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AGO2 (argonaute 2, RISC catalytic component)

Identity

Alias_namesEIF2C2
eukaryotic translation initiation factor 2C, 2
argonaute RISC catalytic component 2
Alias_symbol (synonym)hAGO2
Q10
Other aliasCASC7
LINC00980
PPD
HGNC (Hugo) AGO2
LocusID (NCBI) 27161
Atlas_Id 50645
Location 8q24.3  [Link to chromosome band 8q24]
Location_base_pair Starts at 140520151 and ends at 140635546 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AGO2 (8q24.3) / CNBD1 (8q21.3)AGO2 (8q24.3) / PCMTD1 (8q11.23)AGO2 (8q24.3) / PTK2 (8q24.3)
AGO2 (8q24.3) / STRN3 (14q12)AGO2 (8q24.3) / TRAPPC9 (8q24.3)TRAPPC9 (8q24.3) / AGO2 (8q24.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)AGO2   3263
Cards
Entrez_Gene (NCBI)AGO2  27161  argonaute 2, RISC catalytic component
AliasesCASC7; EIF2C2; LINC00980; PPD; 
Q10
GeneCards (Weizmann)AGO2
Ensembl hg19 (Hinxton)ENSG00000123908 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000123908 [Gene_View]  chr8:140520151-140635546 [Contig_View]  AGO2 [Vega]
ICGC DataPortalENSG00000123908
TCGA cBioPortalAGO2
AceView (NCBI)AGO2
Genatlas (Paris)AGO2
WikiGenes27161
SOURCE (Princeton)AGO2
Genetics Home Reference (NIH)AGO2
Genomic and cartography
GoldenPath hg38 (UCSC)AGO2  -     chr8:140520151-140635546 -  8q24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)AGO2  -     8q24.3   [Description]    (hg19-Feb_2009)
EnsemblAGO2 - 8q24.3 [CytoView hg19]  AGO2 - 8q24.3 [CytoView hg38]
Mapping of homologs : NCBIAGO2 [Mapview hg19]  AGO2 [Mapview hg38]
OMIM606229   
Gene and transcription
Genbank (Entrez)AA909234 AF121255 AI468419 AK092172 AK096164
RefSeq transcript (Entrez)NM_001164623 NM_012154
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)AGO2
Cluster EST : UnigeneHs.743313 [ NCBI ]
CGAP (NCI)Hs.743313
Alternative Splicing GalleryENSG00000123908
Gene ExpressionAGO2 [ NCBI-GEO ]   AGO2 [ EBI - ARRAY_EXPRESS ]   AGO2 [ SEEK ]   AGO2 [ MEM ]
Gene Expression Viewer (FireBrowse)AGO2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)27161
GTEX Portal (Tissue expression)AGO2
Human Protein AtlasENSG00000123908-AGO2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UKV8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UKV8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UKV8
Splice isoforms : SwissVarQ9UKV8
PhosPhoSitePlusQ9UKV8
Domaine pattern : Prosite (Expaxy)PAZ (PS50821)    PIWI (PS50822)   
Domains : Interpro (EBI)AGO2    ArgoL1    ArgoL2    Argonaute_Mid_dom    Argonaute_N    PAZ_dom    Piwi    RNaseH-like_dom   
Domain families : Pfam (Sanger)ArgoL1 (PF08699)    ArgoL2 (PF16488)    ArgoMid (PF16487)    ArgoN (PF16486)    PAZ (PF02170)    Piwi (PF02171)   
Domain families : Pfam (NCBI)pfam08699    pfam16488    pfam16487    pfam16486    pfam02170    pfam02171   
Domain families : Smart (EMBL)DUF1785 (SM01163)  PAZ (SM00949)  Piwi (SM00950)  
Conserved Domain (NCBI)AGO2
DMDM Disease mutations27161
Blocks (Seattle)AGO2
PDB (SRS)3LUC    3LUD    3LUG    3LUH    3LUJ    3LUK    3QX8    3QX9    4F3T    4OLA    4OLB    4W5N    4W5O    4W5Q    4W5R    4W5T    4Z4C    4Z4D    4Z4E    4Z4F    4Z4G    4Z4H    4Z4I    5JS1    5JS2    5KI6    5T7B   
PDB (PDBSum)3LUC    3LUD    3LUG    3LUH    3LUJ    3LUK    3QX8    3QX9    4F3T    4OLA    4OLB    4W5N    4W5O    4W5Q    4W5R    4W5T    4Z4C    4Z4D    4Z4E    4Z4F    4Z4G    4Z4H    4Z4I    5JS1    5JS2    5KI6    5T7B   
PDB (IMB)3LUC    3LUD    3LUG    3LUH    3LUJ    3LUK    3QX8    3QX9    4F3T    4OLA    4OLB    4W5N    4W5O    4W5Q    4W5R    4W5T    4Z4C    4Z4D    4Z4E    4Z4F    4Z4G    4Z4H    4Z4I    5JS1    5JS2    5KI6    5T7B   
PDB (RSDB)3LUC    3LUD    3LUG    3LUH    3LUJ    3LUK    3QX8    3QX9    4F3T    4OLA    4OLB    4W5N    4W5O    4W5Q    4W5R    4W5T    4Z4C    4Z4D    4Z4E    4Z4F    4Z4G    4Z4H    4Z4I    5JS1    5JS2    5KI6    5T7B   
