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ADSL (adenylosuccinate lyase)

Identity

Other namesAMPS
ASASE
ASL
HGNC (Hugo) ADSL
LocusID (NCBI) 158
Location 22q13.1
Location_base_pair Starts at 40742504 and ends at 40762575 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ADSL   291
Cards
Entrez_Gene (NCBI)ADSL  158  adenylosuccinate lyase
GeneCards (Weizmann)ADSL
Ensembl (Hinxton)ENSG00000239900 [Gene_View]  chr22:40742504-40762575 [Contig_View]  ADSL [Vega]
ICGC DataPortalENSG00000239900
AceView (NCBI)ADSL
Genatlas (Paris)ADSL
WikiGenes158
SOURCE (Princeton)NM_000026 NM_001123378
Genomic and cartography
GoldenPath (UCSC)ADSL  -  22q13.1   chr22:40742504-40762575 +  22q13.1   [Description]    (hg19-Feb_2009)
EnsemblADSL - 22q13.1 [CytoView]
Mapping of homologs : NCBIADSL [Mapview]
OMIM103050   608222   
Gene and transcription
Genbank (Entrez)AF067853 AF067854 AK225042 AK291091 AK298187
RefSeq transcript (Entrez)NM_000026 NM_001123378
RefSeq genomic (Entrez)AC_000154 NC_000022 NC_018933 NG_007993 NT_011520 NW_001838745 NW_004929430
Consensus coding sequences : CCDS (NCBI)ADSL
Cluster EST : UnigeneHs.75527 [ NCBI ]
CGAP (NCI)Hs.75527
Alternative Splicing GalleryENSG00000239900
Gene ExpressionADSL [ NCBI-GEO ]     ADSL [ SEEK ]   ADSL [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP30566 (Uniprot)
NextProtP30566  [Medical]
With graphics : InterProP30566
Splice isoforms : SwissVarP30566 (Swissvar)
Catalytic activity : Enzyme4.3.2.2 [ Enzyme-Expasy ]   4.3.2.24.3.2.2 [ IntEnz-EBI ]   4.3.2.2 [ BRENDA ]   4.3.2.2 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)FUMARATE_LYASES (PS00163)   
Domains : Interpro (EBI)AdenyloSucc_lyase_C    Fumarase/histidase_N    Fumarate_lyase_CS    Fumarate_lyase_fam    Fumarate_lyase_N    L-Aspartase-like    Pur_lyase   
Related proteins : CluSTrP30566
Domain families : Pfam (Sanger)ADSL_C (PF10397)    Lyase_1 (PF00206)   
Domain families : Pfam (NCBI)pfam10397    pfam00206   
Domain families : Smart (EMBL)ADSL_C (SM00998)  
DMDM Disease mutations158
Blocks (Seattle)P30566
PDB (SRS)2J91    2VD6    4FFX    4FLC   
PDB (PDBSum)2J91    2VD6    4FFX    4FLC   
PDB (IMB)2J91    2VD6    4FFX    4FLC   
PDB (RSDB)2J91    2VD6    4FFX    4FLC   
Human Protein AtlasENSG00000239900
Peptide AtlasP30566
HPRD00049
IPIIPI00942092   IPI00220887   IPI00909590   IPI00026904   IPI01015286   IPI00916724   IPI00916319   
Protein Interaction databases
DIP (DOE-UCLA)P30566
IntAct (EBI)P30566
FunCoupENSG00000239900
BioGRIDADSL
IntegromeDBADSL
STRING (EMBL)ADSL
Ontologies - Pathways
QuickGOP30566
Ontology : AmiGON6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity  N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity  N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity  cytosol  purine nucleobase metabolic process  purine nucleotide biosynthetic process  AMP biosynthetic process  'de novo' IMP biosynthetic process  metabolic process  purine ribonucleoside monophosphate biosynthetic process  'de novo' AMP biosynthetic process  small molecule metabolic process  protein tetramerization  nucleobase-containing small molecule metabolic process  (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity  
Ontology : EGO-EBIN6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity  N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity  N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity  cytosol  purine nucleobase metabolic process  purine nucleotide biosynthetic process  AMP biosynthetic process  'de novo' IMP biosynthetic process  metabolic process  purine ribonucleoside monophosphate biosynthetic process  'de novo' AMP biosynthetic process  small molecule metabolic process  protein tetramerization  nucleobase-containing small molecule metabolic process  (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity  
Pathways : KEGGPurine metabolism    Alanine, aspartate and glutamate metabolism   
Protein Interaction DatabaseADSL
Wikipedia pathwaysADSL
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)ADSL
SNP (GeneSNP Utah)ADSL
SNP : HGBaseADSL
Genetic variants : HAPMAPADSL
1000_GenomesADSL 
ICGC programENSG00000239900 
CONAN: Copy Number AnalysisADSL 
Somatic Mutations in Cancer : COSMICADSL 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
DECIPHER (Syndromes)22:40742504-40762575
Mutations and Diseases : HGMDADSL
OMIM103050    608222   
MedgenADSL
GENETestsADSL
Disease Genetic AssociationADSL
Huge Navigator ADSL [HugePedia]  ADSL [HugeCancerGEM]
Genomic VariantsADSL  ADSL [DGVbeta]
Exome VariantADSL
dbVarADSL
ClinVarADSL
snp3D : Map Gene to Disease158
General knowledge
Homologs : HomoloGeneADSL
Homology/Alignments : Family Browser (UCSC)ADSL
Phylogenetic Trees/Animal Genes : TreeFamADSL
Chemical/Protein Interactions : CTD158
Chemical/Pharm GKB GenePA24600
Clinical trialADSL
Cancer Resource (Charite)ENSG00000239900
Other databases
Probes
Litterature
PubMed51 Pubmed reference(s) in Entrez
CoreMineADSL
GoPubMedADSL
iHOPADSL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Dec 3 14:53:48 CET 2014

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