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AGAP1 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 1)

Identity

Alias_namesCENTG2
centaurin, gamma 2
Alias_symbol (synonym)KIAA1099
GGAP1
Other aliasAGAP-1
cnt-g2
HGNC (Hugo) AGAP1
LocusID (NCBI) 116987
Atlas_Id 60185
Location 2q37.2  [Link to chromosome band 2q37]
Location_base_pair Starts at 235494089 and ends at 236131800 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ACTB (7p22.1) / AGAP1 (2q37.2)AGAP1 (2q37.2) / AANAT (17q25.1)AGAP1 (2q37.2) / F3 (1p21.3)
AGAP1 (2q37.2) / IGSF21 (1p36.13)AGAP1 (2q37.2) / MYH9 (22q12.3)AGAP1 (2q37.2) / RINT1 (7q22.3)
AGAP1 (2q37.2) / SORBS2 (4q35.1)AGAP1 (2q37.2) / SP140L (2q37.1)AGAP1 (2q37.2) / TRIOBP (22q13.1)
AGAP1 (2q37.2) / UBE2F (2q37.3)AGAP1 (2q37.2) / WDR11 (10q26.12)AGAP1 (2q37.2) / ZC2HC1A (8q21.12)
BPIFB1 (20q11.21) / AGAP1 (2q37.2)SEPT2 (2q37.3) / AGAP1 (2q37.2)SKP1 (5q31.1) / AGAP1 (2q37.2)
TMSB10 (2p11.2) / AGAP1 (2q37.2)AGAP1 RINT1AGAP1 WDR11
AGAP1 FAM164AAGAP1 UBE2FAGAP1 IGSF21
AGAP1 AANATAGAP1 SP140L

