Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ADRB3 (adrenoceptor beta 3)

Identity

Alias_namesadrenergic
Other aliasBETA3AR
HGNC (Hugo) ADRB3
LocusID (NCBI) 155
Atlas_Id 43763
Location 8p11.23  [Link to chromosome band 8p11]
Location_base_pair Starts at 37962996 and ends at 37966666 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ADRB3   288
Cards
Entrez_Gene (NCBI)ADRB3  155  adrenoceptor beta 3
AliasesBETA3AR
GeneCards (Weizmann)ADRB3
Ensembl hg19 (Hinxton)ENSG00000188778 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000188778 [Gene_View]  chr8:37962996-37966666 [Contig_View]  ADRB3 [Vega]
ICGC DataPortalENSG00000188778
TCGA cBioPortalADRB3
AceView (NCBI)ADRB3
Genatlas (Paris)ADRB3
WikiGenes155
SOURCE (Princeton)ADRB3
Genetics Home Reference (NIH)ADRB3
Genomic and cartography
GoldenPath hg38 (UCSC)ADRB3  -     chr8:37962996-37966666 -  8p11.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADRB3  -     8p11.23   [Description]    (hg19-Feb_2009)
EnsemblADRB3 - 8p11.23 [CytoView hg19]  ADRB3 - 8p11.23 [CytoView hg38]
Mapping of homologs : NCBIADRB3 [Mapview hg19]  ADRB3 [Mapview hg38]
OMIM109691   601665   
Gene and transcription
Genbank (Entrez)AK293033 AK309919 AK313857 AY487247 BC075017
RefSeq transcript (Entrez)NM_000025
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ADRB3
Cluster EST : UnigeneHs.2549 [ NCBI ]
CGAP (NCI)Hs.2549
Alternative Splicing GalleryENSG00000188778
Gene ExpressionADRB3 [ NCBI-GEO ]   ADRB3 [ EBI - ARRAY_EXPRESS ]   ADRB3 [ SEEK ]   ADRB3 [ MEM ]
Gene Expression Viewer (FireBrowse)ADRB3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)155
GTEX Portal (Tissue expression)ADRB3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP13945   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP13945  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP13945
Splice isoforms : SwissVarP13945
PhosPhoSitePlusP13945
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)ADR_fam    ADRB3_rcpt    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Domain families : Smart (EMBL)7TM_GPCR_Srsx (SM01381)  
Conserved Domain (NCBI)ADRB3
DMDM Disease mutations155
Blocks (Seattle)ADRB3
PDB (SRS)2CDW   
PDB (PDBSum)2CDW   
PDB (IMB)2CDW   
PDB (RSDB)2CDW   
Structural Biology KnowledgeBase2CDW   
SCOP (Structural Classification of Proteins)2CDW   
CATH (Classification of proteins structures)2CDW   
SuperfamilyP13945
Human Protein AtlasENSG00000188778
Peptide AtlasP13945
HPRD00188
IPIIPI00011286   
Protein Interaction databases
DIP (DOE-UCLA)P13945
IntAct (EBI)P13945
FunCoupENSG00000188778
BioGRIDADRB3
STRING (EMBL)ADRB3
ZODIACADRB3
Ontologies - Pathways
QuickGOP13945
Ontology : AmiGOtemperature homeostasis  diet induced thermogenesis  norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure  desensitization of G-protein coupled receptor protein signaling pathway by arrestin  beta-adrenergic receptor activity  protein binding  nucleus  plasma membrane  integral component of plasma membrane  carbohydrate metabolic process  generation of precursor metabolites and energy  energy reserve metabolic process  receptor-mediated endocytosis  G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  adenylate cyclase-modulating G-protein coupled receptor signaling pathway  activation of adenylate cyclase activity  cell-cell signaling  aging  response to cold  beta3-adrenergic receptor activity  heat generation  beta-3 adrenergic receptor binding  negative regulation of multicellular organism growth  eating behavior  protein homodimerization activity  receptor complex  positive regulation of MAPK cascade  response to antibiotic  brown fat cell differentiation  epinephrine binding  norepinephrine binding  adenylate cyclase-activating adrenergic receptor signaling pathway  
Ontology : EGO-EBItemperature homeostasis  diet induced thermogenesis  norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure  desensitization of G-protein coupled receptor protein signaling pathway by arrestin  beta-adrenergic receptor activity  protein binding  nucleus  plasma membrane  integral component of plasma membrane  carbohydrate metabolic process  generation of precursor metabolites and energy  energy reserve metabolic process  receptor-mediated endocytosis  G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  adenylate cyclase-modulating G-protein coupled receptor signaling pathway  activation of adenylate cyclase activity  cell-cell signaling  aging  response to cold  beta3-adrenergic receptor activity  heat generation  beta-3 adrenergic receptor binding  negative regulation of multicellular organism growth  eating behavior  protein homodimerization activity  receptor complex  positive regulation of MAPK cascade  response to antibiotic  brown fat cell differentiation  epinephrine binding  norepinephrine binding  adenylate cyclase-activating adrenergic receptor signaling pathway  
Pathways : KEGGCalcium signaling pathway    Neuroactive ligand-receptor interaction    Endocytosis    Salivary secretion   
NDEx NetworkADRB3
Atlas of Cancer Signalling NetworkADRB3
Wikipedia pathwaysADRB3
Orthology - Evolution
OrthoDB155
GeneTree (enSembl)ENSG00000188778
Phylogenetic Trees/Animal Genes : TreeFamADRB3
HOVERGENP13945
HOGENOMP13945
Homologs : HomoloGeneADRB3
Homology/Alignments : Family Browser (UCSC)ADRB3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADRB3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADRB3
dbVarADRB3
ClinVarADRB3
1000_GenomesADRB3 
Exome Variant ServerADRB3
ExAC (Exome Aggregation Consortium)ADRB3 (select the gene name)
Genetic variants : HAPMAP155
Genomic Variants (DGV)ADRB3 [DGVbeta]
DECIPHERADRB3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADRB3 
Mutations
ICGC Data PortalADRB3 
TCGA Data PortalADRB3 
Broad Tumor PortalADRB3
OASIS PortalADRB3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADRB3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADRB3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch ADRB3
DgiDB (Drug Gene Interaction Database)ADRB3
DoCM (Curated mutations)ADRB3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADRB3 (select a term)
intoGenADRB3
Cancer3DADRB3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM109691    601665   
Orphanet
MedgenADRB3
Genetic Testing Registry ADRB3
NextProtP13945 [Medical]
TSGene155
GENETestsADRB3
Target ValidationADRB3
Huge Navigator ADRB3 [HugePedia]
snp3D : Map Gene to Disease155
BioCentury BCIQADRB3
ClinGenADRB3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD155
Chemical/Pharm GKB GenePA24598
Clinical trialADRB3
Miscellaneous
canSAR (ICR)ADRB3 (select the gene name)
Probes
Litterature
PubMed323 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADRB3
EVEXADRB3
GoPubMedADRB3
iHOPADRB3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:23:03 CEST 2017

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