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AGAP3 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 3)

Identity

Alias_namesCENTG3
centaurin
Other aliasAGAP-3
CRAG
MRIP-1
cnt-g3
HGNC (Hugo) AGAP3
LocusID (NCBI) 116988
Atlas_Id 52940
Location 7q36.1  [Link to chromosome band 7q36]
Location_base_pair Starts at 150783509 and ends at 150820725 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
AGAP3 (7q36.1) / CDK5 (7q36.1)AGAP3 (7q36.1) / GIMAP1 (7q36.1)AGAP3 (7q36.1) / GIMAP2 (7q36.1)
AGAP3 (7q36.1) / HOXD11 (2q31.1)AGAP3 (7q36.1) / JAZF1-AS1 (7p15.1)AGAP3 (7q36.1) / TP53I11 (11p11.2)
MCM7 (7q22.1) / AGAP3 (7q36.1)PRMT8 (12p13.32) / AGAP3 (7q36.1)AGAP3 7q36.1 / GIMAP1 7q36.1
AGAP3 7q36.1 / GIMAP2 7q36.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)AGAP3   16923
Cards
Entrez_Gene (NCBI)AGAP3  116988  ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
AliasesAGAP-3; CENTG3; CRAG; MRIP-1; 
cnt-g3
GeneCards (Weizmann)AGAP3
Ensembl hg19 (Hinxton)ENSG00000133612 [Gene_View]  chr7:150783509-150820725 [Contig_View]  AGAP3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000133612 [Gene_View]  chr7:150783509-150820725 [Contig_View]  AGAP3 [Vega]
ICGC DataPortalENSG00000133612
TCGA cBioPortalAGAP3
AceView (NCBI)AGAP3
Genatlas (Paris)AGAP3
WikiGenes116988
SOURCE (Princeton)AGAP3
Genetics Home Reference (NIH)AGAP3
Genomic and cartography
GoldenPath hg19 (UCSC)AGAP3  -     chr7:150783509-150820725 +  7q36.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)AGAP3  -     7q36.1   [Description]    (hg38-Dec_2013)
EnsemblAGAP3 - 7q36.1 [CytoView hg19]  AGAP3 - 7q36.1 [CytoView hg38]
Mapping of homologs : NCBIAGAP3 [Mapview hg19]  AGAP3 [Mapview hg38]
OMIM616813   
Gene and transcription
Genbank (Entrez)AB209781 AF359283 AF413079 AK027415 AK055393
RefSeq transcript (Entrez)NM_001042535 NM_001281300 NM_001308304 NM_001308305 NM_031946
RefSeq genomic (Entrez)NC_000007 NC_018918 NT_007933 NW_004929333
Consensus coding sequences : CCDS (NCBI)AGAP3
Cluster EST : UnigeneHs.647075 [ NCBI ]
CGAP (NCI)Hs.647075
Alternative Splicing GalleryENSG00000133612
Gene ExpressionAGAP3 [ NCBI-GEO ]   AGAP3 [ EBI - ARRAY_EXPRESS ]   AGAP3 [ SEEK ]   AGAP3 [ MEM ]
Gene Expression Viewer (FireBrowse)AGAP3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)116988
GTEX Portal (Tissue expression)AGAP3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96P47   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96P47  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96P47
Splice isoforms : SwissVarQ96P47
PhosPhoSitePlusQ96P47
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)    ARFGAP (PS50115)    PH_DOMAIN (PS50003)    RAS (PS51421)   
Domains : Interpro (EBI)Ankyrin_rpt    Ankyrin_rpt-contain_dom    ArfGAP    P-loop_NTPase    PH_dom-like    PH_domain    Small_GTPase    Small_GTPase_Ras   
Domain families : Pfam (Sanger)Ank_2 (PF12796)    ArfGap (PF01412)    Ras (PF00071)   
Domain families : Pfam (NCBI)pfam12796    pfam01412    pfam00071   
Domain families : Smart (EMBL)ANK (SM00248)  ArfGap (SM00105)  PH (SM00233)  
Conserved Domain (NCBI)AGAP3
DMDM Disease mutations116988
Blocks (Seattle)AGAP3
PDB (SRS)3IHW   
PDB (PDBSum)3IHW   