Structural Biology KnowledgeBase3LUC    3LUD    3LUG    3LUH    3LUJ    3LUK    3QX8    3QX9    4F3T    4OLA    4OLB    4W5N    4W5O    4W5Q    4W5R    4W5T    4Z4C    4Z4D    4Z4E    4Z4F    4Z4G    4Z4H    4Z4I    5JS1    5JS2    5KI6    5T7B   
SCOP (Structural Classification of Proteins)3LUC    3LUD    3LUG    3LUH    3LUJ    3LUK    3QX8    3QX9    4F3T    4OLA    4OLB    4W5N    4W5O    4W5Q    4W5R    4W5T    4Z4C    4Z4D    4Z4E    4Z4F    4Z4G    4Z4H    4Z4I    5JS1    5JS2    5KI6    5T7B   
CATH (Classification of proteins structures)3LUC    3LUD    3LUG    3LUH    3LUJ    3LUK    3QX8    3QX9    4F3T    4OLA    4OLB    4W5N    4W5O    4W5Q    4W5R    4W5T    4Z4C    4Z4D    4Z4E    4Z4F    4Z4G    4Z4H    4Z4I    5JS1    5JS2    5KI6    5T7B   
SuperfamilyQ9UKV8
Human Protein Atlas [tissue]ENSG00000123908-AGO2 [tissue]
Peptide AtlasQ9UKV8
HPRD06943
IPIIPI00745433   IPI00929290   IPI00973784   IPI01014654   
Protein Interaction databases
DIP (DOE-UCLA)Q9UKV8
IntAct (EBI)Q9UKV8
FunCoupENSG00000123908
BioGRIDAGO2
STRING (EMBL)AGO2
ZODIACAGO2
Ontologies - Pathways
QuickGOQ9UKV8
Ontology : AmiGORNA 7-methylguanosine cap binding  P-body  RNA polymerase II core binding  core promoter binding  RNA binding  double-stranded RNA binding  single-stranded RNA binding  translation initiation factor activity  endoribonuclease activity  endoribonuclease activity  endoribonuclease activity  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytosol  polysome  mRNA cap binding complex  mRNA cap binding complex  transcription, DNA-templated  translation  translational initiation  Wnt signaling pathway, calcium modulating pathway  protein C-terminus binding  post-embryonic development  RNA secondary structure unwinding  RNA secondary structure unwinding  miRNA metabolic process  membrane  RISC complex  RISC complex  cell junction  dendrite  intracellular ribonucleoprotein complex  gene silencing by RNA  gene silencing by RNA  pre-miRNA processing  micro-ribonucleoprotein complex  siRNA loading onto RISC involved in RNA interference  siRNA loading onto RISC involved in RNA interference  posttranscriptional gene silencing by RNA  production of miRNAs involved in gene silencing by miRNA  siRNA binding  siRNA binding  miRNA binding  miRNA binding  miRNA mediated inhibition of translation  miRNA mediated inhibition of translation  mRNA cleavage involved in gene silencing by miRNA  mRNA cleavage involved in gene silencing by miRNA  miRNA loading onto RISC involved in gene silencing by miRNA  positive regulation of transcription from RNA polymerase II promoter  negative regulation of translational initiation  metal ion binding  phosphatidylinositol-mediated signaling  positive regulation of nuclear-transcribed mRNA poly(A) tail shortening  endoribonuclease activity, cleaving siRNA-paired mRNA  RISC-loading complex  RNA phosphodiester bond hydrolysis, endonucleolytic  endoribonuclease activity, cleaving miRNA-paired mRNA  endoribonuclease activity, cleaving miRNA-paired mRNA  mRNA cleavage involved in gene silencing by siRNA  mRNA cleavage involved in gene silencing by siRNA  mRNA cap binding  positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  positive regulation of miRNA mediated inhibition of translation  
