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AGBL4 (ATP/GTP binding protein like 4)

Identity

Alias (NCBI)CCP6
HGNC (Hugo) AGBL4
HGNC Alias symbFLJ14442
CCP6
HGNC Alias namecytosolic carboxypeptidase 6
LocusID (NCBI) 84871
Atlas_Id 54111
Location 1p33  [Link to chromosome band 1p33]
Location_base_pair Starts at 48532854 and ends at 50023954 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AGBL4 (1p33) / AGBL4 (1p33)AGBL4 (1p33) / DNAH17 (17q25.3)AGBL4 (1p33) / DTL (1q32.3)
AGBL4 (1p33) / ELAVL4 (1p33)AGBL4 (1p33) / FAF1 (1p32.3)AGBL4 (1p33) / HNRNPC (14q11.2)
AGBL4 (1p33) / NTRK2 (9q21.33)AGBL4 (1p33) / SPAG6 (10p12.2)C11orf58 (11p15.1) / AGBL4 (1p33)
DTL (1q32.3) / AGBL4 (1p33)FAF1 (1p32.3) / AGBL4 (1p33)FUT8 (14q23.3) / AGBL4 (1p33)
HIRA (22q11.21) / AGBL4 (1p33)PTGFRN (1p13.1) / AGBL4 (1p33)STRADA (17q23.3) / AGBL4 (1p33)
ZNF267 (16p11.2) / AGBL4 (1p33)AGBL4 1p33 / DTL 1q32.3AGBL4 1p33 / FAF1 1p32.3
DTL 1q32.3 / AGBL4 1p33FUT8 14q23.3 / AGBL4 1p33PTGFRN 1p13.1 / AGBL4 1p33
ZNF267 16p11.2 / AGBL4 1p33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 7 ]
  t(1;1)(p13;p33) PTGFRN/AGBL4
t(1;1)(p32;p33) AGBL4/FAF1
t(1;1)(p33;q32) AGBL4/DTL
t(1;1)(p33;q32) DTL/AGBL4
t(1;9)(p33;q21) AGBL4/NTRK2
t(1;14)(p33;q23) FUT8/AGBL4
t(1;16)(p33;p11) ZNF267/AGBL4