PDB (IMB)3IHW   
PDB (RSDB)3IHW   
Structural Biology KnowledgeBase3IHW   
SCOP (Structural Classification of Proteins)3IHW   
CATH (Classification of proteins structures)3IHW   
SuperfamilyQ96P47
Human Protein AtlasENSG00000133612
Peptide AtlasQ96P47
HPRD16707
IPIIPI00479742   IPI00163185   IPI00973470   IPI00384607   IPI00442323   IPI01015389   IPI00945841   IPI00747315   IPI00383998   IPI00944974   IPI00946702   IPI00945564   
Protein Interaction databases
DIP (DOE-UCLA)Q96P47
IntAct (EBI)Q96P47
FunCoupENSG00000133612
BioGRIDAGAP3
STRING (EMBL)AGAP3
ZODIACAGAP3
Ontologies - Pathways
QuickGOQ96P47
Ontology : AmiGOGTPase activator activity  GTP binding  cytoplasm  small GTPase mediated signal transduction  protein transport  membrane  positive regulation of GTPase activity  metal ion binding  
Ontology : EGO-EBIGTPase activator activity  GTP binding  cytoplasm  small GTPase mediated signal transduction  protein transport  membrane  positive regulation of GTPase activity  metal ion binding  
Pathways : KEGGEndocytosis   
NDEx NetworkAGAP3
Atlas of Cancer Signalling NetworkAGAP3
Wikipedia pathwaysAGAP3
Orthology - Evolution
OrthoDB116988
GeneTree (enSembl)ENSG00000133612
Phylogenetic Trees/Animal Genes : TreeFamAGAP3
HOVERGENQ96P47
HOGENOMQ96P47
Homologs : HomoloGeneAGAP3
Homology/Alignments : Family Browser (UCSC)AGAP3
Gene fusions - Rearrangements
Fusion : MitelmanAGAP3/GIMAP1 [7q36.1/7q36.1]  
Fusion : MitelmanAGAP3/GIMAP2 [7q36.1/7q36.1]  [t(7;7)(q36;q36)]  
Fusion : MitelmanAGAP3/JAZF1-AS1 [7q36.1/7p15.1]  [t(7;7)(p15;q36)]  
Fusion: TCGAAGAP3 7q36.1 GIMAP1 7q36.1 BRCA
Fusion: TCGAAGAP3 7q36.1 GIMAP2 7q36.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAGAP3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AGAP3
dbVarAGAP3
ClinVarAGAP3
1000_GenomesAGAP3 
Exome Variant ServerAGAP3
ExAC (Exome Aggregation Consortium)AGAP3 (select the gene name)
Genetic variants : HAPMAP116988
Genomic Variants (DGV)AGAP3 [DGVbeta]
DECIPHER (Syndromes)7:150783509-150820725  ENSG00000133612
CONAN: Copy Number AnalysisAGAP3 
Mutations
ICGC Data PortalAGAP3 
TCGA Data PortalAGAP3 
Broad Tumor PortalAGAP3
OASIS PortalAGAP3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAGAP3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDAGAP3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch AGAP3
DgiDB (Drug Gene Interaction Database)AGAP3
DoCM (Curated mutations)AGAP3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)AGAP3 (select a term)
intoGenAGAP3
Cancer3DAGAP3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616813   
Orphanet
MedgenAGAP3
Genetic Testing Registry AGAP3
NextProtQ96P47 [Medical]
TSGene116988
GENETestsAGAP3
Huge Navigator AGAP3 [HugePedia]
snp3D : Map Gene to Disease116988
BioCentury BCIQAGAP3
ClinGenAGAP3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD116988
Chemical/Pharm GKB GenePA26413
Clinical trialAGAP3
Miscellaneous
canSAR (ICR)AGAP3 (select the gene name)
Probes
Litterature
PubMed15 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAGAP3
EVEXAGAP3
GoPubMedAGAP3
iHOPAGAP3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:55:11 CET 2017

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