Atlas of Genetics and Cytogenetics in Oncology and Haematology


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AGO3 (argonaute RISC catalytic component 3)

Identity

Alias (NCBI)EIF2C3
HGNC (Hugo) AGO3
HGNC Alias symbhAGO3
FLJ12765
HGNC Alias nameargonaute 3
HGNC Previous nameEIF2C3
HGNC Previous nameeukaryotic translation initiation factor 2C, 3
LocusID (NCBI) 192669
Atlas_Id 56168
Location 1p34.3  [Link to chromosome band 1p34]
Location_base_pair Starts at 35931105 and ends at 36072499 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FRMD5 (15q15.3) / AGO3 (1p34.3)THRAP3 (1p34.3) / AGO3 (1p34.3)VRK2 (2p16.1) / AGO3 (1p34.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)AGO3   18421
Cards
Entrez_Gene (NCBI)AGO3    argonaute RISC catalytic component 3
AliasesEIF2C3
GeneCards (Weizmann)AGO3
Ensembl hg19 (Hinxton)ENSG00000126070 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000126070 [Gene_View]  ENSG00000126070 [Sequence]  chr1:35931105-36072499 [Contig_View]  AGO3 [Vega]
ICGC DataPortalENSG00000126070
TCGA cBioPortalAGO3
AceView (NCBI)AGO3
Genatlas (Paris)AGO3
SOURCE (Princeton)AGO3
Genetics Home Reference (NIH)AGO3
Genomic and cartography
GoldenPath hg38 (UCSC)AGO3  -     chr1:35931105-36072499 +  1p34.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)AGO3  -     1p34.3   [Description]    (hg19-Feb_2009)
GoldenPathAGO3 - 1p34.3 [CytoView hg19]  AGO3 - 1p34.3 [CytoView hg38]
ImmunoBaseENSG00000126070
Genome Data Viewer NCBIAGO3 [Mapview hg19]  
OMIM607355   
Gene and transcription
Genbank (Entrez)AA251146 AK022827 AK027796 AK292870 AK302289
RefSeq transcript (Entrez)NM_024852 NM_177422
Consensus coding sequences : CCDS (NCBI)AGO3
Gene ExpressionAGO3 [ NCBI-GEO ]   AGO3 [ EBI - ARRAY_EXPRESS ]   AGO3 [ SEEK ]   AGO3 [ MEM ]
Gene Expression Viewer (FireBrowse)AGO3 [ Firebrowse - Broad ]
GenevisibleExpression of AGO3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)192669
GTEX Portal (Tissue expression)AGO3
Human Protein AtlasENSG00000126070-AGO3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H9G7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H9G7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H9G7
PhosPhoSitePlusQ9H9G7
Domaine pattern : Prosite (Expaxy)PAZ (PS50821)    PIWI (PS50822)   
Domains : Interpro (EBI)AGO3    ArgoL1    ArgoL2    Argonaute_Mid_dom    Argonaute_N    PAZ_dom    PAZ_dom_sf    Piwi    RNaseH-like_sf    RNaseH_sf   
Domain families : Pfam (Sanger)ArgoL1 (PF08699)    ArgoL2 (PF16488)    ArgoMid (PF16487)    ArgoN (PF16486)    PAZ (PF02170)    Piwi (PF02171)   
Domain families : Pfam (NCBI)pfam08699    pfam16488    pfam16487    pfam16486    pfam02170    pfam02171   
Domain families : Smart (EMBL)DUF1785 (SM01163)  PAZ (SM00949)  Piwi (SM00950)  
Conserved Domain (NCBI)AGO3
PDB (RSDB)5VM9   
PDB Europe5VM9   
PDB (PDBSum)5VM9   
PDB (IMB)5VM9   
Structural Biology KnowledgeBase5VM9   
SCOP (Structural Classification of Proteins)5VM9   
CATH (Classification of proteins structures)5VM9   
SuperfamilyQ9H9G7
AlphaFold pdb e-kbQ9H9G7   
Human Protein Atlas [tissue]ENSG00000126070-AGO3 [tissue]
HPRD09558
Protein Interaction databases
DIP (DOE-UCLA)Q9H9G7
IntAct (EBI)Q9H9G7
BioGRIDAGO3
STRING (EMBL)AGO3
ZODIACAGO3
Ontologies - Pathways
QuickGOQ9H9G7
