ADRA2B (adrenoceptor alpha 2B)

2006-10-01 Affiliation

Identity

HGNC

ADRA2B

LOCATION

2q11.2

LOCUSID

151

ALIAS

ADRA2L1,ADRA2RL1,ADRARL1,ALPHA2BAR,FAME2,alpha-2BAR

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 151
MIM: 104260
HGNC: 282
Ensembl: ENSG00000274286

Variants:

dbSNP: 151
ClinVar: 151
TCGA: ENSG00000274286
COSMIC: ADRA2B

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000274286	ENST00000620793	P18089

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuroactive ligand-receptor interaction	KEGG	ko04080
Neuroactive ligand-receptor interaction	KEGG	hsa04080
cGMP-PKG signaling pathway	KEGG	hsa04022
cGMP-PKG signaling pathway	KEGG	ko04022
Hemostasis	REACTOME	R-HSA-109582
Platelet activation, signaling and aggregation	REACTOME	R-HSA-76002
Platelet Aggregation (Plug Formation)	REACTOME	R-HSA-76009
Adrenaline signalling through Alpha-2 adrenergic receptor	REACTOME	R-HSA-392023
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Amine ligand-binding receptors	REACTOME	R-HSA-375280
Adrenoceptors	REACTOME	R-HSA-390696
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (i) signalling events	REACTOME	R-HSA-418594
G alpha (z) signalling events	REACTOME	R-HSA-418597

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association
PA448665	brimonidine	Chemical	Pathway	associated
PA449051	clonidine	Chemical	Pathway	associated
PA449396	dopamine	Chemical	Pathway	associated
PA449470	epinephrine	Chemical	Pathway	associated
PA450121	isoproterenol	Chemical	Pathway	associated
PA450649	norepinephrine	Chemical	Pathway	associated
PA451946	yohimbine	Chemical	Pathway	associated

References

Pubmed ID	Year	Title	Citations
19874574	2009	Genetical genomic determinants of alcohol consumption in rats and humans.	93
19056576	2009	Effects of novel capsinoid treatment on fatness and energy metabolism in humans: possible pharmacogenetic implications.	49
17660814	2007	A deletion variant of the alpha2b-adrenoceptor is related to emotional memory in Europeans and Africans.	48
19826083	2009	A genetic variation of the noradrenergic system is related to differential amygdala activation during encoding of emotional memories.	42
19826083	2009	A genetic variation of the noradrenergic system is related to differential amygdala activation during encoding of emotional memories.	42
24269973	2014	Tuning to the significant: neural and genetic processes underlying affective enhancement of visual perception and memory.	36
23225885	2013	Blocking A2B adenosine receptor alleviates pathogenesis of experimental autoimmune encephalomyelitis via inhibition of IL-6 production and Th17 differentiation.	35
20424170	2010	Rab8 interacts with distinct motifs in alpha2B- and beta2-adrenergic receptors and differentially modulates their transport.	34
22404651	2012	A triple arg motif mediates α(2B)-adrenergic receptor interaction with Sec24C/D and export.	27
12946937	2004	Regulation of alpha(2)-adrenoceptors in human vascular smooth muscle cells.	21

Citation

Dessen P

ADRA2B (adrenoceptor alpha 2B)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43106/adra2b