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AGO3 (argonaute 3, RISC catalytic component)

Identity

Alias_namesEIF2C3
eukaryotic translation initiation factor 2C, 3
argonaute RISC catalytic component 3
Alias_symbol (synonym)hAGO3
FLJ12765
Other alias
HGNC (Hugo) AGO3
LocusID (NCBI) 192669
Atlas_Id 56168
Location 1p34.3  [Link to chromosome band 1p34]
Location_base_pair Starts at 35931082 and ends at 36056462 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FRMD5 (15q15.3) / AGO3 (1p34.3)THRAP3 (1p34.3) / AGO3 (1p34.3)VRK2 (2p16.1) / AGO3 (1p34.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  THRAP3/AGO3 (1p34)
t(1;2)(p34;p16) VRK2/AGO3
t(1;15)(p34;q15) FRMD5/AGO3


External links

Nomenclature
HGNC (Hugo)AGO3   18421
Cards
Entrez_Gene (NCBI)AGO3  192669  argonaute 3, RISC catalytic component
AliasesEIF2C3
GeneCards (Weizmann)AGO3
Ensembl hg19 (Hinxton)ENSG00000126070 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000126070 [Gene_View]  ENSG00000126070 [Sequence]  chr1:35931082-36056462 [Contig_View]  AGO3 [Vega]
ICGC DataPortalENSG00000126070
TCGA cBioPortalAGO3
AceView (NCBI)AGO3
Genatlas (Paris)AGO3
WikiGenes192669
SOURCE (Princeton)AGO3
Genetics Home Reference (NIH)AGO3
Genomic and cartography
GoldenPath hg38 (UCSC)AGO3  -     chr1:35931082-36056462 +  1p34.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)AGO3  -     1p34.3   [Description]    (hg19-Feb_2009)
EnsemblAGO3 - 1p34.3 [CytoView hg19]  AGO3 - 1p34.3 [CytoView hg38]
Mapping of homologs : NCBIAGO3 [Mapview hg19]  AGO3 [Mapview hg38]
OMIM607355   
Gene and transcription
Genbank (Entrez)AA251146 AK022827 AK027796 AK292870 AK302289
RefSeq transcript (Entrez)NM_024852 NM_177422
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)AGO3
Cluster EST : UnigeneHs.657659 [ NCBI ]
CGAP (NCI)Hs.657659
Alternative Splicing GalleryENSG00000126070
Gene ExpressionAGO3 [ NCBI-GEO ]   AGO3 [ EBI - ARRAY_EXPRESS ]   AGO3 [ SEEK ]   AGO3 [ MEM ]
Gene Expression Viewer (FireBrowse)AGO3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)192669
GTEX Portal (Tissue expression)AGO3
Human Protein AtlasENSG00000126070-AGO3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H9G7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H9G7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H9G7
Splice isoforms : SwissVarQ9H9G7
PhosPhoSitePlusQ9H9G7
Domaine pattern : Prosite (Expaxy)PAZ (PS50821)    PIWI (PS50822)   
Domains : Interpro (EBI)AGO3    ArgoL1    ArgoL2    Argonaute_Mid_dom    Argonaute_N    PAZ_dom    PAZ_dom_sf    Piwi    RNaseH-like_sf    RNaseH_sf   
Domain families : Pfam (Sanger)ArgoL1 (PF08699)    ArgoL2 (PF16488)    ArgoMid (PF16487)    ArgoN (PF16486)    PAZ (PF02170)    Piwi (PF02171)   
Domain families : Pfam (NCBI)pfam08699    pfam16488    pfam16487    pfam16486    pfam02170    pfam02171   
Domain families : Smart (EMBL)DUF1785 (SM01163)  PAZ (SM00949)  Piwi (SM00950)  
Conserved Domain (NCBI)AGO3
DMDM Disease mutations192669
Blocks (Seattle)AGO3
PDB (SRS)5VM9   
PDB (PDBSum)5VM9   
PDB (IMB)5VM9   
PDB (RSDB)5VM9   
Structural Biology KnowledgeBase5VM9   
SCOP (Structural Classification of Proteins)5VM9   
CATH (Classification of proteins structures)5VM9   
SuperfamilyQ9H9G7
Human Protein Atlas [tissue]ENSG00000126070-AGO3 [tissue]
Peptide AtlasQ9H9G7
HPRD09558
IPIIPI00304181   IPI00551009   IPI00514988   
Protein Interaction databases
DIP (DOE-UCLA)Q9H9G7
IntAct (EBI)Q9H9G7
FunCoupENSG00000126070
BioGRIDAGO3
STRING (EMBL)AGO3
ZODIACAGO3
Ontologies - Pathways
QuickGOQ9H9G7