Ontology : AmiGOcondensed nuclear chromosome  P-body  RNA binding  double-stranded RNA binding  single-stranded RNA binding  endoribonuclease activity  protein binding  nucleoplasm  cytoplasm  cytosol  cytosol  mRNA catabolic process  Wnt signaling pathway, calcium modulating pathway  RNA secondary structure unwinding  RNA secondary structure unwinding  positive regulation of gene expression  negative regulation of gene expression  membrane  RISC complex  intracellular receptor signaling pathway  pre-miRNA processing  post-transcriptional gene silencing by RNA  production of miRNAs involved in gene silencing by miRNA  miRNA binding  miRNA mediated inhibition of translation  mRNA cleavage involved in gene silencing by miRNA  miRNA loading onto RISC involved in gene silencing by miRNA  cytoplasmic ribonucleoprotein granule  regulation of megakaryocyte differentiation  metal ion binding  regulation of transcription initiation from RNA polymerase II promoter  RISC-loading complex  regulation of stem cell proliferation  RNA phosphodiester bond hydrolysis, endonucleolytic  endoribonuclease activity, cleaving miRNA-paired mRNA  mRNA cleavage involved in gene silencing by siRNA  positive regulation of NIK/NF-kappaB signaling  
Ontology : EGO-EBIcondensed nuclear chromosome  P-body  RNA binding  double-stranded RNA binding  single-stranded RNA binding  endoribonuclease activity  protein binding  nucleoplasm  cytoplasm  cytosol  cytosol  mRNA catabolic process  Wnt signaling pathway, calcium modulating pathway  RNA secondary structure unwinding  RNA secondary structure unwinding  positive regulation of gene expression  negative regulation of gene expression  membrane  RISC complex  intracellular receptor signaling pathway  pre-miRNA processing  post-transcriptional gene silencing by RNA  production of miRNAs involved in gene silencing by miRNA  miRNA binding  miRNA mediated inhibition of translation  mRNA cleavage involved in gene silencing by miRNA  miRNA loading onto RISC involved in gene silencing by miRNA  cytoplasmic ribonucleoprotein granule  regulation of megakaryocyte differentiation  metal ion binding  regulation of transcription initiation from RNA polymerase II promoter  RISC-loading complex  regulation of stem cell proliferation  RNA phosphodiester bond hydrolysis, endonucleolytic  endoribonuclease activity, cleaving miRNA-paired mRNA  mRNA cleavage involved in gene silencing by siRNA  positive regulation of NIK/NF-kappaB signaling  
NDEx NetworkAGO3
Atlas of Cancer Signalling NetworkAGO3
Wikipedia pathwaysAGO3
Orthology - Evolution
OrthoDB192669
GeneTree (enSembl)ENSG00000126070
Phylogenetic Trees/Animal Genes : TreeFamAGO3
Homologs : HomoloGeneAGO3
Homology/Alignments : Family Browser (UCSC)AGO3
Gene fusions - Rearrangements
Fusion : QuiverAGO3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAGO3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AGO3
dbVarAGO3
ClinVarAGO3
MonarchAGO3
1000_GenomesAGO3 
Exome Variant ServerAGO3
GNOMAD BrowserENSG00000126070
Varsome BrowserAGO3
ACMGAGO3 variants
VarityQ9H9G7
Genomic Variants (DGV)AGO3 [DGVbeta]
DECIPHERAGO3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAGO3 
Mutations
ICGC Data PortalAGO3 
TCGA Data PortalAGO3 
Broad Tumor PortalAGO3
OASIS PortalAGO3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAGO3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DAGO3
Mutations and Diseases : HGMDAGO3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaAGO3
DgiDB (Drug Gene Interaction Database)AGO3
DoCM (Curated mutations)AGO3
CIViC (Clinical Interpretations of Variants in Cancer)AGO3
Cancer3DAGO3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607355   
Orphanet
DisGeNETAGO3
MedgenAGO3
Genetic Testing Registry AGO3
NextProtQ9H9G7 [Medical]
GENETestsAGO3
Target ValidationAGO3
Huge Navigator AGO3 [HugePedia]
ClinGenAGO3
Clinical trials, drugs, therapy
MyCancerGenomeAGO3
Protein Interactions : CTDAGO3
Pharm GKB GenePA38329
PharosQ9H9G7
Clinical trialAGO3
Miscellaneous
canSAR (ICR)AGO3
HarmonizomeAGO3
DataMed IndexAGO3
Probes
Litterature
PubMed53 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXAGO3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 14:58:49 CEST 2021

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