Ontology : EGO-EBIRNA 7-methylguanosine cap binding  P-body  RNA polymerase II core binding  core promoter binding  RNA binding  double-stranded RNA binding  single-stranded RNA binding  translation initiation factor activity  endoribonuclease activity  endoribonuclease activity  endoribonuclease activity  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytosol  polysome  mRNA cap binding complex  mRNA cap binding complex  transcription, DNA-templated  translation  translational initiation  Wnt signaling pathway, calcium modulating pathway  protein C-terminus binding  post-embryonic development  RNA secondary structure unwinding  RNA secondary structure unwinding  miRNA metabolic process  membrane  RISC complex  RISC complex  cell junction  dendrite  intracellular ribonucleoprotein complex  gene silencing by RNA  gene silencing by RNA  pre-miRNA processing  micro-ribonucleoprotein complex  siRNA loading onto RISC involved in RNA interference  siRNA loading onto RISC involved in RNA interference  posttranscriptional gene silencing by RNA  production of miRNAs involved in gene silencing by miRNA  siRNA binding  siRNA binding  miRNA binding  miRNA binding  miRNA mediated inhibition of translation  miRNA mediated inhibition of translation  mRNA cleavage involved in gene silencing by miRNA  mRNA cleavage involved in gene silencing by miRNA  miRNA loading onto RISC involved in gene silencing by miRNA  positive regulation of transcription from RNA polymerase II promoter  negative regulation of translational initiation  metal ion binding  phosphatidylinositol-mediated signaling  positive regulation of nuclear-transcribed mRNA poly(A) tail shortening  endoribonuclease activity, cleaving siRNA-paired mRNA  RISC-loading complex  RNA phosphodiester bond hydrolysis, endonucleolytic  endoribonuclease activity, cleaving miRNA-paired mRNA  endoribonuclease activity, cleaving miRNA-paired mRNA  mRNA cleavage involved in gene silencing by siRNA  mRNA cleavage involved in gene silencing by siRNA  mRNA cap binding  positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  positive regulation of miRNA mediated inhibition of translation  
Pathways : BIOCARTADicer Pathway [Genes]   
NDEx NetworkAGO2
Atlas of Cancer Signalling NetworkAGO2
Wikipedia pathwaysAGO2
Orthology - Evolution
OrthoDB27161
GeneTree (enSembl)ENSG00000123908
Phylogenetic Trees/Animal Genes : TreeFamAGO2
HOVERGENQ9UKV8
HOGENOMQ9UKV8
Homologs : HomoloGeneAGO2
Homology/Alignments : Family Browser (UCSC)AGO2
Gene fusions - Rearrangements
Fusion : MitelmanAGO2/CNBD1 [8q24.3/8q21.3]  
Fusion : MitelmanAGO2/PCMTD1 [8q24.3/8q11.23]  [t(8;8)(q11;q24)]  
Fusion : MitelmanAGO2/PTK2 [8q24.3/8q24.3]  [t(8;8)(q24;q24)]  
Fusion : MitelmanTRAPPC9/AGO2 [8q24.3/8q24.3]  [t(8;8)(q24;q24)]  
Tumor Fusion PortalAGO2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAGO2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AGO2
dbVarAGO2
ClinVarAGO2
1000_GenomesAGO2 
Exome Variant ServerAGO2
ExAC (Exome Aggregation Consortium)ENSG00000123908
GNOMAD BrowserENSG00000123908
Genetic variants : HAPMAP27161
Genomic Variants (DGV)AGO2 [DGVbeta]
DECIPHERAGO2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAGO2 
Mutations
ICGC Data PortalAGO2 
TCGA Data PortalAGO2 
Broad Tumor PortalAGO2
OASIS PortalAGO2 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDAGO2
BioMutasearch AGO2
DgiDB (Drug Gene Interaction Database)AGO2
DoCM (Curated mutations)AGO2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)AGO2 (select a term)
intoGenAGO2
Cancer3DAGO2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606229   
Orphanet
DisGeNETAGO2
MedgenAGO2
Genetic Testing Registry AGO2
NextProtQ9UKV8 [Medical]
TSGene27161
GENETestsAGO2
Target ValidationAGO2
Huge Navigator AGO2 [HugePedia]
snp3D : Map Gene to Disease27161
BioCentury BCIQAGO2
ClinGenAGO2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD27161
Chemical/Pharm GKB GenePA27694
Clinical trialAGO2
Miscellaneous
canSAR (ICR)AGO2 (select the gene name)
Probes
Litterature
PubMed242 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAGO2
EVEXAGO2
GoPubMedAGO2
iHOPAGO2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:02:26 CET 2017

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