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AEBP1 (AE binding protein 1)

Identity

Alias_namesAE-binding protein 1
Alias_symbol (synonym)ACLP
Other alias
HGNC (Hugo) AEBP1
LocusID (NCBI) 165
Atlas_Id 54109
Location 7p13  [Link to chromosome band 7p13]
Location_base_pair Starts at 44104361 and ends at 44114565 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AEBP1 (7p13) / THRA (17q21.1)AEBP1 (7p13) / WDR26 (1q42.11)AIM1 (6q21) / AEBP1 (7p13)
EIF4G1 (3q27.1) / AEBP1 (7p13)PRAF2 (Xp11.23) / AEBP1 (7p13)EIF4G1 3q27.1 / AEBP1 7p13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(3;7)(q27;p13) EIF4G1/AEBP1
t(7;17)(p13;q21) AEBP1/THRA


External links

Nomenclature
HGNC (Hugo)AEBP1   303
Cards
Entrez_Gene (NCBI)AEBP1  165  AE binding protein 1
AliasesACLP
GeneCards (Weizmann)AEBP1
Ensembl hg19 (Hinxton)ENSG00000106624 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000106624 [Gene_View]  ENSG00000106624 [Sequence]  chr7:44104361-44114565 [Contig_View]  AEBP1 [Vega]
ICGC DataPortalENSG00000106624
TCGA cBioPortalAEBP1
AceView (NCBI)AEBP1
Genatlas (Paris)AEBP1
WikiGenes165
SOURCE (Princeton)AEBP1
Genetics Home Reference (NIH)AEBP1
Genomic and cartography
GoldenPath hg38 (UCSC)AEBP1  -     chr7:44104361-44114565 +  7p13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)AEBP1  -     7p13   [Description]    (hg19-Feb_2009)
EnsemblAEBP1 - 7p13 [CytoView hg19]  AEBP1 - 7p13 [CytoView hg38]
Mapping of homologs : NCBIAEBP1 [Mapview hg19]  AEBP1 [Mapview hg38]
OMIM602981   618000   
Gene and transcription
Genbank (Entrez)AB209744 AF053944 AK090931 AK127541 AK296001
RefSeq transcript (Entrez)NM_001129
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)AEBP1
Cluster EST : UnigeneHs.439463 [ NCBI ]
CGAP (NCI)Hs.439463
Alternative Splicing GalleryENSG00000106624
Gene ExpressionAEBP1 [ NCBI-GEO ]   AEBP1 [ EBI - ARRAY_EXPRESS ]   AEBP1 [ SEEK ]   AEBP1 [ MEM ]
Gene Expression Viewer (FireBrowse)AEBP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)165
GTEX Portal (Tissue expression)AEBP1
Human Protein AtlasENSG00000106624-AEBP1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IUX7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IUX7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IUX7
Splice isoforms : SwissVarQ8IUX7
PhosPhoSitePlusQ8IUX7
Domaine pattern : Prosite (Expaxy)CARBOXYPEPT_ZN_1 (PS00132)    FA58C_1 (PS01285)    FA58C_2 (PS01286)    FA58C_3 (PS50022)   
Domains : Interpro (EBI)AEBP1/CPX_M14_CPD    CarboxyPept-like_regulatory    FA58C    Galactose-bd-like_sf    Peptidase_M14   
Domain families : Pfam (Sanger)F5_F8_type_C (PF00754)    Peptidase_M14 (PF00246)   
Domain families : Pfam (NCBI)pfam00754    pfam00246   
Domain families : Smart (EMBL)FA58C (SM00231)  Zn_pept (SM00631)  
Conserved Domain (NCBI)AEBP1
DMDM Disease mutations165
Blocks (Seattle)AEBP1
SuperfamilyQ8IUX7
Human Protein Atlas [tissue]ENSG00000106624-AEBP1 [tissue]
Peptide AtlasQ8IUX7
HPRD04281
IPIIPI00745313   IPI00894097   IPI00926015   IPI00927937   IPI00927714   IPI00927385   IPI00925100   IPI00924915   
Protein Interaction databases
DIP (DOE-UCLA)Q8IUX7
IntAct (EBI)Q8IUX7
FunCoupENSG00000106624
BioGRIDAEBP1
STRING (EMBL)AEBP1
ZODIACAEBP1
Ontologies - Pathways
QuickGOQ8IUX7
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  RNA polymerase II regulatory region sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding  skeletal system development  DNA-binding transcription factor activity  transcription corepressor activity  carboxypeptidase activity  metallocarboxypeptidase activity  calmodulin binding  extracellular region  extracellular space  extracellular space  nucleus  cytoplasm  transcription, DNA-templated  peptide metabolic process  muscle organ development  zinc ion binding  protein processing  collagen-containing extracellular matrix  extracellular exosome  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  RNA polymerase II regulatory region sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding  skeletal system development  DNA-binding transcription factor activity  transcription corepressor activity  carboxypeptidase activity  metallocarboxypeptidase activity  calmodulin binding  extracellular region  extracellular space  extracellular space  nucleus  cytoplasm  transcription, DNA-templated  peptide metabolic process  muscle organ development  zinc ion binding  protein processing  collagen-containing extracellular matrix  extracellular exosome  
NDEx NetworkAEBP1
Atlas of Cancer Signalling NetworkAEBP1
Wikipedia pathwaysAEBP1
Orthology - Evolution
OrthoDB165
GeneTree (enSembl)ENSG00000106624
Phylogenetic Trees/Animal Genes : TreeFamAEBP1
HOVERGENQ8IUX7
HOGENOMQ8IUX7
Homologs : HomoloGeneAEBP1
Homology/Alignments : Family Browser (UCSC)AEBP1
Gene fusions - Rearrangements
Fusion : MitelmanAEBP1/THRA [7p13/17q21.1]  
Fusion : MitelmanEIF4G1/AEBP1 [3q27.1/7p13]  [t(3;7)(q27;p13)]  
Fusion PortalEIF4G1 3q27.1 AEBP1 7p13 SKCM
Fusion : QuiverAEBP1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAEBP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AEBP1
dbVarAEBP1
ClinVarAEBP1
1000_GenomesAEBP1 
Exome Variant ServerAEBP1
ExAC (Exome Aggregation Consortium)ENSG00000106624
GNOMAD BrowserENSG00000106624
Varsome BrowserAEBP1
Genetic variants : HAPMAP165
Genomic Variants (DGV)AEBP1 [DGVbeta]
DECIPHERAEBP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAEBP1 
Mutations
ICGC Data PortalAEBP1 
TCGA Data PortalAEBP1 
Broad Tumor PortalAEBP1
OASIS PortalAEBP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAEBP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDAEBP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch AEBP1
DgiDB (Drug Gene Interaction Database)AEBP1
DoCM (Curated mutations)AEBP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)AEBP1 (select a term)
intoGenAEBP1
Cancer3DAEBP1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602981    618000   
Orphanet
DisGeNETAEBP1
MedgenAEBP1
Genetic Testing Registry AEBP1
NextProtQ8IUX7 [Medical]
TSGene165
GENETestsAEBP1
Target ValidationAEBP1
Huge Navigator AEBP1 [HugePedia]
snp3D : Map Gene to Disease165
BioCentury BCIQAEBP1
ClinGenAEBP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD165
Chemical/Pharm GKB GenePA24604
Clinical trialAEBP1
Miscellaneous
canSAR (ICR)AEBP1 (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAEBP1
EVEXAEBP1
GoPubMedAEBP1
iHOPAEBP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Aug 27 11:08:09 CEST 2018

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