Ontology : AmiGOcondensed nuclear chromosome  P-body  RNA binding  double-stranded RNA binding  single-stranded RNA binding  endoribonuclease activity  protein binding  nucleoplasm  cytoplasm  cytosol  mRNA catabolic process  Wnt signaling pathway, calcium modulating pathway  RNA secondary structure unwinding  RNA secondary structure unwinding  positive regulation of gene expression  membrane  RISC complex  pre-miRNA processing  micro-ribonucleoprotein complex  posttranscriptional gene silencing by RNA  production of miRNAs involved in gene silencing by miRNA  miRNA binding  miRNA mediated inhibition of translation  mRNA cleavage involved in gene silencing by miRNA  miRNA loading onto RISC involved in gene silencing by miRNA  cytoplasmic ribonucleoprotein granule  regulation of megakaryocyte differentiation  RISC-loading complex  regulation of stem cell proliferation  RNA phosphodiester bond hydrolysis, endonucleolytic  endoribonuclease activity, cleaving miRNA-paired mRNA  mRNA cleavage involved in gene silencing by siRNA  positive regulation of NIK/NF-kappaB signaling  
Ontology : EGO-EBIcondensed nuclear chromosome  P-body  RNA binding  double-stranded RNA binding  single-stranded RNA binding  endoribonuclease activity  protein binding  nucleoplasm  cytoplasm  cytosol  mRNA catabolic process  Wnt signaling pathway, calcium modulating pathway  RNA secondary structure unwinding  RNA secondary structure unwinding  positive regulation of gene expression  membrane  RISC complex  pre-miRNA processing  micro-ribonucleoprotein complex  posttranscriptional gene silencing by RNA  production of miRNAs involved in gene silencing by miRNA  miRNA binding  miRNA mediated inhibition of translation  mRNA cleavage involved in gene silencing by miRNA  miRNA loading onto RISC involved in gene silencing by miRNA  cytoplasmic ribonucleoprotein granule  regulation of megakaryocyte differentiation  RISC-loading complex  regulation of stem cell proliferation  RNA phosphodiester bond hydrolysis, endonucleolytic  endoribonuclease activity, cleaving miRNA-paired mRNA  mRNA cleavage involved in gene silencing by siRNA  positive regulation of NIK/NF-kappaB signaling  
NDEx NetworkAGO3
Atlas of Cancer Signalling NetworkAGO3
Wikipedia pathwaysAGO3
Orthology - Evolution
OrthoDB192669
GeneTree (enSembl)ENSG00000126070
Phylogenetic Trees/Animal Genes : TreeFamAGO3
HOVERGENQ9H9G7
HOGENOMQ9H9G7
Homologs : HomoloGeneAGO3
Homology/Alignments : Family Browser (UCSC)AGO3
Gene fusions - Rearrangements
Fusion : QuiverAGO3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAGO3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AGO3
dbVarAGO3
ClinVarAGO3
1000_GenomesAGO3 
Exome Variant ServerAGO3
ExAC (Exome Aggregation Consortium)ENSG00000126070
GNOMAD BrowserENSG00000126070
Varsome BrowserAGO3
Genetic variants : HAPMAP192669
Genomic Variants (DGV)AGO3 [DGVbeta]
DECIPHERAGO3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAGO3 
Mutations
ICGC Data PortalAGO3 
TCGA Data PortalAGO3 
Broad Tumor PortalAGO3
OASIS PortalAGO3 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDAGO3
BioMutasearch AGO3
DgiDB (Drug Gene Interaction Database)AGO3
DoCM (Curated mutations)AGO3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)AGO3 (select a term)
intoGenAGO3
Cancer3DAGO3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607355   
Orphanet
DisGeNETAGO3
MedgenAGO3
Genetic Testing Registry AGO3
NextProtQ9H9G7 [Medical]
TSGene192669
GENETestsAGO3
Target ValidationAGO3
Huge Navigator AGO3 [HugePedia]
snp3D : Map Gene to Disease192669
BioCentury BCIQAGO3
ClinGenAGO3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD192669
Chemical/Pharm GKB GenePA38329
Clinical trialAGO3
Miscellaneous
canSAR (ICR)AGO3 (select the gene name)
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAGO3
EVEXAGO3
GoPubMedAGO3
iHOPAGO3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Aug 27 11:08:15 CEST 2018

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