External links

Nomenclature
HGNC (Hugo)AGBL4   25892
Cards
Entrez_Gene (NCBI)AGBL4  84871  ATP/GTP binding protein like 4
AliasesCCP6
GeneCards (Weizmann)AGBL4
Ensembl hg19 (Hinxton)ENSG00000186094 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000186094 [Gene_View]  ENSG00000186094 [Sequence]  chr1:48532854-50023954 [Contig_View]  AGBL4 [Vega]
ICGC DataPortalENSG00000186094
TCGA cBioPortalAGBL4
AceView (NCBI)AGBL4
Genatlas (Paris)AGBL4
WikiGenes84871
SOURCE (Princeton)AGBL4
Genetics Home Reference (NIH)AGBL4
Genomic and cartography
GoldenPath hg38 (UCSC)AGBL4  -     chr1:48532854-50023954 -  1p33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)AGBL4  -     1p33   [Description]    (hg19-Feb_2009)
GoldenPathAGBL4 - 1p33 [CytoView hg19]  AGBL4 - 1p33 [CytoView hg38]
ImmunoBaseENSG00000186094
genome Data Viewer NCBIAGBL4 [Mapview hg19]  
OMIM616476   
Gene and transcription
Genbank (Entrez)AF075049 AK027348 AK094826 AK294394 AK294633
RefSeq transcript (Entrez)NM_001323573 NM_001323574 NM_001323575 NM_032785
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)AGBL4
Alternative Splicing GalleryENSG00000186094
Gene ExpressionAGBL4 [ NCBI-GEO ]   AGBL4 [ EBI - ARRAY_EXPRESS ]   AGBL4 [ SEEK ]   AGBL4 [ MEM ]
Gene Expression Viewer (FireBrowse)AGBL4 [ Firebrowse - Broad ]
GenevisibleExpression of AGBL4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84871
GTEX Portal (Tissue expression)AGBL4
Human Protein AtlasENSG00000186094-AGBL4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5VU57   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5VU57  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5VU57
Splice isoforms : SwissVarQ5VU57
Catalytic activity : Enzyme3.4.17.- [ Enzyme-Expasy ]   3.4.17.-3.4.17.- [ IntEnz-EBI ]   3.4.17.- [ BRENDA ]   3.4.17.- [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ5VU57
Domains : Interpro (EBI)Pepdidase_M14_N    Peptidase_M14   
Domain families : Pfam (Sanger)Pepdidase_M14_N (PF18027)    Peptidase_M14 (PF00246)   
Domain families : Pfam (NCBI)pfam18027    pfam00246   
Domain families : Smart (EMBL)Zn_pept (SM00631)  
Conserved Domain (NCBI)AGBL4
DMDM Disease mutations84871
Blocks (Seattle)AGBL4
SuperfamilyQ5VU57
Human Protein Atlas [tissue]ENSG00000186094-AGBL4 [tissue]
Peptide AtlasQ5VU57
HPRD07487
IPIIPI01013035   IPI00973592   IPI00064477   IPI01012945   IPI00910518   IPI00477383   IPI00647826   
Protein Interaction databases
DIP (DOE-UCLA)Q5VU57
IntAct (EBI)Q5VU57
FunCoupENSG00000186094
BioGRIDAGBL4
STRING (EMBL)AGBL4
ZODIACAGBL4
Ontologies - Pathways
QuickGOQ5VU57
Ontology : AmiGOmetallocarboxypeptidase activity  Golgi apparatus  centriole  cytosol  proteolysis  zinc ion binding  negative regulation of cell proliferation  tubulin binding  central nervous system neuron development  protein deglutamylation  C-terminal protein deglutamylation  protein side chain deglutamylation  ciliary basal body  defense response to virus  anterograde axonal transport of mitochondrion  retrograde axonal transport of mitochondrion  axon cytoplasm  positive regulation of ubiquitin-dependent protein catabolic process  
Ontology : EGO-EBImetallocarboxypeptidase activity  Golgi apparatus  centriole  cytosol  proteolysis  zinc ion binding  negative regulation of cell proliferation  tubulin binding  central nervous system neuron development  protein deglutamylation  C-terminal protein deglutamylation  protein side chain deglutamylation  ciliary basal body  defense response to virus  anterograde axonal transport of mitochondrion  retrograde axonal transport of mitochondrion  axon cytoplasm  positive regulation of ubiquitin-dependent protein catabolic process  
NDEx NetworkAGBL4
Atlas of Cancer Signalling NetworkAGBL4
Wikipedia pathwaysAGBL4
Orthology - Evolution
OrthoDB84871
GeneTree (enSembl)ENSG00000186094
Phylogenetic Trees/Animal Genes : TreeFamAGBL4
HOGENOMQ5VU57
Homologs : HomoloGeneAGBL4
Homology/Alignments : Family Browser (UCSC)AGBL4
Gene fusions - Rearrangements
Fusion : MitelmanAGBL4/DTL [1p33/1q32.3]  
Fusion : MitelmanAGBL4/FAF1 [1p33/1p32.3]  
Fusion : MitelmanAGBL4/NTRK2 [1p33/9q21.33]  
Fusion : MitelmanDTL/AGBL4 [1q32.3/1p33]  
Fusion : MitelmanFUT8/AGBL4 [14q23.3/1p33]  
Fusion : MitelmanINADL/AGBL4 [1p31.3/1p33]  
Fusion : MitelmanPTGFRN/AGBL4 [1p13.1/1p33]  
Fusion : MitelmanZNF267/AGBL4 [16p11.2/1p33]  
Fusion PortalAGBL4 1p33 DTL 1q32.3 LUAD
Fusion PortalAGBL4 1p33 FAF1 1p32.3 BRCA PRAD
Fusion PortalDTL 1q32.3 AGBL4 1p33 LUAD
Fusion PortalFUT8 14q23.3 AGBL4 1p33 BRCA
Fusion PortalPTGFRN 1p13.1 AGBL4 1p33 BRCA
Fusion PortalZNF267 16p11.2 AGBL4 1p33 BLCA
Fusion : QuiverAGBL4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAGBL4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AGBL4
dbVarAGBL4
ClinVarAGBL4
MonarchAGBL4
1000_GenomesAGBL4 
Exome Variant ServerAGBL4
GNOMAD BrowserENSG00000186094
Varsome BrowserAGBL4
Genetic variants : HAPMAP84871
Genomic Variants (DGV)AGBL4 [DGVbeta]
DECIPHERAGBL4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAGBL4 
Mutations
ICGC Data PortalAGBL4 
TCGA Data PortalAGBL4 
Broad Tumor PortalAGBL4
OASIS PortalAGBL4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAGBL4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DAGBL4
Mutations and Diseases : HGMDAGBL4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch AGBL4
DgiDB (Drug Gene Interaction Database)AGBL4
DoCM (Curated mutations)AGBL4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)AGBL4 (select a term)
intoGenAGBL4
Cancer3DAGBL4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616476   
Orphanet
DisGeNETAGBL4
MedgenAGBL4
Genetic Testing Registry AGBL4
NextProtQ5VU57 [Medical]
TSGene84871
GENETestsAGBL4
Target ValidationAGBL4
Huge Navigator AGBL4 [HugePedia]
snp3D : Map Gene to Disease84871
BioCentury BCIQAGBL4
ClinGenAGBL4
Clinical trials, drugs, therapy
Protein Interactions : CTD84871
Pharm GKB GenePA142672636
Clinical trialAGBL4
Miscellaneous
canSAR (ICR)AGBL4 (select the gene name)
HarmonizomeAGBL4
DataMed IndexAGBL4
Probes
Litterature
PubMed12 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAGBL4
EVEXAGBL4
GoPubMedAGBL4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 14 14:00:49 CEST 2020

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