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AGO4 (argonaute 4, RISC catalytic component)

Identity

Alias_namesEIF2C4
eukaryotic translation initiation factor 2C, 4
argonaute RISC catalytic component 4
Alias_symbol (synonym)hAGO4
KIAA1567
FLJ20033
Other alias
HGNC (Hugo) AGO4
LocusID (NCBI) 192670
Atlas_Id 52084
Location 1p34.3  [Link to chromosome band 1p34]
Location_base_pair Starts at 35808227 and ends at 35857889 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AGO4 (1p34.3) / AGO4 (1p34.3)AGO4 (1p34.3) / FN1 (2q35)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)AGO4   18424
Cards
Entrez_Gene (NCBI)AGO4  192670  argonaute 4, RISC catalytic component
AliasesEIF2C4
GeneCards (Weizmann)AGO4
Ensembl hg19 (Hinxton)ENSG00000134698 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000134698 [Gene_View]  ENSG00000134698 [Sequence]  chr1:35808227-35857889 [Contig_View]  AGO4 [Vega]
ICGC DataPortalENSG00000134698
TCGA cBioPortalAGO4
AceView (NCBI)AGO4
Genatlas (Paris)AGO4
WikiGenes192670
SOURCE (Princeton)AGO4
Genetics Home Reference (NIH)AGO4
Genomic and cartography
GoldenPath hg38 (UCSC)AGO4  -     chr1:35808227-35857889 +  1p34.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)AGO4  -     1p34.3   [Description]    (hg19-Feb_2009)
EnsemblAGO4 - 1p34.3 [CytoView hg19]  AGO4 - 1p34.3 [CytoView hg38]
Mapping of homologs : NCBIAGO4 [Mapview hg19]  AGO4 [Mapview hg38]
OMIM607356   
Gene and transcription
Genbank (Entrez)AB046787 AK000040 AL831908 BC152450 BG186585
RefSeq transcript (Entrez)NM_017629
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)AGO4
Cluster EST : UnigeneHs.744858 [ NCBI ]
CGAP (NCI)Hs.744858
Alternative Splicing GalleryENSG00000134698
Gene ExpressionAGO4 [ NCBI-GEO ]   AGO4 [ EBI - ARRAY_EXPRESS ]   AGO4 [ SEEK ]   AGO4 [ MEM ]
Gene Expression Viewer (FireBrowse)AGO4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)192670
GTEX Portal (Tissue expression)AGO4
Human Protein AtlasENSG00000134698-AGO4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HCK5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HCK5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HCK5
Splice isoforms : SwissVarQ9HCK5
PhosPhoSitePlusQ9HCK5
Domaine pattern : Prosite (Expaxy)PAZ (PS50821)    PIWI (PS50822)   
Domains : Interpro (EBI)AGO4    ArgoL1    ArgoL2    Argonaute_Mid_dom    Argonaute_N    PAZ_dom    PAZ_dom_sf    Piwi    RNaseH-like_sf    RNaseH_sf   
Domain families : Pfam (Sanger)ArgoL1 (PF08699)    ArgoL2 (PF16488)    ArgoMid (PF16487)    ArgoN (PF16486)    PAZ (PF02170)    Piwi (PF02171)   
Domain families : Pfam (NCBI)pfam08699    pfam16488    pfam16487    pfam16486    pfam02170    pfam02171   
Domain families : Smart (EMBL)DUF1785 (SM01163)  PAZ (SM00949)  Piwi (SM00950)  
Conserved Domain (NCBI)AGO4
DMDM Disease mutations192670
Blocks (Seattle)AGO4
SuperfamilyQ9HCK5
Human Protein Atlas [tissue]ENSG00000134698-AGO4 [tissue]
Peptide AtlasQ9HCK5
HPRD09559
IPIIPI00030602   
Protein Interaction databases
DIP (DOE-UCLA)Q9HCK5
IntAct (EBI)Q9HCK5
FunCoupENSG00000134698
BioGRIDAGO4
STRING (EMBL)AGO4
ZODIACAGO4
Ontologies - Pathways
QuickGOQ9HCK5
