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AGL (amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase)

Identity

Alias_namesamylo-1
Other aliasGDE
HGNC (Hugo) AGL
LocusID (NCBI) 178
Atlas_Id 55879
Location 1p21.2  [Link to chromosome band 1p21]
Location_base_pair Starts at 100316045 and ends at 100389579 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Cancer prone implicated (Data extracted from papers in the Atlas) [ 1 ]
  Glycogen storage disease type I (GSD I)


External links

Nomenclature
HGNC (Hugo)AGL   321
Cards
Entrez_Gene (NCBI)AGL  178  amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
AliasesGDE
GeneCards (Weizmann)AGL
Ensembl hg19 (Hinxton)ENSG00000162688 [Gene_View]  chr1:100316045-100389579 [Contig_View]  AGL [Vega]
Ensembl hg38 (Hinxton)ENSG00000162688 [Gene_View]  chr1:100316045-100389579 [Contig_View]  AGL [Vega]
ICGC DataPortalENSG00000162688
TCGA cBioPortalAGL
AceView (NCBI)AGL
Genatlas (Paris)AGL
WikiGenes178
SOURCE (Princeton)AGL
Genetics Home Reference (NIH)AGL
Genomic and cartography
GoldenPath hg19 (UCSC)AGL  -     chr1:100316045-100389579 +  1p21.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)AGL  -     1p21.2   [Description]    (hg38-Dec_2013)
EnsemblAGL - 1p21.2 [CytoView hg19]  AGL - 1p21.2 [CytoView hg38]
Mapping of homologs : NCBIAGL [Mapview hg19]  AGL [Mapview hg38]
OMIM232400   610860   
Gene and transcription
Genbank (Entrez)AB208867 AB621804 AK130308 BC020705 BC057220
RefSeq transcript (Entrez)NM_000028 NM_000642 NM_000643 NM_000644 NM_000645 NM_000646
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)AGL
Cluster EST : UnigeneHs.904 [ NCBI ]
CGAP (NCI)Hs.904
Alternative Splicing GalleryENSG00000162688
Gene ExpressionAGL [ NCBI-GEO ]   AGL [ EBI - ARRAY_EXPRESS ]   AGL [ SEEK ]   AGL [ MEM ]
Gene Expression Viewer (FireBrowse)AGL [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)178
GTEX Portal (Tissue expression)AGL
Protein : pattern, domain, 3D structure
UniProt/SwissProtP35573   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP35573  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP35573
Splice isoforms : SwissVarP35573
Catalytic activity : Enzyme2.4.1.25 [ Enzyme-Expasy ]   2.4.1.252.4.1.25 [ IntEnz-EBI ]   2.4.1.25 [ BRENDA ]   2.4.1.25 [ KEGG ]   
PhosPhoSitePlusP35573
Domains : Interpro (EBI)6-hairpin_glycosidase-like    AGL/Gdb1    AGL_central    AGL_euk_N    AGL_glucanoTrfase    GDE_C    Glyco_hydro_catalytic_dom    Glycogen_debranch_met    Glycoside_hydrolase_SF   
Domain families : Pfam (Sanger)GDE_C (PF06202)    hDGE_amylase (PF14701)    hGDE_central (PF14702)    hGDE_N (PF14699)   
Domain families : Pfam (NCBI)pfam06202    pfam14701    pfam14702    pfam14699   
Conserved Domain (NCBI)AGL
DMDM Disease mutations178
Blocks (Seattle)AGL
SuperfamilyP35573
Human Protein AtlasENSG00000162688
Peptide AtlasP35573
HPRD01984
IPIIPI00514126   IPI00219065   IPI00219066   
Protein Interaction databases
DIP (DOE-UCLA)P35573
IntAct (EBI)P35573
FunCoupENSG00000162688
BioGRIDAGL
STRING (EMBL)AGL
ZODIACAGL
Ontologies - Pathways
QuickGOP35573
Ontology : AmiGOglycogen debranching enzyme activity  4-alpha-glucanotransferase activity  4-alpha-glucanotransferase activity  amylo-alpha-1,6-glucosidase activity  amylo-alpha-1,6-glucosidase activity  protein binding  nucleus  cytoplasm  cytosol  glycogen biosynthetic process  glycogen catabolic process  glycogen catabolic process  response to nutrient  inclusion body  sarcoplasmic reticulum  polysaccharide binding  polyubiquitin binding  isoamylase complex  response to glucocorticoid  
Ontology : EGO-EBIglycogen debranching enzyme activity  4-alpha-glucanotransferase activity  4-alpha-glucanotransferase activity  amylo-alpha-1,6-glucosidase activity  amylo-alpha-1,6-glucosidase activity  protein binding  nucleus  cytoplasm  cytosol  glycogen biosynthetic process  glycogen catabolic process  glycogen catabolic process  response to nutrient  inclusion body  sarcoplasmic reticulum  polysaccharide binding  polyubiquitin binding  isoamylase complex  response to glucocorticoid  
Pathways : KEGGStarch and sucrose metabolism   
NDEx NetworkAGL
Atlas of Cancer Signalling NetworkAGL
Wikipedia pathwaysAGL
Orthology - Evolution
OrthoDB178
GeneTree (enSembl)ENSG00000162688
Phylogenetic Trees/Animal Genes : TreeFamAGL
HOVERGENP35573
HOGENOMP35573
Homologs : HomoloGeneAGL
Homology/Alignments : Family Browser (UCSC)AGL
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAGL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AGL
dbVarAGL
ClinVarAGL
1000_GenomesAGL 
Exome Variant ServerAGL
ExAC (Exome Aggregation Consortium)AGL (select the gene name)
Genetic variants : HAPMAP178
Genomic Variants (DGV)AGL [DGVbeta]
DECIPHER (Syndromes)1:100316045-100389579  ENSG00000162688
CONAN: Copy Number AnalysisAGL 
Mutations
ICGC Data PortalAGL 
TCGA Data PortalAGL 
Broad Tumor PortalAGL
OASIS PortalAGL [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAGL  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDAGL
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
BioMutasearch AGL
DgiDB (Drug Gene Interaction Database)AGL
DoCM (Curated mutations)AGL (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)AGL (select a term)
intoGenAGL
Cancer3DAGL(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM232400    610860   
Orphanet15   
MedgenAGL
Genetic Testing Registry AGL
NextProtP35573 [Medical]
TSGene178
GENETestsAGL
Huge Navigator AGL [HugePedia]
snp3D : Map Gene to Disease178
BioCentury BCIQAGL
ClinGenAGL
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD178
Chemical/Pharm GKB GenePA24618
Clinical trialAGL
Miscellaneous
canSAR (ICR)AGL (select the gene name)
Probes
Litterature
PubMed61 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAGL
EVEXAGL
GoPubMedAGL
iHOPAGL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 14:51:52 CEST 2017

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