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AGO1 (argonaute 1, RISC catalytic component)

Identity

Alias_namesEIF2C1
eukaryotic translation initiation factor 2C, 1
argonaute RISC catalytic component 1
Alias_symbol (synonym)hAGO1
Other aliasEIF2C
GERP95
Q99
hAgo1
HGNC (Hugo) AGO1
LocusID (NCBI) 26523
Atlas_Id 52819
Location 1p34.3  [Link to chromosome band 1p34]
Location_base_pair Starts at 35883195 and ends at 35924298 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
RPL13A (19q13.33) / AGO1 (1p34.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)AGO1   3262
Cards
Entrez_Gene (NCBI)AGO1  26523  argonaute 1, RISC catalytic component
AliasesEIF2C; EIF2C1; GERP95; Q99; 
hAgo1
GeneCards (Weizmann)AGO1
Ensembl hg19 (Hinxton)ENSG00000092847 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000092847 [Gene_View]  chr1:35883195-35924298 [Contig_View]  AGO1 [Vega]
ICGC DataPortalENSG00000092847
TCGA cBioPortalAGO1
AceView (NCBI)AGO1
Genatlas (Paris)AGO1
WikiGenes26523
SOURCE (Princeton)AGO1
Genetics Home Reference (NIH)AGO1
Genomic and cartography
GoldenPath hg38 (UCSC)AGO1  -     chr1:35883195-35924298 +  1p34.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)AGO1  -     1p34.3   [Description]    (hg19-Feb_2009)
EnsemblAGO1 - 1p34.3 [CytoView hg19]  AGO1 - 1p34.3 [CytoView hg38]
Mapping of homologs : NCBIAGO1 [Mapview hg19]  AGO1 [Mapview hg38]
OMIM606228   
Gene and transcription
Genbank (Entrez)AF093097 AK000326 AK001622 AK002003 AK025726
RefSeq transcript (Entrez)NM_001317122 NM_001317123 NM_012199
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)AGO1
Cluster EST : UnigeneHs.656677 [ NCBI ]
CGAP (NCI)Hs.656677
Alternative Splicing GalleryENSG00000092847
Gene ExpressionAGO1 [ NCBI-GEO ]   AGO1 [ EBI - ARRAY_EXPRESS ]   AGO1 [ SEEK ]   AGO1 [ MEM ]
Gene Expression Viewer (FireBrowse)AGO1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26523
GTEX Portal (Tissue expression)AGO1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UL18   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UL18  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UL18
Splice isoforms : SwissVarQ9UL18
PhosPhoSitePlusQ9UL18
Domaine pattern : Prosite (Expaxy)PAZ (PS50821)    PIWI (PS50822)   
Domains : Interpro (EBI)ArgoL1    ArgoL2    Argonaute_Mid_dom    Argonaute_N    PAZ_dom    Piwi    RNaseH-like_dom   
Domain families : Pfam (Sanger)ArgoL1 (PF08699)    ArgoL2 (PF16488)    ArgoMid (PF16487)    ArgoN (PF16486)    PAZ (PF02170)    Piwi (PF02171)   
Domain families : Pfam (NCBI)pfam08699    pfam16488    pfam16487    pfam16486    pfam02170    pfam02171   
Domain families : Smart (EMBL)DUF1785 (SM01163)  PAZ (SM00949)  Piwi (SM00950)  
Conserved Domain (NCBI)AGO1
DMDM Disease mutations26523
Blocks (Seattle)AGO1
PDB (SRS)1SI2    1SI3    4KRE    4KRF    4KXT   
PDB (PDBSum)1SI2    1SI3    4KRE    4KRF    4KXT   
PDB (IMB)1SI2    1SI3    4KRE    4KRF    4KXT   
PDB (RSDB)1SI2    1SI3    4KRE    4KRF    4KXT   
Structural Biology KnowledgeBase1SI2    1SI3    4KRE    4KRF    4KXT   
SCOP (Structural Classification of Proteins)1SI2    1SI3    4KRE    4KRF    4KXT   
CATH (Classification of proteins structures)1SI2    1SI3    4KRE    4KRF    4KXT   
SuperfamilyQ9UL18
Human Protein AtlasENSG00000092847
Peptide AtlasQ9UL18
HPRD06942
IPIIPI00007736   IPI00646765   
Protein Interaction databases
DIP (DOE-UCLA)Q9UL18
IntAct (EBI)Q9UL18
FunCoupENSG00000092847
BioGRIDAGO1
STRING (EMBL)AGO1
ZODIACAGO1
Ontologies - Pathways
QuickGOQ9UL18