Ontology : AmiGOP-body  double-stranded RNA binding  single-stranded RNA binding  protein binding  nucleoplasm  cytoplasm  cytosol  cytosol  mRNA catabolic process  synaptonemal complex assembly  male meiotic nuclear division  Wnt signaling pathway, calcium modulating pathway  male gonad development  RNA secondary structure unwinding  RNA secondary structure unwinding  miRNA metabolic process  membrane  RISC complex  nuclear body  regulation of cell morphogenesis  pre-miRNA processing  micro-ribonucleoprotein complex  posttranscriptional gene silencing by RNA  production of miRNAs involved in gene silencing by miRNA  miRNA binding  miRNA mediated inhibition of translation  mRNA cleavage involved in gene silencing by miRNA  miRNA loading onto RISC involved in gene silencing by miRNA  negative regulation of apoptotic process  regulation of megakaryocyte differentiation  RISC-loading complex  mRNA cleavage involved in gene silencing by siRNA  
Ontology : EGO-EBIP-body  double-stranded RNA binding  single-stranded RNA binding  protein binding  nucleoplasm  cytoplasm  cytosol  cytosol  mRNA catabolic process  synaptonemal complex assembly  male meiotic nuclear division  Wnt signaling pathway, calcium modulating pathway  male gonad development  RNA secondary structure unwinding  RNA secondary structure unwinding  miRNA metabolic process  membrane  RISC complex  nuclear body  regulation of cell morphogenesis  pre-miRNA processing  micro-ribonucleoprotein complex  posttranscriptional gene silencing by RNA  production of miRNAs involved in gene silencing by miRNA  miRNA binding  miRNA mediated inhibition of translation  mRNA cleavage involved in gene silencing by miRNA  miRNA loading onto RISC involved in gene silencing by miRNA  negative regulation of apoptotic process  regulation of megakaryocyte differentiation  RISC-loading complex  mRNA cleavage involved in gene silencing by siRNA  
NDEx NetworkAGO4
Atlas of Cancer Signalling NetworkAGO4
Wikipedia pathwaysAGO4
Orthology - Evolution
OrthoDB192670
GeneTree (enSembl)ENSG00000134698
Phylogenetic Trees/Animal Genes : TreeFamAGO4
HOVERGENQ9HCK5
HOGENOMQ9HCK5
Homologs : HomoloGeneAGO4
Homology/Alignments : Family Browser (UCSC)AGO4
Gene fusions - Rearrangements
Fusion : QuiverAGO4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAGO4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AGO4
dbVarAGO4
ClinVarAGO4
1000_GenomesAGO4 
Exome Variant ServerAGO4
ExAC (Exome Aggregation Consortium)ENSG00000134698
GNOMAD BrowserENSG00000134698
Varsome BrowserAGO4
Genetic variants : HAPMAP192670
Genomic Variants (DGV)AGO4 [DGVbeta]
DECIPHERAGO4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAGO4 
Mutations
ICGC Data PortalAGO4 
TCGA Data PortalAGO4 
Broad Tumor PortalAGO4
OASIS PortalAGO4 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDAGO4
BioMutasearch AGO4
DgiDB (Drug Gene Interaction Database)AGO4
DoCM (Curated mutations)AGO4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)AGO4 (select a term)
intoGenAGO4
Cancer3DAGO4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607356   
Orphanet
DisGeNETAGO4
MedgenAGO4
Genetic Testing Registry AGO4
NextProtQ9HCK5 [Medical]
TSGene192670
GENETestsAGO4
Target ValidationAGO4
Huge Navigator AGO4 [HugePedia]
snp3D : Map Gene to Disease192670
BioCentury BCIQAGO4
ClinGenAGO4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD192670
Chemical/Pharm GKB GenePA38330
Clinical trialAGO4
Miscellaneous
canSAR (ICR)AGO4 (select the gene name)
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAGO4
EVEXAGO4
GoPubMedAGO4
iHOPAGO4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Aug 27 11:08:16 CEST 2018

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