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AGAP3 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 3)

Identity

Alias (NCBI)AGAP-3
CENTG3
CRAG
MRIP-1
cnt-g3
HGNC (Hugo) AGAP3
HGNC Previous nameCENTG3
HGNC Previous namecentaurin, gamma 3
LocusID (NCBI) 116988
Atlas_Id 52940
Location 7q36.1  [Link to chromosome band 7q36]
Location_base_pair Starts at 151086475 and ends at 151144434 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AGAP3 (7q36.1) / CDK5 (7q36.1)AGAP3 (7q36.1) / GIMAP1 (7q36.1)AGAP3 (7q36.1) / GIMAP2 (7q36.1)
AGAP3 (7q36.1) / HOXD11 (2q31.1)AGAP3 (7q36.1) / JAZF1-AS1 (7p15.1)AGAP3 (7q36.1) / TP53I11 (11p11.2)
MCM7 (7q22.1) / AGAP3 (7q36.1)PRMT8 (12p13.32) / AGAP3 (7q36.1)AGAP3 7q36.1 / GIMAP1 7q36.1
AGAP3 7q36.1 / GIMAP2 7q36.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)AGAP3   16923
Cards
Entrez_Gene (NCBI)AGAP3    ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
AliasesAGAP-3; CENTG3; CRAG; MRIP-1; 
cnt-g3
GeneCards (Weizmann)AGAP3
Ensembl hg19 (Hinxton)ENSG00000133612 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000133612 [Gene_View]  ENSG00000133612 [Sequence]  chr7:151086475-151144434 [Contig_View]  AGAP3 [Vega]
ICGC DataPortalENSG00000133612
TCGA cBioPortalAGAP3
AceView (NCBI)AGAP3
Genatlas (Paris)AGAP3
SOURCE (Princeton)AGAP3
Genetics Home Reference (NIH)AGAP3
Genomic and cartography
GoldenPath hg38 (UCSC)AGAP3  -     chr7:151086475-151144434 +  7q36.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)AGAP3  -     7q36.1   [Description]    (hg19-Feb_2009)
GoldenPathAGAP3 - 7q36.1 [CytoView hg19]  AGAP3 - 7q36.1 [CytoView hg38]
ImmunoBaseENSG00000133612
Genome Data Viewer NCBIAGAP3 [Mapview hg19]  
OMIM616813   
Gene and transcription
Genbank (Entrez)AB209781 AF359283 AF413079 AK027415 AK055393
RefSeq transcript (Entrez)NM_001042535 NM_001281300 NM_001308304 NM_001308305 NM_001350102 NM_001350103 NM_001350104 NM_031946
Consensus coding sequences : CCDS (NCBI)AGAP3
Gene ExpressionAGAP3 [ NCBI-GEO ]   AGAP3 [ EBI - ARRAY_EXPRESS ]   AGAP3 [ SEEK ]   AGAP3 [ MEM ]
Gene Expression Viewer (FireBrowse)AGAP3 [ Firebrowse - Broad ]
GenevisibleExpression of AGAP3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)116988
GTEX Portal (Tissue expression)AGAP3
Human Protein AtlasENSG00000133612-AGAP3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96P47   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96P47  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96P47
PhosPhoSitePlusQ96P47
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)    ARFGAP (PS50115)    PH_DOMAIN (PS50003)    RAS (PS51421)   
Domains : Interpro (EBI)Ankyrin_rpt    Ankyrin_rpt-contain_dom    Ankyrin_rpt-contain_sf    ARFGAP/RecO    ArfGAP_dom    ArfGAP_dom_sf    P-loop_NTPase    PH-like_dom_sf    PH_domain    Small_GTPase    Small_GTPase_Ras-type   
Domain families : Pfam (Sanger)Ank_2 (PF12796)    ArfGap (PF01412)    Ras (PF00071)   
Domain families : Pfam (NCBI)pfam12796    pfam01412    pfam00071   
Domain families : Smart (EMBL)ArfGap (SM00105)  PH (SM00233)  
Conserved Domain (NCBI)AGAP3
PDB (RSDB)3IHW   
PDB Europe3IHW   
PDB (PDBSum)3IHW   
PDB (IMB)3IHW   
Structural Biology KnowledgeBase3IHW   
