AFM (afamin)

2009-06-01  

Identity

HGNC
AFM
LOCATION
4q13.3
LOCUSID
173
ALIAS
ALB2,ALBA,ALF
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 173
MIM: 104145
HGNC: 316
Ensembl: ENSG00000079557

Variants:

dbSNP: 173
ClinVar: 173
TCGA: ENSG00000079557
COSMIC: AFM

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000079557ENST00000226355P43652

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
193365612009Afamin and apolipoprotein A-IV: novel protein markers for ovarian cancer.31
159527362005Afamin is a novel human vitamin E-binding glycoprotein characterization and in vitro expression.28
124637522002Characterization of the vitamin E-binding properties of human plasma afamin.21
190464072009Afamin is synthesized by cerebrovascular endothelial cells and mediates alpha-tocopherol transport across an in vitro model of the blood-brain barrier.11
273291542016Afamin promotes glucose metabolism in papillary thyroid carcinoma.7
247687832014The vitamin E-binding protein afamin increases in maternal serum during pregnancy.6
208584482010The vitamin E-binding protein afamin is altered significantly in the peritoneal fluid of women with endometriosis.5
252089732014Afamin serum concentrations are associated with insulin resistance and metabolic syndrome in polycystic ovary syndrome.4
291535072017Structural Evidence for a Role of the Multi-functional Human Glycoprotein Afamin in Wnt Transport.4
294059722018Combination of first trimester serum afamin levels and three-dimensional placental bed vascularization as a possible screening method to detect women at-risk for adverse pregnancy complications like pre-eclampsia and gestational diabetes mellitus in low-risk pregnancies.2

Citation

Dessen P

AFM (afamin)

Atlas Genet Cytogenet Oncol Haematol. 2009-06-01

Online version: http://atlasgeneticsoncology.org/gene/50979/afm