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AGK (acylglycerol kinase)

Identity

Alias_namesMULK
multiple substrate lipid kinase
Alias_symbol (synonym)FLJ10842
Other aliasCATC5
CTRCT38
MTDPS10
HGNC (Hugo) AGK
LocusID (NCBI) 55750
Atlas_Id 51085
Location 7q34  [Link to chromosome band 7q34]
Location_base_pair Starts at 141551278 and ends at 141654409 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AGK (7q34) / AGK (7q34)AGK (7q34) / BRAF (7q34)AGK (7q34) / NDUFB2 (7q34)
AGK (7q34) / WDR60 (7q36.3)BRAF (7q34) / AGK (7q34)LRRC37BP1 (17q11.2) / AGK (7q34)
AGK 7q34 / BRAF 7q34BRAF 7q34 / AGK 7q34

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)AGK   21869
Cards
Entrez_Gene (NCBI)AGK  55750  acylglycerol kinase
AliasesCATC5; CTRCT38; MTDPS10; MULK
GeneCards (Weizmann)AGK
Ensembl hg19 (Hinxton)ENSG00000006530 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000006530 [Gene_View]  chr7:141551278-141654409 [Contig_View]  AGK [Vega]
ICGC DataPortalENSG00000006530
TCGA cBioPortalAGK
AceView (NCBI)AGK
Genatlas (Paris)AGK
WikiGenes55750
SOURCE (Princeton)AGK
Genetics Home Reference (NIH)AGK
Genomic and cartography
GoldenPath hg38 (UCSC)AGK  -     chr7:141551278-141654409 +  7q34   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)AGK  -     7q34   [Description]    (hg19-Feb_2009)
EnsemblAGK - 7q34 [CytoView hg19]  AGK - 7q34 [CytoView hg38]
Mapping of homologs : NCBIAGK [Mapview hg19]  AGK [Mapview hg38]
OMIM212350   610345   614691   
Gene and transcription
Genbank (Entrez)AJ278150 AK001704 AK222769 AK299131 AK304502
RefSeq transcript (Entrez)NM_018238
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)AGK
Cluster EST : UnigeneHs.743318 [ NCBI ]
CGAP (NCI)Hs.743318
Alternative Splicing GalleryENSG00000006530
Gene ExpressionAGK [ NCBI-GEO ]   AGK [ EBI - ARRAY_EXPRESS ]   AGK [ SEEK ]   AGK [ MEM ]
Gene Expression Viewer (FireBrowse)AGK [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55750
GTEX Portal (Tissue expression)AGK
Human Protein AtlasENSG00000006530-AGK [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ53H12   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ53H12  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ53H12
Splice isoforms : SwissVarQ53H12
Catalytic activity : Enzyme2.7.1.107 [ Enzyme-Expasy ]   2.7.1.1072.7.1.107 [ IntEnz-EBI ]   2.7.1.107 [ BRENDA ]   2.7.1.107 [ KEGG ]   
PhosPhoSitePlusQ53H12
Domaine pattern : Prosite (Expaxy)DAGK (PS50146)   
Domains : Interpro (EBI)ATP-NAD_kinase_dom_1    Diacylglycerol_kinase_cat_dom    NAD/diacylglycerol_kinase   
Domain families : Pfam (Sanger)DAGK_cat (PF00781)   
Domain families : Pfam (NCBI)pfam00781   
Domain families : Smart (EMBL)DAGKc (SM00046)  
Conserved Domain (NCBI)AGK
DMDM Disease mutations55750
Blocks (Seattle)AGK
SuperfamilyQ53H12
Human Protein Atlas [tissue]ENSG00000006530-AGK [tissue]
Peptide AtlasQ53H12
HPRD08554
IPIIPI00019353   IPI00553233   IPI00946597   IPI00945912   IPI00945593   
Protein Interaction databases
DIP (DOE-UCLA)Q53H12
IntAct (EBI)Q53H12
FunCoupENSG00000006530
BioGRIDAGK
STRING (EMBL)AGK
ZODIACAGK
Ontologies - Pathways
QuickGOQ53H12
Ontology : AmiGOceramide kinase activity  NAD+ kinase activity  diacylglycerol kinase activity  ATP binding  mitochondrion  mitochondrial outer membrane  cytosol  long-chain fatty-acyl-CoA biosynthetic process  intracellular membrane-bounded organelle  glycerolipid metabolic process  ceramide biosynthetic process  lipid phosphorylation  acylglycerol kinase activity  
Ontology : EGO-EBIceramide kinase activity  NAD+ kinase activity  diacylglycerol kinase activity  ATP binding  mitochondrion  mitochondrial outer membrane  cytosol  long-chain fatty-acyl-CoA biosynthetic process  intracellular membrane-bounded organelle  glycerolipid metabolic process  ceramide biosynthetic process  lipid phosphorylation  acylglycerol kinase activity  
Pathways : KEGGGlycerolipid metabolism   
NDEx NetworkAGK
Atlas of Cancer Signalling NetworkAGK
Wikipedia pathwaysAGK
Orthology - Evolution
OrthoDB55750
GeneTree (enSembl)ENSG00000006530
Phylogenetic Trees/Animal Genes : TreeFamAGK
HOVERGENQ53H12
HOGENOMQ53H12
Homologs : HomoloGeneAGK
Homology/Alignments : Family Browser (UCSC)AGK
Gene fusions - Rearrangements
Fusion : MitelmanAGK/WDR60 [7q34/7q36.3]  
Fusion: TCGA_MDACCAGK 7q34 BRAF 7q34 THCA
Fusion: TCGA_MDACCBRAF 7q34 AGK 7q34 THCA
Tumor Fusion PortalAGK
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAGK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AGK
dbVarAGK
ClinVarAGK
1000_GenomesAGK 
Exome Variant ServerAGK
ExAC (Exome Aggregation Consortium)ENSG00000006530
GNOMAD BrowserENSG00000006530
Genetic variants : HAPMAP55750
Genomic Variants (DGV)AGK [DGVbeta]
DECIPHERAGK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAGK 
Mutations
ICGC Data PortalAGK 
TCGA Data PortalAGK 
Broad Tumor PortalAGK
OASIS PortalAGK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAGK  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDAGK
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch AGK
DgiDB (Drug Gene Interaction Database)AGK
DoCM (Curated mutations)AGK (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)AGK (select a term)
intoGenAGK
Cancer3DAGK(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM212350    610345    614691   
Orphanet433    14011   
DisGeNETAGK
MedgenAGK
Genetic Testing Registry AGK
NextProtQ53H12 [Medical]
TSGene55750
GENETestsAGK
Target ValidationAGK
Huge Navigator AGK [HugePedia]
snp3D : Map Gene to Disease55750
BioCentury BCIQAGK
ClinGenAGK (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55750
Chemical/Pharm GKB GenePA162375851
Clinical trialAGK
Miscellaneous
canSAR (ICR)AGK (select the gene name)
Probes
Litterature
PubMed41 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAGK
EVEXAGK
GoPubMedAGK
iHOPAGK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:02:25 CET 2017

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