SCOP (Structural Classification of Proteins)3IHW   
CATH (Classification of proteins structures)3IHW   
SuperfamilyQ96P47
AlphaFold pdb e-kbQ96P47   
Human Protein Atlas [tissue]ENSG00000133612-AGAP3 [tissue]
HPRD16707
Protein Interaction databases
DIP (DOE-UCLA)Q96P47
IntAct (EBI)Q96P47
BioGRIDAGAP3
STRING (EMBL)AGAP3
ZODIACAGAP3
Ontologies - Pathways
QuickGOQ96P47
Ontology : AmiGOGTPase activity  GTPase activator activity  GTP binding  nucleus  nucleus  cytoplasm  signal transduction  membrane  polyubiquitin modification-dependent protein binding  cellular response to reactive oxygen species  proteasome-mediated ubiquitin-dependent protein catabolic process  proteasome-mediated ubiquitin-dependent protein catabolic process  metal ion binding  regulation of catalytic activity  cell periphery  
Ontology : EGO-EBIGTPase activity  GTPase activator activity  GTP binding  nucleus  nucleus  cytoplasm  signal transduction  membrane  polyubiquitin modification-dependent protein binding  cellular response to reactive oxygen species  proteasome-mediated ubiquitin-dependent protein catabolic process  proteasome-mediated ubiquitin-dependent protein catabolic process  metal ion binding  regulation of catalytic activity  cell periphery  
Pathways : KEGGEndocytosis   
NDEx NetworkAGAP3
Atlas of Cancer Signalling NetworkAGAP3
Wikipedia pathwaysAGAP3
Orthology - Evolution
OrthoDB116988
GeneTree (enSembl)ENSG00000133612
Phylogenetic Trees/Animal Genes : TreeFamAGAP3
Homologs : HomoloGeneAGAP3
Homology/Alignments : Family Browser (UCSC)AGAP3
Gene fusions - Rearrangements
Fusion : MitelmanAGAP3/GIMAP1 [7q36.1/7q36.1]  
Fusion : MitelmanAGAP3/GIMAP2 [7q36.1/7q36.1]  
Fusion : MitelmanAGAP3/JAZF1-AS1 [7q36.1/7p15.1]  
Fusion : QuiverAGAP3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAGAP3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AGAP3
dbVarAGAP3
ClinVarAGAP3
MonarchAGAP3
1000_GenomesAGAP3 
Exome Variant ServerAGAP3
GNOMAD BrowserENSG00000133612
Varsome BrowserAGAP3
ACMGAGAP3 variants
VarityQ96P47
Genomic Variants (DGV)AGAP3 [DGVbeta]
DECIPHERAGAP3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAGAP3 
Mutations
ICGC Data PortalAGAP3 
TCGA Data PortalAGAP3 
Broad Tumor PortalAGAP3
OASIS PortalAGAP3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAGAP3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DAGAP3
Mutations and Diseases : HGMDAGAP3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaAGAP3
DgiDB (Drug Gene Interaction Database)AGAP3
DoCM (Curated mutations)AGAP3
CIViC (Clinical Interpretations of Variants in Cancer)AGAP3
Cancer3DAGAP3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616813   
Orphanet
DisGeNETAGAP3
MedgenAGAP3
Genetic Testing Registry AGAP3
NextProtQ96P47 [Medical]
GENETestsAGAP3
Target ValidationAGAP3
Huge Navigator AGAP3 [HugePedia]
ClinGenAGAP3
Clinical trials, drugs, therapy
MyCancerGenomeAGAP3
Protein Interactions : CTDAGAP3
Pharm GKB GenePA26413
PharosQ96P47
Clinical trialAGAP3
Miscellaneous
canSAR (ICR)AGAP3
HarmonizomeAGAP3
DataMed IndexAGAP3
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXAGAP3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 14:58:47 CEST 2021

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