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AEN (apoptosis enhancing nuclease)

Identity

Alias_namesISG20L1
interferon stimulated exonuclease gene 20kDa-like 1
Alias_symbol (synonym)FLJ12484
FLJ12562
Other aliaspp12744
HGNC (Hugo) AEN
LocusID (NCBI) 64782
Atlas_Id 53064
Location 15q26.1  [Link to chromosome band 15q26]
Location_base_pair Starts at 88621296 and ends at 88632281 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)AEN   25722
Cards
Entrez_Gene (NCBI)AEN  64782  apoptosis enhancing nuclease
AliasesISG20L1; pp12744
GeneCards (Weizmann)AEN
Ensembl hg19 (Hinxton)ENSG00000181026 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000181026 [Gene_View]  chr15:88621296-88632281 [Contig_View]  AEN [Vega]
ICGC DataPortalENSG00000181026
TCGA cBioPortalAEN
AceView (NCBI)AEN
Genatlas (Paris)AEN
WikiGenes64782
SOURCE (Princeton)AEN
Genetics Home Reference (NIH)AEN
Genomic and cartography
GoldenPath hg38 (UCSC)AEN  -     chr15:88621296-88632281 +  15q26.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)AEN  -     15q26.1   [Description]    (hg19-Feb_2009)
EnsemblAEN - 15q26.1 [CytoView hg19]  AEN - 15q26.1 [CytoView hg38]
Mapping of homologs : NCBIAEN [Mapview hg19]  AEN [Mapview hg38]
OMIM610177   
Gene and transcription
Genbank (Entrez)AB209323 AF318330 AF327352 AK022546 AK022624
RefSeq transcript (Entrez)NM_022767
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)AEN
Cluster EST : UnigeneHs.436102 [ NCBI ]
CGAP (NCI)Hs.436102
Alternative Splicing GalleryENSG00000181026
Gene ExpressionAEN [ NCBI-GEO ]   AEN [ EBI - ARRAY_EXPRESS ]   AEN [ SEEK ]   AEN [ MEM ]
Gene Expression Viewer (FireBrowse)AEN [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64782
GTEX Portal (Tissue expression)AEN
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8WTP8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8WTP8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8WTP8
Splice isoforms : SwissVarQ8WTP8
Catalytic activity : Enzyme3.1.-.- [ Enzyme-Expasy ]   3.1.-.-3.1.-.- [ IntEnz-EBI ]   3.1.-.- [ BRENDA ]   3.1.-.- [ KEGG ]   
PhosPhoSitePlusQ8WTP8
Domains : Interpro (EBI)Exonuclease_RNaseT/DNA_pol3    RNaseH-like_dom   
Domain families : Pfam (Sanger)RNase_T (PF00929)   
Domain families : Pfam (NCBI)pfam00929   
Domain families : Smart (EMBL)EXOIII (SM00479)  
Conserved Domain (NCBI)AEN
DMDM Disease mutations64782
Blocks (Seattle)AEN
SuperfamilyQ8WTP8
Human Protein AtlasENSG00000181026
Peptide AtlasQ8WTP8
HPRD08573
IPIIPI00141525   IPI00074083   IPI00556382   
Protein Interaction databases
DIP (DOE-UCLA)Q8WTP8
IntAct (EBI)Q8WTP8
FunCoupENSG00000181026
BioGRIDAEN
STRING (EMBL)AEN
ZODIACAEN
Ontologies - Pathways
QuickGOQ8WTP8
Ontology : AmiGOnucleic acid binding  exonuclease activity  protein binding  nucleus  nucleoplasm  nucleolus  response to ionizing radiation  nuclear membrane  intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  nucleic acid phosphodiester bond hydrolysis  
Ontology : EGO-EBInucleic acid binding  exonuclease activity  protein binding  nucleus  nucleoplasm  nucleolus  response to ionizing radiation  nuclear membrane  intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  nucleic acid phosphodiester bond hydrolysis  
NDEx NetworkAEN
Atlas of Cancer Signalling NetworkAEN
Wikipedia pathwaysAEN
Orthology - Evolution
OrthoDB64782
GeneTree (enSembl)ENSG00000181026
Phylogenetic Trees/Animal Genes : TreeFamAEN
HOVERGENQ8WTP8
HOGENOMQ8WTP8
Homologs : HomoloGeneAEN
Homology/Alignments : Family Browser (UCSC)AEN
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAEN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AEN
dbVarAEN
ClinVarAEN
1000_GenomesAEN 
Exome Variant ServerAEN
ExAC (Exome Aggregation Consortium)AEN (select the gene name)
Genetic variants : HAPMAP64782
Genomic Variants (DGV)AEN [DGVbeta]
DECIPHERAEN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAEN 
Mutations
ICGC Data PortalAEN 
TCGA Data PortalAEN 
Broad Tumor PortalAEN
OASIS PortalAEN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAEN  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDAEN
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch AEN
DgiDB (Drug Gene Interaction Database)AEN
DoCM (Curated mutations)AEN (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)AEN (select a term)
intoGenAEN
Cancer3DAEN(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610177   
Orphanet
MedgenAEN
Genetic Testing Registry AEN
NextProtQ8WTP8 [Medical]
TSGene64782
GENETestsAEN
Target ValidationAEN
Huge Navigator AEN [HugePedia]
snp3D : Map Gene to Disease64782
BioCentury BCIQAEN
ClinGenAEN
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD64782
Chemical/Pharm GKB GenePA162375720
Clinical trialAEN
Miscellaneous
canSAR (ICR)AEN (select the gene name)
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAEN
EVEXAEN
GoPubMedAEN
iHOPAEN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 18:56:31 CEST 2017

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