ADRM1 (ADRM1 26S proteasome ubiquitin receptor)

2003-06-01  

Identity

HGNC
LOCATION
20q13.33
LOCUSID
ALIAS
ARM-1,ARM1,GP110,PSMD16
FUSION GENES

Other Information

Locus ID:

NCBI: 11047
MIM: 610650
HGNC: 15759
Ensembl: ENSG00000130706

Variants:

dbSNP: 11047
ClinVar: 11047
TCGA: ENSG00000130706
COSMIC: ADRM1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130706ENST00000253003Q16186
ENSG00000130706ENST00000462554A0A087WUX6
ENSG00000130706ENST00000491935Q16186
ENSG00000130706ENST00000620230A0A087WX59

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
ProteasomeKEGGko03050
ProteasomeKEGGhsa03050
Proteasome, 19S regulatory particle (PA700)KEGGhsa_M00341
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
Proteasome, 19S regulatory particle (PA700)KEGGM00341
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
UCH proteinasesREACTOMER-HSA-5689603
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
184978172008Proteasome subunit Rpn13 is a novel ubiquitin receptor.261
169061462006Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1.144
169908002006A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes.111
171392572006hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37.99
204719462010Structure of proteasome ubiquitin receptor hRpn13 and its activation by the scaffolding protein hRpn2.55
248117492014Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates.55
257028702015Mechanism of UCH-L5 activation and inhibition by DEUBAD domains in RPN13 and INO80G.38
285984142017Structure of the Rpn13-Rpn2 complex provides insights for Rpn13 and Uch37 as anticancer targets.28
206344242010Regulation of NF-kappaB activity and inducible nitric oxide synthase by regulatory particle non-ATPase subunit 13 (Rpn13).27
168154402006Adrm1, a putative cell adhesion regulating protein, is a novel proteasome-associated factor.23

Citation

Dessen P

ADRM1 (ADRM1 26S proteasome ubiquitin receptor)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/591/adrm1