Identity
HGNC
LOCATION
2q11.2
LOCUSID
ALIAS
ADRA2L1,ADRA2RL1,ADRARL1,ALPHA2BAR,FAME2,alpha-2BAR
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 151
MIM: 104260
HGNC: 282
Ensembl: ENSG00000274286
Variants:
dbSNP: 151
ClinVar: 151
TCGA: ENSG00000274286
COSMIC: ADRA2B
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000274286 | ENST00000620793 | P18089 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA448665 | brimonidine | Chemical | Pathway | associated | |||
| PA449051 | clonidine | Chemical | Pathway | associated | |||
| PA449396 | dopamine | Chemical | Pathway | associated | |||
| PA449470 | epinephrine | Chemical | Pathway | associated | |||
| PA450121 | isoproterenol | Chemical | Pathway | associated | |||
| PA450649 | norepinephrine | Chemical | Pathway | associated | |||
| PA451946 | yohimbine | Chemical | Pathway | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37525034 | 2023 | ADRA2B and HTR1A: An Updated Study of the Biogenic Amine Receptors Reveals Novel Conserved Motifs Which Play Key Role in Mental Disorders. | 2 |
| 37805907 | 2023 | ASSOCIATION BETWEEN GLN27GLU POLYMORPHISM IN THE Β2 ADRENERGIC RECEPTOR GENE AND OBESITY RISK IN PATIENTS WITH EARLY-ONSET AND LATE-ONSET BRONCHIAL ASTHMA. | 0 |
| 37525034 | 2023 | ADRA2B and HTR1A: An Updated Study of the Biogenic Amine Receptors Reveals Novel Conserved Motifs Which Play Key Role in Mental Disorders. | 2 |
| 37805907 | 2023 | ASSOCIATION BETWEEN GLN27GLU POLYMORPHISM IN THE Β2 ADRENERGIC RECEPTOR GENE AND OBESITY RISK IN PATIENTS WITH EARLY-ONSET AND LATE-ONSET BRONCHIAL ASTHMA. | 0 |
| 32385805 | 2021 | Involvement of Histamine 2 Receptor in Alpha 1 Adrenoceptor Mediated Cardiac Hypertrophy and Oxidative Stress in H9c2 Cardio Myoblasts. | 1 |
| 33900865 | 2021 | Alpha-2 beta-adrenergic receptor (301-303 I/D) gene polymorphism in hypertension and type 2 diabetes mellitus diseases among Saudi cases in the Qassim region. | 0 |
| 32385805 | 2021 | Involvement of Histamine 2 Receptor in Alpha 1 Adrenoceptor Mediated Cardiac Hypertrophy and Oxidative Stress in H9c2 Cardio Myoblasts. | 1 |
| 33900865 | 2021 | Alpha-2 beta-adrenergic receptor (301-303 I/D) gene polymorphism in hypertension and type 2 diabetes mellitus diseases among Saudi cases in the Qassim region. | 0 |
| 30858399 | 2019 | Aging and the Combined effects of ADRA2B and CB1 deletions on Affective Working Memory. | 1 |
| 31090375 | 2019 | Interrelation of cardiovascular risk factors with high albuminury among patients with arterial hypertension living in Mountain Shoriya. | 0 |
| 30858399 | 2019 | Aging and the Combined effects of ADRA2B and CB1 deletions on Affective Working Memory. | 1 |
| 31090375 | 2019 | Interrelation of cardiovascular risk factors with high albuminury among patients with arterial hypertension living in Mountain Shoriya. | 0 |
| 29212846 | 2018 | Associations of Del 301-303 alpha2B-adrenoceptor gene polymorphism with central hemodynamic parameters in the northern Russian population. | 0 |
| 29751052 | 2018 | ADRA2B deletion variant and enhanced cognitive processing of emotional information: A meta-analytical review. | 8 |
| 29212846 | 2018 | Associations of Del 301-303 alpha2B-adrenoceptor gene polymorphism with central hemodynamic parameters in the northern Russian population. | 0 |
Citation
Dessen P
ADRA2B (adrenoceptor alpha 2B)
Atlas Genet Cytogenet Oncol Haematol. 2006-10-01
Online version: http://atlasgeneticsoncology.org/gene/43106/adra2b