Ontology : AmiGOP-body  nuclear-transcribed mRNA catabolic process  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II core binding  core promoter binding  RNA binding  double-stranded RNA binding  single-stranded RNA binding  endoribonuclease activity  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  polysome  transcription, DNA-templated  Wnt signaling pathway, calcium modulating pathway  RNA secondary structure unwinding  RNA secondary structure unwinding  miRNA metabolic process  RISC complex  intracellular ribonucleoprotein complex  gene silencing by RNA  pre-miRNA processing  micro-ribonucleoprotein complex  posttranscriptional gene silencing by RNA  production of miRNAs involved in gene silencing by miRNA  miRNA binding  miRNA mediated inhibition of translation  mRNA cleavage involved in gene silencing by miRNA  miRNA loading onto RISC involved in gene silencing by miRNA  positive regulation of transcription from RNA polymerase II promoter  phosphatidylinositol-mediated signaling  RISC-loading complex  mRNA cleavage involved in gene silencing by siRNA  positive regulation of NIK/NF-kappaB signaling  
Ontology : EGO-EBIP-body  nuclear-transcribed mRNA catabolic process  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II core binding  core promoter binding  RNA binding  double-stranded RNA binding  single-stranded RNA binding  endoribonuclease activity  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  polysome  transcription, DNA-templated  Wnt signaling pathway, calcium modulating pathway  RNA secondary structure unwinding  RNA secondary structure unwinding  miRNA metabolic process  RISC complex  intracellular ribonucleoprotein complex  gene silencing by RNA  pre-miRNA processing  micro-ribonucleoprotein complex  posttranscriptional gene silencing by RNA  production of miRNAs involved in gene silencing by miRNA  miRNA binding  miRNA mediated inhibition of translation  mRNA cleavage involved in gene silencing by miRNA  miRNA loading onto RISC involved in gene silencing by miRNA  positive regulation of transcription from RNA polymerase II promoter  phosphatidylinositol-mediated signaling  RISC-loading complex  mRNA cleavage involved in gene silencing by siRNA  positive regulation of NIK/NF-kappaB signaling  
Pathways : BIOCARTADicer Pathway [Genes]   
NDEx NetworkAGO1
Atlas of Cancer Signalling NetworkAGO1
Wikipedia pathwaysAGO1
Orthology - Evolution
OrthoDB26523
GeneTree (enSembl)ENSG00000092847
Phylogenetic Trees/Animal Genes : TreeFamAGO1
HOVERGENQ9UL18
HOGENOMQ9UL18
Homologs : HomoloGeneAGO1
Homology/Alignments : Family Browser (UCSC)AGO1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAGO1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AGO1
dbVarAGO1
ClinVarAGO1
1000_GenomesAGO1 
Exome Variant ServerAGO1
ExAC (Exome Aggregation Consortium)AGO1 (select the gene name)
Genetic variants : HAPMAP26523
Genomic Variants (DGV)AGO1 [DGVbeta]
DECIPHERAGO1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAGO1 
Mutations
ICGC Data PortalAGO1 
TCGA Data PortalAGO1 
Broad Tumor PortalAGO1
OASIS PortalAGO1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDAGO1
BioMutasearch AGO1
DgiDB (Drug Gene Interaction Database)AGO1
DoCM (Curated mutations)AGO1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)AGO1 (select a term)
intoGenAGO1
Cancer3DAGO1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606228   
Orphanet
MedgenAGO1
Genetic Testing Registry AGO1
NextProtQ9UL18 [Medical]
TSGene26523
GENETestsAGO1
Target ValidationAGO1
Huge Navigator AGO1 [HugePedia]
snp3D : Map Gene to Disease26523
BioCentury BCIQAGO1
ClinGenAGO1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD26523
Chemical/Pharm GKB GenePA27693
Clinical trialAGO1
Miscellaneous
canSAR (ICR)AGO1 (select the gene name)
Probes
Litterature
PubMed93 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAGO1
EVEXAGO1
GoPubMedAGO1
iHOPAGO1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:23:07 CEST 2017

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