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)AGAP1   16922
Cards
Entrez_Gene (NCBI)AGAP1  116987  ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
AliasesAGAP-1; CENTG2; GGAP1; cnt-g2
GeneCards (Weizmann)AGAP1
Ensembl hg19 (Hinxton)ENSG00000157985 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000157985 [Gene_View]  chr2:235494089-236131800 [Contig_View]  AGAP1 [Vega]
ICGC DataPortalENSG00000157985
TCGA cBioPortalAGAP1
AceView (NCBI)AGAP1
Genatlas (Paris)AGAP1
WikiGenes116987
SOURCE (Princeton)AGAP1
Genetics Home Reference (NIH)AGAP1
Genomic and cartography
GoldenPath hg38 (UCSC)AGAP1  -     chr2:235494089-236131800 +  2q37.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)AGAP1  -     2q37.2   [Description]    (hg19-Feb_2009)
EnsemblAGAP1 - 2q37.2 [CytoView hg19]  AGAP1 - 2q37.2 [CytoView hg38]
Mapping of homologs : NCBIAGAP1 [Mapview hg19]  AGAP1 [Mapview hg38]
OMIM608651   
Gene and transcription
Genbank (Entrez)AB029022 AF413078 AK001722 AK295520 AK300763
RefSeq transcript (Entrez)NM_001037131 NM_001244888 NM_014914
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)AGAP1
Cluster EST : UnigeneHs.435039 [ NCBI ]
CGAP (NCI)Hs.435039
Alternative Splicing GalleryENSG00000157985
Gene ExpressionAGAP1 [ NCBI-GEO ]   AGAP1 [ EBI - ARRAY_EXPRESS ]   AGAP1 [ SEEK ]   AGAP1 [ MEM ]
Gene Expression Viewer (FireBrowse)AGAP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)116987
GTEX Portal (Tissue expression)AGAP1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UPQ3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UPQ3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UPQ3
Splice isoforms : SwissVarQ9UPQ3
PhosPhoSitePlusQ9UPQ3
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)    ARFGAP (PS50115)    PH_DOMAIN (PS50003)    RAB (PS51419)   
Domains : Interpro (EBI)Ankyrin_rpt    Ankyrin_rpt-contain_dom    ArfGAP    P-loop_NTPase    PH_dom-like    PH_domain    Small_GTPase   
Domain families : Pfam (Sanger)Ank_2 (PF12796)    ArfGap (PF01412)    Ras (PF00071)   
Domain families : Pfam (NCBI)pfam12796    pfam01412    pfam00071   
Domain families : Smart (EMBL)ANK (SM00248)  ArfGap (SM00105)  PH (SM00233)  
Conserved Domain (NCBI)AGAP1
DMDM Disease mutations116987
Blocks (Seattle)AGAP1
SuperfamilyQ9UPQ3
Human Protein AtlasENSG00000157985
Peptide AtlasQ9UPQ3
HPRD16359
IPIIPI00456242   IPI00456244   IPI00456246   IPI00903295   IPI00916750   IPI00916317   IPI00917678   IPI00917239   IPI00917469   
Protein Interaction databases
DIP (DOE-UCLA)Q9UPQ3
IntAct (EBI)Q9UPQ3
FunCoupENSG00000157985
BioGRIDAGAP1
STRING (EMBL)AGAP1
ZODIACAGAP1
Ontologies - Pathways
QuickGOQ9UPQ3
Ontology : AmiGOGTPase activity  GTPase activator activity  GTP binding  phospholipid binding  cytoplasm  protein transport  positive regulation of GTPase activity  metal ion binding  
Ontology : EGO-EBIGTPase activity  GTPase activator activity  GTP binding  phospholipid binding  cytoplasm  protein transport  positive regulation of GTPase activity  metal ion binding  
Pathways : KEGGEndocytosis   
NDEx NetworkAGAP1
Atlas of Cancer Signalling NetworkAGAP1
Wikipedia pathwaysAGAP1
Orthology - Evolution
OrthoDB116987
GeneTree (enSembl)ENSG00000157985
Phylogenetic Trees/Animal Genes : TreeFamAGAP1
HOVERGENQ9UPQ3
HOGENOMQ9UPQ3
Homologs : HomoloGeneAGAP1
Homology/Alignments : Family Browser (UCSC)AGAP1
Gene fusions - Rearrangements
Fusion: TCGAAGAP1 RINT1
Fusion: TCGAAGAP1 WDR11
Fusion: TCGAAGAP1 FAM164A
Fusion: TCGAAGAP1 UBE2F
Fusion: TCGAAGAP1 IGSF21
Fusion: TCGAAGAP1 AANAT
Fusion: TCGAAGAP1 SP140L
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAGAP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AGAP1
dbVarAGAP1
ClinVarAGAP1
1000_GenomesAGAP1 
Exome Variant ServerAGAP1
ExAC (Exome Aggregation Consortium)AGAP1 (select the gene name)
Genetic variants : HAPMAP116987
Genomic Variants (DGV)AGAP1 [DGVbeta]
DECIPHERAGAP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAGAP1 
Mutations
ICGC Data PortalAGAP1 
TCGA Data PortalAGAP1 
Broad Tumor PortalAGAP1
OASIS PortalAGAP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAGAP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDAGAP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch AGAP1
DgiDB (Drug Gene Interaction Database)AGAP1
DoCM (Curated mutations)AGAP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)AGAP1 (select a term)
intoGenAGAP1
Cancer3DAGAP1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608651   
Orphanet
MedgenAGAP1
Genetic Testing Registry AGAP1
NextProtQ9UPQ3 [Medical]
TSGene116987
GENETestsAGAP1
Target ValidationAGAP1
Huge Navigator AGAP1 [HugePedia]
snp3D : Map Gene to Disease116987
BioCentury BCIQAGAP1
ClinGenAGAP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD116987
Chemical/Pharm GKB GenePA26412
Clinical trialAGAP1
Miscellaneous
canSAR (ICR)AGAP1 (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAGAP1
EVEXAGAP1
GoPubMedAGAP1
iHOPAGAP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 15:37:40 CEST 2017

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