ADRB3 (adrenoceptor beta 3)

2007-02-01 Affiliation

Identity

HGNC

ADRB3

LOCATION

8p11.23

LOCUSID

155

ALIAS

BETA3AR

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 155
MIM: 109691
HGNC: 288
Ensembl: ENSG00000188778

Variants:

dbSNP: 155
ClinVar: 155
TCGA: ENSG00000188778
COSMIC: ADRB3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000188778	ENST00000345060	P13945
ENSG00000188778	ENST00000345060	A8KAG8

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Calcium signaling pathway	KEGG	ko04020
Neuroactive ligand-receptor interaction	KEGG	ko04080
Calcium signaling pathway	KEGG	hsa04020
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Endocytosis	KEGG	ko04144
Endocytosis	KEGG	hsa04144
Salivary secretion	KEGG	ko04970
Salivary secretion	KEGG	hsa04970
cGMP-PKG signaling pathway	KEGG	hsa04022
cGMP-PKG signaling pathway	KEGG	ko04022
Regulation of lipolysis in adipocytes	KEGG	hsa04923
Renin secretion	KEGG	hsa04924
Renin secretion	KEGG	ko04924
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Amine ligand-binding receptors	REACTOME	R-HSA-375280
Adrenoceptors	REACTOME	R-HSA-390696
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (s) signalling events	REACTOME	R-HSA-418555

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA128406954	Weight gain	Disease	ClinicalAnnotation	associated	PD	19193342
PA447216	Schizophrenia	Disease	ClinicalAnnotation	associated	PD	19193342
PA450688	olanzapine	Chemical	ClinicalAnnotation	associated	PD	19193342

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
23454374	2013	White-to-brown transdifferentiation of omental adipocytes in patients affected by pheochromocytoma.	64
19587357	2009	A systematic meta-analysis of genetic association studies for diabetic retinopathy.	57
11872697	2002	Association between a novel variant of the human type 2 deiodinase gene Thr92Ala and insulin resistance: evidence of interaction with the Trp64Arg variant of the beta-3-adrenergic receptor.	49
19056576	2009	Effects of novel capsinoid treatment on fatness and energy metabolism in humans: possible pharmacogenetic implications.	49
15123695	2004	Hetero-oligomerization between beta2- and beta3-adrenergic receptors generates a beta-adrenergic signaling unit with distinct functional properties.	43
19271249	2009	Extended tracts of homozygosity identify novel candidate genes associated with late-onset Alzheimer's disease.	43
22306453	2012	Chronic stress enhances progression of acute lymphoblastic leukemia via β-adrenergic signaling.	43
18936436	2009	Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994.	42
11854867	2002	A polymorphism in the beta1 adrenergic receptor is associated with resting heart rate.	40

Citation

Dessen P

ADRB3 (adrenoceptor beta 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43763/adrb3