPortalADRA2B
AceView (NCBI)ADRA2B
Genatlas (Paris)ADRA2B
WikiGenes151
SOURCE (Princeton)ADRA2B
Genetics Home Reference (NIH)ADRA2B
Genomic and cartography
GoldenPath hg38 (UCSC)ADRA2B  -     chr2:96112875-96116245 -  2q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADRA2B  -     2q11.2   [Description]    (hg19-Feb_2009)
EnsemblADRA2B - 2q11.2 [CytoView hg19]  ADRA2B - 2q11.2 [CytoView hg38]
Mapping of homologs : NCBIADRA2B [Mapview hg19]  ADRA2B [Mapview hg38]
OMIM104260   607876   
Gene and transcription
Genbank (Entrez)AA887330 BC133021 BC136537 BF475329 CV806541
RefSeq transcript (Entrez)NM_000682
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ADRA2B
Cluster EST : UnigeneHs.247686 [ NCBI ]
CGAP (NCI)Hs.247686
Alternative Splicing GalleryENSG00000274286
Gene ExpressionADRA2B [ NCBI-GEO ]   ADRA2B [ EBI - ARRAY_EXPRESS ]   ADRA2B [ SEEK ]   ADRA2B [ MEM ]
Gene Expression Viewer (FireBrowse)ADRA2B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)151
GTEX Portal (Tissue expression)ADRA2B
Protein : pattern, domain, 3D structure
UniProt/SwissProtP18089   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP18089  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP18089
Splice isoforms : SwissVarP18089
PhosPhoSitePlusP18089
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)ADR_fam    ADRA2B_rcpt    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Domain families : Smart (EMBL)7TM_GPCR_Srsx (SM01381)  
Conserved Domain (NCBI)ADRA2B
DMDM Disease mutations151
Blocks (Seattle)ADRA2B
PDB (SRS)2CVA   
PDB (PDBSum)2CVA   
PDB (IMB)2CVA   
PDB (RSDB)2CVA   
Structural Biology KnowledgeBase2CVA   
SCOP (Structural Classification of Proteins)2CVA   
CATH (Classification of proteins structures)2CVA   
SuperfamilyP18089
Human Protein AtlasENSG00000274286
Peptide AtlasP18089
HPRD00086
IPIIPI00297315   
Protein Interaction databases
DIP (DOE-UCLA)P18089
IntAct (EBI)P18089
FunCoupENSG00000274286
BioGRIDADRA2B
STRING (EMBL)ADRA2B
ZODIACADRA2B
Ontologies - Pathways
QuickGOP18089
Ontology : AmiGOalpha2-adrenergic receptor activity  protein binding  plasma membrane  integral component of plasma membrane  regulation of smooth muscle contraction  G-protein coupled receptor signaling pathway  cell-cell signaling  negative regulation of norepinephrine secretion  negative regulation of norepinephrine secretion  regulation of vasoconstriction  platelet activation  activation of protein kinase B activity  negative regulation of epinephrine secretion  epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway  positive regulation of neuron differentiation  epinephrine binding  adenylate cyclase-activating adrenergic receptor signaling pathway  activation of MAPK activity by adrenergic receptor signaling pathway  
Ontology : EGO-EBIalpha2-adrenergic receptor activity  protein binding  plasma membrane  integral component of plasma membrane  regulation of smooth muscle contraction  G-protein coupled receptor signaling pathway  cell-cell signaling  negative regulation of norepinephrine secretion  negative regulation of norepinephrine secretion  regulation of vasoconstriction  platelet activation  activation of protein kinase B activity  negative regulation of epinephrine secretion  epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway  positive regulation of neuron differentiation  epinephrine binding  adenylate cyclase-activating adrenergic receptor signaling pathway  activation of MAPK activity by adrenergic receptor signaling pathway  
Pathways : KEGGNeuroactive ligand-receptor interaction   
NDEx NetworkADRA2B
Atlas of Cancer Signalling NetworkADRA2B
Wikipedia pathwaysADRA2B
Orthology - Evolution
OrthoDB151
GeneTree (enSembl)ENSG00000274286
Phylogenetic Trees/Animal Genes : TreeFamADRA2B
HOVERGENP18089
HOGENOMP18089
Homologs : HomoloGeneADRA2B
Homology/Alignments : Family Browser (UCSC)ADRA2B
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADRA2B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADRA2B
dbVarADRA2B
ClinVarADRA2B
1000_GenomesADRA2B 
Exome Variant ServerADRA2B
ExAC (Exome Aggregation Consortium)ADRA2B (select the gene name)
Genetic variants : HAPMAP151
Genomic Variants (DGV)ADRA2B [DGVbeta]
DECIPHERADRA2B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADRA2B 
Mutations
ICGC Data PortalADRA2B 
TCGA Data PortalADRA2B 
Broad Tumor PortalADRA2B
OASIS PortalADRA2B [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDADRA2B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ADRA2B
DgiDB (Drug Gene Interaction Database)ADRA2B
DoCM (Curated mutations)ADRA2B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADRA2B (select a term)
intoGenADRA2B
Cancer3DADRA2B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM104260    607876   
Orphanet11734   
MedgenADRA2B
Genetic Testing Registry ADRA2B
NextProtP18089 [Medical]
TSGene151
GENETestsADRA2B
Target ValidationADRA2B
Huge Navigator ADRA2B [HugePedia]
snp3D : Map Gene to Disease151
BioCentury BCIQADRA2B
ClinGenADRA2B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD151
Chemical/Pharm GKB GenePA36
Clinical trialADRA2B
Miscellaneous
canSAR (ICR)ADRA2B (select the gene name)
Probes
Litterature
PubMed116 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADRA2B
EVEXADRA2B
GoPubMedADRA2B
iHOPADRA2B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 16:54:33 CEST 2017

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